• The Transactions of the Korean Institute of Electrical Engineers
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• v.39 no.2
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• pp.192-198
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• 1990

The performance of the proportional navigation guidance(PNG) law for a target with constant acceleration has been extensively studied in the prior literature. In this papaer, we consider the performance of the PNG law for a randomly maneuvering target. By means of Lyapunov method, we prove that an ideal missile guided by the conventional PNG law can always intercept a randomly maneuvering target if the initial missile heading error is small and the navigation constant is chosen sufficiently large. To the authors' best knowledge, this is the first analytic result on the performance of the PNG law for a target with time-varying acceleration.

• Journal of Technology Innovation
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• v.8 no.1
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• pp.31-48
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• 2000

Nowadays the role of region has been increased, as knowledge, science and technology become important in economic development. This paper argues that a system approach is needed to enhance regional S&T capabilities. Under the this approach, we can identify a concept of regional innovation systems as sub-systems of a national innovation system. This paper investigates Korean regional innovation systems based on R&D budget of regional governments. According to this paper, Korean regional governments' R&D investment is very insufficient. There were no co-relationship between regional governments' fiscal autonomy from the central government and their R&D investment. This paper argues that such a poor investment will restrict the future development of Korean regional innovation systems. Therefore, this paper suggests some strategic options for the development of regional innovation systems as follows. First, regional governments should increase their R&D budget. Second, their R&D efforts should be related with their specific industrial sectors. Third, they should target not only to create new promising industrial sectors but also to enhance technological capabilities of existing sectors. Fourth, their target group should be small and medium-sized enterprises. Finally, regional governments should adopt small and incremental approach to improve their innovation systems.

• Journal of Integrative Natural Science
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• v.5 no.4
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• pp.216-219
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• 2012

Structure-based drug design possibly benefit from in silico methods that precisely predict the binding affinity of small molecules to target macromolecules. There are many limitations arise from the difficulty of predicting the binding affinity of a small molecule to a biological target with the current scoring functions. There is thus a strong interest in novel methodologies based on MD simulations that claim predictions of greater accuracy than current scoring functions, helpful for a regular use designed for drug discovery in the pharmaceutical industry. Herein, we report a short review on free energy calculations using MMPBSA method a useful method in structure based drug discovery.

• Journal of the Korean Ceramic Society
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• v.32 no.3
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• pp.366-370
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• 1995

The ballistic efficiency of alumina tiles with various sizes, shapes, and target configurations was measured by the thick backing plate technique. The ballistic efficiency of square tiles roughly 8 mm thick struck by 12.7mm diameter bullets rapidly increased with tile size up to about 100mm, then tended to saturate. Circular shape tiles had lower ballistic efficiencies than those of square shape tiles for the same width and thickness. Small tiles (50mm) that were recessed in aluminum wells had a significantly higher ballistic efficiency than tiles placed on a flat surface. However, the difference in the ballistic efficiency between the two target configurtions became small at larger tile sizes. All the results could be explained by the effect of reflected waves at edges and the propagation of resulting cracks on the penetration process.

• Biotechnology and Bioprocess Engineering:BBE
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• v.11 no.3
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• pp.273-276
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• 2006

RNA interference (RNAi), a process of sequence-specific gene suppression, has been known as a natural gene regulatory mechanism in a wide range of lower organisms. Recently, we have reported that a transfection of human U6 promoter (hU6) driven hairpin small-interference RNA (siRNA) plasmid specifically knocks down the target gene by post-transcriptional gene silencing in mammalian cells. Here we report that transfection of polymerase chain reaction (PCR) products, containing human U6 promoter with hairpin siRNA, knocks down the target gene expression in human teratocarcinoma NT-2/D1 cells. Moreover, we showed 3' end termination sequence, 5 Ts, is not critical elements for knocking down in PCR-based siRNA system. Therefore, the PCR-based siRNA system is a promising tool not only for the screening but also to temporally regulate gene expression in the human progenitor cells.

