• 수면정신생리
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• 제6권1호
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• pp.61-67
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• 1999

목 적 : 본 연구의 목적은 간호사들의 심인적, 신체적 그리고 사회적 적응에 대한 교대근무의 영향을 조사하는데 있다. 방 법 : 299명(교대근무 179, 비교대근무 120)의 간호사를 대상으로 본 연구의 목적에 알맞게 고안된 56항의 설문지를 이용하여 조사하였다. 결 과 : 교대근무는 간호사들의 심인적, 신체적, 사회적 그리고 수면관련 요소에 부정적인 영향을 미치고 있었다. 교대 근무 간호사들의 심인적, 신체적 건강에 대한 주관적인 인식이 비교대 근무자들에 비하여 유의하게 부정적이었다. 교대근무 간호사들은 비교대근무 간호사들에 비하여 교대근무와 관련된 사회생활의 장애 및 사회활동의 제한을 호소하고 있었고, 수면과 관련된 장애들을 유의하게 더 많이 호소하고 있었다. 결 론 : 본 연구결과는 교대근무가 정신생리적 기능의 일주기 리듬에 장애를 초래할 수 있기 때문에 교대근무자들의 정신적, 신체적 건강에 부정적인 영향을 줄 수 있음을 뒷받침 한다. 또한 교대 근무자들은 가족 및 일반적인 사회관계에서 여러움을 겪고 있음을 알 수 있다. 이상의 결과들은 교대근무의 부작용을 최소화하기 위한 적절한 대응전략이 필요함을 시사한다.

• 동의신경정신과학회지
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• 제35권2호
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• pp.205-216
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• 2024

Objectives: To evaluate the effectiveness of Mindfulness & Loving Beingness (M&L) psychotherapy combined with traditional Korean medicine in treating acute sleep disorders in patients hospitalized following traffic accidents. Methods: We applied traditional Korean medicine treatments in conjunction with various mindfulness meditation techniques from M&L therapy, including Resource Mindfulness and Nourishment Brief Therapy. This study was conducted on three patients who reported acute sleep disorder symptoms on the first day of hospitalization following a traffic accident. The effectiveness of these interventions was assessed using the PTSD Checklist for DSM-5 (PCL-5-K), Insomnia Severity Index (ISI), EuroQol 5-Dimension (EQ-5D), Numerical Rating Scale (NRS), and Patient Global Impression of Change (PGIC). Results: ISI and PCL-5-K scores showed significant improvements after treatment, indicating reduced sleep disturbances and stress symptoms. Additionally, EQ-5D and PGIC scores were enhanced, reflecting an overall improvement in quality of life. Conclusions: This study suggests that integrating M&L therapy with traditional Korean medicine could significantly improve symptoms in patients with acute sleep disorders following traffic accidents.

• Journal of Oral Medicine and Pain
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• 제33권3호
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• pp.257-267
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• 2008

