• Nuclear Engineering and Technology
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• 제49권7호
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• pp.1495-1504
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• 2017

In a previous study, a set of polygon-mesh (PM)-based skin models including a $50-{\mu}m-thick$ radiosensitive target layer were constructed and used to calculate skin dose coefficients (DCs) for idealized external beams of electrons. The results showed that the calculated skin DCs were significantly different from the International Commission on Radiological Protection (ICRP) Publication 116 skin DCs calculated using voxel-type ICRP reference phantoms that do not include the thin target layer. The difference was as large as 7,700 times for electron energies less than 1 MeV, which raises a significant issue that should be addressed subsequently. In the present study, therefore, as an extension of the initial, previous study, skin DCs for three other particles (photons, protons, and helium ions) were calculated by using the PM-based skin models and the calculated values were compared with the ICRP-116 skin DCs. The analysis of our results showed that for the photon exposures, the calculated values were generally in good agreement with the ICRP-116 values. For the charged particles, by contrast, there was a significant difference between the PM-model-calculated skin DCs and the ICRP-116 values. Specifically, the ICRP-116 skin DCs were smaller than those calculated by the PM models-which is to say that they were under-estimated-by up to ~16 times for both protons and helium ions. These differences in skin dose also significantly affected the calculation of the effective dose (E) values, which is reasonable, considering that the skin dose is the major factor determining effective dose calculation for charged particles. The results of the current study generally show that the ICRP-116 DCs for skin dose and effective dose are not reliable for charged particles.

• Journal of Pharmaceutical Investigation
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• 제32권3호
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• pp.161-164
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• 2002

Gentisic acid is a skin-whitening agent which inhibits the tyrosinase activity, an essential enzyme in the process of biological synthesis of melanin. Since melanin is synthesized in melanocytes located between the viable epidermis and dermis layer, drug amount delivered into the epidermis/dermis layer can provide valuable information for the biological effect of skin-whitening agents. The purpose of this study was to prepare the gentisic acid patches with 2% dodecylamine as enhancer, and to observe the in vitro skin permeation and in vivo skin deposition of gentisic acid. Gentisic acid in DuroTak 87-2510 patch formulation permeated across hairless mouse skin at the rate of $40.79\;{\mu}g/cm^2/hr$. In vivo study showed that the gentisic acid amount in both the stratum corneum and the viable epidermis/dermis increased with the increase of application time. The amount of gentisic acid in the stratum corneum was higher than that in the epidermis/dermis layer, and was expected to provide a reservoir effect even after removing the patches. Thus, the patch formulation seems to be useful for the topical delivery of skin-whitening agent into the epidermis/dermis layer, the target site.

• 한국멀티미디어학회논문지
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• 제18권9호
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• pp.1019-1026
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• 2015

In this paper, we propose a new method of eye, face, and lip makeup techniques on the target face image from several makeup examples without losing detail features such as eyelids, eyebrows, hair. After detection of the feature layer for the skin, we applied our makeup techniques to the target face by using a blending technique. We used a cartoon rendering using bilateral filter. In order to smoothly makeup the target face, we created two Gaussian Weight maps for natural skin makeup effects. Our method did not need to perform complex operations, so the makeup results are so natural. Our experimental results show good performances in various makeups.

• IMMUNE NETWORK
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• 제11권5호
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• pp.227-244
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• 2011

MicroRNAs (miRNAs) are small noncoding RNA molecules that negatively regulate gene expression via degradation or translational repression of their target messenger RNAs (mRNAs). Recent studies have clearly demonstrated that miRNAs play critical roles in several biologic processes, including cell cycle, differentiation, cell development, cell growth, and apoptosis and that miRNAs are highly expressed in regulatory T (Treg) cells and a wide range of miRNAs are involved in the regulation of immunity and in the prevention of autoimmunity. It has been increasingly reported that miRNAs are associated with various human diseases like autoimmune disease, skin disease, neurological disease and psychiatric disease. Recently, the identification of miRNAs in skin has added a new dimension in the regulatory network and attracted significant interest in this novel layer of gene regulation. Although miRNA research in the field of dermatology is still relatively new, miRNAs have been the subject of much dermatological interest in skin morphogenesis and in regulating angiogenesis. In addition, miRNAs are moving rapidly center stage as key regulators of neuronal development and function in addition to important contributions to neurodegenerative disorder. Moreover, there is now compelling evidence that dysregulation of miRNA networks is implicated in the development and onset of human neruodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Tourette's syndrome, Down syndrome, depression and schizophrenia. In this review, I briefly summarize the current studies about the roles of miRNAs in various autoimmune diseases, skin diseases, psychoneurological disorders and mental stress.

