• Journal of Pharmaceutical Investigation
• /
• v.25 no.1
• /
• pp.31-36
• /
• 1995

Solid dispersions and inclusion complex were prepared for the enhancement of solubility and dissolution rate of poorly water-soluble ibuprofen(IPF) as a model drug. Polyethylene glycol 4000(PEG4000) and polyvinylpyrrolidone(PVP) were used for the preparation of solid dispersion. $2-Hydroxypropyl-{\beta}-cyclodextrin(2-HP{\beta}CD)$ was also used for the preparation of inclusion complex. The solubility of IPF increased as the concentration of PEG4000, PVP and $2-HP{\beta}CD$ increased. Solubilization capacity of $2-HP{\beta}CD$ was increased about 10 times when compared to PEG 4000 and PVP. The dissolution rate of drug from solid dispersions and inclusion complex in the simulated gastric fluid was enhanced when compared to pure IPF and commercial $BR4^{\circledR}$ tablet as a result of improvement of solubility. In case of solid dispersions, dissolution rate of drug was proportional to polymer concentration in the formulation. The marked enhancement of dissolution rate of drug by inclusion complexation with $2-HP{\beta}CD$ was noted. However, dissolution rate of drug from solid dispersions and inclusion complex in the simulated intestinal fluid was not significant because IPF was readily soluble in that condition. From these findings, water-soluble polymers and cyclodextrin were useful to improve solubility and dissolution rate of poorly water-soluble drugs. However, easiness and reliability of preparation method, scale-up and cost of raw materials must be considered for the practical application of solid dispersion and inclusion complex in pharmaceutical industry.

• Bulletin of the Korean Chemical Society
• /
• v.35 no.7
• /
• pp.1939-1943
• /
• 2014

Solid dispersion (SD) system of everolimus (EVR) with Gelucire 50/13 (Stearoyl polyoxyl-32 glycerides) was prepared using melt granulation technique with the aim of improving the physicochemical properties and dissolution rate. The solid state characterization using scanning electron microscopy and X-ray powder diffraction, indicated that the drug was homogeneously distributed in the surfactant carrier in a stable amorphous form. The dissolution rate of EVR from the optimized SD composed of the drug, Gelucire 50/13 and microcrystalline cellulose in a weight ratio of 1:5:10, was markedly rapid and higher than that from the drug powder and the market product (Afinitor$^{(R)}$, Novartis Pharmaceuticals) in all dissolution mediums tested from pH 3.0 to pH 6.8. The results of this study suggest that formulation of SD with Gelucire 50/13 using melt granulation procedure may be a simple and promising approach for improving the dissolution rate and oral absorption of the anti-cancer agent without the need for using an organic solvent.

• Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
• /
• 1999.11a
• /
• pp.219-224
• /
• 1999

The effects of solid lubricants on wear and friction characteristics of friction materials were studied using a pad-on-disk type friction tester. Friction materials with ten formulations containing different relative amounts of solid lubricants(graphite, MoS$_2$and Sb$_2$S$_3$) were investigated. Results of this work showed that each formulation with different relative amounts of the lubricants had unique friction characteristics. At low brake temperatures, friction materials containing rich graphite showed a small amount of $\mu$ change during sliding. At elevated temperatures, on the other hand, friction materials with rich Sb$_2$S$_3$and graphite showed smaller $\mu$ changes suggesting complementary lubrication of Sb$_2$S$_3$and graphite during sliding. However, the friction materials with rich Sb$_2$S$_3$showed a large amount of wear.

• Journal of the Korean Society of Propulsion Engineers
• /
• v.26 no.1
• /
• pp.12-19
• /
• 2022

The propellants used in the gas generator of the ducted rocket are fuel-rich propellants, which contain an excessive amount of metal fuel and a small amount of oxidizing agent compared to general solid rocket propellants. In this paper, boron powder and MgAl(Magnesium-Aluminium alloy) were applied to produce fuel-rich propellants. The optimum formulation was determined by characterizing these metal fuel-rich propellants. Analysis of combustion products in the gas generators confirmed that the fuel-rich propellants containing fine boron powder itself instead of boron-bead could be useful in gas generators.