정신신체질환은 개개인의 서로 다른 성격, 정서적 스트레스에 대한 반응과 기질적인 요소 등이 함께 반응하여 소화기계, 순환기계, 호흡기계 및 근골격계 등에 수많은 질환을 야기하며, 그 중에 만성통증도 역시 포함한다. 구강안면 영역의 증상으로 내원하는 이유 중 가장 많은 비율을 차지하는 것은 통증이며 증상에 영향을 주는 기여요인은 생물학적 요인, 행동요인, 환경요인, 사회요인, 정서요인, 인지요인 등을 포함한다. 이러한 기여요인은 개인의 성격, 인성에 좌우되어 증상의 경로에 영향을 미치게 된다. 통증에 있어 수면은 하나의 기여요인으로 작용하며, 통증은 수면장애를 가져오거나 악화시키기도 하며, 수면장애 역시 통증을 악화시킬 수 있다. 수면의 질의 저하는 정서적 스트레스를 가속화 시킬 수 있는 한 요인으로 작용할 수 있다. 이에 구강안면 영역에 증상을 보이는 환자에게 비교적 정확하고 간단하게 시행할 수 있는 수면의 질 평가 및 정신 검사를 필히 시행하여 평가해야 한다. 본 연구는 PSQI를 통한 수면의 질 평가와 간이정신진단검사(SCL-90-R)를 비교 평가하여 수면과 정서적, 심리적 상태와의 관계를 규명하고자 하였으며, 다음과 같은 결과를 얻었다. poor sleeper 는 남자가 18명, 여자가 1명이었으며, PSQI 총수면 지수는 남자에서 $6.11{\pm}2.38$, 여자에서 $4.67{\pm}2.18$로 나타났다. SCL-90-R 지수는 남녀간 차이를 보이지 않았고 poor sleeper에서 신체화(SOM), 강박증(O-C), 대인예민성(I-S), 불안(ANX), 공포불안(PHOB), 정신증(PSY)에서 유의성 있게 높은 평균치를 보였으며 전체 심도지수(GSI), 표출증상합계(PST)가 유의성 있게 높았다. 또한 수면의 질에 따른 SCL-90-R의 T-점수는 주관적 수면의 질이 나쁠수록 강박증(O-C), 대인 예민성(I-S)에서, 수면장애가 심할수록 편집증(PAR), 정신증(PSY), 표출증상합계(Positive symptom total, PST)가, 주간수면장애에서는 우울(DEP), 불안(ANX), 적대감(HOS), 공포불안(PHOB), 편집증(PAR), 전체 심도지수(GSI)에서 유의하게 높은 평균치를 보였다. 이와 같이 수면의 질과 정서적 상태는 서로 밀접한 연관성을 지닌다고 할 수 있으며, 이는 구강안면 영역의 만성 통증에 영향을 미치리라 생각된다. 이에 구강안면통증을 다루는 임상가들은 환자의 수면의 질과 정서적 상태에 대해 적절히 평가하는 것이 반드시 필요하며, 추후 구강안면통증에 있어 수면과 정서적, 심리적 인성관계에 대한 연구가 더 필요하리라 사료된다.

• 생물정신의학
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• 제16권4호
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• pp.229-237
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• 2009

Recent Korean statistics show that a Korean woman can now expect to live until her mid-80s, which implies living at least one-third of her life after menopause. The menopausal transition is typically marked by intense hormonal fluctuations, accompanied by sleep disturbance, vasomotor symptoms(e.g., hot flashes, night sweats), increased risk for osteoporosis, cardiovascular disease, and developing depression as well as mood disturbances. These symptoms can affect a woman's quality of life negatively. Therefore, a comprehensive understanding of the accurate detection and appropriate treatment of various menopause-related symptoms including depression in the menopausal transitions and postmenopause is mandatory. This review primarily focused on the current knowledge about the treatment of menopause-related depression.

• 생약학회지
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• 제49권3호
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• pp.189-202
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• 2018

Hop cones (Humuli Strobili) are the female inflorescences of hop plants (Humulus lupulus L.) belonging to the family Cannabaceae. They have been used as herbal remedies to treat mood and sleep disturbances, and mainly to add as a bittering ingredient in brewing process. Considerable interests on pharmacological and biological activities of hop cones have been focused on their major constituents, namely, phloroglucinols (humulone, lupulone), terpenes (myrcene, humulene), and prenylated flavonoids (xanthohumol, isoxanthohumol, 6-prenylnaringenin, and 8-prenylnaringenin). The present review describes and discusses biological activity profiles of these major compounds in the hop cones.

• Journal of mucopolysaccharidosis and rare diseases
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• 제5권1호
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• pp.22-28
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• 2021

Mucopolysaccharidosis type III (MPS III) or Sanfilippo disease is an orphan-inherited lysosomal storage disease. It is one of the most common MPS subtypes. The classical presentation is an infantile-onset neurodegenerative disease characterized by intellectual regression, behavioral and sleep disturbances, loss of ambulation, and early death. Unlike other MPS, no disease-modifying therapy has been approved. Here, we review the curative therapy developed for MPS III, from historically ineffective hematopoietic stem cell transplantation and substrate reduction therapy to the promising enzyme replacement therapy or adeno-associated/lentiviral vector-mediated gene therapy. Preclinical studies are presented with recent translational first-in-man trials. We also present experimental research with preclinical mRNA and gene-editing strategies. Lessons from animal studies and clinical trials have highlighted the importance of early therapy before extensive neuronal loss. Disease-modifying therapy for MPS III will likely mandate the development of new early diagnosis strategies.

