• Toxicological Research
• /
• 제32권4호
• /
• pp.353-358
• /
• 2016

The generation and collection of cigarette smoke (CS) is a prerequisite for any toxicology study on smoking, especially an in vitro CS exposure study. In this study, the effects on blood and vascular function were tested with two widely used CS preparations to compare the biological effects of CS with respect to the CS preparation used. CS was prepared in the form of total particulate matter (TPM), which is CS trapped in a Cambridge filter pad, and cigarette smoke extract (CSE), which is CS trapped in phosphate-buffered saline. TPM potentiated platelet reactivity to thrombin and thus increased aggregation at a concentration of $25{\sim}100{\mu}g/mL$, whereas 2.5~10% CSE decreased platelet aggregation by thrombin. Both TPM and CSE inhibited vascular contraction by phenylephrine at $50{\sim}100{\mu}g/mL$ and 10%, respectively. TPM inhibited acetylcholine-induced vasorelaxation at $10{\sim}100{\mu}g/mL$, but CSE exhibited a minimal effect on relaxation at the concentration that affects vasoconstriction. Neither TPM nor CSE induced hemolysis of erythrocytes or influenced plasma coagulation, as assessed by prothrombin time (PT) and activated partial thromboplastin time (aPTT). Taken together, CS affects platelet activity and deteriorates vasomotor functions in vitro. However, the effect on blood and blood vessels may vary depending on the CS preparation. Therefore, the results of experiments conducted with CS preparations should be interpreted with caution.

• 한국화재소방학회논문지
• /
• 제21권2호
• /
• pp.64-73
• /
• 2007

호흡기 내에서 유해물질의 체내흡수 및 방어특성은 영역별로 다르며 흡입연기의 장 단기 인체 유해성은 연기의 호흡기 내 침착위치 및 침착밀도와 밀접한 관계를 가지고 있다. 이 연구에서는 미소부피 위치 추적법을 이용한 입자침착율 계산 기법을 사용하여 휴식 및 가벼운 운동에 해당하는 호흡조건별로 또한 구강 및 비강 호흡별로 각 입자크기에 대하여 호흡기 각 영역별로 단위 면적당 침착분율 등 침착 특성을 구하였다. 이 결과는 연기에 흡착된 유해물질의 체내 흡수량 산정 등에 이용되어 연기의 인체 유해성 판정에 도움을 줄 수 있을 것으로 판단된다.

• Tuberculosis and Respiratory Diseases
• /
• 제74권3호
• /
• pp.120-123
• /
• 2013

Inhalation of toxic gases can lead to pneumonitis. It has been known that methane gas intoxication causes loss of consciousness or asphyxia. There is, however, a paucity of information about acute pulmonary toxicity from methane gas inhalation. A 21-year-old man was presented with respiratory distress after an accidental exposure to methane gas for one minute. He came in with a drowsy mentality and hypoxemia. Mechanical ventilation was applied immediately. The patient's symptoms and chest radiographic findings were consistent with acute pneumonitis. He recovered spontaneously and was discharged after 5 days without other specific treatment. His pulmonary function test, 4 days after methane gas exposure, revealed a restrictive ventilatory defect. In conclusion, acute pulmonary injury can occur with a restrictive ventilator defect after a short exposure to methane gas. The lung injury was spontaneously resolved without any significant sequela.

• 동력기계공학회지
• /
• 제15권6호
• /
• pp.11-15
• /
• 2011

This study investigated the symptoms of the a reduction in output while driving on the road, or increasing of fumer out exhaust gas on inclined road while working air-conditioner in summer. Notice how the experiment in 2010, the Ministry of Environment(Chapter No. 2010-46), and how the vehicle emissions inspection was carried out. 2500cc Diesel cars used in the study were used and compare to output of engine, exhaust gas, inhalation temperature measurement Inhalation of cold air has not been supplied to all agencies when comparing the results when cold air intake temperature of the supply air-conditioning switch range control from 1 to 4, the temperature drops $98^{\circ}C$ to $78^{\circ}C$. At the momentum of switch level 4, output from 63ps to 66ps after the connection has increased 9.6 percent, the highest concentration of exhaust emissions were reduced by 42.8%. This research can contribute in part to the reduction of exhaust directly supply into the cooling air intake line, doing the output of diesel cars in the summer. In addition, construction equipment and machinery that are currently being used excluding the engine's intercooler cooling of the supply line via a separate output in the summer and help reduce exhaust emissions is expected.

