• Journal of Ocean Engineering and Technology
• /
• v.27 no.1
• /
• pp.51-58
• /
• 2013

Recently, there has been an increase in the demand for natural gas as a source of clean energy, which has increased the demand for LNG carriers. However, LNG carriers require a capital investment to obtain equipment for the regasification process, which prevents fires and explosions. Thus, on account of NIMBY, a CNG carrier is suggested that eliminates the need for regasification equipment. Meanwhile, carbon dioxide emissions are more and more regulated by international conventions such as the Kyoto Protocol. Because of this, $CO_2$ carriers have also received international attention as a methodology to transport and store $CO_2$ cargoes. Several vessels or tanks to transport and store $CO_2$ gas have been studied in various countries. This paper proposes a conceptual design for a 20ft container shaped tank to effectively transport small cargoes of $CO_2$ and CNG. The proposed pressure vessel or tank will be carried by a conventional containership or special cargo ship. The influences of the design parameters for proposed pressure vessel or tank. Including the materials, scantlings, and shape of the pressure vessel, are studied theoretically and computationally.

• Tuberculosis and Respiratory Diseases
• /
• v.40 no.1
• /
• pp.79-83
• /
• 1993

A 38-year-old female was admitted due to progressive exertional dyspnea and intermittent blood tinged sputum. Chest PA showed diffuse reticular infiltration accompanied by hyperinflation. $PaO_2$ was normal in resting state but profoundly decreased during exercise. Spirometry showed severe obstructive pattern but DLCO was markedly decreased. Lung volumes measured by helium equilibrium method was increased. On HRCT, numerous and relatively uniform sized cysts were evenly distributed throughout the bilateral lung fields. Open lung biopsy was performed and pulmonary lymphangioleiomyomatosis(LAM) was diagnosed based on the findings of abnormal proliferation of smooth muscle cells in the walls of lymphatic vessels, bronchioles, and small pulmonary veins. Immunohistochemical staining was negative for estrogen receptor but positive for progesterone receptor. Medroxyprogesterone therapy was initiated.

• BMB Reports
• /
• v.41 no.4
• /
• pp.278-286
• /
• 2008

Angiogenesis, the formation of blood vessels, is essential for preparing a closed circulatory system in the body, and for supplying oxygen and nutrition to tissues. Major diseases such as cancer, rheumatoid arthritis, and atherosclerosis include pathological angiogenesis in their malignant processes, suggesting anti-angiogenic therapy to be a new strategy for suppression of diseases. However, until the 1970s, the molecular basis of angiogenesis was largely unknown. In recent decades, extensive studies have revealed a variety of angiogenic factors and their receptors, including vascular endothelial growth factor (VEGF)-VEGFRs, Angiopoietin-Tie, Ephrin-EphRs and Delta-Notch to be the major regulators of angiogenesis in vertebrates. VEGF and its receptors play a central role in physiological as well as pathological angiogenesis, and functional inhibitors of VEGF and VEGFRs such as anti-VEGF neutralizing antibody and small molecules that block the tyrosine kinase activity of VEGFRs have recently been approved for use to treat patients with colorectal, lung, renal and liver cancers. These drugs have opened a novel field of cancer therapy, i.e. anti-angiogenesis therapy. However, as yet they cannot completely cure patients, and cancer cells could become resistant to these drugs. Thus, it is important to understand further the molecular mechanisms underlying not only VEGF-VEGFR signaling but also the VEGF-independent regulation of angiogenesis, and to learn how to improve anti-angiogenesis therapy.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• v.23 no.1
• /
• pp.115-120
• /
• 2020

Klippel-Trenaunay syndrome (KTS) is a rare disorder characterized by a triad of abnormal bone and soft tissue growth, the presence of a port-wine stain, and venous malformations. Gastrointestinal (GI) manifestations of KTS are relatively common and generally do not cause significant problems. However, persistence can lead to chronic GI blood loss or even massive bleeding in rare cases. The majority of the severe GI manifestations associated with KTS present as vascular malformations around the GI tract and exposed vessels can lead to serious bleeding into the GI tract. Herein, we report a case of a 16-year-old boy with severe iron deficiency anemia who was previously misdiagnosed as hemorrhoid due to small amount of chronic bleeding. The actual cause of chronic GI bleeding was from an uncommon GI manifestation of KTS as rectal polyposis.

• Ocean Systems Engineering
• /
• v.6 no.4
• /
• pp.305-324
• /
• 2016

Wave load prediction at zero forward speed using finite depth Green function is a well-established method regularly used in the offshore and marine industry. The forward speed approximation in deep water condition, although with limitations, is also found to be quite useful for engineering applications. However, analysis of vessels with forward speed in finite water depth still requires efficient computing methods. In this paper, a method for analysis of wave induced forces and corresponding motion on freely floating three-dimensional bodies with low to moderate forward speed is presented. A finite depth Green function is developed and incorporated in a 3D frequency domain potential flow based tool to allow consideration of finite (or shallow) water depth conditions. First order forces and moments and mean second order forces and moments in six degree of freedom are obtained. The effect of hull flare angle in predicting added resistance is incorporated. This implementation provides the unique capability of predicting added resistance in finite water depth with flare angle effect using a Green function approach. The results are validated using a half immersed sphere and S-175 ship. Finally, the effect of finite depth on a tanker with forward speed is presented.

