• Title/Summary/Keyword: Solid Circulation

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Solid Cultivation of Fibrinolytic Enzyme (Bacillokinase) from Bacilis subtilis BK-17 (Bacillus subtilis BK-17 유래 혈전용해효소(Bacillokinase)의 고체배양)

  • Jeong, Yong-Kee;Beak, Hyun;Seo, Min-Jeong;Kim, Min-Jeong;Lee, Hye-Hyeon;Joo, Woo-Hong;Kim, Jeong-In;Choi, Yung-Hyun;Chung, Kyung-Tae
    • Journal of Life Science
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    • v.19 no.10
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    • pp.1478-1483
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    • 2009
  • A solid-state culture based on grain materials was attempted to produce a fibrinolytic enzyme for blood circulation improvement using Bacillus subtilis BK-17. The spore, rather than vegetative cell inoculation, of B. subtilis BK-17 on the solid-state culture was effective in the production of a fibrinolytic enzyme. Maximum spore production was obtained with a SFM medium (0.8% nutrient broth, 0.05% yeast extract, $10^{-1}$ M $MgCl_2$, $10^{-3}$ M $FeCl_3$, $10^{-4}$ $MnCl_2$, $10^{-5}$ M dipicolic acid, pH 6.5). Optimal pH and temperature were pH 6 and $30^{\circ}C$, respectively. The spore production reached a maximum at 60 hours of incubation. Bacillus subtilis BK-17 on the mung bean solid-state culture produced greater fibrinolytic activity, and less activity was seen in other grains such as kidney bean, soybean and corn. Protein and lipid contents of fermented soybeans were about 10 - 30% more than those of unfermented soybeans. Amino acid content was also 5 - 20% more than that of unfermented soybeans. These results indicated that fermented solid-state culture medium, fermented soybean in this case, can be utilized as a food supplement.

Riser Design Approach for Particle-Circulation-Type Heat Exchangers (입자 순환식 열교환기의 상승관 설계방법)

  • Jun Yong-Du
    • Proceedings of the KSME Conference
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    • 2002.08a
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    • pp.311-312
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    • 2002
  • In this paper a systematic design approach to determine the optimum size (height) of circulating fluidized bed heat exchanger for exhaust gas heat recovery is prososed. Unlike the convensional heat exchangers where the length of the heat exchanger section is not very much emphasized, the vertical length of heat exchanger tube in the case of fluidized bed heat exchangers is important because this length determines the time interval during which particles reside and transfer heat in the heat exchanger section. For particles initial conditions are nearly stationary, accelerating particles motion should be considered rather than simply assuming fully developed condition. A way to estimate optimum tube length at different fluid velocity and particle sizes is suggested based on the required conditioning time for heat transfer from the flue gas to solid particles.

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Tumour Lysis Syndrome: Implications for Cancer Therapy

  • Mika, Denish;Ahmad, Sabrina;Guruvayoorappan, C.
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.8
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    • pp.3555-3560
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    • 2012
  • The tumour lysis syndrome (TLS) is a group of metabolic abnormalities caused by rapid and unexpected release of cellular components into the circulation as a result of massive destruction of rapidly proliferating malignant cells. It usually develops in patients with hematologic malignancies like acute lymphoid leukemia, non-Hodgkin and Burkitt's lymphoma after initiation of chemotherapy or may, rarely, occur spontaneously. Though TLS is seldom observed in relation to solid tumours, there have been reports of connections with examples such as lung, liver, breast, gastric carcinomas. The clinical manifestations of TLS include hyperuricemia, hyperkalemia, hyperphosphatemia and hypocalcemia. These indications if untreated lead to life-threatening complications such as acute renal failure, cardiac arrhythmias, seizures, and eventually death due to multiorgan failure. Therefore early detection of TLS is of vital importance. This can be accomplished by identification of high risk patients, implementation of suitable prophylactic measures andmonitoring of the electrolyte levels in patients undergoing chemotherapy.

Dielectric Breakdown Voltage According to Flow Velocity and Temperature of Vegetable Oils (식물성절연유의 유동속도와 온도에 따른 절연파괴전압)

  • Choi, Sun-Ho;Huh, Chang-Su
    • The Transactions of The Korean Institute of Electrical Engineers
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    • v.61 no.6
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    • pp.821-826
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    • 2012
  • The streaming electrification process of vegetable insulating oils occurring when the oils contacted with solid material in a high power transformer circulation system seems to cause electrical discharge incidents and may cause failures. We therefore measured the dielectric breakdown voltage tendency of vegetable insulating oils flowing on the surface of the charging device with various velocity and temperature. First, the relation between the velocity and breakdown voltage tendency of vegetable oils, can be explained by volume effect and v-t effect. Second, experimental results show that applied voltage have little effect on dielectric breakdown voltage, when vegetable insulating oils used for large power transformer.

