• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.38B no.9
• /
• pp.736-743
• /
• 2013

In IRST(infrared search and track) system, the small target detection is very difficult because the IR(infrared) image have various clutter and sensor noise. The noise and clutter similar to the target intensity value produce many false alarms. In this paper. We propose the adaptive detection method which obtains optimal target detection using the image intensity information and the prior information of target. In order to enhance the target, we apply the human visual system. we determine the adaptive threshold value using image intensity and distance measure in target enhancement image. The experimental results indicate that the proposed method can efficiently extract target region in various IR images.

• Journal of Korea Multimedia Society
• /
• v.15 no.11
• /
• pp.1305-1318
• /
• 2012

Image segmentation is one of the difficult research problems in machine vision and pattern recognition field. A commonly used segmentation method is the Otsu method. It is simpler and easier to implement but it fails if the histogram is unimodal or similar to unimodal. And if some target area is smaller than background object, then its histogram has the distribution close to unimodal. In this paper, we proposed an improved image segmentation method based on 1D Otsu method for a small target detection. To overcome drawbacks by unimodal histogram effect, we depressed the background histogram using a logarithm function. And to improve a signal to noise ratio, we used a local average value by the neighbor window for thresholding using 1D Otsu method. The experimental results show that our proposed algorithm performs better segmentation result than a traditional 1D Otsu method, and needs much less computational time than that of the 2D Otsu method.

• The Journal of the Institute of Internet, Broadcasting and Communication
• /
• v.21 no.5
• /
• pp.11-18
• /
• 2021

The small radio frequency tracking radar is a tracking system with a radio frequency sensor that identifies a target through all-weather radio frequency signal processing for a target and searches, detects and tracks the target for the major target. In this paper, we describe the development of a board equipped with TMS320C6678 and XILINX FPGA (Field Programmable Gate Array), a high-speed multi-core DSP that acquires target information through all-weather radio frequency and identifies a target through real-time signal processing. We propose DSP-FPGA combination architecture for DSP and FPGA selection and signal processing, and also explain the design of SRIO for high-speed data transmission.

• IMMUNE NETWORK
• /
• v.22 no.6
• /
• pp.51.1-51.20
• /
• 2022

Trypanosoma cruzi, the etiological agent of Chagas disease, is an intracellular protozoan parasite, which is now present in most industrialized countries. About 40% of T. cruzi infected individuals will develop severe, incurable cardiovascular, gastrointestinal, or neurological disorders. The molecular mechanisms by which T. cruzi induces cardiopathogenesis remain to be determined. Previous studies showed that increased IL-6 expression in T. cruzi patients was associated with disease severity. IL-6 signaling was suggested to induce pro-inflammatory and pro-fibrotic responses, however, the role of this pathway during early infection remains to be elucidated. We reported that T. cruzi can dysregulate the expression of host PIWI-interacting RNAs (piRNAs) during early infection. Here, we aim to evaluate the dysregulation of IL-6 signaling and the piRNAs computationally predicted to target IL-6 molecules during early T. cruzi infection of primary human cardiac fibroblasts (PHCF). Using in silico analysis, we predict that piR_004506, piR_001356, and piR_017716 target IL6 and SOCS3 genes, respectively. We validated the piRNAs and target gene expression in T. cruzi challenged PHCF. Secreted IL-6, soluble gp-130, and sIL-6R in condition media were measured using a cytokine array and western blot analysis was used to measure pathway activation. We created a network of piRNAs, target genes, and genes within one degree of biological interaction. Our analysis revealed an inverse relationship between piRNA expression and the target transcripts during early infection, denoting the IL-6 pathway targeting piRNAs can be developed as potential therapeutics to mitigate T. cruzi cardiomyopathies.

