• 한국산학기술학회논문지
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• 제17권1호
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• pp.421-424
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• 2016

본 연구에서 남해안산 전복으로 부터 얻어진 일반 열수 전복 추출물과 발효추출물의 화장품 원료로서의 사용가능성을 평가하고자 기본적인 피부 안전성 시험으로 추물물과 이를 이용한 액정크림 제형에서의 피부 일차 첩포 테스트를 수행하였다. 비교군으로 정제수, 1,3-부틸렌글리콜, 액정크림으로 하였고 시료군은 전복추출물과 전복추출물을 함유한 액정크림 제형이었다. 피부 일차 첩포 테스트 결과, 비교군과 시료군 모두 피부의 자극이 없는 것으로 나타났다. 그러므로 전복 추출물이 화장품 원료로서 피부 안전성을 확인하였다.

• Journal of Medicine and Life Science
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• 제15권1호
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• pp.1-5
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• 2018

Allergy is conditions when a hypersensitivity reaction happens with a certain element, called as an allergen, which is commonly not reactive to ordinary individuals. Allergic diseases involve various organs or systems in the body. The purpose of allergy tests is to make a diagnosis of allergic diseases and to identify the affecting allergens. In vivo tests, more relevant in clinical situation, include skin test, patch test and provocation test. In in vitro tests, there are specific IgE test, histamine releasing assay, and lymphocyte activation test, safer and more objective than in vivo tests. In the view point of clinical practice, skin test, provocation test, total IgE test and specific IgE test were reviewed in depth.

• 한국의류산업학회지
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• 제7권1호
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• pp.81-84
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• 2005

Skin patch test and antibacterial properties of the reaction products between poly(hexamethyl biguanide) hydrochloride and trimethylol melamine on textile fabrics were examined. Antibacterial activities of anti-microbial agent treated samples are very good. The reduction ratios against four kinds of colonies are 99.9 % after repeated laundering ten times. Skin patch test results for anti-microbial agent treated samples are almost-negative by Hi-scope judgement and macroscopical judgement.

• Toxicological Research
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• 제9권1호
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• pp.119-123
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• 1993

LBD-007, a newly developed recombinant human interferon ${\alpha}$A, was tested for primary eye and skin irritation in male New Zealand White rabbits. In the primary eye irritation test, 0.1ml of a solution of LBD-007 was instilled into the eye. In rinsing group, the eye was washed with water 30 seconds after instillation. No reaction was observed at the cornea, iris and conjunctivae by LBD-007. In the primary skin irritation test, LBD-007 was applied to the back of rabbits for 24 hours. Primary irritation index was "0" in test and control sites of all animals. Thus LBD-007 was evaluated as a non-irritant on the basis of the criteria of Draize et al.,(1994).

• Clinical and Experimental Pediatrics
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• 제62권2호
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• pp.75-78
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• 2019

Although rare, antihistamines can cause adverse effects, including drug-induced eruptions or anaphylaxis. A 4-year-old child visited the pediatric department of a hospital for skin eruptions after administration of antihistamines, (e.g., ucerax [hydroxyzine] or leptizine [levocetirizine]), for cholinergic rashes; he did not have pruritus. Skin prick, intradermal, and drug provocation tests were performed to determine the relationship between the antihistamines and eruptions. Levocetirizine induced wheals in the skin prick test and a rash in the oral drug provocation test. In contrast, ketotifen induced no reaction in the skin prick test but showed a positive reaction in the oral provocation test. Our case report highlights that children can experience the same types of adverse reactions as seen in adults, and cross-reactivity between various antihistamines can occur.

• 대한한의학회지
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• 제25권1호
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• pp.161-171
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• 2004

Objectives: Sasang Constitutional Medicine is popularly appliedto treatment in Korea. Constitution is a holistic concept contained internal and external characteristics, and physical traits including ordinary symptoms. Skin is one of constitutional property elements. So we researched a correlation female facial skin and sasang constitution. This is a basic study to find constitution can be a major factor to care and manage skin. Methods: We examined sasang constitution and facial skin condition of 100 healthy women who aged from 30 to 59. Hydration and sebum of facial skin was measured by skin diagnostic instrument and skin type was calculated from the data. Keratin, pore size, acne, and brightness of face was measured by skin magnifying lens and subjective skin troubles in ordinary times was also investigated. Constitution diagnosis and Skin diagnosis was investigated separately as a blind test andthe data was statistically analyzed with chi-square test, Correlation analysis, One-way analysis of variance. Results: 1. In sasang constitution, Taeeumingroup bad significant tendencies of larger hydration and sebum amount, combination degree of forehead and cheek was also higher than other constitutions(p<0.05). 2. Facial skin type was significantly different according to Sasang Constitution, Soeumin and Soyangin had a tendency of dry skin comparatively, but Taeeumin had mainly a tendency of combination skin and secondly dry skin(p<0.05). On the other hand, there was no correlation between age and skin type. 3. In subjective skin trouble, Soeumin group had less acne trouble than Soyangin and Taeeumin group(p<0.1). Pore size trouble was more frequent in Soyangin group than Soeumin group(p<0.05). Keratin trouble was more frequent in Soeumin group than Soyangin and Taeumin group(p<0.1). Conclusions: Korean healthy women's skin condition was different according to sasang constitution.