• Journal of Pharmaceutical Investigation
• /
• v.32 no.4
• /
• pp.299-303
• /
• 2002

The oral bioavailability of itraconazole is variable and low in fasting state. This is mainly due to the low solubility of this drug. Bioavailability can be improved by changing the formulation and it is general that the liquid preparations show greater bioavailability than the solid dosage forms such as tablets and capsules do. Benzyl alcohol-water binary mixture showed the excellent solubilizing capacity for itraconazole but the release of the drug from the preparation needs to be enhanced. In this study, various nonionic surfactants and hydrophilic polymers, poloxamers, were screened to investigate their effects on the releasε of itraconazole from the liquid preparations. Poloxamer 407 showed the most enhancing effect on the drug release and the release rate was proportional to thε amount of poloxamer 407 added. A liquid preparation of itraconazole, consisting of benzyl alcohol/water/poloxamer 407 ternary solvent system, releasεd more than 80% of the total drug amount at 5 min and showεd the possibility of a new formulation development.

• Proceedings of the Plant Resources Society of Korea Conference
• /
• 2018.04a
• /
• pp.71-71
• /
• 2018

The aim of this study was to prepare a new functional food with enriched bioactive compound by the combination of Tartary buckwheat and bean flour mixes. Two types of bean such as: black bean and white bean with the ratio of 5, 10, 15 % were used to develope a food formulation. The solid formulation of functional food was prepared by the hot melt extrusion process (HME) at the temperature of 60, 90, $120^{\circ}C$. Total phenolic content (TPC), total flavonoid (TF) and DPPH were analysed of the prepared food by the use of spectrophotometer. Results demonstrated that TPC (254 mg/g), TF (18.22 mg/g) and DPPH (88%) were significanlty increased in the receipe of 10% black bean and 90% Tartary buckwheat mixes among the formulation at $90^{\circ}C$. As therefore, it is concluded that the optimum ratio of bean and Tartary buckwheat flour mixes should be considerd for the preparation of high quality functional food.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.39 no.5
• /
• pp.415-423
• /
• 2015

In this study, we present a grid refinement model in the lattice Boltzmann method (LBM) for two-dimensional incompressible fluid flow. That is, the model combines the desirable features of the lattice Boltzmann method and stream function-vorticity formulations. In order to obtain an accurate result, very fine grid (or lattice) is required near the solid boundary. Therefore, the grid refinement model is used in the lattice Boltzmann method for stream function-vorticity formulation. This approach is more efficient in that it can obtain the same accurate solution as that in single-block approach even if few lattices are used for computation. In order to validate the grid refinement approach for the stream function-vorticity formulation, the numerical simulations of lid-driven cavity flows were performed and good results were obtained.

• Transactions of the Korean Society of Mechanical Engineers
• /
• v.16 no.7
• /
• pp.1314-1321
• /
• 1992

In analyzing the plastic flow of axisymmetric tube extrusion a new method of formulation using the stream function approach and upper-bound theorem is proposed which permits the prediction of plastically deformed zone in analytic expression as well as metal flow. It is shown that the formulation proposed in this work covers the solid extrusion and tube extrusion in axisymmetric case. The effect of some process parameters such as area reduction, the ratio of radii(inner radius to outer radius) and friction factor on extrusion pressure, deformation zone and plastic flow through stream-lined dies has been studied. The presented theoretical analysis can be effectively used for the prediction of deformation zone and plastic flow.

• Proceedings of the Korean Geotechical Society Conference
• /
• 2010.09a
• /
• pp.808-812
• /
• 2010

A great deal of attention is focused on coupled Thermo-Hydro-Mechanical (THM) behavior of multiphase porous media in diverse geo-mechanical and geo-environmental areas. This paper presents general governing equations for coupled THM processes in unsaturated porous media. Coupled partial differential equations are derived from 3 mass balances equations (solid, water, and air), energy balance equation, and force equilibrium equation. Finite element code is developed from the Galerkin formulation and time integration of these governing equations for 4 main variables (displacement $\underline{u}$, gas pressure $P_g$, liquid pressure $P_l$), and temperature T). The code is validated with theoretical solutions for linear material with simple boundary conditions.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.33 no.3
• /
• pp.170-177
• /
• 2009

In the present study, a finite element analysis of conjugate heat transfer problem inside a cavity with a heat-generating conducting body, where constant heat flux is generated, is conducted. A conduction heat transfer problem inside the solid body is automatically coupled with natural convection inside the cavity by using a finite element formulation. A finite element formulation based on SIMPLE type algorithm is adopted for the solution of the incompressible Navier-Stokes equations coupled with energy equation. The proposed algorithm is verified by solving the benchmark problem of conjugate heat transfer inside a cavity having a centered body. Then a conjugate natural heat transfer problem inside a cavity having a heat-generating conducting body with constant heat flux is solved and the effect of the Rayleigh number on the heat transfer characteristics inside a cavity is investigated.