• 대한화장품학회지
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• 제44권1호
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• pp.73-79
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• 2018

일차 섬모(primary cilia)는 세포에서 안테나처럼 돌출되어 나온 기관인데, 외부 자극에 반응할 수 있는 각종 수용체와 채널, 신호 전달 인자들을 가지고 있다. 피부는 자외선, 온도, 습도, 중력, 장력 등 외부 환경에 반응하여 멜라닌이나 콜라겐을 만들고 피부 장벽을 형성한다. 피부에서는 일차 섬모가 없으면 헤어의 생성이나 각질의 분화가 억제된다는 보고가 있다. 또한 피부 색소 생성과 관련하여서는 일차 섬모가 sonic hedgehog-smoothened-GLI2 신호 전달에 의해 활성화되면 멜라닌 생성이 억제된다는 것이 알려져 있다. 피부가 자외선을 받으면 멜라닌 생성 호르몬의 양이 증가하고 멜라닌 생성 호르몬은 멜라닌 생성 세포 내 cAMP의 양을 증가시켜 멜라닌 생성 효소의 발현을 높인다. 이에 멜라닌 생성 호르몬과 세포 내 cAMP의 양을 증가시키는 물질을 처리하여 멜라닌 생성을 높였을 때 일차 섬모의 변화를 확인한 결과 일차 섬모가 감소하는 것을 확인하였다. 또한 기존 미백 원료인 유용성 감초 추출물(an ethanol extract of Glycyrrhiza glabra (EGG) root)과 Melasolv (3,4,5-trimethoxy cinnamate thymol ester (TCTE))가 일차 섬모의 발현을 증가시키고 멜라닌 생성 효소인 tyrosinase의 발현을 억제함을 확인할 수 있었다. 따라서 일차 섬모를 조절할 수 있다면 피부 색소 침착을 효과적으로 조절할 수 있을 것이다.

• International Journal of Naval Architecture and Ocean Engineering
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• 제10권4호
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• pp.427-438
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• 2018

The reduction of $CO_2$ emissions has been a key target in the marine industry since the IMO's MEPC published its findings in 2009. Air lubrication method is one of the mature technologies for commercialization to reduce the frictional resistance and enhance fuel efficiency of ships. Air layer is formed by the coalescence of the injected air bubbles beyond a certain air flow rate. In this study, a model ship (${\lambda}=33.33$) of a 50,000 ton medium range tanker is equipped with an air lubrication system. The experiments were conducted in the 100 m long towing tank facility at the Pusan National University. By selecting optimal air injector configuration and distribution ratio between two injectors, the total resistance of model $R_{TM}$ was able to be reduced down to 18.1% in the model scale. Key issue was found to suppress the sideway leakage of injected air by appropriate injection parameters.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2004년도 학술대회 논문집 정보 및 제어부문
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• pp.319-321
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• 2004

The average glandular dose (AGD) is determined by the breast entrance skin exposure, x-ray tube target material, beam quality (half-value layer), breast thickness, and breast composition. Almost breast cancer always arises in glandular breast tissue. As a result, the average radiation absorbed dose to glandular tissue is the preferred measure of the radiation risk associated with mammography. If the normalized average glandular dose is known, the average glandular dose can be computed from the product of the normalized average glandular dose and breast entrance skin exposure. In this study, AGD was calculated by the breast thickness and various x-ray energy (HVL) in 50% glandular 50% adipose breast by Mo.-Rh. assembly. AGD is 84 mrad in compressed 5 cm breast. These results show that as increasing the breast thickness, dose also increases. But as increasing the x-ray tube voltage, dose decreases because of high penetrating ratio through the object. But high tube voltage is reducing the subject contrast. From this result, we have to consider the trade-off between subject contrast of image and dose to the patient and choose proper x-ray energy range.