Numerical Simulation of External Gear Pump Using Immersed Solid Method (Immersed Solid Method 를 이용한 외접형 기어 펌프의 수치해석)

  • Yoon, Yong Han;Park, Byung Ho;Han, Yong Oun;Hong, Byeong Joo;Shim, Jaesool
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.38 no.1
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    • pp.95-101
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    • 2014
  • In this study, an ISM (immersed solid method) was used for investigating the mass flow rate and efficiency of an involute-gear pump featuring very high rotational speed. For considering circulation flow at the gear pump and housing, fluid flow was assumed as turbulent, and the rotational speed of the gear pump increased under the condition of constant pressure at both the inlet and outlet. The efficiency and mass flow rate of the gear pump were studied by varying its rotational speed and the clearance between the gear tip and the housing. In the simulation results, as the rotational speed were increased, the average mass flow rate and efficiency increased. Furthermore, as the clearance between the gear tip and the housing was increased, the average mass flow rate and efficiency decreased. The efficiency was 85.11, 90.94, and 93.62 at rotational speeds of 6,000 rpm, 8,000 rpm, and 10,000 rpm, respectively, under the condition that there was no clearance. In addition, the efficiency was 93.62, 93.29, and 92.74 at clearances of 0 m, 0.00001 m, and 0.00003 m respectively.

A Study on the physiological characteristics of Eight Extra Meridians - Focused on the interpretation of "There are Eight Extra Meridians and they don't be arrested by Twelve Regular Meridians" in Nanjing 27Nan - (기경팔맥(奇經八脈)의 생리적 특성에 대한 고찰 -『난경(難經)·이십칠난(二十七難)』"맥유기경팔맥자(脈有奇經八脈者), 부구어이십경(不拘於十二經)"에 대한 해석을 중심으로-)

  • Lyu, Jeong-Ah;Jeong, Chang-Hyun
    • Journal of Korean Medical classics
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    • v.26 no.4
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    • pp.71-87
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    • 2013
  • Subject : The physiological characteristic of Eight Extra Meridians. Objective : This study research physiological characteristic of Eight Extra Meridians that differentiate from the physiological characteristic of Twelve Regular Meridians. Method : First, we researched the meaning of "There are Eight Extra Meridians and they don't be arrested by Twelve Regular Meridians" in Nanjing 27Nan compared with the contents of regular Meridians circulation in Huangdineijing. Second, we studied on the origin of Eight Extra Meridians and researched their route. Third, from these researches we drew some physiological characteristics of Eight Extra Meridians. Conclusion : In Huangdineijing, the regular Meridians circulation include the route of Governor Meridian, Conception Meridian, and Heel Meridian. So the sentence in Nanjing 27Nan is contradictory to the contents of Huangdineijing. The origin of Eight Extra Meridians could be found in Huangdineijing. The collateral Meridians of the Uterus and Epiglottis Meridian are specifically formulated to supplying for the Uterus or Epiglottis. Eight Extra Meridians have third qualities of Meridian, collateral Meridian, and the solid viscera keep the Essence Gi, so named 'Extra'. And they have an intimate association with Extraordinary Organs. They place at the middle axis of human body, thus do higher physiological function that control and regulate the function of Twelve Regular Meridians and Five Viscera & six Bowels for adaptation to the environment.

Free Vascularized Fibular Transfer with Double Barrel Fashion (혈관부착 생비골 중첩 이식술)

  • Chung, Duke-Whan
    • Archives of Reconstructive Microsurgery
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    • v.7 no.1
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    • pp.54-61
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    • 1998
  • Free vascularized fibular is the most usuful bony donor of the long bone reconstruction in reconstructive microsurgical field. It has many benifits such as very strong strut tubular bone, very reliable vascular anatomy with large vascular diameter with long pedicle, minimal donor site morbity too. In that situations of the huge long bone defects in distal femur or proximal tibia, the defective bony shape and strength of the transplanted fibular bone is not enough if only one strut of the fibula is transfered. The bony circulation of the fibula has two ways, one from nutrient artery via peroneal artery through nutrient foramen which makes endosteal arterial network inside of the fibula, another way is periosteal network through outside encircling vascular network of the bone which distributed in muscle sleeves of the fibular diaphysis. Authors modified free vascularized fibular bone graft with transverse osteotomy is made from the anterolateral aspect of the fibular shaft just distal to entry of the nutrient artery. This produces two vascularized bone struts that may be folded pararell to each other but that remain connected by the periosteum and muscle cuff surrounding the peroneal artery and veins. The proximal strut is vascularized by both a periosteal and endosteal blood supply, whereas the distal strut is vascularized by a periosteal blood supply alone. This procedure can call "doule barrel" free vascularized fibular graft. We performed 7 cases of doule barrel fashined fibular transplantation on distal femur and proximal tibial large defects. Average bone union time takes 7 months from that procedure. There were no significant bone union time differences between both proximal and distal struts. After solid union of the transfered double barrel fibular graft, there were no stress fracture in our series. We can propose double barrel free vascualized fibular graft is usuful method in that cases with very large bone defect on large long bones especially metaphyseal defects.