• 제어로봇시스템학회:학술대회논문집
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• 1995.10a
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• pp.174-177
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• 1995

Detecting a small threat object either fast moving or floating on shallow water presents a formidable challenge to shipboard sensor systems, which must determine whether or not to launch defensive weapons in a timely manner. An integrated multisensor concept is envisioned wherein the combined use of active and passive sensor is employed for the detection of short duration targets in dense ocean surface clutter to maximize detection range. The objective is to develop multisensor integration techniques that operate on detection data prior to track formation while simultaneously fusing contacts to tracks. In the system concept, detections from a low grazing angle search radar render designations to a sensor-search infrared sensor for target classification which in turn designates an active electro-optical sensor for sector search and target verification.

• BMB Reports
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• v.43 no.11
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• pp.711-719
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• 2010

Kinomics is an emerging and promising approach for deciphering kinomes. Chemical kinomics is a discipline of chemical genomics that is also referred to as "chemogenomics", which is derived from chemistry and biology. Chemical kinomics has become a powerful approach to decipher complicated phosphorylation-based cellular signaling networks with the aid of small molecules that modulate kinase functions. Moreover, chemical kinomics has played a pivotal role in the field of kinase drug discovery as it enables identification of new molecular targets of small molecule kinase modulators and/or exploitation of novel functions of known kinases and has also provided novel chemical entities as hit/lead compounds. In this short review, contemporary chemical kinomics technologies such as activity-based protein profiling, T7 kinasetagged phages, kinobeads, three-hybrid systems, fluorescenttagged kinase binding assays, and chemical genomic profiling are discussed along with a novel allosteric Bcr-Abl kinase inhibitor (GNF-2/GNF-5) as a successful application of chemical kinomics approaches.

• Journal of the Korean Institute of Navigation
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• v.25 no.3
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• pp.237-245
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• 2001

Radar is an indispensible equipment in all vessels under way. In Korea there are many fishing net buoys near the coast, which causes an enormous threat to safe navigation because it is very difficult to detect the buoys by radar due to their small radar cross section. In this study RTE(Radar Target Enhancer) was installed on the fishing net buoy and its echo was analysed carefully. The results showed the possibility of wide detection of targets, especially small targets such as fishing net buoys, navigation buoys and etc.

• IEMEK Journal of Embedded Systems and Applications
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• v.17 no.2
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• pp.101-107
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• 2022

In this article, we propose a new protocol at fast scan mode for a sea-surface small target detection. The conventional fast scan mode is composed of coherent intrascan integration to suppress sea clutter and non-coherent interscan integration to exclude sea spikes. The proposed method realizes the coherent interscan integration by the new Fourier relationship between carrier-frequency and initial-radial-range, which can be analytically derived by using multiple carrier frequencies at fast scan mode, leading to improved detection performance, compared to the conventional non-coherent methods. In simulations, our proposed method is verified.

• Korean Security Journal
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• no.47
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• pp.85-117
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• 2016

These days, ISIS terrorists have been expanding not only to european countries, but also to asian countries so South Korea is no longer safe from terrorists' attacks. Especially, 'soft target terrorism' makes many people maximizing fear of terrorism because it is caused by small groups - those who are armed with small arms and light weapons - and they are able to carry out hit and run attacks on civilian targets. It poses even more dangerous to kill massively. That is why November 2015 Paris attacks and January 2016 Jakarta attacks killed and injured many people because of 'soft target terrorism.' Therefore, the South Korea has also recognized the seriousness of terrorism by ISIS. The study has shown the precautionary measures about 'soft target terrorism' and how to defend against 'soft target terrorism' by looking through overseas examples. It is for the possibilities of 'soft terrorism' in South Korea because of the expansion of ISIS. As a result, 'soft target terrorism', caused by ISIS, could happen in South Korea. The counterplan is as in the following. First of all, 'soft target terrorism', which is collaborated with ISIS and domestic terrorists, could be caused by negative awareness of foreign residents and xenophobia so the public should change stereotypes about the foreign residents and there should be legislation about racial discrimination enacted by parliament and the government must practice the law. Second, the Korean anti-terrorism laws should be modified to minimize violations of human rights, related to the Korean citizens' personal information, and to stop the concentration of power into the hands of one law enforcement. Third, the government has to develop and to initiate the refuge&evacuation simulation, which prepares for 'soft target terrorism' and minimizes the damages if terrorists attack hot spots like central commercial areas or event halls.