• The Korean Journal of Physiology and Pharmacology
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• v.16 no.4
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• pp.231-236
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• 2012

We studied the effects of acetylcholinesterase inhibitors, donepezil and galantamine, and an N-methyl-D-aspartate (NMDA) receptor blocker, memantine, on sleep-wake architecture in rats. Screw electrodes were chronically implanted into the frontal and parietal cortex for the electroencephalography (EEG). EEG was recorded with a bio-potential amplifier for 8 h from 09:30 to 17:30. Vibration was recorded to monitor animal activity with a vibration measuring device. Sleep-wake states such as wake (W), slow-wave sleep (S) and paradoxical or rapid eye movement sleep (P), were scored every 10 sec by an experimenter. We measured mean episode duration and number of episode to determine which factor sleep disturbance was attributed to. Donepezil and memantine showed a significant increase in total W duration and decreases in total S and P duration and delta activity. Memantine showed increases in sleep latency and motor activity. Changes of S and P duration in memantine were attributed from changes of mean episode duration. Galantamine had little effect on sleep architecture. From these results, it is showed that galantamine may be an anti-dementia drug that does not cause sleep disturbances and memantine may be a drug that causes severe sleep disturbance.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.32 no.1
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• pp.91-102
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• 2024

This study aimed to investigate the sleep-wake patterns, social jetlag (SJL), and daytime sleepiness (DS) among air traffic controllers (ATCs) with rotating shifts. A total of 133 shift-rotating ATCs participated by completing self-report questionnaires regarding their sleep-wake patterns and DS. SJL, indicating the mid-sleep difference between workdays (W) and free days (F), was calculated for each shift. Night-shift workdays had the shortest sleep duration (SD) (5.28 hours), whereas free days following day shifts had the longest SD (6.66 hours). SJL for day and night shifts was 2.73 and 2.71 hours, respectively. The average DS score was 7.92 out of 24, with a 28.6% prevalence of DS. There was a negative correlation between SD following day shifts and SJL for the day shifts. Given these findings, it is recommended to implement effective interventions and work schedules to maintain consistent sleep patterns and minimize social jetlag to address sleep issues for shift-working ATCs.

• Journal of Physiology & Pathology in Korean Medicine
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• v.31 no.2
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• pp.83-93
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• 2017

This study covers pattern differentiation based on Korean medical references, research trend and modern clinical applications about Sleep-Wake disorders of Diagnostic and Statistical Manual of Mental Disorders(DSM-V) published by American Psychiatric Association. Insomnia disorder is mostly caused by yin deficiency of liver-kidney or liver qi depression and main patterns are heart-kidney non-interaction, deficiency-excess complex pattern containing phlegm-heat due to qi stagnation and blood stasis. Hypersomnolence disorder is more due to yang deficiency rather than yin deficiency and it's major pattern is spleen-kidney yang deficiency. Cataplexy is main feature in narcolepsy and corresponds to depressive psychosis or fainting in terms of Korean Medicine and narcolepsy is assumed to be relevant to liver wind. Breathing-related sleep disorders are related with phlegm-fluid retention brought on spleen deficiency with dampness encumbrance. Pattern of circadian rhythm sleep-wake disorders is combined with yin deficiency of liver-kidney or liver qi depression of insomnia disorder and spleen-kidney yang deficiency or dampness-phlegm of hypersomnolence disorder. Yin deficiency with effulgent fire brought on drugs or alcohol is one of main patterns of substance/medication-induced sleep disorder and combined patterns with yin deficiency of liver-kidney and blood stasis or dampness-phlegm-heat are mostly applied clinically. This study drew major and frequently applied patterns of sleep-wake disorders based on Koran medical literature and modern clinical applications. And that can be the groundwork for the task ahead like clinical practice guideline of sleep-wake disorders containing pattern differentiation, diagnosis and prescriptions.

• Sleep Medicine and Psychophysiology
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• v.4 no.2
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• pp.147-155
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• 1997

To assess the reliability of chronobiological models of sleep/wake regulation, it is necerssary that the models predict the data which has been studied in sleep research, and they should be generalized across all ages. To date, many adult human data on such models have accumulated, yet it is evident that a comprehensive theory of the biorhythmic aspects of sleep/wake states has not established. Circadian rhythms such as the time going to bed, sleep onset, slow wave sleep pressure, periodicity of REM sleep, daytime performance, and early evening alertness are resumed everyday. Even in adult humans, sleep is inherently polyphasic. In both the disentrained and entrained states, naps when allowed tend to recur in a temporally lawful manner. The monophasic sleep pattern of most industrial societies therefore appears to be purely of social origin. The endogenous biorhythmic nature of circasemidian sleep tendency is supported by the ubiquity of the phenomenon across all ages. The NREM/REM sleep cycle within sleep with its inherent physiological, endocrine, and neurochemical fluctuations represents the best-documented ultradian sleep rhythms. Also, a daytime ultradian variation in sleepiness with a periodicity similar to nocturnal NREM/REM cycle(BRAC hypothesis) is suggested. This review article provides a brief synoptic review of the evidences for circadian, circasemidian, and ultradian sleep/wake rhythms, and then the authour will suggest the issues which expedite fuller modeling of sleep/wake system, to be further discussed.

