• Journal of Communications and Networks
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• v.15 no.3
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• pp.312-320
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• 2013

Home evolved Node-B (HeNB), also called a femtocell or a femto base station, is introduced to provide high data rate to indoor users. However, two main problems arise in femtocell networks: (1) Small coverage area of HeNB, which results in limited cell-splitting gain and ping-pong handover (HO) problems and (2) high inter-femtocell interference because HeNBs may be densely deployed in a small region. In this study, an efficient cooperation mechanism called an HeNB-aided virtual-HO (HaVHO) scheme is proposed to expand the coverage area of femtocells and to reduce inter-femtocell interference. The cooperation among neighbor HeNBs is exploited in HaVHO by enabling an HeNB to relay the data of its neighbor HeNB without an HO. The HaVHO procedure is compatible with the existing long term evolution specification, and the information exchange overhead in HaVHO is relatively low. To estimate the signal to interference plus noise ratio improvement, the area average channel state metric is proposed, and the amount of user throughput enhancement by HaVHO is derived. System-level simulation shows that HaVHO has a better performance than the other four schemes, such as lesser radio link failure, lesser ping-pong handover, lesser short-stay handover, and higher user throughput.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.11 no.7
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• pp.3370-3392
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• 2017

Next Generation Beyond 4G/5G systems will rely on the deployment of small cells over conventional macrocells for achieving high spectral efficiency and improved coverage performance, especially for indoor and hotspot environments. In such heterogeneous networks, the expected performance gains can only be derived with the use of efficient interference coordination schemes, such as Fractional Frequency Reuse (FFR), which is very attractive for its simplicity and effectiveness. In this work, femtocells are deployed according to a spatial Poisson Point Process (PPP) over hexagonally shaped, 6-sector macro base stations (MeNBs) in an uncoordinated manner, operating in hybrid mode. A newly introduced intermediary region prevents cross-tier, cross-boundary interference and improves user equipment (UE) performance at the boundary of cell center and cell edge. With tools of stochastic geometry, an analytical framework for the signal-to-interference-plus-noise-ratio (SINR) distribution is developed to evaluate the performance of all UEs in different spatial locations, with consideration to both co-tier and cross-tier interference. Using the SINR distribution framework, average network throughput per tier is derived together with a newly proposed harmonic mean, which ensures fairness in resource allocation amongst all UEs. Finally, the FFR network parameters are optimized for maximizing average network throughput, and the harmonic mean using a fair resource assignment constraint. Numerical results verify the proposed analytical framework, and provide insights into design trade-offs between maximizing throughput and user fairness by appropriately adjusting the spatial partitioning thresholds, the spectrum allocation factor, and the femtocell density.

• BMB Reports
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• v.37 no.1
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• pp.83-92
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• 2004

As a result of the enormous amount of information that has been collected with E. coli over the past half century (e.g. genome sequence, mutant phenotypes, metabolic and regulatory networks, etc.), we now have detailed knowledge about gene regulation, protein activity, several hundred enzyme reactions, metabolic pathways, macromolecular machines, and regulatory interactions for this model organism. However, understanding how all these processes interact to form a living cell will require further characterization, quantification, data integration, and mathematical modeling, systems biology. No organism can rival E. coli with respect to the amount of available basic information and experimental tractability for the technologies needed for this undertaking. A focused, systematic effort to understand the E. coli cell will accelerate the development of new post-genomic technologies, including both experimental and computational tools. It will also lead to new technologies that will be applicable to other organisms, from microbes to plants, animals, and humans. E. coli is not only the best studied free-living model organism, but is also an extensively used microbe for industrial applications, especially for the production of small molecules of interest. It is an excellent representative of Gram-negative commensal bacteria. E. coli may represent a perfect model organism for systems biology that is aimed at elucidating both its free-living and commensal life-styles, which should open the door to whole-cell modeling and simulation.

• IMMUNE NETWORK
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• v.11 no.5
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• pp.227-244
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• 2011

MicroRNAs (miRNAs) are small noncoding RNA molecules that negatively regulate gene expression via degradation or translational repression of their target messenger RNAs (mRNAs). Recent studies have clearly demonstrated that miRNAs play critical roles in several biologic processes, including cell cycle, differentiation, cell development, cell growth, and apoptosis and that miRNAs are highly expressed in regulatory T (Treg) cells and a wide range of miRNAs are involved in the regulation of immunity and in the prevention of autoimmunity. It has been increasingly reported that miRNAs are associated with various human diseases like autoimmune disease, skin disease, neurological disease and psychiatric disease. Recently, the identification of miRNAs in skin has added a new dimension in the regulatory network and attracted significant interest in this novel layer of gene regulation. Although miRNA research in the field of dermatology is still relatively new, miRNAs have been the subject of much dermatological interest in skin morphogenesis and in regulating angiogenesis. In addition, miRNAs are moving rapidly center stage as key regulators of neuronal development and function in addition to important contributions to neurodegenerative disorder. Moreover, there is now compelling evidence that dysregulation of miRNA networks is implicated in the development and onset of human neruodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Tourette's syndrome, Down syndrome, depression and schizophrenia. In this review, I briefly summarize the current studies about the roles of miRNAs in various autoimmune diseases, skin diseases, psychoneurological disorders and mental stress.

