• Proceedings of the Korean Magnestics Society Conference
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• 2004.06a
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• pp.202-203
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• 2004

• Archives of Pharmacal Research
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• v.18 no.6
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• pp.385-390
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• 1995

The analytical methods for the analysis of cyclosporine (CsA), a fluorescence polarization immunoassay (FPIA) and HPLC method, were compared in a pharmacokinetic study of two CsA soft capsule formultaions ($Sandimmun^{\circledR}$; Sandoz, $Implanta^{\circledR}$; Hanmi). Sixteen healthy volunteers completed the study and each subjected single doses ($4{\tiems}100$ mg) of the test and the reference formulations in a two-way crossover design with a one-week drug-free interval between doses. Following each administration, whole blood concentrations of CsA were monitored over a period of 24 hour by both FPIA and HPLC methods. Blood concentrations nad pharmacokinetic parameters determined by either analytical method showed large intersubject variation, with the FPIA data showing relatively higher magnitude of intersubjecte variation than the HPLC data. The blood concentrations determined by FPIA were 1.1-1.3 times higher than those determined by HPLC. There were strong and significant correlations between the two methods (r>0.83 : p<0.0001). Intersubuject variation for the $AUC_{inf}{\;}and{\;}AUC_{24hr}$ of the test formulation was slightly reduced without statistical significance (paried -t test : p>0.05 $t_{max}$ was earlier nad $C_{max}$ was slightly lower for the test formulation, $AUC_{24h}, {\;}C_{max}, {\;}T_{max}$ and MRT determined separately from the data obtained by the two methods for the two formulations were examined by analyses of variance (ANOVA) for the bioequivalency evaluation. Results of ANOVA and confidence limits of terst/reference ratios of $AUC_{24th}$, $C_{max}$, $t_{max}$ and MRT, and statistical tests indicated the bioequivalence of the two formulations (i.e., test/reference ratio was within $100{\times}20%$) except for $C_{max}$ and $t_{max}$. The mean of tmax also showed 11.1% and 9.3% differences but the detection limit were 29.2% and 29.6% as determined by FPIA and HPLC resepctively. This experiments suggest that the data yielded for the two formulations demonstrated that they were bioequivalent.

• Journal of the Korean Geotechnical Society
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• v.24 no.8
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• pp.125-135
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• 2008

Rigid-soft particle mixtures, which consist of sand and rubber, are investigated for the understanding of the stress-deformation and elastic moduli. Specimens are prepared with various size ratio sr between sand and rubber particles, and different volumetric sand fraction sf. Small strain shear waves are measured under $K_o$-loading condition incorporated with the stress-deformation test by using oedometer cell with bender elements. The stress-deformation and small strain shear wave characteristics of rigid-soft particle mixtures show the transition from a rigid particle behavior regime to a soft particle behavior regime under fixed size ratio. A sudden rise of $\Lambda$ factor and the maximum value of the $\zeta$ exponent in $G_{max}=\;{\Lambda}({\sigma}'_{o}/kPa)^{\zeta}$ are observed at $sf\;{\approx}\;0.4{\sim}0.6$ regardless of the size ratio sf. Transition mixture shows high sensitivity to confining stress. The volume fraction for the minimum porosity may depend on the applied stress level in the rigid-soft particle mixtures because the soft rubber particles easily distort under load. In this experimental study, the size ratio and volumetric sand fraction are the important factors which determine the behavior of rigid and soft particle mixtures.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.37A no.9
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• pp.738-745
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• 2012

This paper proposes an approximated soft decision demapping algorithm with low computational complexity for coded 4+12+16 amplitude phase shift keying (APSK) in an additive white Gaussian noise (AWGN) channel. To derive the proposed algorithm, we approximate the decision boundaries for 4+12+16 APSK symbols, and then decide the log likelihood ratio (LLR) value for each bit from the approximated decision boundaries. Although the proposed algorithm shows about 0.6~1.1dB degradation on the error performance compared with the conventional max-log algorithm, it gives a significant result in terms of the computational complexity.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.9 no.6
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• pp.175-185
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• 2009

In this paper, performance of OFDM systems with turbo code is analyzed and simulated in a satellite broadcasting channel. The performance is evaluated in terms of bit error probability. The satellite channel is modeled as a combination of Rayleigh fading with shadowing and Rician fading channels. As turbo decoding algorithms, MAP (maximum a posteriori), Max-Log-MAP, and SOVA (soft decision Viterbi output) algorithms are chosen and their performances are compared. From simulation results, it is demonstrated that Max-Log-MAP algorithm is promising in terms of performance and complexity. It is shown that performance is substantially improved by increasing the number of iterations and interleaver length of a turbo encoder. The results in this paper can be applied to OFDM-based satellite broadcasting systems.