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A Model on a Bubbling Fluidized Bed Process for CO2 Capture from Flue Gas (연소기체로부터 CO2를 포집하는 기포 유동층 공정에 관한 모델)

  • Choi, Jeong-Hoo;Youn, Pil-Sang;Kim, Ki-Chan;Yi, Chang-Keun;Jo, Sung-Ho;Ryu, Ho-Jung;Park, Young-Cheol
    • Korean Chemical Engineering Research
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    • v.50 no.3
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    • pp.516-521
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    • 2012
  • This study developed a simple model to investigate effects of important operating parameters on performance of a bubbling-bed adsorber and regenerator system collecting $CO_2$ from flue gas. The chemical reaction rate was used with mean particles residence time of a reactor to determine the extent of conversion in both adsorber and regenerator reactors. Effects of process parameters - temperature, gas velocity, solid circulation rate, moisture content of feed gas - on $CO_2$ capture efficiency were investigated in a laboratory scale process. The $CO_2$ capture efficiency decreased with increasing temperature or gas velocity of the adsorber. However, it increased with increasing the moisture content of the flue gas or the regenerator temperature. The calculated $CO_2$ capture efficiency agreed to the measured value reasonably well. However the present model did not agree well to the effect of the solid circulation rate on $CO_2$ capture efficiency. Better understanding on contact efficiency between gas and particles was needed to interpret the effect properly.

Physical Properties of Soils under the Grass Block Porous Pavements (투수성 잔디블록 포장 하부 토양의 물리성)

  • Han, Seung-Ho;Kim, Won-Tae;Kang, Jin-Hyoung
    • Journal of the Korean Institute of Landscape Architecture
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    • v.34 no.4 s.117
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    • pp.96-104
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    • 2006
  • Impervious pavement is primary contributor to the malfunctioning of the urban water circulation system. The aim of this research is to provide basic information and data for new pavement materials and paving technology which could enhance the urban water circulation system. For the study purposes, physical properties of soils sampled from 16 stations were analyzed. The sampling spots were paved with grass block porous pavement material. The findings from the analysis are as follows. The hardness of soils under the pavement was $17{\sim}22mm$ for thoroughfare and $6{\sim}32mm$ for parking areas. The bulk density was $1.42{\sim}1.81g/cm^{3}$ for thoroughfare and $1.38{\sim}1.75g/cm^{3}$ for parking area. The solid phase ration was $46.9{\sim}62.5m^{3}/m^{3}$ for thoroughfare and $45.6{\sim}61.3m^{3}/m^{3}$ for parking area. The porosity was $37.5{\sim}53.1m^{3}/m^{3}$ for thoroughfare and $38.7{\sim}54.4m^{3}/m^{3}$ for parking area. The saturated hydraulic conductivity was $8{\sim}164mm/hr$ for thoroughfare and $14{\sim}201mm/hr$ for parking area. The saturated hydraulic conductivity of the H sample area (the area was completed three months ago) and that of the other area were compared. There was up to 80% decreases of the saturated hydraulic conductivity within one year after the completion of pavement. After the first year, decrease in the saturated hydraulic conductivity was modest. Also there are changes in both surface and under soil physical properties of the grass block porous pavement depending on compaction. The extent of change depends on the degree of compaction. All these factors are combined to influence the permeability of the soil under the pavements. The results of this suggest that it is required to develop a new pavement technology which ensures both the durability and porosity of the pavement to improve the water circulation system by applying Ecological Area Rate.

Development and Cost-effective Evaluation of Grass Blocks Minimizing Construction Waste (건설폐기물을 최소화한 비용 효율적 잔디 블록 기법 개발 및 평가)

  • Jeon, Minsu;Hong, Jungsun;Jeon, Jechan;Kim, Lee-Hyung
    • Journal of Wetlands Research
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    • v.19 no.3
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    • pp.359-365
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    • 2017
  • Impermeable surfaces such as transportation land uses including roads and parking lots accumulate high heavy metals and particulate matters concentration especially during dry season which worsens the river water quality and distort the water circulation system during rainfall events. Recently, the government has been promoting policies to install Low Impact Development (LID) facilities such as permeable pavements or grass blocks in parking lots or pavements. However, transition of asphalt-paved surfaces to permeable pavement generated asphalt wastes which are detrimental to the environment and has cost implications due to its removal and disposal. Therefore this study was conducted to provide a method of constructing a cost-effective permeable pavement to reduce waste generation and cost. In this study, comparative analysis of the water circulation capacity and economic efficiency of the traditional construction method and new method proposed in this study through the lab-scale experiment. The proposed method was to make holes in existing asphalt pavements, layout geotextile fabric and permeable base media such as sand before compaction. After compaction, layout grass blocks on the compacted base media then layout sand in between each grass blocks before compaction. Apparently, there was no significant difference between the traditional installation method of permeable pavement and the proposed method in this study considering surface runoff, infiltrated volume, stored volume, and rainfall-runoff delay time. The proposed method in this study generated 86% less wastes compared to the traditional installation method and has 70% cost reduction considering asphalt removal and disposal. The construction method proposed in this study yielded similar performance compared to the traditional installation method and water circulation effect, but was proven to be less complicated and economical.