• Title/Summary/Keyword: Skin equivalent

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Analysis of Inverter-Fed Induction Motor Using F.E.M and Harmonic Equivalent Circuit (슬롯피치 경계 조건을 이용한 인버터 구동 유도 전동기의 회전자 등가회로 정수 추출 및 특성해석)

  • Lee, Geon-Ho;Kim, Byeong-Tae;Gwon, Byeong-Il
    • The Transactions of the Korean Institute of Electrical Engineers B
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    • v.51 no.7
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    • pp.331-338
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    • 2002
  • An inverter-fed induction is driven by a harmonic voltage source so that it is necessary to be analysed by time-stepping F.E.M. But it takes so long time that disadvantageous to design. This paper presents a simple analysis method for inverter-fed induction motor using FEM and harmonic equivalent circuit. First, the rotor bar resistance and the leakage reactance are determinated by FEA for 1 slot region in rotor to consider the skin effect and the saturation. Secondly, the characteristic of the motor is analyzed by the harmonic equivalent circuits consisting of the obtained parameters from the FEA. This method is carried out to analyze an induction motor driven by the sinusoidal voltage and the inverter. The results are verified by comparing with those of the time-step F.E.A and the experiment.

Effects of Rotated Endotracheal Tube Fixation Method on Unplanned Extubation, Oral Mucosa and Facial Skin Integrity in ICU Patients (기관내관 순환고정방법이 중환자실 환자의 비계획적 발관 및 구강.안면 피부 통합성에 미치는 효과)

  • Choi, Young-Soon;Chae, Young-Ran
    • Journal of Korean Academy of Nursing
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    • v.42 no.1
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    • pp.116-124
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    • 2012
  • Purpose: The study was done to compare effects of two endotracheal tube (ET tube) fixation methods (rotated fixation versus conventional) on unplanned extubation and skin integrity for orally intubated patients in intensive care units. Methods: The research design was a non-equivalent control group with repeated measures design. Participants were 80 patients; 40 participants assigned to each group. ET tube for the experimental participants fixed with rotated method every morning. Unplanned extubation was assessed by bedside nurses using the unplanned extubation report form. Oral mucosa and facial skin integrity were assessed using oral assessment guide and facial skin integrity assessment guide at day 3, 7, 10 and 14. Results: There was no difference in the unplanned extubation rate between the two groups. Oral mucosa impairment scores for the rotated fixation method were significantly lower at day 7 (p=.044), 10 (p=.048) and day 14 (p=.037). Also facial skin integrity impairment scores for the same group were significantly lower at day 7 (p=.010), 10 (p=.003), and 14 (p=.002). Conclusion: Results of the study suggest that the rotated fixation method is effective for these patients, to prevent impairment of oral mucosa and facial skin integrity. Further research is needed to prevent unplanned extubation.

A Study on the circuit design and measurement method for the measurement of active points on skin (피부 활성점 측정을 위한 회로설계 및 측정방법연구)

  • Kim, Min Soo;Cho, Young Chang
    • Journal of IKEEE
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    • v.24 no.3
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    • pp.713-718
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    • 2020
  • The method of measuring skin active points is a technique for obtaining a lot of biometric information because it is measured with convenience, low cost and non-invasive methods. In this paper, we used in a three electrode measure method that has the advantage of measuring the impedance of the APs under the skin. The impedance measuring method is well illustrated by a simple model of an equivalent electrical circuit that correlates well with experimental results. The characteristic frequencies of APs are about 15-30HZ higher than that of surrounding skin and the values of measured reactance are about 35-77KΩ smaller. This technology analyzed accurately and objectively the reactance and characteristic frequency of APs and the surrounding skin using a non-invasive measuring system.

Equivalence Principles Based Skin Deformation of Character Animation

  • You, L.H.;Chaudhry, E.;You, X.Y.;Zhang, Jian J.
    • International Journal of CAD/CAM
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    • v.9 no.1
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    • pp.61-69
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    • 2010
  • Based on the equivalence principles of physical properties, geometric properties and externally applied forces between a surface and the corresponding curves, we present a fast physics and example based skin deformation method for character animation in this paper. The main idea is to represent the skin surface and its deformations with a group of curves whose computation incurs much less computing overheads than the direct surface-based approach. The geometric and physical properties together with externally applied forces of the curves are determined from those of the surface defined by these curves according to the equivalence principles between the surface and the curves. This ensures the curve-based approach is equivalent to the original problem. A fourth order ordinary differential equation is introduced to describe the deformations of the curves between two example skin shapes which relates geometric and physical properties and externally applied forces to shape changes of the curves. The skin deformation is determined from these deformed curves. Several examples are given in this paper to demonstrate the application of the method.

