• BMB Reports
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• v.44 no.12
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• pp.811-815
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• 2011

Inhalational anthrax is caused by B. anthracis, a virulent sporeforming bacterium which secretes anthrax toxins consisting of protective antigen (PA), lethal factor (LF) and edema factor (EF). LF is a Zn-dependent metalloprotease and is the main determinant in the pathogenesis of anthrax. Here we report the identification of a lead small-molecule inhibitor of anthrax lethal factor by screening an available synthetic small-molecule inhibitor library using fluorescence-based high-throughput screening (HTS) approach. Seven small molecules were found to have inhibitory effect against LF activity, among which SM157 had the highest inhibitory activity. All theses small molecule inhibitors inhibited LF in a noncompetitive inhibition mode. SM157 and SM167 are from the same family, both having an identical group complex, which is predicted to insert into S1' pocket of LF. More potent small-molecule inhibitors could be developed by modifying SM157 based on this identical group complex.

• Journal of Korean Library and Information Science Society
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• v.51 no.4
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• pp.157-183
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• 2020

This study was a basic study for the establishment of basic policies for the operation of Sejong City Library. It was intended to establish and operate the functions and roles of Sejong City Library by conducting a general survey on the current status, user demand, expert opinion, and librarian opinion survey. As a result, the Sejong City Library is the representative library of Sejong Special Self-Governing City, which oversees all public and small libraries in Sejong Special Self-Governing City and carries out support and cooperation projects, and should improve the development of the local community and the quality of life of local residents by providing more convenient and equal access to provide information services and cultural programs. Second, apart from providing library services to local residents in Sejong Special Self-Governing City, the functions of the Sejong Special Self-Governing City's representative library and hub library, knowledge and information center, lifelong education center, social and cultural center, leisure culture center, leisure and convenience center, and furthermore, it should function as a policy information support center. Finally, in order to enhance the brand value of Sejong City Library, the Sejong City Library as a landmark in Sejong area, the Sejong City Library as an art and cultural hub in Sejong area, the Sejong City Library as a complex cultural space in Sejong area, and the Sejong City Library as a center for Sejong Studies were proposed.

• Journal of Korean Society of Rural Planning
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• v.19 no.3
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• pp.183-193
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• 2013

In 2011, neighborhood parks occupied a total area of $280,135,257m^2$ in small and medium sized city areas and this excluded the metropolitan regions. In the rural area, the park area per person($22.64m^2$) is larger than the urban area($9.50m^2$). It is a questionable why there is a higher park ratio in the rural area compared to the cities, where the function of the neighborhood parks is not being utilized well. But, there are already a lot of parks that has been constructed in the rural areas and a lot of money is being spent in maintaining them. Hence, rather than reducing the number of "country parks", it can be suggested that these "country parks" ought to be utilized in a different manner than the parks in the city. In that point of view, this study examined the issues of the country park usage along with the utilization of the local festivals within the parks. Firstly in this context, this study compared the amount of neighborhood parks between small and medium sized cities and metropolitan areas, and analyzed those results. Secondly, daily newspaper articles were collected and categorized to find the usage of the rural park which were then analyzed. Then, the extraction of the essential points in composing the festival space was carried out. Also, the general design guides of making the neighborhood parks were drawn. Last but not least, using these two resources, this study suggested design guidelines for using neighborhood parks as a Festival Space in small and medium sized cities.

• Korean Journal of Occupational Health Nursing
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• v.10 no.1
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• pp.55-65
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• 2001

The purpose of this study was to find out the status of occupational health management and the degree of recognition about the occupational health management of employees 248 small-scale enterprises which have been managed by the small-scale enterprises health care management support institution in 1999, were selected for study, in Kwang-Ju City. 98 employees were selected in 116 industries of them to grasp recognition of employees about the occupational health management. ► The Status of Occupational Health Management 1. Of the sample industries, 62.1 percent employed eleven to twenty-nine workers. Of the sample workers, 72.1 percent occupied workers who were engaged in the production line. 2. Environment evaluation was made on 82.7 percent of the sample industries and general exam made on 66.5 percent and specific health exam done on 73.4 percent. 3. The harmful factors in the sample industries were found to lie noise, dust, solvent, heavy metal, etc. 4. In general health exam 1,774 workers were participated and 148 workers got the result of above grade C and were diagnosed as having the problems with digestive system (63.6%), circulatory system(20.6%). etc. ► The Degree of Recognition about The Occupational Health Management of Employees. 1. Respondents were mainly in the twenties (42.9%), males(69.1%), duration of working period of five to ten years(24.0%), office workers(51.0%), monthly income under one million(55.7%). 2. Recognition of employees about the occupational health management consists of workplace environmental evaluation, health education, health exam and protector management. Their recognition on health education showed high score (mean 3.1), but generally the score was low(mean 2.9).

