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Mutation Effects on FAS1 Domain 4 Related to Protein Aggregation by Molecular Dynamics Simulations and Solvation Free Energy Analysis

  • Cho, Sunhee;Ham, Sihyun
    • Proceeding of EDISON Challenge
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    • 2015.03a
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    • pp.70-75
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    • 2015
  • Fasciclin 1 (FAS1) is an extracellular protein whose aggregation in cornea leads to visual impairment. While a number of FAS1 mutants have been studied that exhibit enhanced/decreased aggregation propensity, no structural information has been provided so far that is associated with distinct aggregation potential. In this study, we have investigated the structural and thermodynamic characteristics of the wild-type FAS1 and its two mutants, R555Q and R555W, by using molecular dynamics simulations and three-dimensional reference interaction site model (3D-RISM) theory. We find that the hydrophobic solvent accessible surface area increases due to hydrophobic core repacking in the C-terminus caused by the mutation. We also find that the solvation free energy of the mutants increases due to the enhanced non-native H-bonding. These structural and thermodynamic changes upon mutation contribute to understand the aggregation of these mutants.

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Auto-Detection of Stator Winding Fault of Small Induction Motor using LabVIEW (LabVIEW를 이용한 소형 유도전동기의 권선고장 자동진단)

  • Song, Myung-Hyun;Park, Kyu-Nam;Han, Dong-Gi;Woo, Hyeok-Jae
    • The Transactions of the Korean Institute of Electrical Engineers P
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    • v.55 no.4
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    • pp.202-206
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    • 2006
  • In this paper, an auto detection method of stator winding fault of small induction motor is suggested. The Park's vector pattern which is obtained from 3-phase current signal by d-q transforming, is very good to detect winding fault. Comparing the Park's vector pattern of testing motor with its of healthy motor, the Park's vector pattern of fault motor is became an ellipse and the asymmetry is increased by the winding fault series. So for detecting the dis-symmetry, id-filtered function, Min-value, and Max-value are suggested for auto detecting. Using LabVIEW programing, 3-phase healthy motor and several kind of winding fault motors are tested and the test results are shown that the suggested method can gives us a possibility of an auto detecting winding fault.

The Design of High Speed Bit and Word Processor (비트 및 워드 연산용 초고속 프로세서 설계)

  • Her, Jae-Dong;Yang, Oh
    • Proceedings of the KIEE Conference
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    • 2002.07d
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    • pp.2534-2536
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    • 2002
  • This paper presents the design of high speed bit and word processor for sequence logic control using a FPGA. This FPGA is able to execute sequence instruction during program fetch cycle, because the program memory was separated from the data memory for high speed execution at 40MHz clock. Also this processor has 274 instructions set with a 32bit fixed width, so instruction decoding time and data memory interface time was reduced. This FPGA was synthesized by V600EHQ240 and Foundation tool of Xilinx company. The final simulation was successfully performed under Foundation tool simulation environment. And the FPGA programmed by VHDL for a 240 pin HQFP package. Finally the benchmark was performed to prove that the designed for bit and word processor has better performance than Q4A of Mitsubishi for the sequence logic control.

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Electrical Characteristics of the Hexagon-type Piezoelectric Transformer (육각형 압전변압기의 전기적 출력 특성)

  • Lee, Jong-Pil;Hong, Jin-Woong
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2002.11a
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    • pp.296-299
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    • 2002
  • In this paper, a hexagon-type piezoelectric transformer was investigated to increase the output power. The length of its side was 14mm and 17.5mm, respectively. The piezoelectric ceramics was composed to PZT-PMN-PSN. This composition showed the characteristics which had an about 1500 of the mechanical Q-factor, 0.55 of the electromechanical coupling coefficient, $320{\times}10^{-12}C/N$ of the piezoelectric constant $d_{31}$, 0.3 % of the dissipation factor, etc. The voltage step-up ratio increased with increasing the load resistance, $R_{L}$, so it reached 80 with $R_{L}$ of $1M{\Omega}$ and was proportion to the length of side of the hexagon-type piezoelectric transformer. Also, the output power increased with increasing the size of the hexagon-type piezoelectric transformer.