Gelatinase, a Possible Etiologic Factor of Photoaging, is Present in Healthy Human Facial Skin and is Inhibited by Turmeric Extract

  • Takada, Keiko;Amano, Satoshi;Matsunaga, Yukiko;Kohno, Yoshiyuki;Inomata, Shinji
    • Proceedings of the SCSK Conference
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    • 2003.09a
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    • pp.387-412
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    • 2003
  • Influence of gelatinase on basement membrane (BM) structure was investigated by using a skin equivalent (SE) model. The results showed that (1) gelatinase produced by cells degraded the BM and (2) the addition of matrix metalloproteinase-specific inhibitor to the SE medium accelerated the formation of BM structure, indicating that gelatinase is involved in BM impairment. The activity of gelatinase was also studied in healthy human facial skin tissues. The result of in situ zymography revealed gelatinase activity around the basal layer of the epidermis, where BM integrity was severely compromised. Therefore, this enzyme was suggested to be associated with BM decomposition in human facial skin. To assess the behavior of gelatinase in stratum corneum (SC) non-invasively, an immunological study was performed. Since positive immunostaining of pro-gelatinase B was observed in SC stripped from sun-exposed skin, whereas no positive staining detected in SC of non-irradiated skin, gelatinase in the epidermis could be non-invasively detected by measuring gelatinase in SC. Gelatinase in SC of healthy female volunteers was monitored using a special film that sensitively and conveniently detects gelatinase. Ninetr percent of SC from facial skin (l00 women, 40's-50's) was gelatinase-positive. On the other hand, SC from non-irradiated skin was negative. These results strongly suggest that (1) gelatinase is constantly produced in the facial epidermis of most middle-aged woman during their daily life, and (2) the enzyme might be involved in the aging-related degeneration of both BM and the matrix fibers of the upper layer of the dermis, acting as a very important aging factor. Strong inhibitory activity against gelatinase was found in turmeric extract and identified curcumin as the major ingredient. Topical application of cream containing turmeric extract significantly decreased the number of gelatinase-positive SC clusters in human facial skins. These results indicated that turmeric is an effective ingredient to prevent skin from photo aging by suppressing chlonically upregulated gelatinase activity by UV and to improve skin condition.

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Clinical and radiobiological consideration of cyclical hypofractionated radiation therapy also known as QUAD Shot for neglected skin cancer disfiguring the face of a non-compliant patient who was refusing surgery and protracted radiation therapy: case report

  • Kil, Whoon Jong;Camphausen, Kevin;Cho, In Hye
    • Radiation Oncology Journal
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    • v.37 no.2
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    • pp.143-148
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    • 2019
  • Although surgery is the mainstay of local treatment for skin cancer, definitive radiation therapy (RT) has been also applied for patients who are unable to tolerate surgery. Definitive RT regimens usually consist of daily treatment for 4-7 weeks. Such protracted daily RT regimens, however, would not be feasible for non-compliant patients or patients who are unable to make multiple daily trips for weeks. Without treatment, however, skin cancers can continuously progress and cause distressing symptoms. A cyclical hypofractionated RT (QUAD Shot: 14 Gy in 4 fractions, twice-daily treatments with 6 hours interval on 2 consecutive days) can be a practical RT regimen for those patients. In this report, we present the successful treatment course of repeated QUAD Shots in a 79-year-old patient with neglected skin cancer that was disfiguring his face yet declined definitive surgery and protracted RT. We also evaluated and compared biologically equivalent doses between QUAD Shots and conventionally fractionated protracted RT regimens.

