• Clinical and Experimental Pediatrics
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• 제48권10호
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• pp.1038-1049
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• 2005

Asthma is characterized by a chronic inflammatory disorder of the airways that leads to tissue injury and subsequent structural changes collectively called airway remodelling. Characteristic changes of airway remodelling in asthma include goblet cell hyperplasia, deposition of collagens in the basement membrane, increased number and size of microvessels, hypertrophy and hyperplasia of airway smooth muscle, and hypertrophy of submucosal glands. Apart from inflammatory cells, such as eosinophils, activated T cells, mast cells and macrophages, structural tissue cells such as epithelial cells, fibroblasts and smooth muscle cells can also play an important effector role through the release of a variety of mediators, cytokines, chemokines, and growth factors. Through a variety of inflammatory mediators, epithelial and mesenchymal cells cause persistence of the inflammatory infiltrate and induce airway structural remodelling. The end result of chronic airway inflammation and remodelling is an increased thickness of the airway wall, leading to a increased the bronchial hyperresponsiveness and fixed declined lung function.

• International Journal of Air-Conditioning and Refrigeration
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• 제9권3호
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• pp.57-62
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• 2001

Falling film heat transfer analyses with aqueous lithium bromide solution were performed to investigate the transfer characteristics of the copper tubes. Finned (knurled) tube and a smooth tube were selected as test specimens. Averaged generation fluxes of water and the heat flux were obtained. As the film flow rate of the solution increased, the generation fluxes of water decreased for both tubes due to the fact that the heat transfer resistance increased with the film thickness. The effect of the enlarged surface area at the knurled tube was supposed to be dominant at a small flow rate. The generation fluxes of water increased with the increasing degree of tube wall superheat. Nucleate boiling is supposed to occur at a wall superheat of 20K for a smooth tube, and at 10K for a knurled tube. The increased performance of the knurled tube was supposed to mainly come from the effect of the increased heating surface area.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.207.3-208
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• 2003

Objectives:We have reported that oral administration of Saiko-ka-Ryukotsu-Borei-To (SRB), a traditional Chinese formulation, inhibited the intimal thickening in carotid artery after balloon injury in cholesterol-fed rats. To elucidate its mechanism, the effects of SRB on migration and proliferation of vascular smooth muscle cell (VSMC) were examined in vivo and in vitro.Methods: ＜ In vivo-study＞ Rats were fed on diet containing 1% cholesterol and SRB 3 days before and 4 days after denudation. Simvastatin was used as a positive control. (omitted)

• 동력기계공학회지
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• 제11권2호
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• pp.51-57
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• 2007

As a shot sleeve in die casting plays a critical role in delivering molten metal to a die cavity, any disruption to its function in the injection stage results in deterioration of the quality of final castings. To guarantee a smooth operation of a shot sleeve, its structural stability should be maintained. Despite the simple geometry, design of shot sleeve is based on individual engineer's experience and no agreement on the design is present. In this study, we newly propose a systematic methodology to determine a minimum wall thickness of a shot sleeve to prevent yielding or plastic deformation. Analytical calculations incorporating numerical analysis produce a rational design rule for minimum thickness of a shot sleeve subject to metal intensification pressure and geometric die constraint. To validate the proposed design guideline, authors present real data on a collection of actual shot sleeves. Upon checking their conformity to the new design rule, we discovered a strong correlation between the design of wall thickness and premature failures.

• Steel and Composite Structures
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• 제28권5호
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• pp.541-557
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• 2018

This paper presents the influence of carbon nanotubes (CNTs) waviness and aspect ratio on the vibrational behavior of functionally graded nanocomposite sandwich annular sector plates resting on two-parameter elastic foundations. The carbon nanotube-reinforced (CNTR) sandwich plate has smooth variation of CNT fraction along the thickness direction. The distributions of CNTs are considered functionally graded (FG) or uniform along the thickness and their mechanical properties are estimated by an extended rule of mixture. In this study, the classical theory concerning the mechanical efficiency of a matrix embedding finite length fibers has been modified by introducing the tube-to-tube random contact, which explicitly accounts for the progressive reduction of the tubes' effective aspect ratio as the filler content increases. Effects of CNT distribution, volume fraction, aspect ratio and waviness, and also effects of Pasternak's elastic foundation coefficients, sandwich plate thickness, face sheets thickness and plate aspect ratio are investigated on the free vibration of the sandwich plates with wavy CNT-reinforced face sheets. The study is carried out based on three-dimensional theory of elasticity and in contrary to two-dimensional theories, such as classical, the first- and the higher-order shear deformation plate theories, this approach does not neglect transverse normal deformations. The sandwich annular sector plate is assumed to be simply supported in the radial edges while any arbitrary boundary conditions are applied to the other two circular edges including simply supported, clamped and free.

