• Journal of Korean Neurosurgical Society
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• v.47 no.3
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• pp.224-227
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• 2010

Small bowel injury resulting from unforeseen penetration of the anterior annulus fibrosus and longitudinal ligament is a rare complication of lumbar microdiscectomy. The patient complained of abdominal tenderness and distention immediately after microdiscectomy for L4-5 and L5-S1 disc herniation. Using abdominal computed tomography, we found several foci of air overlying the anterior aspect of the vertebral body at the L5-S1 level. Segmental resection of the small bowel including small tears and primary anastomosis of the jejunum were performed. Here, we present a case of intestinal perforation after lumbar microdiscectomy and discuss technical methods to prevent this complication with a review of literature.

• YAKHAK HOEJI
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• v.12 no.1_2
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• pp.16-31
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• 1968

Comparative studies were made on some sulfonamides, used individually and combined with parasympatholytic agents as regards (1) the absorption rate through isolated rat small intestine (in vitro), (2) the absorption rate through rat small intestine (in vivo), and (3) the blood concentration of sulfonamides were examined by its oral administration with each combined drug to rabbits, and the following effects were found, parasympatholytic agents inhibit the absorption of sulfonamides from the small intestinal tract. Comparison of the inhibitic efficiency of parasympatholytic agents is as follows: oxazepam, oxyphencyclimine hydrochloride, probantheline bromide, atropine sulfate (The examples are from the weakest to the strongest). Decrement of the absorption rate of sulfonamides is as follows: sulfadiazine, sulfathiazole, sulfamethoxypyridazine, sulfadimethoxine, sulfamerazine, sulfamethazine (The example are from the strongest to the weakest). Additionally, it is assumed that if the combined drugs were absorbed from the small intestine in the original form, those inhibitic effects should be best regarding to their sulfonamide per parasympatholytic agent combined rate "25:1" than to their any other rates.her rates.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.12 no.2
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• pp.230-234
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• 2009

Trichobezoars are commonly found within the stomach, but rarely induce small bowel obstruction. We report an 8-year-old girl who presented with bilious vomiting and colicky abdominal pain. She had a history of depression and trichophagia. A diagnosis of small bowel obstruction was made on computed tomography and a trichobezoar in the ileum was evacuated by exploratory laparatomy.

• Journal of Veterinary Clinics
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• v.36 no.4
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• pp.225-228
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• 2019

Inflammatory bowel disease and alimentary lymphoma are common gastrointestinal disorder in cats. More recently, ultrasonographic features associated with feline alimentary lymphoma has been recognized as a diffuse thickening of muscular layer of small intestine. We investigated correlation between thickening of muscular layer of small intestine and such disease. We found a significantly increased thickness of the muscular layer of small intestine in cats with lymphoma or IBD compared with healthy cats. When a muscularis to submucosa ratio > 1 and regional lymphadenopathy were found during ultrasonography on cats with gastrointestinal signs, full-thickness biopsy could be recommended to make sure presence confirmation of inflammatory bowel disease or alimentary lymphoma.

• Korean Journal of Veterinary Research
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• v.42 no.3
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• pp.289-297
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• 2002

The regional distribution and relative frequency of neurohormonal peptides-producing cells were demonstrated in the gut of the stomach teleost, the Mandarin fish, Siniperca scherzeri Steindachner, using 7 types of specific antisera raised against mammalian regulatory peptides. The gastrointestinal tract of the Mandarin fish was divided into three portions from proximal to distal, stomach, small intestine and large intestine. Cells showing immunoreactivities against regulatory peptides were situated in the epithelial lining, between epithelial cells, and gastric or intestinal gland regions with various frequencies along with gastrointestinal tract. Mast of immunoreactive cells in the epithelial lining portion were generally spherical or spindle shape having long cytoplasmic process that were reached to the lumen (open type cell) while cells showing round in shape (closed type cell) were found in the gastric gland of the stomach occasionally. Serctonin-, samatostatin-, gastrin-, cholecystokinin (CCK)-8- and human pancreatic polypeptide (HPP)-immunoreactive cells were observed in this study. However, no insulin- and glucagon-immunoreactive cells were found. Serotonin- and somatostatin-immunoreactive cells were restricted to the stomach regions with moderate and numerous frequencies, respectively. Gastrin-immunoreactive cells were demonstrated in the stomach and small intestinal portions with a few and moderate frequencies, respectively and CCK-8-immunoreactive cells were restricted to the small intestinal portions with moderate frequency. In addition, HPP-immunoreactive cells were demonstrated in the stomach and small intestine with numerous frequencies, respectively. In conclusion, the distribution and relative frequency of these immunoreactive cells in the gastrointestinal tract of the Mandarin fish shows peculiar patterns compared to those of other stomach and/or stomachless teleost.