• Toxicological Research
• /
• 제12권2호
• /
• pp.259-263
• /
• 1996

The preventive effects of ginseng and aloe extract on cigarette smoke-induced hepatotoxicity to Spague-Dawley rats were investigated. The experimental rats were exposed smoke by inhalation for 5 weeks, 3 times per day, and 15 minutes each time. Also ginseng and aloe extract (Group G+A), aloe (Group A) or ginseng (Group G) were administered to each group, but the positive control rats (Group C) were exposed smoke without any other special treatments. Group C showed decreased food intake and increased water consumption. Also the reduction of body weight and the increase in serumAST, ALT, triglyceride and alkaline phosphatase were observed. The relative liver weights of group C were increased and the hepatic parenchyma revealed light brownish red grossly. On histopathologic observation, the hepatocytes of group C animals exhibited diffuse swelling which narrowed the, sinusoidal lumen and disarrayed the hepatic cord-like arrangement. Diffuse necrosis of the hepatocytes was also observed. However, degeneration and necrosis of the hepatocytes were milder in group G+A. In the case of group A, the damage was moderate, while the group G showed marginal improvement from group C. Electronmicroscopically, peroxisome increased and mitochodria decreased in group C. Various hepatic damages related to smoking in group C revealed recovering tendency in group G+A. This study indicated that daily administration of ginseng and aloe could decrease and even prevent cigarette smokeinduced hepatotoxicity.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• 제31권4호
• /
• pp.291-299
• /
• 2005

Objectives : It is well known that cigarette smoking is harzardous to the osseointegration of dental implant, due to the impaired wound healing accompanied by reduced alveolar bone density. The aim of this study is to evaluate the influence of cigarette smoke on the implant osseointegration by the time factor consideration. Materials and methods : Twenty-four male Spraque-Dawley rats (8 weeks, weighting 200 to 250g) were used in this study. In the experimental group, 13 rats were exposed to cigarette smoke, 8 minutes per day during 6 weeks, and 12 rats in the control group were not exposed at any time. RBM (Resorbed blasting media) surfaced implant (diameter 3.3mm, length 5.0mm, AVANA Co., Korea) was placed in the right femur of each rat. Each implant with surrounding bone was prepared with microtome (cutting band 0.2mm$^{(R)}$, EXAKT Co., Germany) after 1 day, 2, 4, 8 and 12 weeks and stained with toluidine blue (1%). Another clinical investigation of each implant was also done at each evaluation time. Results : Clinical investigation around implant fixture showed that there were no significant differences between the control and experimental group. Microscopic observation around implant fixture showed that there were significant differences between the control and experimental group at the initial stage after implant fixture installation. Experimental group showed a decreased bone to implant contact within 4 weeks compared to control group, but showed similar characteristics after 4 weeks. Conclusion : Smoking inhalation effect on the dental implant showed the impaired wound healing by vasoconstriction and decreased intramedullary blood flow at initial stage of osseointegration. This experimental results can be clinically useful to the implant surgery of smoking patients.

• 한국기계가공학회지
• /
• 제19권1호
• /
• pp.29-35
• /
• 2020

Car inspection systems are regularly carried out by the state to ensure the safety and emission status of cars, thereby improving the safety and quality of life by reducing fine dust and greenhouse gases that are the main culprits of vehicle defects and air pollution. These automobile inspections are largely divided into either regular or comprehensive inspections. This study analyzed the smoke measuring probes used in the lug - down 3 mode. In the previously issued paper "Improvement of Soot Probe Efficiency for Automotive Emission Measurement," an improved smoke measurement probe(B) improved on the problems that arise from the current smoke measurement probe (A). In this study, a technique that can improve the probe's inhalation efficiency over the improved (B) probes was applied to probes (C). Probe (C) involves a structure designed close to the center of the circumference of the exhaust pipe, and the suction efficiency was improved by adding a variable center unit.