• CELLMED
• /
• v.3 no.2
• /
• pp.12.1-12.4
• /
• 2013

Identification of target protein is an important procedure in the course of drug discovery. Because of complexity, action mechanisms of herbal medicine are rather obscure, unlike small-molecular drugs. Inverse docking simulation is a reverse use of molecular docking involving multiple target searches for known chemical structure. This methodology can be applied in the field of target fishing and toxicity prediction for herbal compounds as well as known drug molecules. The aim of this review is to introduce a series of in silico works for predicting potential drug targets and side-effects based on inverse docking simulations.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.21 no.4
• /
• pp.834-847
• /
• 1996

A selective coding scheme is proposed that describes a method for coding image sequences distinguishing bits between background and target region. The suggested method initially estimates global motion parameters and local motion vectors. Then segmentation is performed with a hierarchical clustering scheme and a quadtree algorithm in order to divide the processing image into the backgraound and target region. Finally image coding is done by assigning more bits to the target region and less bits to background so that the target region may be reconstructed with high quality. Simulations show that the suggested algorithm performs well especially in the circumstances where background changes and target regionis small enough compared with that of background.

• Tribology and Lubricants
• /
• v.24 no.6
• /
• pp.326-331
• /
• 2008

The contact surfaces between mold and target should be in parallel for a proper imprinting process. However, large size of contacting area makes it difficult for both mating surfaces (mold and target planes) to be in all uniform contact with the expected precision level in terms of thickness and position. This is caused by the waviness of mold and target although it is very small relative to the area scale. The gripping force for both mold and target by the vacuum chuck is other major effect to interrupt the uniform contact, which must be avoided in imprinting mechanism. In this study, the cause of non-conformal contact mechanism between mold and target is investigated with the consideration of deformation due to the vacuum gripping for the size $470{\times}370\;mm^2$ LCD panel.

• International Journal of Aeronautical and Space Sciences
• /
• v.2 no.2
• /
• pp.73-81
• /
• 2001

This paper describes the procedure to develop a robust estimator design method for a target tracker that accounts for both structured real parameter uncertainties and unknown inputs. Two robust design approaches are combined: the Mini-p-Norm. design method to consider real parameter uncertainties and the $H_{\infty}$ design technique for unknown disturbances and unknown inputs. Constant estimator gains are computed that guarantee the robust performance of the estimator in the presence of parameter variations in the target model and unknown inputs to the target. The new estimator has two design parameters. One design parameter allows the trade off between small estimator error variance and low sensitivity to unknown parameter variations. Another design parameter allows the trade off between the robustness to real parameter variations and the robustness to unknown inputs. This robust estimator design method was applied to the longitudinal motion tracking problem of a T-38 aircraft.

• Biomedical Science Letters
• /
• v.17 no.1
• /
• pp.1-5
• /
• 2011

Previously, we have identified 14 putative downstream target genes of Hoxc8 homeoprotein in F9 murine embryonic teratocarcinoma cells through proteomics analysis. Among those, we tested a possibility of a DNA-k type molecular chaperone, Grp78, as a direct downstream target of Hoxc8, by cloning a 2.4 kb upstream region of murine Grp78 into a reporter plasmid and by testing if Hoxc8 can regulate its expression. We observed that Hoxc8 proteins could transactivate the reporter gene, which was affected by small interference RNAs (siRNAs) against to Hoxc8, suggesting that Grp78 is a novel downstream target of Hoxc8 in vivo.

• BMB Reports
• /
• v.49 no.3
• /
• pp.135-136
• /
• 2016

Small interfering RNAs (siRNAs) have been developed to intentionally repress a specific gene expression by directing RNA-induced silencing complex (RISC), mimicking the endogenous gene silencer, microRNAs (miRNAs). Although siRNA is designed to be perfectly complementary to an intended target mRNA, it also suppresses hundreds of off-targets by the way that miRNAs recognize targets. Until now, there is no efficient way to avoid such off-target repression, although the mode of miRNA-like interaction has been proposed. Rationally based on the model called "transitional nucleation" which pre-requires base-pairs from position 2 to the pivot (position 6) with targets, we developed a simple chemical modification which completely eliminates miRNA-like off-target repression (0%), achieved by substituting a nucleotide in pivot with abasic spacers (dSpacer or C3 spacer), which potentially destabilize the transitional nucleation. Furthermore, by alleviating steric hindrance in the complex with Argonaute (Ago), abasic pivot substitution also preserves near-perfect on-target activity (∼80-100%). Abasic pivot substitution offers a general means of harnessing target specificity of siRNAs to experimental and clinical applications where misleading and deleterious phenotypes from off-target repression must be considered.