• 한국가시화정보학회지
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• 제14권1호
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• pp.27-32
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• 2016

The reduction of $CO_2$ emissions has been a key target in the Marine Industry since the IMO's Marine Environment Protection Committee published its findings in 2009. The representative emission index is termed as the EEDI (Energy Efficiency Design Index) for the new ships. Among various flow control techniques ever proposed, the air lubrication method is the one of most promising one in terms of practical applicability. The present study examines the basic characteristics of the flat plate test with intention of applying the air lubrication technology to the reduction of the resistance of a ship. Image analysis technique is proposed as a tool to quantify the effectiveness of the air lubrication method.

• 한국콘텐츠학회논문지
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• 제8권11호
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• pp.235-241
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• 2008

두경부 종양에서 표적용적(target volume)을 하나의 조사야로 포함하지 못하는 경우는 조사야를 둘, 또는 그 이상으로 접합시켜 방사선치료를 시행한다. 방사선치료 시 두 조사야 경계면에서 균등한 선량을 부여하는 것이 매우 중요하다. 하지만 환자의 외형적인 인자나 전신 상태에 따라 피부 접합면( skin Junction area)의 불일치가 발생할 수 있으며 이로 인한 접합면에서의 과선량 또는 저선량 영역이 존재할 수 있다. 본 연구는 두경부 종양의 측면 조사면 끝단 차폐물(edge block)을 회전 가변형으로 제작하여 피부 접합면에 균등한 선량을 부여할 수 있는 치료 기술에 대하여 연구하였다. 모의치료에서 전방 상쇄골 하림프절(supraclavicle lymph node)의 중심선을 우측방 조사야 하단과 접합면으로 하여 회전 가변형 차 폐물을 이용하여 변형되는 거리와 회전각을 측정하였다. 연구 결과에서 원발병소와 상부 경부 림프절 우측방 조사야의 하단에서 회전 가변형 차폐물의 변형 거리는 Y축 중심선에 수직인 ${\pm}$10cm 거리에서 2mm 이내 였으며, 회전각은 평균적으로 약 1.28도의 회전 변형이 발생하였다. 하지만 조사면 끝단 차폐물을 회전 가변형으로 제작함으로서 기존에 발생하던 피부 접합면에서의 불일치를 최소화 할 수 있었다. 두경부 종양의 경우는 원발병소와 상, 하부 경부 임파절에 적절한 선량을 부여하기 위한 조사면 끝단 차폐물을 이용한 방법이 임상에서 적용할 수 있는 효율적인 방안이라 사료된다.

• Archives of Plastic Surgery
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• 제42권5호
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• pp.572-579
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• 2015

Background Facial rejuvenation can be achieved using a variety of techniques. Since minimally invasive procedures for face lifting have become popular because of their convenience and short operating time, numerous minimally invasive surgical procedures have been developed. In this study, a nonabsorbable polypropylene mesh is introduced as a new face lifting instrument, with the nasolabial fold as the main target area. In this paper, we report the efficacy and safety of a polypropylene mesh in midface rejuvenation. Methods Thirty-three subjects with moderate-to-severe nasolabial folds were enrolled from two medical institutions for a noncomparative single-sample study. A mesh was inserted above the superficial muscular aponeurotic system layer, reaching the nasolabial folds through a temporal scalp incision. After 3 weeks, the temporal end of the mesh was pulled to provide a lifting effect. Then, the mesh was fixed to the deep temporal fascia using nonabsorbable sutures. To evaluate efficacy, we compared the scores on the Wrinkle Severity Rating Scale and a visual analog scale for patient satisfaction between the baseline and 7 weeks postoperatively. In addition, we evaluated safety based on the incidence of adverse events. Results The treatment was deemed effective at improving wrinkles in 23 of 28 cases, and patient satisfaction improved significantly during the study period. There were seven cases of skin or subcutaneous tissue complications, including edema and erythema, but there were no suspected serious adverse events. Conclusions Face lifting using a nonabsorbable mesh can improve nasolabial folds without serious adverse effects. Thus, this technique is safe and effective for midface rejuvenation.