• BMB Reports
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• 제55권3호
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• pp.148-153
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• 2022

Etoposide is a chemotherapeutic medication used to treat various types of cancer, including breast cancer. It is established that pulsed electromagnetic field (PEMF) therapy can enhance the effects of anti-cancer chemotherapeutic agents. In this study, we investigated whether PEMFs influence the anti-cancer effects of etoposide in MCF-7 cells and determined the signal pathways affected by PEMFs. We observed that co-treatment with etoposide and PEMFs led to a decrease in viable cells compared with cells solely treated with etoposide. PEMFs elevated the etoposide-induced PARP cleavage and caspase-7/9 activation and enhanced the etoposide-induced down-regulation of survivin and up-regulation of Bax. PEMF also increased the etoposide-induced activation of DNA damage-related molecules. In addition, the reactive oxygen species (ROS) level was slightly elevated during etoposide treatment and significantly increased during co-treatment with etoposide and PEMF. Moreover, treatment with ROS scavenger restored the PEMF-induced decrease in cell viability in etoposide-treated MCF-7 cells. These results combined indicate that PEMFs enhance etoposide-induced cell death by increasing ROS induction-DNA damage-caspase-dependent apoptosis.

• 한국정보시스템학회지:정보시스템연구
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• 제6권2호
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• pp.85-105
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• 1997

The objective of this research is to construct and build a software platform to enable collaboration among enterprise headquarters, product designers, software engineers, manufacturing plants, and suppliers which are locate at different remote locations via internet. In specific, agent technology is adopted as a software vehicle to automate demand and supply process in the internet environment. Agents are programs that act on behalf of their human users to perform laborious tasks such as information locating, accessing, filtering, integrating, adapting and resolving inconsistencies. Global competion is forcing the present day industry to produce high quality product more fast and inexpensively. In Korea, most labor-intensive industries have moved to China and other Asian countries for cost reduction. The need for fast information exchange has increased among the remote locations for the cooperation and coordination. In this research, a virtual global purchasing and ordering system will be constructured that distributes production schedule among remote places, acts as a bridge between the headquarters and manufacturing plants, distributes tasks and collates different solutions between demand and supply using agent. The external communication protocol takes HTML format, internal message handling requires SGML for document exchange, and KQML for agent implementation. The expected benefits will be : reduced cost of real-time information exchange, realization of global manufacturing environment, the maximum utilization of internet for the enterprise data exchange.

• 한국정보처리학회논문지
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• 제6권9호
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• pp.2493-2503
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• 1999

여러 통신망을 총괄적이고 효율적으로 운용하고자 출현한 TMN(Telecommunication Management Network)은 구축과정에서 서로 다른 하드웨어와 운영체제 등의 상이한 플랫폼 환경 하에서 개발되는 분산객체 내 클래스의 개발 및 유지보수에 여러 문제점을 내포하게 된다. 대표적인 문제점으로는 TMN 시스템 내의 모든 에이전트들이 동일한 기능을 수행하는 소프트웨어 및 데이터 블록들을 중복하여 유지해야 한다는 점을 들 수 있다. 이로 인하여 TMN 에이전트의 개발에 있어 다중 플랫폼을 지원할 수 없게 된다. 이러한 문제들을 해결하기 위하여 Farmer 모델에 기본을 둔 Farming 방법론을 제안하였다. Farming 방법론은 각각의 분산객체에 중복되어 저장되어 있는 소프트웨어 및 데이터 컴포넌트들을 플랫폼에 독립적인 컴포넌트웨어 형태로 변형하여 플랫폼독립형 클래스저장소(PICR)에 저장시켜 놓은 후 각 분산객체내의 프레임워크에 명시된 대로 실행에 필요한 컴포넌트웨어들을 PICR에서 정적 또는 동적으로 로딩하여 사용하는 것이다. Farmer 모델을 이용하여 개인휴대통신망의 분산 TMN 에이전트를 디자인하고 구현하였다.

