• The Journal of Korean Medical History
• /
• v.27 no.1
• /
• pp.113-118
• /
• 2014

Objectives : The homepage is used for introduction and information about person, company, school, hospital, clinc, library, government office, etc. Realted to Traditional Korean Medicine (TKM), they have hompage ; The Association of Korean Medicine, The Society of Korean Medicine and its academic division, TKM clinic, TKM hospital. Most of all, we have concern that 11 universities and 1 graduate school which educate TKM, provide homepages to show their contents such as study course, greetings, Q&A and so on. Also we need compare those homepages to evaluate qualities and updates of contents. Methods : We visited to compare and evaluate 11 universities and 1 graduate school homepage. Results : 1st, there are differences on contents depending on emphasis of universities and graduate school. 2nd, we realize that universities and graduate school need high quality and high relevant contents related to TKM and TKM education. 3rd, the homepage is required feedback action about informations continuously. Conclusions : Till now, 11 universities and 1 graduate school homepages related to TKM have not upgraded and just have used 'notice contents' to inform their news. To make sure for homepage functions, 11 universities and 1 graduate school need rebuild or renovate or update their homepages.

• Journal of Biomedical Engineering Research
• /
• v.19 no.4
• /
• pp.351-360
• /
• 1998

Digital gamma camera has many advantages over analog gamma camera. These include convenient quality control, easy calibration and operation, and possible image quantitation which results in improving diagnostic accuracies. The digital data can also be utilized for telemedicine and picture archiving and communication system. However, many hospitals still operate analog cameras and have difficult situation to replace them with digital cameras. We have studied a feasibility of digitalizing an analog gamma camera into a digital camera using Gamma-PF interface board. The physical characteristics that we have measured are spatial resolution, sensitivity, uniformity, and image contrast. The patient's data obtained for both analog and digital camera showed very similar image quality. The results suggest that it may be feasible to upgrade an analog camera into a digital gamma camera in clinical environments.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.13 no.3
• /
• pp.514-521
• /
• 2009

The current control for Interior-mounted Permanent Magnet Motor(IPM Motor) is more complicate than Surface-mounted Permanent magnet Motor(SPM Motor) because of its torque characteristic depending on the reluctance. For high performance torque control, it requirs state decoupling between d-axis current and q-axis current dynamics. However the variation of the inductances, which couples the state dynamics of the currents, makes the state decoupling difficult. So some decoupling methods have developed to cope this variation and each current can be regulated independently. This paper proposes a novel approach for fully decoupling the states cross-coupling using sliding mode control with virtual state for IPM Motor. As a result, in spite of the parameter uncertainty and disturbance, the proposed sliding surface can have the dynamics of nominal system controlled by PI controller.

• Journal of Pharmaceutical Investigation
• /
• v.34 no.6
• /
• pp.529-540
• /
• 2004

After new medical system of separation of dispensary from medical practice was started in 2000 in Korea, to expand bioequivalence-proven drug products and to ensure the credibility of the therapeutic equivalence of generic drugs are hot issues in Korea. It will be obligatory to submit bioequivalence reports for getting licenses of all generic prescription drugs in the near future. Like other countries such as US and Japan, the KFDA also has a plan to re-evaluate the already approved drugs by bioequivalence studies. Therefore, it becomes more necessary to develop bioequivalence-demonstrating methods for specific preparations such as topical drug products among already approved drug products. There are some differences between US and Japanese guidances of bioequivalence studies of generic drug products for topical use. The information on Japanese guidance and the guidance's Q&As is already provided in our previous paper. In this paper, we examined the US guideline published in 1995 and compared with the Japanese guideline, which will give a useful information to make a guidance on bioequivalence studies of topical drug products in Korea.

• Journal of Pharmaceutical Investigation
• /
• v.34 no.4
• /
• pp.333-340
• /
• 2004

A new medical system of separation of dispensary from medical practice was started in 2000 in Korea. To expand bioequivalence-proven drug products and to ensure the credibility of the therapeutic equivalence of generic drug are hot issues in Korea. The KFDA also has a plan to revise the pharmaceutical affairs law that bioequivalence reports of all the generic prescription drugs should be submitted to the KFDA in the application for drug approval. Therefore, it becomes more necessary to develop bioequivalence-demonstrating methods for specific preparations such as topical drug products. There are some differences between US and Japanese guidances of bioequivalence studies of generic drug products for topical use. In this paper, we examined the recently published Japanese guideline, Guideline for Bioequivalence Studies of Generic Products For Topical Uses, and Q&A of the guideline, which will be references to make a guidance on bioequivalence studies of topical drug products in Korea.

• The Transactions of the Korean Institute of Power Electronics
• /
• v.19 no.1
• /
• pp.64-70
• /
• 2014

In this paper, the new LLCL filter is proposed for grid connected three-phase PWM inverter for passive damping. LLCL filter inserts a small inductor in the branch of the capacitor of the traditional LCL filter to compose a series resonant circuit to reduce the switching-frequency component on grid current. Using LLCL filter, the switching-frequency current ripple components can be attenuated much better than the LCL filter, leading to a decrease in the total inductance. However, the resonance phenomena caused by zero impedance from the addition of LC branch in LLCL filter can be a big problem. Resonance phenomena of LLCL filter can be a source of grid system instability, so proper damping methods are required. However, it is difficult to apply a passive damping method in the conventional LLCL filter, because the damping resistor increase impedance of the LC branch. Therefore, switching frequency component of grid current can not much attenuated by low Q of LC series resonance effect. In this paper, a new LLCL filter is proposed to overcome the conventional LLCL filter with passive damping. The validity of the proposed method is proven by simulation and experimental result.