• 대한한방내과학회지
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• 제37권5호
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• pp.831-838
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• 2016

Objective: To describe the effectiveness of traditional Korean medicine (TKM) on a patient showing aggressive behavior after a traumatic brain injury. Methods: We used complex TKM treatments. The acupoints used were as follows: Soyangin Taegeuk acupuncture (HT3, KI3, and SP3) and acupoints frequently used in hemiparesis (GV20, GV24, ST4, LI11, LI4, ST36, GB34, SP9, and LR3). Moxibustion was also applied to GV20, and herbal medicine (Samulanshin-tang-gami, 四物安神湯 加味方) was administered. The efficacy was evaluated at baseline, week 8, and week 16 using the Modified Overt Aggression Scale (MOAS). Results: After 8 weeks, the total MOAS score was decreased from 13 to 5, and this score was maintained until week 16. The average sleep time was increased and waking up during the night was decreased. Conclusions: We suggest that TKM could be effective for reducing aggressive behavior and alleviating sleep disturbances. Further studies are needed.

• 한국임상약학회지
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• 제23권3호
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• pp.213-222
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• 2013

Purpose: The aim of this study was to investigate the current state of antidepressant prescriptions in breast cancer patients and factors affecting the prescription of antidepressants. Methods: This study targeted female breast cancer patients who were prescribed antidepressants by a psychiatrist at least once between August 2010 and July 2011 at the Asan Medical Center in Seoul. The prescription history of each study subject was investigated to analyze the current state of antidepressant prescriptions in breast cancer patients. Results: The analysis of the prescription histories of 136 subjects in the antidepressant group determined that escitalopram, mirtazapine, and trazodone were the three most commonly prescribed medications with an average of 1.54 antidepressants prescribed per patient. A logistic regression analysis showed a statistically significant increase in antidepressant prescriptions in patients who were divorced or widowed, had sleep disturbances, or had undergone oncologic surgery for the breast cancer (p<0.050). In contrast, the prescription rate was lower for patients with tumour sizes greater than 50 mm (p<0.050). Conclusion: The sociodemographic factor of marital status, clinical factors of sleep disorders and tumour size, and a treatment-specific factor of the use of surgical therapy were identified as affecting the prescription of antidepressants in female breast cancer patients.

• 대한한방내과학회지
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• 제40권5호
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• pp.804-813
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• 2019

The purpose of this study was to evaluate the effect of Korean medicine in a patient with cognitive impairment, emotional disturbance, and sleep disturbance due to a diffuse axonal injury associated with a traumatic brain injury. The patient was treated with herbal medicine and acupuncture. The treatment effects were evaluated using the Korean version of the Mini-Mental State Examination (MMSE-K) and the Global Detraction Scale (GDS), and by observing clinical symptoms. Improvements in the total scores of MMSE-K and GDS were observed after the Korean medicine treatments; the MMSE-K score increased from 13 to 23 and the GDS score decreased from 5 to 4. The emotional and sleep disturbances were also reduced. These case report findings suggest that Korean medicine may be effective for treating symptoms of diffuse axonal injury in patients with traumatic brain injury.

• 한방안이비인후피부과학회지
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• 제37권2호
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• pp.104-112
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• 2024

Objectives : This study aimed to report improvement of patient with chronic cough treated with Korean medical treatment. Methods : A 12-year-old male patient who began coughing at the end of October 2023 misdiagnosed by a tic disorder and was prescribed oral medication. However, the cough worsened, persisting throughout the day without respite, accompanied by sleep disturbances (desire to sleep continuously) and gait disturbance (only able to walk with support). The patient visited the clinic on December 15, 2023, and was re-diagnosed with chronic cough. And the patient received Korean medical treatment, including herbal medicine(Ryokankyomishinge-tang, Ryokankyomishingenin-tang, Sogunjung-tang), and acupuncture. The severity of chronic cough was evaluated by VAS before and after administration of each treatment term. Results : The patient's symptoms improved and VAS changed 10 to 0. Conclusions : This case study showed an effectiveness of Korean medical treatment on chronic cough.