• Journal of Ginseng Research
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• v.47 no.5
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• pp.654-661
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• 2023

Background: Ginseng has been used as a traditional medicine and functional cosmetic ingredients for many years. Recent studies have focused on the potential biological effects of the ginseng berry and its ingredients. (+)-Syringaresinol (SYR) is enriched in ginseng berry and its beneficial effects on the skin have been recently reported. However, little is known about the its effects on the wound healing process of skin. Methods: Here, we evaluated the skin wound healing effect of (+)-SYR using the human fibroblast Hs68 cell and ex vivo pig and human skin tissue model. Scratch wound test and hydrogen peroxide (HPO) induce chemical wound model were employed. Results: (+)-SYR promoted the migration and proliferation of Hs68 cells without significant cytotoxicity at the tested concentrations. Especially, in ex vivo pig and human skin tissue, HPO-induced chemical wound was recovered almost completely by (+)-SYR. In line with the finding in Hs68, the protein expression levels of TGF-β and PCNA, a proliferation marker were increased, demonstrating the beneficial effects of (+)-SYR on skin wound repair. Conclusion: Collectively, we demonstrated that (+)-SYR from ginseng berry, can enhance the wound healing effect by accelerating cell proliferation and skin regeneration, suggesting the potential utility of (+)-SYR for skin wound repair.

• Journal of the Korean Geotechnical Society
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• v.21 no.1
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• pp.93-103
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• 2005

Both static pile load test with load transfer measuring system and the pile dynamic load test are performed to estimate the skin friction and behavior characteristics of a large drilled shaft. And the numerical modeling of large drilled shaft is performed by applying the FDM program. Since the magnitude of friction resistance depends on the relative displacement between soil and shaft, load and displacement at the arbitrary depth along the large drilled shaft are estimated to analyze the correlation. According to the measuring results of load transfer, unit skin friction along the large drilled shaft was fully mobilized at gravel layer in the middle of shaft and the frictional resistance transmitted to bedrock was relatively small. Also, even for the same drilled shaft, the results of PDA and static load test are different with each other and the difference is discussed.

• Journal of agricultural medicine and community health
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• v.6 no.1
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• pp.5-12
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• 1981

Paragonimus infection is prevalent in Korea, establishing several endemic foci. Kim(1969) reported an endemic area in Hyeonbuk Myeon. Yangyang-Gun, but thereafter no further epidemiologic study of Paragonimus infection was performed in the Gangweon-Do. Hoengseong-Gun is mountainous area which is located in the southwestern part of Gangweon-Do and borders with Hongcheon-Gun on the east, with Pyeongchang-Gun on the east, with Yeongweol-Gun and Weonseong-Gun on the south, and with Yangpyeong-Gun on west. The author carried out an epidemiologic study of Paragonimus infection by intradermal test with V.B.S antigen, and of intermediate host (crayfish) in Hoengseong-Gun, Gangweon-Do. The results are summarized as follows: 1. The positive skin test reaction to Paragonimus antigen was 14.5% from 2,807 examiness; 16.0% in male and 11.6% in female and no sex or age difference on the skin test positive reactions was noticed among the villages. 2. The positive skin test reactions were 31.3% in Gapcheon-Myeon, 20.5% in Cheongil-Myeon and 19.8% in Woocheon-Myeon. Primary school children in Byeongjibang-ri, Gapcheon-Myeon showed positive in 36.4%. 3. The prevalence by skin test reaction by social strata was 16.1% (226 out of 1,408) in primary school children, 12.8% out of 725) in middle school, 6.4% (11 out of 172) in high school students, and 15.3% (77 out of 502) in inhabitants of Heongseong-Gun. 4. Metacercarial positives of Paragonimus in crayfish were 20.9%. Through the survey results, it is postulated that Heongseong-Gun, Gangweon-Do is to be categorized as an endemic area of Paragonimus infection.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.19 no.2
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• pp.99-107
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• 2006

Objectives : This experimental study was performed to investigate the effects of the Hominis placenta extracts on skin barrier. Methods : Male hairless mice, average weight 20g, were divided into two groups, intact and treatment group(paired, n=15). Intact group was not applied YB-301(an ointment including Hominis placenta). Treatment group was applied YB-301(an ointment including Hominis placenta) two times a day for 8 days. We observed skin melanin, skin erythema, skin pH, skin humidity, transepidermal water loss. Statistical analysis was performed by using paired sample T-test. Statistical significance was achieved if the probability was less than 5%(p<0.05) or 1%(p <0.01) Results : 1. YB-301(an ointment including Hominis placenta) showed statistically significant effect on skin melamin, skin pH, skin humidity(p<0.05). 2. YB-301(an ointment including Hominis placenta) showed statistically significant inhibitory effect on transepidermal water loss(p<0.01). 3. YB-301(an ointment including Hominis placenta) showed statistically no significant effect on skin erythema(p<0.05). conclusions : YB-301(an ointment including Hominis placenta) was effective m skin melanin, skin pH, skin humidity, transepidermal water loss in our study, so we suggest that Hominis placenta can be used as a ointment ingredient for strengthening the function of skin barrier.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.41 no.4
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• pp.413-420
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• 2015