• Journal of Communications and Networks
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• v.17 no.3
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• pp.231-240
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• 2015

To facilitate the base station planning in high speed railway communication systems, it is necessary to consider the functional relationships between the base station transmit power and space parameters such as train velocity and cell radius. Since these functions are able to present some inherent system properties determined by its spatial topology, they will be referred to as the power-space functions in this paper. In light of the fact that the line-of-sight path persists the most power of the received signal of each passing train, this paper considers the average transmission rate and bounds on power-space functions based on the additive white Gaussian noise channel (AWGN) model. As shown by Monte Carlo simulations, using AWGN channel instead of Rician channel introduces very small approximation errors, but a tractable mathematical framework and insightful results. Particularly, lower bounds and upper bounds on the average transmission rate, as well as transmit power as functions of train velocity and cell radius are presented in this paper. It is also proved that to maintain a fixed amount of service or a fixed average transmission rate, the transmit power of a base station needs to be increased exponentially, if the train velocity or cell radius is increased, respectively.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.4
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• pp.1477-1482
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• 2012

Squamous cell carcinoma and adenocarcinoma are the major histological types of non-small cell lung cancer. Because they differ on the basis of histopathological and clinical characteristics and their relationship with smoking, their etiologies may be different; for example, different tumor suppressor genes may be related to the genesis of each type. We used microarray data to construct three regulatory networks to identify potential genes related to lung adenocarcinoma and squamous cell carcinoma and investigated the similarity and specificity of them. In the network, some of the observed transcription factors and target genes had been previously proven to be related to lung adenocarcinoma and squamous cell carcinoma. We also found some new transcription factors and target genes related to SCC. The results demonstrated that regulatory network analysis is useful in connection analysis between lung adenocarcinoma and squamous cell carcinoma.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.7 no.9
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• pp.2154-2172
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• 2013

A centralized cognitive radio (CR) network is proposed and its system capacity is studied. The CR network is designed with power control and multi-user scheduling schemes to support best-effort traffics under peak interference power constraints. We provide an analytical framework to quantify its system capacity, taking into account various key factors such as interference constraints, density of primary users, cell radius, the number of CR users, and propagations effects. Furthermore, closed-form formulas are derived for its capacities when only path loss is considered in the channel model. Semi-analytical expressions for the capacities are also given when more realistic channel models that include path loss, shadowing, and small-scale fading are used. The accuracy of the proposed analytical framework is validated by Monte Carlo simulations. Illustrated with a practical example, the provided analytical framework is shown to be useful for the strategic planning of centralized CR networks.

• The KIPS Transactions:PartC
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• v.9C no.6
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• pp.945-952
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• 2002

For a successful inter-system handoff, several important issues must be handled and additional new features must be considered. This paper focuses on the cellular structure of small cells which are required for the high density of population and a handoff scheme designed between two heterogenous networks. Incase of inter-system handoff (ISHO), the time required to complete the handoff can vary and depends on the structure of networks. And also the transmission of additional signals can increase the probability of failure for ISHO. Here we propose the sub-boundary cell base station (Sub-BBS) to alleviate the role of the BBS. The Sub-BBS is adjacent to BBS in the same regional mobile network. 쪼en the mobile terminal enters Sub-BBS, the network starts finding a new route and after entering BBS, it initiates the transformation process. The proposed scheme significantly reduces the ISHO failure rate compared to the existing one which is the most recent and known as efficient.

• Journal of Information Processing Systems
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• v.6 no.1
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• pp.53-66
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• 2010

The energy efficiency is a key design issue to improve the lifetime of the underwater sensor networks (UWSN) consisting of sensor nodes equipped with a small battery of limited energy resource. In this paper, we apply a hexagon tessellation with an ideal cell size to deploy the underwater sensor nodes for two-dimensional UWSN. Upon this setting, we propose an enhanced hybrid transmission method that forwards data packets in a mixed transmission way based on location dependent direct transmitting or uniform multi-hop forwarding. In order to select direct transmitting or uniform multi-hop forwarding, the proposed method applies the threshold annulus that is defined as the distance between the cluster head node and the base station (BS). Our simulation results show that the proposed method enhances the energy efficiency compared with the existing multi-hop forwarding methods and hybrid transmission methods

• The Journal of Korean Institute of Communications and Information Sciences
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• v.38C no.9
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• pp.764-774
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• 2013

The number of users and data packets has increased in 4G cellular networks. Therefore, 4G cellular network providers suffer from the network capacity problem. In order to solve this problem, femtocell concept is suggested. It can reduce the coverage hole and enhance the QoS. However, only small number of femtocells experience the large amount of loads. To solve this problem, Mobility Load Balancing (MLB) algorithm is suggested, which is a kind of load balancing algorithm. To distribute the traffic load, MLB algorithm modifies the handover region. If the handover region is reduced by MLB algorithm, some cell edge users are compulsively handed over to neighbor femtocell. In this paper, we analyze the relation between MLB performing period and performance indicators. For example throughput and blocking probability is reduced, if period is decreased. On the contrast, if period is increased, the number of handover frequency is decreased. Using this relation, we suggest the adaptive periodic MLB algorithm. This algorithm includes the advantage of both long period and short period MLB algorithm, such as high throughput, the small number of handover frequency, and low blocking probability.