• The Korean Journal of Physiology and Pharmacology
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• 제14권5호
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• pp.291-297
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• 2010

The sleep homeostatic response significantly affects the state of anesthesia. In addition, sleep recovery may occur during anesthesia, either via a natural sleep-like process to occur or via a direct restorative effect. Little is known about the effects of isoflurane anesthesia on sleep homeostasis. We investigated whether 1) isoflurane anesthesia could provide a sleep-like process, and 2) the depth of anesthesia could differently affect the post-anesthesia sleep response. Nine rats were treated for 2 hours with $ad$ $libitum$ sleep (Control), sleep deprivation (SD), and isoflurane anesthesia with delta-wave- predominant state (ISO-1) or burst suppression pattern-predominant state (ISO-2) with at least a 1-week interval. Electroencephalogram and electromyogram were recorded and sleep-wake architecture was evaluated for 4 hours after each treatment. In the post-treatment period, the duration of transition to slow-wave-sleep decreased but slow wave sleep (SWS) increased in the SD group, but no sleep stages were significantly changed in ISO-1 and ISO-2 groups compared to Control. Different levels of anesthesia did not significantly affect the post-anesthesia sleep responses, but the deep level of anesthesia significantly delayed the latency to sleep compared to Control. The present results indicate that a natural sleep-like process likely occurs during isoflurane anesthesia and that the post-anesthesia sleep response occurs irrespective to the level of anesthesia.

• 수면정신생리
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• 제16권1호
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• pp.5-9
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• 2009

Relatively little is known about the neurobiology of insomnia, despite its wide prevalence and broad medical impact. Although much is still to be learned about the pathophysiology of the disorder, identification, systematic assessment, and appropriate treatment are clearly beneficial to patients. Recent research, using quantitative EEG, polysomnography (PSG), multiple sleep latency test (MSLT) and neuroimaging techniques, suggests that some broad areas can be identified as possible pathophysiological models. Sleep-wake homeostat model hypothesizes a failure in homeostatic regulation of sleep, an attenuated increase in sleep drive with time awake, and/or defective sensing of sleep need. Circadian clock model hypothesizes a dysfunctional circadian clock, resulting in changes in the timing of sleep-wake propensity that are incompatible with normal sleep. Intrinsic sleep-wake state mechanism model suggests that abnormal function of insomnia comprises the systems responsible for expression of the sleep states themselves. Extrinsic over-ride mechanism (stress-response) model suggests that insomnia reflects the consequences of overactivity of one of the systems considered "extrinsic" to normal sleep-wake control. Many current therapies for insomnia are based on these physiological models. Several attempts have been made to create a physiological model that would explain this disorder and could be used as a foundation for treatment. However, it appeared that no model can fully explain and clarify all aspects of insomnia. Future research should be necessary to expand our knowledge on the biological dimensions of insomnia.

• The Korean Journal of Physiology and Pharmacology
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• 제16권4호
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• pp.231-236
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• 2012

We studied the effects of acetylcholinesterase inhibitors, donepezil and galantamine, and an N-methyl-D-aspartate (NMDA) receptor blocker, memantine, on sleep-wake architecture in rats. Screw electrodes were chronically implanted into the frontal and parietal cortex for the electroencephalography (EEG). EEG was recorded with a bio-potential amplifier for 8 h from 09:30 to 17:30. Vibration was recorded to monitor animal activity with a vibration measuring device. Sleep-wake states such as wake (W), slow-wave sleep (S) and paradoxical or rapid eye movement sleep (P), were scored every 10 sec by an experimenter. We measured mean episode duration and number of episode to determine which factor sleep disturbance was attributed to. Donepezil and memantine showed a significant increase in total W duration and decreases in total S and P duration and delta activity. Memantine showed increases in sleep latency and motor activity. Changes of S and P duration in memantine were attributed from changes of mean episode duration. Galantamine had little effect on sleep architecture. From these results, it is showed that galantamine may be an anti-dementia drug that does not cause sleep disturbances and memantine may be a drug that causes severe sleep disturbance.