• 한국정보과학회논문지:컴퓨팅의 실제 및 레터
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• 제5권6호
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• pp.727-737
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• 1999

프로세스 중심 소프트웨어 개발 환경(PSEE : Process-centered Software Engineering Environment)은 소프트웨어 개발자를 위한 여러가지 정보의 제공과 타스크의 수행, 소프트웨어 개발 도구의 수행 및 제어, 필수적인 규칙이나 업무의 수행등과 같은 다양한 행위를 제공하는 프로세스 모형의 수행을 통하여 소프트웨어 개발 행위를 지원한다. SEED(Software Engineering Environment for Development)는 효율적인 소프트웨어 개발과 프로세스 모형의 수행을 제어하기 위해 ETRI에서 개발된 PSEE이다.본 논문에서는 SEED에서 프로세스 모형을 설계하기 위해 사용되는 SimFlex 프로세스 프로그래밍 언어와, 수행지원시스템인 SEED Engine의 구현에 대하여 기술한다. SimFlex는 간단한 언어 구조를 가진 프로세스 프로그래밍 언어이며, 적절한 적합화를 통하여 다른 PSEE에서 사용될 수 있다. SimFlex 컴파일러는 SimFlex에 의해 기술된 프로세스 모형을 분석하고, 모형의 오류를 검사하며, SEED Engine에 의해 참조되는 중간 프로세스 모형을 생성한다. 중간 프로세스 모형을 사용하여 SEED Engine은 외부 모니터링 도구와 연관하여 사용자를 위한 유용한 정보뿐만 아니라 SimFlex에 의해 기술된 프로세스 모형의 자동적인 수행을 제공한다. SimFlex 언어와 수행지원 시스템의 지원을 통하여 소프트웨어 프로세스를 모형화하는데 드는 비용과 시간을 줄일 수 있으며, 편리하게 프로젝트를 관리하여 양질의 소프트웨어 생산물을 도출할 수 있다. Abstract Process-centered Software Engineering Environments(PSEEs) support software development activities through the enaction of process models, providing a variety of activities such as supply of various information for software developers, automation of routine tasks, invocation and control of software development tools, and enforcement of mandatory rules and practices. The SEED(Software Engineering Environment for Development) system is a PSEE which was developed for effective software process development and controlling the enactment of process models by ETRI.In this paper, we describe the implementation of the SimFlex process programming language used to design process models in SEED, and its runtime support system called by SEED Engine. SimFlex is a software process programming language to describe process models with simple language constructs, and it could be embedded into other PSEEs through appropriate customization. The SimFlex compiler analyzes process models described by SimFlex, check errors in the models, and produce intermediate process models referenced by the SEED Engine. Using the intermediate process models, the SEED Engine provides automatic enactment of the process models described by SimFlex as well as useful information for agents linked to the external monitoring tool. With the help of the SimFlex language and its runtime support system, we can reduce cost and time in modeling software processes and perform convenient project management, producing well-qualified software products.

• The Journal of Asian Finance, Economics and Business
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• 제7권12호
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• pp.959-968
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• 2020

Tourist loyalty is created through good tourism service quality and the availability of tourism products. This study discussed the various attributes of tourism service quality, namely, tour agents, efficient personnel, accessible transportation, and information service quality. Whereas for tourism product availability attributes were varieties of product availability, wide selection of tour agents and tourist products, and wide variety of amenity services. As a general rule, the minimum is to have at least five times as many observations as the number of variables to be analyzed, and the more acceptable sample size would have a 10:1 ratio. A total of 424 questionnaires were returned, with 35 removed due to errors. Finally, 389 questionnaires respondents were used via accidental sampling method through the distribution of questionnaires to foreign tourists at Soekarno Hatta International Airport. In addition, AMOS 7.0 software is used to test models in confirmatory factor analysis (CFA) as well as hypothetical testing using structural equation modeling (SEM). The results showed that all hypotheses were accepted, except for the effect of tourism service quality on tourist loyalty in Indonesia. This research aims to contribute significantly to the existing knowledge of tourism, specifically from a foreign tourist perspective in Indonesia.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2004년도 ICCAS
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• pp.879-884
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• 2004

This paper describes the development of a synthetic multi-agent called KMITL Cadence 2003. KMITL Cadence 2003 is a robotic soccer simulation team consisting of eleven autonomous software agents. Each agent operates in a physical soccer simulation model called Robocup Soccer Server which provides fully distributed and real-time multi-agent system environment. All teammates have to cooperate to achieve the common goal of winning the game. The simulation models many aspects of the football field such as noise in ball movements, noisy sensors, unreliable communication channel between teammates and actuators, limited physical abilities and restricted communication. This paper addresses the algorithm to develop the soccer agents to perform basic actions which are scoring, passing ball and blocking the opponents effectively. The result of this development is satisfactory because the successful scoring attempts is increased from 11.1% to 33.3%, successful passing ball attempts is increased from 22.08% to 63.64%, and also, successful intercepting attempts is increased from 88% to 97.73%.