• Childhood Kidney Diseases
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• v.11 no.1
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• pp.106-111
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• 2007

[ $Henoch-Sch\ddot{o}nlein$ ] Purpura(HSP) is a form of vasculitis that typically affects small arteries in the skin, joints, intestinal tract and kidneys. It usually resolves spontaneously but sometimes can cause serious problems in the kidneys and intestinal tract. A 6-year-old girl with purpura, arthralgia and abdominal pain for 2 weeks was admitted. She also showed gross hematuria, generalized edema and decreased urine output. Blood pressure was in the upper normal range. Initial laboratory findings showed hypoalbuminemia, hyperlipidemia, microhematuria and nephrotic-range proteinuria(27.2 g/day). Initially, she was treated with pulse methylprednisolone, azathioprine, albumin and furosemide. Her renal biopsy revealed diffuse mesangial proliferation with strong IgA deposition. There were no crescents. On the third hospital day, she complained of severe abdominal pain and free peritoneal air was seen on abdominal X-ray. Primary repair of small bowel was performed and two pin-point sized holes were found. One week later, she still showed heavy proteinuria. Therefore, we added an ACE inhibitor and dipyridamole, and changed azathioprine to cyclosporine. One month later, the urine protein/creatinine ratio was decreased to 17.8 from 57, but heavy proteinuria has been still persisted. Here we report a rare case of a patient with HSP who had both severe nephrritc-nephrotic syndrome and small bowel perforation.

• Advances in pediatric surgery
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• v.4 no.2
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• pp.166-171
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• 1998

Segmental dilatation of the small intestine is a rare form of the congenital intestinal anomaly. Many other combined anomalies have been reported in, but the association with colonic duplication has not been reported in the literature. We report a case of segmental dilatation of the distal ileum associated with colonic duplication. The main clinical and pathogenic aspects are discussed, and the literatures are reviewed.

• Journal of Veterinary Clinics
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• v.18 no.2
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• pp.178-181
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• 2001

Four dead wild racoons found in Chonnam province were examined parasitologically, pathologically and bacteriologically. Using standard flotation technique with feces many number of ancylostoma eggs which were oval in shape and $60-70{\times}35-45 {\mu}m$ in size were detected. Grossly, severe anemia, multiple congestion and consolidation of lung and catarrhal exudate in small intestine were observed. One of racoons had multifocal white to yellow nodules in the liver. Histopathologically, ancylostoma larvas were found in intestinal lumen. Some of them penetrated and attached to intestinal mucosa. Lungs revealed multiple severe fibrinopurulent pneumonia in which bacterial colonies were scattered. Liver had multiple microabscesses containing peripheral bacterial colony. By Gram stain using paraffin sections of liver and lung, bacterial colony was Gram negative. Isolated bacteria from lung and liver was Gram negative rod. This bacteria was identical with Escherichia coli by biochemical tests. From these results, ancylostomiasis caused severe problems in Korean wild racoons. This is the first report about ancylostomiasis in wild racoons in Korea.

• Journal of Pharmaceutical Investigation
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• v.22 no.1
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• pp.55-62
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• 1992

In order to measure the bioavailability of Coptidis Rhizoma preparations, berberine was extracted by the mixture (1:1 v/v) of methanol and water from Coptidis Rhizoma and formulated into pills with some excipients. Disintegration time, dissolution rate, intestinal absorption rate, antibacterial effect, and serum concentration were measured. All pills were disintegrated about 60 minutes in gastric and intestinal juices and disintegration time did not change upon storage at $40^{\circ}C$ for 30 days. The pills manufactured using the extract which was extracted with the solvent containing dilute sulfuric acid showed faster dissolution and absorption from the small intestine than the other samples. It also showed not only the largest area under the serum concentration time curve and relative bioavailability, but also more potent antibacterial effect against gram-positive and gram-negative bacterias than the other samples. The correlation of the dissolution rate with absorption rate constant or $t_{max}$ showed a significant linear relationship.

• Development and Reproduction
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• v.23 no.4
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• pp.305-311
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• 2019

Small intestine has a structure called villi that increases the mucosal surface area for nutrient absorption. Intricate and tight epithelial-mesenchymal interactions are required for villi development. These interactions are regulated by signaling molecules, physical forces, and epithelial deformation. Signaling molecules include hedgehog (Hh), bone morphogenetic protein (BMP) and Wnt ligands. The Hh ligand is expressed from the epithelium and binds to the underlying mesenchymal cells, resulting in aggregation into mesenchymal clusters. The clusters express BMP and Wnt ligands to control its size and spacing between clusters. The clusters then form villi. Despite the fact that the villi formation is studied extensively, we do not have a complete understanding. In addition, the recent study shows there is a great relationship between the overexpression of the Hh signal and development of cancer in the gastrointestinal tract. Therefore, signaling between epithelial and mesenchymal cells and their physical interactions will be discussed on this review.