• 한국통신학회논문지
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• 제37권2B호
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• pp.130-137
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• 2012

본 논문은 백본 망에서 발생하는 에너지를 절감하기 위하여 LPI(Low Power Idle)를 이용하는 OBS 코어 및 에지 라우터 구조를 제안하고 이를 평가한다. 제안한 LPI를 이용하는 코어 라우터는 코어 라우터 라인 카드와 BCP 스위치, 버스트 스위치, 스위치 제어기 및 LPI 기능을 위한 Sleep/Wake 제어기로 구성된다. 망 부하가 낮을 때 네트워크 제어 패킷을 수신한 Sleep/Wake 제어기는 코어 라우터 라인 카드의 수면/활성 상태를 제어함으로써 에너지를 절감 할 수 있다. 에지 라우터는 액세스 라인 카드 스위치, SCU 그리고 OBS 에지 라우터 라인 카드로 구성된다. 에지 라우터에서 LPI 기능은 네트워크 수준 제어를 통하여 에지 라우터 라인 카드 개별적으로 수행되며 버스트를 생성하는 동안 에지 라우터 라인 카드의 PHY/Transceiver를 수면 상태로 천이시킴으로서 에너지 절감을 할 수 있다. 제안된 코어 및 에지 라우터 구조의 에너지 절감 성능 평가를 위하여 본 논문에서는 제안된 라우터 구조의 전력 소모율을 비교/분석하였으며, OPNET을 이용한 시뮬레이션을 수행하여 코어 라우터와 에지 라우터 라인 카드의 PHY/Transceiver의 수면시간 관점에서 코어 및 에지 라우터의 에너지 절감 성능을 평가하였다.

• 한국직업건강간호학회지
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• 제25권4호
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• pp.373-383
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• 2016

Purpose: The purpose of this study was to identify the factors affecting shiftwork tolerance among nurses and provide basic data, ultimately, in formulating a plan for improving their shiftwork tolerance. Methods: The participants were 317 nurses who were working at three general hospitals in Daejeon and Seoul. Data analyzed t-test, ANOVA, correlation analysis, and regression analysis using SPSS 20.0 program. Results: As for the sub-areas of shiftwork tolerance for the respondents, more than a half of nurses working at shifts suffered from insomnia, felt drowsy, complained of chronic fatigue, and were at the anxious and depressed state. Shiftwork tolerance differed by the daily intake of coffee and exercise. Shiftwork tolerance was significantly positively correlated with sleep-wake habits, hardiness, and flexibility and negatively correlated with a languidity. Regression analysis revealed that shiftwork tolerance was affected by age, sleep-wake habits, languidity, flexibility, and hardiness. Conclusion: To put the results, nurses had shiftwork tolerance affected by sleep-wake habits, languidity, and hardiness. It is therefore necessary to make a scheme for allowing nurses to improve hardiness and flexibility and decrease the languidity with the objective of improving their shiftwork tolerance.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제19권1호
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• pp.12-19
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• 2016

Purpose: This study was performed to evaluate the quality of sleep in snoring obese children without obstructive sleep apnea (OSA); and to study the possible relationship between sleep interruption and gastroesophageal reflux (GER) in snoring obese children. Methods: Study subjects included 13 snoring obese children who were referred to our sleep lab for possible sleep-disordered breathing. Patients underwent multichannel intraluminal impedance and esophageal pH monitoring with simultaneous polysomnography. Exclusion criteria included history of fundoplication, cystic fibrosis, and infants under the age of 2 years. Significant association between arousals and awakenings with previous reflux were defined by symptom-association probability using 2-minute intervals. Results: Sleep efficiency ranged from 67-97% (median 81%). A total of 111 reflux episodes (90% acidic) were detected during sleep, but there were more episodes per hour during awake periods after sleep onset than during sleep (median 2.3 vs. 0.6, p=0.04). There were 279 total awakenings during the sleep study; 56 (20.1%) of them in 9 patients (69.2%) were preceded by reflux episodes (55 acid, 1 non-acid). In 5 patients (38.5%), awakenings were significantly associated with reflux. Conclusion: The data suggest that acid GER causes sleep interruptions in obese children who have symptoms of snoring or restless sleep and without evidence of OSA.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2021년도 춘계학술대회
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• pp.423-424
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• 2021