• 한국산학기술학회논문지
• /
• 제18권11호
• /
• pp.602-607
• /
• 2017

과학기술의 발달로 인류의 평균 수명이 늘어나고 그에 따라 노인 인구의 수가 크게 증가하게 되었다. 이러한 노인 인구들은 현대 사회의 핵가족화, 노령화, 서구문명의 영향에 따른 경로 효친 사상의 약화 등에 따라 가족과의 동거가 아닌 노인전문 시설에서 요양하게 되는 경우가 크게 증가하였으며, 이에 맞추어 노인요양시설의 수가 크게 증가하고 있는 추세이다. 그러나 최근 2014년 5월 28일 전남 장성에 위치한 노인요양병원에서 화재가 발생하였는데, 소방대원의 빠른 화재 진압에도 불구하고 사상자 28명 중 21명이 연기로 인한 질식으로 인해 사망하였다. 이러한 사고들에 대하여 화재 시 대피가 어려운 노인들이 위치한 병실로 연기유입을 방지하기 위한 대책을 마련하고자 본 연구를 진행하였다. 연기유입 방지를 위해서 에어커튼 방식을 이용하는 것으로 계획하고 연기발생기로 연기를 발생시켜 실험을 진행하였다. 실험 결과 에어 커튼이 설치된 병실에 병실 문이 닫혀 있을 경우 90% 이상의 연기유입을 차단하는 효과를 확인하였다.

• 대한간호학회지
• /
• 제41권5호
• /
• pp.652-662
• /
• 2011

Purpose: The suicide rate of adolescents in Korea is increasing annually. Therefore, this research was done to identify the suicide attempt rate of middle and high school students and to identify factors that influence suicidal attempts. Methods: The Korea Youth Health Risk Behavior Web-based Survey (2007) was used as data. Discriminant analysis and logistic regression were performed to analyze the data depending on gender to consider the gender difference in assessing the influence of each independent variable on suicidal attempts. Results: Discriminant analysis according on gender showed that 13 factors correlated with suicidal attempts for boys, and 20 factors for girls. The most highly correlated factors were smoking, depression and inhalation experience. For inhalation experience, boys had 2.7 times higher possibility of suicide attempts (95% CI 1.8-3.0) and girls, a 2.4 times higher possibility (95% CI 1.7-3.5). Conclusion: The results of the study indicate a need to classify adolescents for expectation of suicide risk and high danger for suicidal attempts through, and introduce suicide prevention programs for these adolescents. In particular, it is necessary to start intervention with students who smoke, have sexual and inhalation experiences and high levels of depression.

• 대한의생명과학회지
• /
• 제12권3호
• /
• pp.281-287
• /
• 2006

Cigarette smoke causes atypical structure of pulmonary and oxidative damage. Therefore, we carried out to determine if exposure to cigarette smoke alters pulmonary structure and anti-oxidant related enzyme in a animal model, when natural product extracts using by Nebulizer. The rat were divided into four groups: $H_2O-treated$ (Control), natural product (Camellia sinensis) extracts-treated (CS), natural product extracts-treated with cigarette smoke-exposed (CS+SM) and cigarette smoke-expose (SM). All groups are similar to Control group in weight, but SM group is lower than the other groups. Microscopic image of the pulmonary structure in SM group showed deleterious alterations in the morphology, but the other groups are maintained in normal structure. In anti-oxidant related enzymes, SOD (superoxide dismutase) and catalase, SM group represents the lowest enzyme activity among all groups. But G6PD (glucose-6-phosphate dehydrogenase) and LPO (lipid peroxidation) is SM group represents the highest enzyme activity among all groups. These result indicate that the natural product extracts is an efficient tissue protective substance against smoke-induced lung injury.