• 한국전기전자재료학회논문지
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• 제29권11호
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• pp.725-728
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• 2016

We investigated the characterizations of carbon films fabricated by dual magnetron sputtering under various film thickness for the electrodes in TCO-less DSSC (dye-sensitized solar cells). Carbon films prepared at various conditions were exhibited smooth and uniform surfaces without defects. Also, the rms surface roughness of carbon films was decreased from 2.25 nm to 1.0 nm with the increase of film thickness. The sheet resistance as the electrical properties are improved from $11.2{\times}10^{-3}$ to $2.28{\times}10^{-3}$ with the increase of film thickness. In the results, the performance of TCO-less DSSC critically depended on the film thickness of working electrodes, indicating the conductivity of carbon films.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2007년도 춘계학술대회 논문집
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• pp.1827-1832
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• 2007

The purpose of a railway track is to provide a smooth surface for safe and economical train transportation. The performance of the track results from a complex interaction of the track and subgrade components in response to train loading and environmental actions. In the past, the role of subgrade as the track foundation were not recognized adequately. There are insufficient information and inadequate methods for subgrade design, assessment and improvement. This situation has survived for a long time largely because a subgrade defect can often be adjusted by adding more ballast under the ties or applying more frequent track maintenance. Therefore, the application of reinforced roadbed technology will be expected to increase in the future. The reinforced roadbed thickness is set depending on subgrade reaction modulus$(K_{30})$ in the condition of upper subgrade through PBT in both conventional railroad and KTX railroads. As train velocity (V), train passing tonnage (N), and train axial load (P) are not considered in design, the roadbed thickness could be overestimated (or underestimated). Therefore, In this study, the computer model, GEOTRACK, was analyzed the influence of reinforced roadbed thickness factors on track modulus and the characteristics of stress pulses in track and subgrade generated by repeated axle loading.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2007년도 추계학술대회 논문집
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• pp.1279-1286
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• 2007

The purpose of a railway track is to provide a smooth surface for safe and economical train transportation. The performance of the track results from a complex interaction of the track and subgrade components in response to train loading and environmental actions. In the past, the role of subgrade as the track foundation were not recognized adequately. There are insufficient information and inadequate methods for subgrade design, assessment and improvement. This situation has survived for a long time largely because a subgrade defect can often be adjusted by adding more ballast under the ties or applying more frequent track maintenance. Therefore, the application of reinforced roadbed technology will be expected to increase in the future. The reinforced roadbed thickness is set depending on subgrade reaction modulus($K_{30}$) in the condition of upper subgrade through PBT in both conventional railroad and KTX railroads. As train velocity (V), train passing tonnage (N), and train axial load (P) are not considered in design, the roadbed thickness could be overestimated (or underestimated). Therefore, in this study has proposed a determination method of reinforced roadbed thickness using design chart made by resilience modulus and properties of earthwork materials.

• 대한기계학회논문집B
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• 제26권6호
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• pp.893-901
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• 2002

Effect of boundary layer thickness on the flow characteristics around a rectangular prism has been investigated by using a PIV(Particle Image Velocimetry) technique. Three different boundary layers(thick, medium and thin)were generated in the Atmospheric Boundary Layer Wind Tunnel at Pusan National University. The thick boundary layer having 670 mm thickness was generated by using spires and roughness elements. The medium thickness of boundary layer($\delta$=270 mm) was the natural turbulent boundary layer at the test section floor with fairly long developing length(18 m). The thin boundary layer($\delta$=36.5 mm) was generated on the smooth panel elevated 70cm from the wind tunnel floor. The Reynolds number based on the free stream velocity(3 ㎧) and the height of the model(40 mm) was 7.9$\times$10$^3$. The mean velocity vector fields and turbulent kinetic energy distributions were measured and compared. The effect of boundary layer thickness was clearly observed not only in the length of separation bubble but also in the location of reattachment point. The thinner the boundary layer thickness, the higher the turbulent kinetic energy Peak around the model roofbecame. It is strongly recommended that the height ratio between the model and the approaching boundary layer thickness should be encountered as a major parameter.

• 치위생과학회지
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• 제8권2호
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• pp.89-96
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• 2008

태아형성 시기에 투여된 불소가 법랑모세포의 법랑질형성과정에 미치는 효과를 알아보고자 생후 11일 된 흰쥐의 하악 절치를 대상으로 대조군과 두 그룹의 실험군으로 나누어 실험하였다. 전자현미경을 이용한 형태학적 분석결과, 흰쥐태아 치아기의 조직학적 구성은 전분비대, 분비대 및 성숙대로 관찰되었으며 특히 성숙대에서는 법랑질에서 물과 유기물질을 선택적으로 제거하는 평탄끝 법랑모세포(smooth-ended ameloblast)와 무기이온을 추가로 공급하는 주름끝 법랑모세포(ruffle-ended ameloblast)가 관찰되었다. 이러한 조직학적 구성은 흰쥐태아에서도 성체에서 관찰되는 구조들과 동일한 것으로 확인되었다. 한편, 법랑모세포의 전환주기를 알아보기 위한 형광물질(calcein)을 이용한 검사결과, 전환주기가 대조군에 비하여 실험군에서 평균 1회가 감소되었는데 불소농도가 증가할수록 평탄끝 법랑모세포의 두께는 감소하는 양상을 나타내었다. 또한 대조군에 비해 실험군에서 시상총길이에 대한 주름끝 법랑모세포의 두께 비율보다 평탄끝 법랑모세포의 두께 비율이 증가함을 볼 수 있었다. 그리고 치아의 총길이에 있어서 100 ppm 불소투여군은 대조군과 유사하였으나 200 ppm 불소투여군에서는 다소 짧아지는 경향을 나타내었다. 그리고 실험군의 평탄끝 법랑모세포의 두께와 주름끝 법랑모세포의 두께가 절단연으로 갈수록 좁아지는 경향을 띄었고 성숙대의 길이도 절단연으로 갈수록 짧아지는 양상을 나타내었다. 따라서 대조군에 비해 실험군에서 불소투여 농도가 높아짐에 따라 전환주기가 감소되고 이것은 치아의 총길이도 감소하게 되어, 결국 치아성장을 저해함을 확인하였다.