• Journal of Korean Medical Science
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• 제33권53호
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• pp.342.1-342.6
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• 2018

We validated the diagnostic performance of a previously developed blood-based 7-protein biomarker panel, $AptoDetect^{TM}$-Lung (Aptamer Sciences Inc., Pohang, Korea) using modified aptamer-based proteomic technology for lung cancer detection. Non-small cell lung cancer (NSCLC), 200 patients and benign nodule controls, 200 participants were enrolled. In a high-risk population corresponding to ${\geq}55years$ of age and ${\geq}30pack-years$, the diagnostic performance was improved, showing 73.3% sensitivity and 90.5% specificity with an area under the curve of 0.88. $AptoDetect^{TM}$-Lung (Aptamer Sciences Inc.) offers the best validated performance to discriminate NSCLC from benign nodule controls in a high-risk population and could play a complementary role in lung cancer screening.

• 한국임상수의학회:학술대회논문집
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• 한국임상수의학회 2009년도 춘계학술대회
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• pp.53-54
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• 2009

• 한국응용과학기술학회지
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• 제38권3호
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• pp.689-699
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• 2021

코로나19 확산으로 개인의 비대면 활동이 증가함에 따라 의료정보를 얻기 위해 의료기관 웹사이트와 모바일 콘텐츠 활용이 증가하고 있다. 본 연구에서 제시한 가설들을 검정하기 위해 구조방정식 분석을 실시한 결과, 소형병원 웹사이트와 모바일 콘텐츠의 e-서비스품질의 모든 하위 요인들인 이용편리성, 보안성, 반응성, 디자인성, 의료정보제공성 요인은 관계의 질에 유의한 영향을 미치고 있었으며, 관계의 질은 e-충성도에 유의한 영향을 미치고 있었다. 또한, 구조모형의 적합도는 χ²/df=2.021, NFI=.954, TLI=.969, CFI=.976, RMSEA=.046으로 모두 기준치를 상회하였다. 이와 같은 가설검정 결과를 통해 소형병원들은 웹사이트와 모바일 콘텐츠 운영에 있어 사용자들에게 빠르고 정확한 응답을 할 수 있는 시스템 개발을 통해 이용자들과의 관계의 질을 향상시키며, 또한 e-서비스품질과 관계의 질 향상을 통해 e-충성도를 향상시킬 필요가 있다. 향후 연구에서는 소형병원 이외에 대형병원에 대한 실증연구를 통해 비대면 의료정보 탐색에 대한 e-서비스품질을 더 명확히 측정할 수 있는 요인 및 측정변수 개발이 필요할 것이다.

• 한국실내디자인학회:학술대회논문집
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• 한국실내디자인학회 2005년도 춘계학술발표대회 논문집
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• pp.235-236
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• 2005

Recently the small medical clinics designed well are appearing even in the small and medium city. Especially in the rural area, these clinics have the role not only as medical facilities but also as community place for their fellowship. This project was launched by order of a female doctor, an otolaryngologist. Her order is focused on otolaryngology but I also proposed the design alternatives such as plastic surgery and dental surgery clinic designed under the same conditions. This project was also related with the classwork of interior architecture course of our faculty and I tried to let the students understand the relation between theory and practice. The design goal was to join together harmoniously two stories which were completely separated and I consistently concentrated on the expression of immateriality and superimposition of space.

• Journal of Veterinary Science
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• 제19권6호
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• pp.725-734
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• 2018

Ovaries of 21 bitches presented with gynecopathies were surgically removed and histologically examined. Standard histological, as well as immunohistochemical, classification of 193 cystic structures resulted in the classification of 72 cysts of subsurface epithelial structures (SES), 61 follicular cysts (FCs), 38 cystic rete ovarii (CRO), 13 lutein cysts (LCs), and 9 non-classifiable cysts (NCCs). In addition to the histological classification, results were interpreted according to subject medical history, clinical examination outcome, and macroscopic observations during ovariohysterectomy. Dogs with ovarian cysts (OCs) and associated reproductive perturbations were mostly nulliparous, of large breed, and had an average of $9.5{\pm}3$ years. Prolonged or shortened inter-estrus intervals of past heats, however, seemed to be relatively low-risk factors for the development of OCs in dogs. Furthermore, we provide histological observations of a rarely seen canine LC including a degenerated oocyte in the central cavity.

• 한국의학물리학회지:의학물리
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• 제25권4호
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• pp.288-297
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• 2014