The skin is one of the largest organs in our body and participates in many of the human organism's physiological and pathological events. Skin function were known for self-maintenance and self-repair, mechanical and chemical stress protection, protection against UV and environmental pathogenic micro-organisms, production of vitamin D, and social and psychological function through the physical aspect. The aim of this study was to evaluate the variation of biophysical parameters and to find relation with skin biomarkers in different anatomical site and age in Korean women. About 70 healthy volunteers in age range 20 to 49 were participated in this test. Test areas were the forearms and the cheek. Investigation to determine biophysical parameters on human skin, was carried out using various non-invasive methods. For analysis to skin biomarkers, we studied to examine various biomarkers for the quantitative determination of cortisol, fibronectin, keratin-1, 10, and 11, involucrin, and keratin-6 in human face and forearm. And we measured to skin biophysical parameters for skin anatomical site and age difference with non-invasive methods. As results of measuring site, some parameters were have following significant difference, stratum corneum hydration, trans epidermal water loss and skin color (L and a value). As results of age difference, skin colors were had only significant difference with age. For cortisol, keratin-6, fibronectin, keratin-1, 10, 11 contents, there were no significant difference in age and site. However, involucrin level in the cheeks were the highest for age group 30 ~ 39 compared to other age groups. These results suggest that in individual skin condition may explain detailed skin state variation.

• Journal of Rhinology
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• v.25 no.2
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• pp.91-98
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• 2018

Background and Objectives: The present study evaluated the results of skin prick test using 55 allergens at 20 centers in the Republic of Korea in 2006, 2010, and 2014-2015. The aim was to assess changes in the positive rate of allergens according to temporal, regional, and environmental factors. Materials and Method: In total, 20 hospitals were selected based on the population distribution in the Republic of Korea. A skin prick test panel comprising 55 aeroallergens was distributed to 18 hospitals for this prospective study. The 2006 and 2010 skin prick test results were collected and analyzed retrospectively from 20 hospitals, while the 2014/2015 skin prick test results (from June 2014 to May 2015) were collected prospectively from 18 hospitals. Results: A total of 14,897 SPT test results were analyzed: 4,319 in 2006, 7,431 in 2010, and 1,852 in 2014/2015. The overall rate of skin prick test positivity to more than two allergens was significantly higher in males than females. The positive rates of alder pollens and birch, oak and ragweed pollen positivity were increased in older patients. Several positive rates were increased according to the temperature in spring. The positive rates for beech pollen, birch pollen, hazel pollen, oak pollen, Tyrophagus putrescentiae, mugwort, cat, Acarus siro, Lepidoglyphus destructor and Tyrophagus putrescentiae were significantly increased, while those of Cult rye pollen and dandelion were significantly decreased over the three test periods. The overall positive rate for allergens in Jeju province varied significantly from Seoul and other cities. Conclusion: Change in the positive rate of multiple aeroallergens was evaluated in the Republic of Korea over time. Our findings can be used to recommend aeroallergens suitable for inclusion in skin prick test panels in the Republic of Korea and will facilitate further investigation of changes in the patterns of allergic diseases.

• Proceedings of the Korean Society of Near Infrared Spectroscopy Conference
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• 2001.06a
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• pp.1624-1624
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• 2001