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Flowrate characteristics and application of screw pump (스크류펌프의 유량특성과 적용)

  • Lim, Jong-Soon
    • 유체기계공업학회:학술대회논문집
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    • 2004.12a
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    • pp.614-625
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    • 2004
  • The main purpose of this study is to get flowrate coefficient 'q' and to study characteristics of flowrate of screw pump. This study is based on Muskin's formula and depends on the computer simulation. The results of study are as follows. 1. Flowrate coefficient will reduce according to increase of inclination. The larger the pitch ratio is and the smaller the diameter ratio is, the more coefficient reduces. 2. As a rule, the coefficient increases according to reduction of the diameter ratio, but the coefficient tends to reduce when the ratio is less than 0.45. So, in actual application, it is recommended that the ratio should be above 0.45. 3. If the pitch ratio increases, the coefficient increases in case of small inclination and decreases in case of large inclination. 4. The coefficient increases according to number of windings. Especially, singles winding is not used in actual application because it has too small coefficient. 5. The coefficient decreases when the influent water level falls. Flowrate is almost zero when the water level is below $40\%$ of Filling Points.

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A Study on Stabilization of Container Cranes Using an Optimal Modulation Controller (최적 변조제어기를 이용한 컨테이너 크레인의 안정화에 관한연구)

  • 허동렬
    • Journal of Advanced Marine Engineering and Technology
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    • v.23 no.5
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    • pp.630-636
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    • 1999
  • In this paper in optimal modulation controller for position control and anti-sway of container crane systems is designed by a recursive algorithm that determines the state weighting matrix Q of a linear quadratic performance. The optimal modulation controller is based on optimal control. The basic feature of the recursive algorithm is the reduction of the number of iterations as well as minimization of the calculations involved So in order to obtain a mathematical model which rep-resents the equation of motion of the trolley and load Lagrange equation is used. The optimal modulation controller has been verified and simulated to show that it is robust when a load dis-turbance is applied and a reference is changed.

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The time response of second order band pass filter (2차식 대역통과여파기의 시간응답)

  • 고병준;김재공
    • Journal of the Korean Institute of Telematics and Electronics
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    • v.8 no.5
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    • pp.20-26
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    • 1971
  • A function relationship between the envlope rise time and Q v91ue of band pass filter is studied by using the time response to the step and sinusodal inputs. It is discovered that the above relationship is linear in the very low frequency band. The filter was constructed by the Analog computer so as to do the function of 2nd order RC active band pass.

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Synthesis and Antiproliferative Activity of New Aminoisoquinolinylurea Derivatives against Melanoma Cell Line

  • Cho, Hye Jung;El-Gamal, Mohammed I.;Oh, Chang-Hyun;Lee, So Ha;Kim, Garam;Hong, Jun Hee;Choi, Hong Seok;Yoo, Kyung Ho
    • Bulletin of the Korean Chemical Society
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    • v.33 no.11
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    • pp.3635-3639
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    • 2012
  • A series of new diarylureas possessing aminoisoquinoline scaffold was synthesized, and their in vitro antiproliferative activity against A375P human melanoma cell line was tested. Compounds 1d, 1l, 1n, 1p, 1q, and 1t showed superior potency against A375P to Sorafenib. The highest potency was shown by compound 1p possessing 3,5-bis(trifluoromethyl)phenyl terminal ring with $IC_{50}$ value of $0.41{\mu}M$.

The Inductance Computation of IPMSM using Current Vector Control Test (전류벡터제어시험법에 의한 IPMSM의 인덕턴스 산정)

  • Cho, Gyu-Won;Lee, Jung-Gyu;Kim, Gyu-Tak
    • The Transactions of The Korean Institute of Electrical Engineers
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    • v.61 no.12
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    • pp.1807-1812
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    • 2012
  • In this paper, the d, q-axis inductance of IPMSM(Interior Permanent Magnet Synchronous Motor) was calculated by the FEA(Finite Element Analysis). And the CVCT(Current Vector Control Test) was performed, and compared with FEA. Therefore the inductance experiment according to the variation of the current phase angle was performed. However, the error was generated in the fundamental wave detection of the voltage and current waveform. So, error has largely effect on the result of computation, it has to note specially. In addition, by using the calculated inductance, the torque calculation was performed and this result was compared through the dynamometer experiment.

Low Power and Small Area Source Driver Using Low Temperature Poly-Si(LTPS) Thin Film Transistors(TFTs) for Mobile Displays

  • Hong, Sueng-Kyun;Byun, Chun-Won;Yoon, Joong-Sun;Kwon, Oh-Kyong
    • 한국정보디스플레이학회:학술대회논문집
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    • 2007.08a
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    • pp.833-836
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    • 2007
  • A low power and small area source driver using LTPS TFTs is proposed for mobile applications. This source driver adopts level shifter with holding latch function and new R-to-R type digital-to-analog converter (DAC). The power consumption and layout area of the proposed source driver are reduced by 23% and 25% for 16M colors and qVGA AM-OLED panel, respectively.

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