• Korean Journal of Acupuncture
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• 제20권3호
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• pp.29-34
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• 2003

Objectives : The purpose of this study was to investigate the Effect of Acupuncture Chok-samni(ST36) on Skin temperature(ST), Galvanic skin response(GSR) and Heart rate(HR) in humans. ST36 is used in uneasiness, high fever, stroke, paralysis on oriental medicine. Methods : Subjects were 18 healthy oriental medical students volunteers(15male, 3female, mean age-28). Under sequence of ST36 acupuncture, the first group was observed ST, the second group was observed GSR and the third group was observed HR. Skin temperature was measured on Haegye acupoint(ST41) before and after acupuncture stimulation. Each test took 15minutes. This test was performed twice in order to increase the statistical authenticity. Results : Our result indicates that acupuncture stimulation of ST36 statistically decreased skin temperature on ST41. Also statistically decreased in HR. The change of GSR after ST36 acupuncture was decreased, but there is no statistical. Conclusions : These results suggested that acupuncture stimulation of ST 36 has effect on ST and HR in human body, and may be used by treatment as control the nerve system.

• 한방안이비인후피부과학회지
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• 제15권2호
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• pp.210-219
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• 2002

Background and Objectives The diagnosis of allergic rhinitis includes detailed clinical history, physical examination and the use of either in vivo or vitro tests for relevant allergens. Skin test has been used the most commonly. Recently MAST CLA is used for determination of serum spcecific IgE, This study attempted to find out the distribution of Sasang Constitution and to compare the MAST CLA with skin tests in allergic rhinitis patients. Methods Skin tests, MAST CLA and Sasang Constitution study were performed for 35 allergic rhinitis patients who visited Kyunghee Oriental Medical Center from Sept. 2001 to Nov. 2001. Results 1. The ratio between male and female was 1:1.5. the peak age was the thirties(42.9$\%$) 2. 45.7$\%$ of patients had family history of allergic diseases and allergic rhinitis was the most common. 3. 51.4$\%$ of patients lived in A.P.T. and in preference of cool and warm, 54.3$\%$ of patients prefered both of cool and warm. 4. Among 24 cases who were consulted to dept. of Sasang, 45.8$\%$ was Taeumin. 5. 65.7$\%$ of patients reacted positive to skin test and the common offending allergen was D. pteronyssinus(82.6$\%$). 6. 25.7$\%$ of patients reacted positive to MAST CLA and the common offending allergen was D. farinae(88.9$\%$). 7. Among 22 cases who was performed skin test and MAST CLA the sensivity and specificity of MAST CLA was 27.4$\%$ and 94.9$\%$. There was significant correlations between MAST CLA and skin test(p=0.005, r=0.574, 1, spearman correlation coefficienct).

• 한국식품영양과학회지
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• 제39권8호
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• pp.1213-1219
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• 2010

본 연구는 흑마늘을 기능성 화장품 소재로 활용하기 위하여 그 기능성을 in vitro에서 tyrosinase 및 elastase 저해 활성을 측정한 결과 피부노화에 관여하는 두 효소의 활성을 모두 저해하였다. 흑마늘 추출물을 hartley계 기니픽 수컷을 사용하여 피부 1차 자극 실험을 실시한 결과 1차 피부자극지수(P.I.I.)가 0.23으로 practically non-irritation(비자극성)에 해당하는 자극으로 피부 자극이 거의 없었음을 알 수 있었다. Maximization test법으로 피부 감작성을 확인한 결과 시험물질에 의한 홍반과 부종 등이 전혀 유발되지 않았다. 이상의 결과로부터 흑마늘 추출물에 대한 기니픽의 피부 감작율은 0%로, 피부에 대한 피부 감작성이 없는 것으로 확인되었다. 따라서 이러한 본 연구의 결과는 흑마늘 추출물이 기능성 화장품 소재로 피부노화를 억제하는 기능성과 안전성확보된 소재임을 추정할 수 있었다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7769-7779
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• 2015

Background: This study was conducted with the purpose of evaluating the effect of skin cancer training provided to maritime high school students on their knowledge and behaviour. Materials and Methods: The study had a quasi-experimental design with pre-test and post-test intervention and control groups. Two maritime high schools located in the city of Antalya were included within the scope of the study between March and June 2013, covering a total of 567 students. Results: While the knowledge mean scores of students regarding skin cancer and sun protection did not vary in the pre-test ($6.2{\pm}1.9$) and post-test ($6.8{\pm}1.9$) control group, the knowledge mean scores of students in the experimental group increased from $6.0{\pm}2.3$ to $10.6{\pm}1.2$ after the provided training. Some 25.4% of students in the experimental group had low knowledge level and 62.2% had medium knowledge level in the pre-test; whereas no students had low knowledge level and 94.3% had high knowledge level in the post-test. It was determined that tenth grade students, those who had previous knowledge on the subject, who considered themselves to be protecting from the sun better, had higher knowledge levels and their knowledge levels increased as the risk level increased. It was found that the provided training was effective and increased positively the knowledge, attitude and behaviour levels of students in the experimental group in terms of skin cancer and sun protection. Conclusions: Along with the provided training which started to form a lifestyle, appropriate attitudes and behaviours concerning skin cancer and sun protection could be brought to students who will work in outdoor spaces and are members of the maritime profession within the risk group.