이 논문에서는 수면 환경을 감지하는 센서들로부터 데이터를 수집하고 이를 바탕으로 수면 환경을 최적으로 조절하여 숙면을 취할 수 있도록 도와주는 시스템을 제안한다. 수면 환경 분석은 로드셀을 통한 뒤척임 감지에 의한 수면 단계 판단을 기본으로 하고 온도, 습도, 조도 등의 데이터를 바탕으로 온열 장치, 가습기, 블라인드 등을 제어하여 숙면을 취할 수 있는 환경을 조성한다. 수면 상태에 따른 수면 환경 제어는 기상하기 쉬운 수면 상태를 유도함으로써 기상 시에 피로감을 줄일 수 있다.

• 한국정보통신학회논문지
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• 제25권11호
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• pp.1596-1602
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• 2021

사물인터넷 시스템에서 배터리로 동작하는 사물인터넷 장치는 저전력 소모가 필수이다. 일반적으로 사물인터넷 장치들은 주기적으로 수면 상태에 진입하여 전력 소모를 줄인다. 하지만 비동기 사용자 요구 환경에서는 응답시간을 줄이기 위해 듀티 사이클을 줄여야 하므로 전력 소모 절감 효과가 줄어든다. 본 논문에서는 실내 전등 제어와 같은 비동기 제어가 필요한 환경에서도 장치의 전력 소모 절감 효과를 높일 수 있는 새로운 기법을 제안한다. 제안하는 반복 깨우기(repetitive wake-up) 기법은 스마트폰에서 깨우기 신호를 반복적으로 전송하고 사물인터넷 장치는 듀티 사이클을 최소화함으로써 전력 소모를 줄일 수 있다. 스마트폰 앱과 사물인터넷 장치를 구현하고 실험을 통해 제안하는 반복 깨우기 기법이 기존의 동기적 수면/활동 기법보다 최대 5배 이상 전력 소모를 줄일 수 있음을 보였다.

• 수면정신생리
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• 제1권2호
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• pp.182-187
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• 1994

The Authors report a case of sleep paralysis patient who is 25-years old man. He complained that he has been experiencing episode "being suffocated" during sleep and could not move by himself while semiconsciousness state. He was a only son of divorced parents and could not attach anybody from yong childhood. His symptoms was began intermittently after his early teens. Medical history and physical examination revealed no significant finding. A nocturnal polysomnogram showed loss of muscle tone during terminal REM period and sudden hyperventilation attack followed by wake-up. Psychosocial stress and insufficient sleep were presumed to be an etiological factors. Imipramine 50mg per day almost completely relieved symptoms.

• 수면정신생리
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• 제5권1호
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• pp.12-17
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• 1998

Circadian rhythms in subjective alertness, mood, and performance can be classified as psychological rhythm, compared with physiological rhythm such as body temperature and hormonal change. While in normal condition entrained by 24hr zeitgeber, subjective alertness would reach its maximum value around midday, subjective alertness would parallel body temperature rhythm with its peak at evening in non-entrained, free-running state. With desynchronization technique, subjective alertness rhythm is thought to be controlled by both temperature and sleep-wake rhythm oscillator. Circadian performance rhythms depend on the kind of task tested. It shows parallelism with body temperature rhythm when subjects are tested with simple, repetitive task. But when tested with tasks requiring complex verbal reasoning or immediate memory, subjects would perform them best at early morning, with performance decreasing as time of day advances. The desynchronization technique shows that circadian performance rhythm of simple, repetitive task is dependent on temperature oscillator but circadian performance rhythm of complex verbal reasoning is influenced by both temperature and sleep-wake rhythm oscillator or another independent oscillator. It would be worthwhile to compare psychological rhythm with hormonal change such as cortisol and melatonin. And more simple and time-saving method than desynchronization technique may facilitate the study of the mechanism underlying psychological rhythm.