Testing and finite element modeling of stressed skin diaphragms

  • Liu, Yang;Zhang, Qilin;Qian, Weijun
    • Steel and Composite Structures
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    • v.7 no.1
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    • pp.35-52
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    • 2007
  • The cold formed light-gauge profiled steel sheeting can offer considerable shear resistance acting in the steel building frame. This paper conducted the full-scale test on the shear behavior of stressed skin diaphragm using profiled sheeting connected by the self-tapping screws. A three-dimensional finite element model that simulates the stressed skin diaphragm was developed. The sheet was modeled using thin element model while the supporting members were simulated using beam elements. Fasteners were represented in the numerical model as equivalent springs. A joint test program was conducted to characterize the properties of these springs and results were reported in this study. Finite element model of the full-scale test was analyzed by use of the ANSYS package, considering nonlinearity caused by the large deflection and slip of fasteners. The experimental data was compared with the results acquired by the EUR formulas and finite element analysis.

A New CMOS RF Model for RF IC Design (RF IC 설계를 위한 새로운 CMOS RF 모델)

  • 박광민
    • Journal of the Institute of Electronics Engineers of Korea SD
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    • v.40 no.8
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    • pp.555-559
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    • 2003
  • In this paper, a new CMOS RF model for RF IC design including the capacitance effect, the skin effect, and the proximity effect between metal lines on the Si surface is proposed for tile first time for accurately predicting the RF behavior of CMOS devices. The capacitances between metal lines on the Si surface are modeled with the layout. And the skin effect is modeled with a parallel branch added in equivalent circuit of metal line. The proximity effect is modeled by adding the mutual inductance between cross-coupled inductances in the ladder circuit representation. Compared to the BSIM 3v3. the proposed RF model shows good agreements with the measured data and shows well the frequency dependent behavior of devices in GHz ranges.

Betaine Induces Epidermal Differentiation by Enhancement of Autophagy through an mTOR-independent Pathway (Betaine의 mTOR 비의존적 자가포식 작용 촉진에 의한 표피 분화 유도 효과)

  • Choi, Seon-Guk;Kim, Mi-Sun;Kim, Jin-Hyun;Park, Sun Gyoo;Lee, Cheon Koo;Kang, Nae-Gyu
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.44 no.1
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    • pp.95-101
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    • 2018
  • The epidermis which is stratified by epithelial tissue renewal based on keratinocyte differentiation protects the organism from various environmental insults by forming a physical barrier. Autophagy is a mechanism which mediates lysosomal delivery and degradation of protein aggregates, damaged organelles and intracellular microorganisms. Recent reports have shown that autophagy has critical roles for proper terminal differentiation to stratum corneum via removing metabolic organelles and nuclei. However, whether increasing autophagy can activate epidermal differentiation is unknown. Here, we screened a library of natural single compounds and discovered that betaine specifically increased the LC3 positive cytosolic punctate vesicles and LC3-I to LC3-II conversion in HaCaT human keratinocyte cell line, indicating increased autophagy flux. mTOR pathway, which negatively regulates autophagy, was not affected by betaine treatment, suggesting betaine-induced autophagy through an mTOR-independent pathway. Betaine-induced autophagy was also observed in primary human keratinocyte and skin equivalent. Furthermore, epidermal thickness was increased in skin equivalent under betaine treatment. Overall, our finding suggests that betaine as a novel regulator of autophagy may induce epidermal turnover and improve the skin barrier abnormality of the aged epidermis.

Effects of Dermal Cell Combination on the Formation of Basement membrane and Epidermis in Skin Equivalents (진피세포의 조성이 인공피부의 기저막과 표피형성에 미치는 영향)

  • Li, Hai-Lan;Jeong, Hyo-Soon;Kim, Jan-Di;Yun, Hye-Young;Baek, Kwang-Jin;Kwon, Nyoun-Soo;Min, Young-Sil;Park, Kyoung-Chan;Kim, Dong-Seok
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.38 no.3
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    • pp.219-224
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    • 2012
  • European Union prohibited the marketing of cosmetic products containing constituents that have been examined through animal experiments. Thus, non-animal test models are needed to replace animal experiments. The reconstructed skin models are important as a test system for cosmetic, pharmaceutical, and medical device safety testing. In the present study, we tried to develop an optimal skin equivalent model containing basement membrane and epidermis. For this purpose, we used mesenchymal stem cells (MSCs) and/or preadipocytes as well as fibroblasts as the dermal matrix cells. The formation of basement membrane and epidermis was verified by immunohistochemical stains. Among various models, the epidermis was thickest when MSCs were used in the dermal matrix. Furthermore, PCNA and involucrin distribution showed that dermal matrix with MSCs resembled human skin. Therefore, skin equivalents with MSCs could be developed as a non-animal test model to replace animal experiments.