Dynamic conformal arc therapy (DCAT) and flattening-filter-free (FFF) beams are commonly adopted for efficient conformal dose delivery in stereotactic body radiation therapy (SBRT). Off-axis geometry (OAG) may be necessary to obtain full gantry rotation without collision, which has been shown to be beneficial for peripheral targets using flattened beams. In this study dose distributions in OAG using FFF were evaluated and the effect of mechanical rotation induced uncertainty was investigated. For the lateral target, OAG evaluation, sphere targets (2, 4, and 6 cm diameter) were placed at three locations (central axis, 3 cm off-axis, and 6 cm off-axis) in a representative patient CT set. For each target, DCAT plans under the same objective were obtained for 6X, 6FFF, 10X, and 10FFF. The parameters used to evaluate the quality of the plans were homogeneity index (HI), conformality indices (CI), and beam on time (BOT). Next, the mechanical rotation induced uncertainty was evaluated using five SBRT patient plans that were randomly selected from a group of patients with laterally located tumors. For each of the five cases, a plan was generated using OAG and CAG with the same prescription and coverage. Each was replanned to account for one degree collimator/couch rotation errors during delivery. Prescription isodose coverage, CI, and lung dose were evaluated. HI and CI values for the lateral target, OAG evaluation were similar for flattened and unflattened beams; however, 6FFF provided slightly better values than 10FFF in OAG. For all plans the HI and CI were acceptable with the maximum difference between flattened and unflattend beams being 0.1. FFF beams showed better conformality than flattened beams for low doses and small targets. Variation due to rotational error for isodose coverage, CI, and lung dose was generally smaller for CAG compared to OAG, with some of these comparisons reaching statistical significance. However, the variations in dose distributions for either treatment technique were small and may not be clinically significant. FFF beams showed acceptable dose distributions in OAG. Although 10FFF provides more dramatic BOT reduction, it generally provides less favorable dosimetric indices compared to 6FFF in OAG. Mechanical uncertainty in collimator and couch rotation had an increased effect for OAG compared to CAG; however, the variations in dose distributions for either treatment technique were minimal.

• Asian Pacific Journal of Cancer Prevention
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• 제15권18호
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• pp.7817-7819
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• 2014

Childhood cancers are relatively uncommon in comparison to adult cancers. There is no literature available to shed light on clinic-pathological types and patterns of care for childhood cancers in our population in North-East India. In this analysis we therefore tried to determine the common childhood cancers diagnosed in our institute, clinical profile of the patients, types of treatment and compliance, and median survival estimates. Leukemia was most common, followed by retinoblastoma, central nervous system tumours and lymphomas. Ascertaining the clinic-pathological profile of childhood cancers in our population is essential for allocation and management of resources for this small but important group of patients.

• Tuberculosis and Respiratory Diseases
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• 제59권6호
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• pp.679-683
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• 2005

저자들은 시야 결손 등의 시력 변화를 주 증상으로 내원한 환자에서 소세포 폐암과 이로 인한 부종양성증후군으로 동반된 암 관련 망막증을 진단하고 항암화학요법을 시행하여, 원발 병변의 부분 관해 보였으나, 시야 결손은 회복되지 않았던 1예를 경험하였기에 문헌 고찰과 함께 보고 하는 바이다.

• 보건행정학회지
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• 제3권2호
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• pp.100-129
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• 1993

This study is designed to find out some intra-clinic factors affecting the content of practice provided by primary care physicians in Korea, and proposed factors in this study are characteristcs of each private clinc --- physician-related variables(age, sex, specialty), bfed-related variables for inpatient care, laboratory-related variables for precise diagnosis. We have tried to estimate the difference of disease entities cared by each primary care physician according to above factors by analyzin gdisease data claimed during one month(April, 1992) to National Federation of Medical Insurance. The diagnosis codes by ICD-9 in the research disease data were reclassified to 'diagnosis clusters' by virtue of clinical similarities for effective analyses. We have converted frequent-tsing ICD-9 codes to 86 diagnosis clusters, which incorporated 97.4 percents of all ambulatory visits to private clinics. This result means proposed diagnosis-cluster method is effective tool for analysis of the content of ambulatory medical care carried out by primary care physicians. Comparisons and analyses of multiple diagnosis-clusters made on the basis of presented factors were done and the results were as follows; - Major factors affecting the difference between diagnosis-cluster pattern by each variables were phyusician's age, sex, specialty and bed counts of each private clinic for inpatient care and the size of laboratories of each clinic. - Middle aged(30th to 40th) group physicians are providing more comprehensive care than 20th or above 50th aged groups. Male physicians are more adequate for comprehensive care than female physicians, because woman-doctors are providing narrow-spectrum care. The content of practice of obstetricians and gynecologists shows much difference from primary medical practice, and they cannot be included in primary care physician, this study suggested. Pediatricians are also providing short-spectum acre, and nearly all visits to pediatricians were incorporated only 2-3 diagnosis-clusters. General surgeons' practices are very similar to general practioners' or family physicians' practices, the means they are providing primary care rather than special surgical care. And small number of beds(under 5 beds) and only basic(2-3 sorts of)diagnostic apparatuses are sufficient for primary physicians' clinic to carry out primary care. In conclusion, to reinforce primary care department in Korea, there must be support with health policy to expand office-based primary care practice-- with small number of beds for inpatient care and only basic laboratories-- provided by general practitioner of family physician.

• 디지털융복합연구
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• 제19권10호
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• pp.491-500
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• 2021

유방암 환자의 제 특성을 파악하여, 유방암 조기 검진의 중요성과 젊은 유방암의 심각성을 알리기 위해 시행하였다. 2010년 5월 1일부터 2020년 4월 30일까지(10년간) 일 유방 클리닉에 내원한 환자 23,200명 중 유방암으로 진단받은 483명의 의무기록을 이용한 후향적 조사연구이다. 유방암으로 진단받은 483명의 나이는 40대(36.0%)가 가장 많았으며, 30대(25.9%)가 다음으로 많았다. 유방암 가족력이 있는 경우가 5.4%, 폐경 상태는 29.2%였으며, 내원 동기로는 종괴가 54.2%로 가장 많았고, 유방 검진 경험은 출산 경험자가 비출산자보다 많았으며, 20-30대에서 유방검사 경험이 가장 적었다. 젊은 여성을 대상으로 유방암 검진의 중요성을 교육할 필요가 있으며, 유방암의 국가암검진 연령에 대한 재검토를 제언한다.