• Journal of Energy Engineering
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• v.15 no.3 s.47
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• pp.181-187
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• 2006

This paper is proposed to a solar cell power system used in fire emergency equipment. Also it is designed with a high efficiency power converter in order to increase efficiency of power system. The controlling switches used in DC-DC booster chopper and DC-AC inverter are operated with soft switching, which is applied to resonant circuit method to reduce switching loss. The result is that the system gets to high efficiency. In this paper, A detection circuit of maximum power point of solar cell is described in this paper. And the performance evaluations for the photovoltaic power system of high efficiency are examined by the analysis of a new tracking controller with a maximum power $P_{max}$ detection of solar cell.

• Journal of the Korean Society for Railway
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• v.16 no.1
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• pp.47-51
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• 2013

In this study, we carried out an experimental shield TBM excavation model test using a down-scale device in soft clay, to understand tunnel-face stability properties in relation to changes in slurry pressure. We performed five tests according to tunnel depth (0.5D, 0.75D, 1.0D, 1.25D, 1.5D), and compared theoretical tunnel-face pressure with model test results. The range in theoretical tunnel-face slurry pressure ($P_{min}{\leq}P_{slurry\;pressure}{\leq}P_{max}$), which is determined by earth pressure and water level, was very similar to the model test result. This result was due to the more isotropic condition of the soft clay ground, than of rocky ground.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.28 no.11C
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• pp.1045-1051
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• 2003

The SOVA, which produces the soft decision value, can be used as a sub-optimum solution for concatenated codes such as turbo codes, since it is computationally efficient compared with the optimum MAP algorithm. In this paper, we propose an efficient implementation of the SOVA used for decoding turbo codes, by reducing the number of calculations for soft decision values and trace-back operations. In order to utilize the memory efficiently, the whole block of turbo codes is divided into several sub-blocks in the proposed algorithm. It is demonstrated that the proposed algorithm requires less computation than the conventional algorithm, while providing the same overall performance.

• Journal of the Korean Geotechnical Society
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• v.29 no.9
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• pp.43-54
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• 2013

This study proposed a new embankment stability control method to analyze the measurement data on the slope activities of the soft ground, using the Stability Control Index (SCI) obtained from the p-q stress paths. In order to validate this new technique, the data from triaxial compression tests (CU) and field measurement were compared. SCI is calculated from the current path of the effective stress points ($p^{\prime}=p-{\Delta}u$) using the relative position between the Total Stress Path $p_{max}$ and the point of $k_f$ line $p_f$. From this result, the point of effective stress $p^{\prime}(=p-{\Delta}u)$ will have access to the point $p_f$ of $k_f$ line when the pore water pressure occurs or the point of total stress pass $p^{\prime}_{max}$ when the pore pressure dissipates. Thus, the Stability Control Index (SCI) can evaluate quantitatively the safety of embankment from the relative position of the effective stress path.

• Journal of Veterinary Science
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• v.23 no.5
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• pp.64.1-64.9
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• 2022

Background: Fluralaner is a novel drug belonging to the isoxazoline class that acts on external parasites of domestic animals. It is used systemically via drinking water, especially against red poultry mite in layer chickens. Fluralaner is frequently used in layers infected with D. gallinae. However, no study to date has investigated the effects of feed intake and water hardness. Objectives: This study aimed to investigate the effects of variable water hardness and feed intake on the pharmacokinetic profile of fluralaner. Methods: Layer chickens were divided into four groups (n = 8): fed + purified water (Group 1), feed restricted + purified water (Group 2), feed restricted + hard water (Group 3), and feed restricted + soft water (Group 4). After administering a single dose of the drug with drinking water, the blood samples were collected for 21 days. Fluralaner concentrations in plasma samples were determined by liquid chromatography/tandem mass spectrometry. The maximum plasma concentration (C_max), time to reach maximum plasma concentration (t_max), area under the concentration-time curve values (AUC_0-21d), half-life (t_1/2), and other pharmacokinetic parameters were calculated. Results: Although the highest maximum plasma concentration (C_max) was determined in Group 1 (fed + purified water), no statistically significant difference was found in the C_max, t_max, t_1/2, MRT_{0-inf_obs}, Vz/F_obs, and Cl/F_{_obs} parameters between the experimental groups. Conclusions: It was concluded that the feed intake or water hardness did not change the pharmacokinetic profile of fluralaner in layer chickens. Therefore, fluralaner could be used before or after feeding with the varying water hardness in poultry industry.