• 한국산학기술학회:학술대회논문집
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• 한국산학기술학회 2012년도 춘계학술논문집 1부
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• pp.182-186
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• 2012

human tyrosinase (hTyr) catalyzes first and the rate limiting step in the synthesis of polymerized pigment, melanin which determines skin, hair and eye colors. Mutation of hTyr often brings about decrease of melanin production and further albinism. Meanwhile, a number of cosmetic companies providing skincare products for woman in Asia-Pacific region have tried to develop inhibitors to bright skin color for several decades. In this study, we built a 3D structure by comparative modeling technique based on the crystal structure of tyrosinase from bacillus megaterium as a template to serve structural information of hTyr. According to our model and sequence analysis of type 3 copper protein family proteins, two copper atoms of active site located deep inside are coordinated with six strictly conserved histidine residues coming from four-helix-bundle. Cavity which accommodates substrates was like funnel shape of which entrance was wide and expose to solvent. In addition, protein-substrate and protein-inhibitor complex were modeled with the guide of van der waals surface generated by in house software. Our model suggested that only phenol group or its analogs can fill the binding site near nuclear copper center because inside of binding site has narrow shape relatively. In conclusion, the results of this study may provide helpful information for designing and screening new anti-melanogensis agents.

• 한국방송∙미디어공학회:학술대회논문집
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• 한국방송공학회 2002년도 정기총회 및 학술대회
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• pp.243-246
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• 2002

지능형 방송 서비스는 시청자의 방송 프로그램 선호도 및 프로그램 관련 정보를 기반으로, 사용자가 원하는 방송 프로그램을, 원하는 때에 원하는 형태의 프로그램으로 제공하는, 새로운 방송 환경을 의미한다. 이러한 지능형 방송은 맞춤형 방송 또는 personal casting 방송환경을 제공하며, 미래의 사용자 중심의 방송에 근간으로 자리잡을 것이다. 본 논문에서는 소프트웨어 에이전트 국제표준화 단체인 FIPA(foundation fur Intelligent Physical Agents)의 에이전트 프레임워크를 이용하여 에이전트 기반 개인형 맞춤 및 지능형 멀티미디어 방송 프레임워크 구축에 대한 연구 결과를 제안한다. 방송프로그램 서버 에이전트와 사용자 단말 에이전트 사이의 통신(메시지 교환)은 FIPA 에이전트 통신 언어인 Agent Communication Language를 이용하였으며 사용자 취항 정보는 MPEG-7 MDS(Multimedia Description Schemes)의 사용자 선호도 기술구조(user preference description scheme)를 따랐다.

• 한국시뮬레이션학회논문지
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• 제12권4호
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• pp.25-40
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• 2003

With the growing usage of the networks, the world-wide Internet has become the main means to exchange data and carry out transactions. It has also become the main means to attack hosts. To solve the security problems which occur in the network such as Internet, we import software products of network security elements like an IDS (Intrusion Detection System) and a firewall. In this paper, we have designed and constructed the general simulation environment of network security model composed of multiple IDSes and a firewall which coordinate by CNP (Contract Net Protocol) for the effective detection of the intrusion. The CNP, the methodology for efficient integration of computer systems on heterogeneous environment such as distributed systems, is essentially a collection of agents, which cooperate to resolve a problem. Command console in the CNP is a manager who controls the execution of agents or a contractee, who performs intrusion detection. In the network security model, each model of simulation environment is hierarchically designed by DEVS(Discrete Event system Specification) formalism. The purpose of this simulation is that the application of rete pattern-matching algorithm speeds up the inference cycle phases of the intrusion detection expert system and we evaluate the characteristics and performance of CNP architecture with rete pattern-matching algorithm.

• 한국정보과학회논문지:소프트웨어및응용
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• 제31권2호
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• pp.101-110
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• 2004

사회시스템이나 경제시스템 같이 동적으로 변하는 시스템에서는 그 구성원들 간에 복잡한 상호작용(행동)이 나타나게 되는데 구성원들의 행동은 변화하는 환경에 따라 적응하는 경향을 보인다. 그리고 이들의 행동양상은 흔히 생물학 분야의 조건반사에 비유되기도 한다. 본 논문에서는 복잡한 사회 현상을 모델링하고 분석하기 위하여 반복적 죄수의 딜레마 게임 상에서 에이전트들의 전략적 연합을 통하여 변화하는 환경에 잘 적응하는 일반화 능력이 우수한 에이전트들을 자동 생성하는 방법을 제안한다. 또한 에이전트에 신뢰도를 부여하여 연하의 의사결정에 참가하게 함으로써 일반화 성능을 향상시키는 방법을 소개한다 실험결과, 전략적 연합을 이용하여 진화된 에이전트들은 테스트 에이전트들에 비하여 일반화 성능이 우수함을 확인할 수 있었다.