Near-infrared spectroscopy (NIRS) was used to investigate the possibility for application in identification of apple cultivars. Three apple cultivars ‘Kamhong, Hwahong, and Fuji’ produced in Korea were scanned over the range of 1100-2500nm using NIRS (Infra Alzer 500). Two types of samples were used for scanning; one was apple with skin and the other was apple without skin. For cultivar identification, the NIR absorbance spectrums were analyzed by qualitative calibration in “Sesame” analysis program, and the various influence properties such as sugar contents, acidity, color, firmness, and micro-structure were compared in scanned samples. The ‘Kamhong’ cultivar could be identified from ‘Hwahong’ and ‘Fuji’ cultivars using the cluster model analysis. The test samples in calibration between ‘Kamhong’ and ‘Fuji’ cultivars could be completely identified. The test samples in calibration between ‘Kamhong’ and ‘Hwahong’ cultivars could be identified most of all. But, ‘Hwahong’ and ‘Fuji’ cultivars could not be quite classified each other. The apple skin influenced the identification process of apple cultivars. The samples without skin were more difficult to classify in calibration than the samples with skin. The physicochemical properties of apple cultivars showed like the result of identification in calibration using NIRS. Some physicochemical properties of ‘Kamhong’ cultivar were different from those of the other cultivars. Those of ‘Hwahong’ and ‘Fuji’ cultivars showed. similar to each other. The sucrose contents of ‘Kamhong’ cultivar were higher and the fructose contents and firmness of skin and flesh were lower than those of the others. The hypodermis layer of skin in ‘Kamhong’ cultivar was thinner than those of the others. In this studies, the identification of all apple cultivars by NIRS was not quite accurate because of the physicochemical properties which were different in the same cultivar, and inconsistent patterns by culivars in some properties. To solve these problems in NIRS application for apple cultivar identification, further study should be focused on the use of peculiar properties among the apple cultivars.

• The Journal of Korean Medicine
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• v.37 no.3
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• pp.27-38
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• 2016

Objectives: According to Korean Medicine theory, the skin color of LU10 serves as a diagnostic clue to dyspeptic symptoms. The aims of this study were (1) to find the difference of skin color in LU10 region between functional dyspepsia (FD) and healthy control (HC) and (2) to examine the relationship between LU10 skin color parameters and dyspeptic symptoms. Methods: 39 participants (29 FD and 10 HC) have participated in this study. They were asked to complete gastrointestinal scale (GIS), gastrointestinal symptom rating scale (GSRS), Nepean dyspepsia index (NDI), functional dyspepsia-related quality of life (FD-QoL), visual analogue scale (VAS) for dyspeptic symptoms, food retention questionnaire (FRQ) and cold heat questionnaire (CHQ). $L^*$ (luminance), $a^*$ (red-green balance) and $b^*$ (yellow-blue balance) values of LU10 region were calculated through digital images of the participant's hand. Then we evaluated test-retest reliability of $L^*$, $a^*$ and $b^*$ values of LU10 region. Additionally, we compared $L^*$, $a^*$ and $b^*$ values of LU10 between FD and HC, and examined the relationship between LU10 color parameters and seven questionnaires scores. Results: Only $L^*$ values in LU10 region were significantly higher in FD compared with HC. GIS scores and the subset scores of NDI had a positive correlation with $L^*$ values significantly. Correlation coefficients of test-retest reliability of skin color measurement of LU10 ranged from 0.871 to 0.936 representing very strongly statistically significant (P<0.001). Conclusions: We confirmed the difference of skin color in LU10 region between FD and HC, and relationship between LU10 skin color parameters and dyspeptic symptoms.

• Child Health Nursing Research
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• v.14 no.2
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• pp.129-137
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• 2008

Purpose: To examine the effects on skin injury, pain, and anxiety when nurses and children simultaneous wash their hands before IV injections. Method: A nonequivalent control group, non-synchronized design study was used with 61 children. For a month and a half, children in the experimental group(30) following hand-washing guidelines, washed their hands with nurses before IV insertion. Anxiety and pain were observed and recorded during IV insertion using the Anxiety Reaction Scale and FACES pain scale. After 48-72 hours on IV therapy with an arm-board, skin condition was checked by a research assistant according to guidelines for assessing skin injury developed by the researcher. t-test, ${\chi}^2$-test, Pearson correlation, and Kendall's tau b were used to analyze data with the SPSS program. Results: Children who washed their hands with the nurse before IV insertion showed less pain (p =.021) and skin injury (p <.001) compared to the control group. Conclusion: This finding suggests that simultaneous hand washing by nurse and child before IV injection has a strong effect on skin injury caused by arm-boards used to maintain IV therapy as well as on pain during IV insertion. This program demonstrates an effective intervention to prevent skin injuries in children on IV therapy.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.46 no.3
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• pp.243-252
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• 2020

Using Fervidobacterium islandicum AW-1, polar low molecular weight keratin peptides were produced and confirmed through factors related to the skin elasticity. As a result of confirming the cytotoxicity and collagen synthesis ability according to the concentration of the polar low molecular weight keratin peptide in human fibroblasts, it was confirmed that the cytotoxicity did not appear and the collagen synthesis in human fibroblasts was increased. A mask pack containing a polar low-molecular weight keratin peptide was used, and a test product was used for 4 weeks in 22 healthy women subjects. As a result, it showed statistically significant effects on skin elasticity, skin torsion elasticity, skin color and moisture improvement. Through this test, it was confirmed that the polar low-molecular keratin peptide can be used as a cosmetic ingredient that helps improve skin elasticity.