• Journal of Microbiology
• /
• v.35 no.3
• /
• pp.165-171
• /
• 1997

A sulfer-oxidizing bacterium was isolated from mine wastewater and characterized. The isolate was gra-negative, rod (0.2 * 1.2-1.5.mu.m), nonmotiloe, catalase positive, and oxidase prositive. The opotimal pH and temperature for growth were 7.0 and 30.deg.C. respectively. The optimum thiosulfate concentration was 70 mM and the maximum growth rate was 0.081 hr. The major ubiquinone contained in the isolate was Q-8. The cellular fatty acid composition was $C_{16 : 0}$, $C_{18 : 1}$, $C_{17cyc}$,and $C_{19cyc}$ as nonpolar fatty acids, and 3-OH C10 : 0 and 3-OH $C_{12 : 0}$ as hydroxylated fatty acids. The isolate was a facultative chemolithoautotroph which can grow autotrophically on sodium thiosulfate and sodium sulfide and which can grow heterotrophically on yeast extract. It can also grow mixotrophically on sodium thiosulfate and yeast extract. Comparison of the 16S rRNA gene sequence of the isolate with that of Thiobacillus species and Paracoccus thiocyanatus revealed that it is closely related to T. caldus which belongs to the .betha.-subclass of the class Proteobacteria. However, the isolated could not grow at extremely low pH (pH 1-3.5). On the basis of the phenotypic, chemotaxonomic and phylogenetic data, the isolate was tentatively named Thiobacillus sp. strain C.ain C.

• Journal of Genetic Medicine
• /
• v.14 no.1
• /
• pp.43-47
• /
• 2017

Cat eye syndrome (CES) is a very rare chromosomal syndrome characterized by various malformations such as anal atresia, preauricular malformation, coloboma of the iris, and congenial heart and renal defects. This genetic disorder is caused by partial duplication of chromosome 22, mostly as a result of a supernumerary isodicentric marker chromosome idic(22)(q11.2). Various congenital abnormalities and extreme phenotypic variability in CES patients have been reported, which have made prenatal diagnosis of CES difficult. We report the first case diagnosed with CES prenatally by multiplex ligation-dependent probe amplification in a woman who was referred to our hospital, for a fetus presenting with heart anomaly.

• Journal of the korean society of oceanography
• /
• v.32 no.4
• /
• pp.163-170
• /
• 1997

Some CMP gathers acquired from shallow marine seismic reflection survey in offshore Korea do not show the hyperbolic trend of moveout. It originated from so-called swell effect of source and streamer, which are towed under rough sea surface during the data acquisition. The observed time deviations of NMO-corrected traces can be entirely ascribed to the swell effect. To correct these time deviations, a residual statics is introduced using Genetic Algorithms (GA) into the swell correction. A new class of global optimization methods known as GA has recently been developed in the field of Artificial Intelligence and has a resemblance with the genetic evolution of biological systems. The basic idea in using GA as an optimization method is to represent a population of possible solutions or models in a chromosome-type encoding and manipulate these encoded models through simulated reproduction, crossover and mutation. GA parameters used in this paper are as follows: population size Q=40, probability of multiple-point crossover P$_c$=0.6, linear relationship of mutation probability P$_m$ from 0.002 to 0.004, and gray code representation are adopted. The number of the model participating in tournament selection (nt) is 3, and the number of expected copies desired for the best population member in the scaling of fitness is 1.5. With above parameters, an optimization run was iterated for 101 generations. The combination of above parameters are found to be optimal for the convergence of the algorithm. The resulting reflection events in every NMO-corrected CMP gather show good alignment and enhanced quality stack section.

• Journal of Ginseng Research
• /
• v.45 no.6
• /
• pp.695-705
• /
• 2021

Background: Ginsenosides have beneficial effects on several airway inflammatory disorders primarily through glucocorticosteroid-like anti-inflammatory activity. Among inflammatory cells, eosinophils play a major pathogenic role in conferring a risk of severe refractory diseases including chronic rhinosinusitis (CRS). However, the role of ginsenosides in reducing eosinophilic inflammation and CRS pathogenesis is unexplored. Methods: We investigated the therapeutic efficacy and underlying mechanism of ginsenoside F1 (G-F1) in comparison with those of dexamethasone, a representative glucocorticosteroid, in a murine model of CRS. The effects of G-F1 or dexamethasone on sinonasal abnormalities and infiltration of eosinophils and mast cells were evaluated by histological analyses. The changes in inflammatory cytokine levels in sinonasal tissues, macrophages, and NK cells were assessed by qPCR, ELISA, and immunohistochemistry. Results: We found that G-F1 significantly attenuated eosinophilic inflammation, mast cell infiltration, epithelial hyperplasia, and mucosal thickening in the sinonasal mucosa of CRS mice. Moreover, G-F1 reduced the expression of IL-4 and IL-13, as well as hematopoietic prostaglandin D synthase required for prostaglandin D2 production. This therapeutic efficacy was associated with increased NK cell function, without suppression of macrophage inflammatory responses. In comparison, dexamethasone potently suppressed macrophage activation. NK cell depletion nullified the therapeutic effects of G-F1, but not dexamethasone, in CRS mice, supporting a causal link between G-F1 and NK cell activity. Conclusion: Our results suggest that potentiating NK cell activity, for example with G-F1, is a promising strategy for resolving eosinophilic inflammation in CRS.