• Journal of Distribution Science
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• v.6 no.1
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• pp.25-46
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• 2008

The latest flow in Korea's distribution market is characterized by the deterioration of small/medium distribution market due to the rapid growth of multinational discount stores. As various multinational discount stores have merged with Korean discount stores (Homever acquired Carrefour and E-Mart acquired Wal-Mart), these discount stores have enlarged in size and dominated the market. On the contrary, small/medium distributors with relatively weak infrastructures are losing competitiveness in the market. Traditional marketplaces in local areas, in particular, are facing a serious crisis as they are neglected in the depressed local markets and have been beaten by the increasing discount stores and the diversifying distributors. The purpose of this study was to propose alternative plans to revitalize traditional marketplaces that are endangered by the unbalanced development of the distribution industry. This study analyzed the distribution performances and problems of Daejeon Metropolitan City and used the analysis to point out the problems specific to traditional marketplaces and propose a way to revitalize them. I hope that this study can help discount stores and small/medium distributors find balance in the market, and give traditional marketplaces the competitiveness to pursue sustainable growth.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.5
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• pp.2695-2702
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• 2014

This study was conducted in order to the investigate factors associated with turnover intention and the relationship among nursing professionalism, job satisfaction and turnover intention of nurses working in a small and medium-Sized hospital. From Oct 2011 to Jun 2012, "I" City, a nurse 240 working in a small and medium-Sized hospital. Average nursing professionalism score $3.23{\pm}.44$, $2.81{\pm}.47$, average job satisfaction score points, and the average turnover intention score was $2.70{\pm}.87$ points. Clinical experience, number of hours worked by the difference in the turnover intention was significan,. turnover intention is to describe the main variables job satisfaction(${\beta}$ = .533) than the other relevant factors, the most showed a lot of influence. Through this study, to reduce turnover intention need to continuously study on job the satisfaction of nurses in small-medium sized hospital.

• Journal of The Korean Society of Agricultural Engineers
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• v.64 no.5
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• pp.53-65
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• 2022

Most of the reservoirs managed by the city and county are small and it is difficult to respond to climate change because the drainage area is small and the inflow increases rapidly when a heavy rain occurs. In this study, the current status of reservoirs managed by city and county in Gyeonggi-do was reviewed and flood vulnerability due to climate change was analyzed. In order to analyze the impact of climate change, CMIP6-based future climate scenario provided by IPCC was used, and future rainfall data was established through downscaling of climate scenario (SSP8-8.5). The flood vulnerability of reservoirs due to climate change was evaluated using the concept provided by the IPCC. The future annual precipitation at six weather stations appeared a gradual increase and the fluctuation range of the annual precipitation was also found to increase. As a result of calculating the flood vulnerability index, it was analyzed that the flood vulnerability was the largest in the 2055s period and the lowest in the 2025s period. In the past period (2000s), the number of D and E grade reservoirs was 58, but it was found to increase to 107 in the 2055s period. In 2085s, there were 17 E grade reservoirs, which was more than in the past. Therefore, it is necessary to take measures against the increasing risk of flooding in the future.

• Journal of the Korean Institute of Landscape Architecture
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• v.33 no.3 s.110
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• pp.78-83
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• 2005

The purpose of this project is to create small parks in elementary schools in order to improve the educational environment and also to increase the amount of greenspace in the city. Above all, the main goal is to create space for local residents in which they can enjoy their leisure time. During a basic investigation and document investigation of elementary schools in Daegu, I placed the priority on choosing the schools that showed the most promise. Also, by doing a survey about the present conditions at schools, I verified, compared, and analyzed the validity of creating small parks in elementary schools. The summary of the results are as follows. The average area available for building small parte in Daegu elementary schools is $7,447m^2$. Even though this area is not as large as a neighborhood parti the difference is not that great. Therefore, I assumed that building small parks in schools would be as effective as building neighborhood parks. The standard size for a children's parks is $1,500m^2$, and if small parks were to be constructed in all school areas with available space larger than a children's park (i.e., larger than $1,500m^2$), the amount of added park greenspace would equal $1,217,953m^2$. The number of schools with areas under $1,500m^2$ is only 3% of all schools in which small parte can be created(5 schools). Schools that have between $1,500m^2$ and $8,000m^2$of greenspace make up 59.7% of all schools in which small parte can be created (98 schools). Schools that have greenspace of more than $8,000m^2$ make up 37% of all school in which small parks can be created (61 schools). The standard area for neighborhood parte is $10,000m^2$ (building-to-land ratio 20%). Schools that have areas that are larger than the standard area for neighborhood parte make up 31% of all elementary schools in Daegu (61 schools). Therefore city greenspace would increase to a total of $694,805m^2$ by making use of these schools, which would represent 7% of the park greenspace in Daegu.

• Journal of the Korean Institute of Landscape Architecture
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• v.28 no.1
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• pp.11-18
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• 2000

Taegu is notorious as hot and dry summer among Korea cities. One of the most important goals of the open space planning is to ameliorate urban climate of the city. The objective of this research is to evaluate the thermal mitigation effect of the cool islands in Taegu metropolitan city. Cool islands of this paper includes parks and rivers surrounded by or adjacent to urbanized areas. Based on the analysis of the thermal band of Landsat TM at May 17, 1997, the thermal mitigation effect of open spaces in the city could be summarized as follows ; Kumho river showed the largest mitigation effect in terms of the width of mitigation zone and temperature difference. Evaporation from wide water surface and evapo-transpiration from riparian grass land could bring into results. Significant mitigation effect of parks covered with forest can be observed. The temperature range of such parks were between 19.05$^{\circ}C$ and 19.44$^{\circ}C$ However, the thermal mitigation effect of Dalsung park and Apsan park was insignificant. The small size and high percentage of hard paving of the former and the relative low density of the residential areas adjacent to the latter could be the main reason. In conclusion, the thermal mitigation effect in urban ope spaces could be detectedby the employment of thermal band data of Landsat TM and GIS buffering technique.

• Journal of Korean Library and Information Science Society
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• v.40 no.3
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• pp.5-23
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• 2009

This study focuses on the collaboration among public libraries and communities through 'One Book, One City' reading campaign. This study introduced the meaning and trend of 'One Book, One City' program on the world. And this study also suggests the ideas for the collaboration among public libraries and communities making use of this reading campaign; activation of reading campaign, building library network, establishing partnership model between private and public sectors.