• 대한상한금궤의학회지
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• v.11 no.1
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• pp.153-167
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• 2019

Objective : To explore the meaning of Eumyangyeokchahunobok-byung (陰陽易差後勞復病) through two cases and finding the relationship with the DSM-5 sleep-wake disorder. Methods : Following a disease pattern identification diagnostic system based on Shanghanlun provisions (DPIDS), we analyzed cases with chronic fatigue and diplopia caused after sleep disorders. The patients were treated with the Soshiho-tang and Yijoong-tang. Results : The two herbal medicines showed remarkable improvement in the patients. The sleep disorders and the secondary pathologies were rapidly relieved within a month. Conclusions : The patterns of sleep disorders of the two patients were found to be very similar to the circadian rhythm sleep-wake disorders, as described in DSM-5. Although the etymology of the Chinese characters has not been clearly known yet, it was possible to present the original hypotheses on 更and 了due to clinical inference.

• Sleep Medicine and Psychophysiology
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• v.27 no.2
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• pp.51-55
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• 2020

In this paper, we reviewed domestic and foreign cases and evaluation methods for validation of sleep products for development of the domestic sleep industry. Foreign companies and organizations are trying to verify products relatively systematically for demonstration purposes, but they are using different methods depending on the institution, and standardized validation guidelines have not been established. In Korea, there has been little evaluation including objective verification for sleep products. Sleep-wake evaluation for validation of sleep products requires expert evaluation of the product and of the product effectiveness by users, and subjective and objective sleep-wake evaluations and circadian rhythm evaluation methods can be used. For more accurate verification, experimental designs such as randomization method, control product utilization method, and cross-experiment design can be used.

• Sleep Medicine and Psychophysiology
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• v.19 no.1
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• pp.5-10
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• 2012

The release of hormones and the metabolism of human body are controlled by the circadian rhythm related to sleep-wake cycle. Growth hormone, prolactin, thyroid stimulating hormone, cortisol, glucose, and insulin-secretion rates fluctuate according to the sleep-wake cycle. In addition, sleep is related to the appetite regulation and carbohydrate and other energy metabolism. Hypocretin (orexin), an excitatory neuropeptide, regulates waking and diet intake, and the poor sleep increases diet intake. The short sleep duration increases one's body mass index and impairs the function of the endocrine and metabolism, causing increases in the risk of glucose intolerance and diabetes. The poor sleep quality and sleep disorders have similar impact on the metabolic function. In short, the sleep loss and the poor quality of sleep have a detrimental effect on the endocrine and energy metabolism. The improvement of sleep quality by the future research and appropriate clinical treatment would contribute to the decrease of the metabolic diseases such as diabetes.

• Journal of the Ergonomics Society of Korea
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• v.29 no.3
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• pp.337-345
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• 2010

The purpose of this study was to investigate the effects of sleep/wake behavior for shiftwork in air traffic controllers (ATCs) using wrist actigraph for ten workers on a continuous full-day three-team three-shift system of forward rotation including on-duty and off-duty periods. The wrist actigraph data were recorded for three days (one shift cycle) for each subject. The mean activity counts during an on-duty period progressively increased from the night, the swing, to the morning shifts. The doze length during on-duty periods showed decreases in the morning and swing shifts as compared to the night shift. Total sleep time (TST) and sleep efficiency (SE) during off-duty periods increased in the morning-1 and swing-night shift compared to the morning-2 shift. Finally, I discussed the role of doze-taking during the burden on night shift ATCs.

• The Korean Journal of Physiology and Pharmacology
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• v.14 no.5
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• pp.291-297
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• 2010

The sleep homeostatic response significantly affects the state of anesthesia. In addition, sleep recovery may occur during anesthesia, either via a natural sleep-like process to occur or via a direct restorative effect. Little is known about the effects of isoflurane anesthesia on sleep homeostasis. We investigated whether 1) isoflurane anesthesia could provide a sleep-like process, and 2) the depth of anesthesia could differently affect the post-anesthesia sleep response. Nine rats were treated for 2 hours with $ad$ $libitum$ sleep (Control), sleep deprivation (SD), and isoflurane anesthesia with delta-wave- predominant state (ISO-1) or burst suppression pattern-predominant state (ISO-2) with at least a 1-week interval. Electroencephalogram and electromyogram were recorded and sleep-wake architecture was evaluated for 4 hours after each treatment. In the post-treatment period, the duration of transition to slow-wave-sleep decreased but slow wave sleep (SWS) increased in the SD group, but no sleep stages were significantly changed in ISO-1 and ISO-2 groups compared to Control. Different levels of anesthesia did not significantly affect the post-anesthesia sleep responses, but the deep level of anesthesia significantly delayed the latency to sleep compared to Control. The present results indicate that a natural sleep-like process likely occurs during isoflurane anesthesia and that the post-anesthesia sleep response occurs irrespective to the level of anesthesia.

• Korean Journal of Occupational Health Nursing
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• v.16 no.1
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• pp.37-47
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• 2007

Purpose: To find out the relationship between the shift work, and disrupted sleep and consequent fatigue symptoms. Methods: The questionnaires were given to 345 nurses of 4 hospitals with over 400 beds in Daejeon. Results: The shift workers showed worse subjective quality of sleep than the daytime workers, and had significantly higher frequency of "cannot get to sleep within 30 minutes", "wake up in the middle of the night" and "wake up in the early morning". The shift workers had significantly higher scores of subjective symptoms of fatigue than the daytime workers, and the fatigue was found to be the mental type. The subjective symptoms of fatigue scores were significantly higher in the group who had "cannot get to sleep within 30 minutes", "wake up in the middle of the night" and "wake up in the early morning". Conclusion: The study results indicated that the shift workers had the higher level of subjective symptoms of physical fatigue as well as the worse quality of sleep than the daytime workers. It is speculated that the factors attributable to the poor quality of sleep or sleep induction disorders of nurses of hospitals could be due in major part to adaptational difficulties resulting from frequent night shifts.