• Journal of Korean Neurosurgical Society
• /
• v.57 no.3
• /
• pp.204-207
• /
• 2015

We are reporting an unusual case of dural arteriovenous fistula (AVF) of the superior sagittal sinus (SSS) after tamoxifen treatment for breast cancer. A 30-year-old female arrived at the emergency room with a sudden headache and left sided weakness and sensory loss. In her past medical history, she was diagnosed with breast cancer 1 year prior, and subsequently underwent a breast conserving mastectomy with whole breast radiation and adjuvant chemotherapy with tamoxifen. At the time of admission, computed tomography showed a small acute intracerebral hemorrhage at the right parietal cortex, and magnetic resonance imaging showed that a dural AVF at the SSS with a prominent and tortuous venous enhancement along the centrum semiovale was present. Cerebral angiography showed that the dural AVF at the mid-portion of the SSS with meningeal arterial feeding vessels entering the wall of the SSS, then draining through the dilated cortical veins. Our patient had no signs of active malignancy or any abnormalities in her coagulation profile, so it can be concluded that the tamoxifen was the likely cause of the SSS thrombosis and dural AVF. The dural AVF was treated by an endovascular coil embolization for the arterialized segment of the SSS. The patient dramatically recovered favorably from left side motor and sensory deficit. The best clinical approach is to screen potential patients of tamoxifen hormonal therapy and educate them on the sign and symptoms of life threatening thromboembolic events while taking tamoxifen.

• Clinical and Experimental Pediatrics
• /
• v.45 no.12
• /
• pp.1601-1605
• /
• 2002

Henoch-Sh${\ddot{o}}$nlein Purpura(HSP) is an immuologically mediated systemic vasculitis of small blood vessels affecting predominantly the skin, gastrointestinal tract, joints, and kidneys. Clinical neurological manifestations such as headaches, behavioral changes, mental changes, seizures, and visual loss are described, but neurological complication are rare during the course of HSP. We experienced a case of an 8 year-old male with HSP who presented with seizures. Magnetic resonance imaging(MRI) showed multiple high signal intensity in both cortical and subcortical areas of frontal and parieto-occipital lobes and magnetic resonance(MR) angiogram showed stenosis of cerebral arteries, compatible with MRI and MR angiogram findings of cerebral vasculitis. We report this case with related literature.

• Proceedings of the Korean Society of Precision Engineering Conference
• /
• 1996.11a
• /
• pp.697-701
• /
• 1996

King Sejong's Striking water-clock which brought in use on the first of July in 1434 was mainly composed of timekeeping and time announcing parts signalling twelve double-hours, and five night-watches and night-watch-divisions automatically by means of ball-operating jackworks. The clock was arranged with dual timekeeping system, the one for a full day(twelve double-hours) and the other for five night-watches achieving twelve double-hours and one-hundred interval horary systems. The vessels were arrayed in inflow-type water-clock, a large reservoir on the highest story, a constant-level tank for supplying water to the measuring vessel evenly in the middle, and the lowest tank to receive water from the above constant-level tank. An indicator-rod on the float was raised upwards depending on the water-level increase to show timing scales and also to release small bronze balls from the ball-rack mechanisms implanted on the measuring vessel to signal timing intervals.

• Archives of Plastic Surgery
• /
• v.32 no.6
• /
• pp.739-743
• /
• 2005

Subcondylar fractures have generally been treated by intermaxillary fixation except in cases where there is an absolute indication for open reduction. The reason behind a less aggressive surgical approach lies on the inherent difficulties in manipulating fragments in such a small area at the risk of damaging facial nerves or vessels such as the internal maxillary artery. However, long-term follow-up studies showed that conservative treatment of subcondylar fractures results in disturbances of occlusal function, deviation of the mandible, internal derangement of the temporomandibular joint, and ankylosis of the joint. We carried out open reduction of dislocated subcondylar fractures in 14 patients from 2000 to 2004 by a retromandibular approach. After the reduction of fractured bone, two H-shaped miniplates with 6 holes were fixed with screws at the anterior and posterior surfaces of the subcondyle. The retromandibular approach allowed good access and easy manipulation of the subcondyle. Immediate relief from malocclusion and correction of mandibular midline shifting were observed in all patients. Late temporomandibular dysfunction and ankylosis were not observed. Open reduction with plate osteosynthesis made it possible to avoid IMF in 7 of the 14 patients. The present study shows that open reduction through this retromandibular approach can produce good outcome in adult patients with subcondylar fracture.

• Journal of Veterinary Clinics
• /
• v.37 no.2
• /
• pp.88-90
• /
• 2020

A one year old spayed female Bichon Frise dog presented with gait abnormalities and seizure. Serum biochemical results showed elevated levels of alkaline phosphatase, alanine aminotransferase, and ammonia. Serum bile acid level was also increased to be over 30 μmol/L on preprandial. Urinalysis identified the presence of ammonium urate crystal. Abdominal ultrasonography and CT revealed aberrant, tortuous, and multiple small vessels connected to the caudal vena cava between left kidney and caudal vena cava. Macroscopic specific findings associated with extrahepatic congenital portosystemic shunts (PSS) or other liver diseases were not identified. Liver biopsy was performed. Histopathologic evaluation revealed hepatic lobular hypoplasia with portal arterial duplication and vascular shunts. Based on these finding, this case was diagnosed as multiple acquired PSS secondary to hepatic microvascular dysplasia (HMD) and hepatic encephalopathy. A liver biopsy is recommended to differentiate HMD from other liver diseases and to confirm HMD when a young dog has multiple acquired PSS.