• 제목/요약/키워드: Skeletal structures

검색결과 100건 처리시간 0.022초

Genetic Characteristics of 207 Microsatellite Markers in the Korean Population and in other Asian Populations

  • Choi, Su-Jin;Song, Hye-Kyung;Jeong, Jae-Hwan;Jeon, In-Ho;Yoon, Ho-Sung;Chung, Ki Wha;Won, Yong-Jin;Choi, Je-Yong;Kim, Un-Kyung
    • Molecules and Cells
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    • 제25권2호
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    • pp.301-304
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    • 2008
  • Microsatellites, short tandem repeats, are useful markers for genetic analysis because of their high frequency of occurrence over the genome, high information content due to variable repeat lengths, and ease of typing. To establish a panel of microsatellite markers useful for genetic studies of the Korean population, the allele frequencies and heterozygosities of 207 microsatellite markers in 119 unrelated Korean, Indian and Pakistani individuals were compared. The average heterozygosity of the Korean population was 0.71, similar to that of the Indian and Pakistani populations. More than 80% of the markers showed heterozygosity of over 0.6 and were valuable as genetic markers for genome-wide screening for disease susceptibility loci in these populations. To identify the allelic distributions of the multilocus genetic data from these microsatellite markers, the population structures were assessed by clustering. These markers supported, with the most probability, three clustering groups corresponding to the three geographical populations. When we assumed only two hypothetical clusters (K), the Korean population was separate from the others, suggesting a relatively deep divergence of the Korean population. The present 207 microsatellite markers appear to reflect the historical and geographical origins of the different populations as well as displaying a similar degree of variation to that seen in previously published genetic data. Thus, these markers will be useful as a reference for human genetic studies on Asians.

두부방사선 계측사진에 의한 6세에서 11세 사이의 악간 공간에 관한 누년적 연구 (A LONGITUDINAL ROENTGENO-CEPHALOMETRIC STUDY ON THE INTERMAXILLARY SPACE OF NORMAL KOREAN CHILDREN AGED FROM 6 TO 11 YEARS)

  • 유영규
    • 대한치과교정학회지
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    • 제15권1호
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    • pp.141-148
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    • 1985
  • It has been a long time since the cephalometrics was introduced to orthodontic field for diagnosis and treatment planning, but it's main concern was limited to hard, skeletodental tissue. It is well known that perioral and facial soft tissue determine the position of individual teeth and that the abnormality in size and shape of the soft tissue are able to cause malformed occlusion. Because of our lack of knowledge about resultant morphologic changes in the relationship between skeletal pattern and specific pattern of lingual and facial muscles, we can't help setting greater value on only abnormalities of teeth in the skeletal interrelationship. In a point of view that the orthodontist is dealing primarily with muscular structures around the dentition, the tongue, lips, and cheeks, therefore it may be desirable to estimate these structure and their potential influence on the dentition on developmental and time base. The author hit upon on idea of the aspect above, so studied on the intermaxillary space and tongue space and this study used the data from cephalometric films of 33 male and 40 female subject aged from 6 to 11 years of normal Korean children following results were obtained: 1. Means and standard deviation of Korean children were obtained. 2. Yearly increment of each variables were obtained. 3. There is the correlationship more than average among the variables except posterior intermaxillary height item. 4. There are differences between male children and female children in all variables except posterior intermaxillary space item. 5. All variables increased as the age increased except posterior intermaxillary height item of male children.

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혼합치열기의 악안면 경ㆍ연조직에 관한 방사선학적 연구 (A LATERAL CEPHALOMETRIC STUDY OF THE HARD-AND SOFT TISSUE PROFILE AROUND THE FACE IN THE MIXED DENTITION)

  • 이상래
    • 치과방사선
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    • 제8권1호
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    • pp.49-61
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    • 1978
  • A study was made to investigate a relationship existing in the dentoskeletal framework and the soft tissue profile around the face, and compare the sexual differences between boys and girls having the normal occlusion in the mixed dentition. The lateral cephalograms were composed of 67 boys aged 10.3 years and 68 girls aged 10.4 years, respectively. By means of the lateral cephalograms, both the hard-and soft tissue structures were simultaneously analyzed, measured and evaluated by introducing the several reference items: S-N plane, palatal plane, mandibular plane, N-A line and A-P line for the dentoskeletal structures and N’-P’line for the soft tissue, and the 21 measuring points for the both structures. The significant findings were as follows: 1. In general the boys showed the larger nasal component dimension than did the girls, but the length and height of nose(N’-Prn and NA-Prn) showed the significant sexual difference among those when evaluated statistically. 2. The lip-thickness was found to be minimal in the region of nasion, greater in the region of pogonion, and much greater in the region of point A in the both sexes, but the only thickness over point A(A-A’) showed the significant sexual difference statistically. 3. The upper and lower lip position were found to be located anteriorly to the esthetic line in the both sexes, but upper lip position showed the significant sexual difference when evaluated statistically. 4. The regions of nose and upper lip had a tendency not to be following the underlying skeletal profile.

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An experimental study of the behaviour of double sided welded plate connections in precast concrete frames

  • Gorgun, Halil
    • Steel and Composite Structures
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    • 제29권1호
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    • pp.1-22
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    • 2018
  • Multi-storey precast concrete skeletal structures are assembled from individual prefabricated components which are erected on-site using various types of connections. In the current design of these structures, beam-to-column connections are assumed to be pin jointed. Welded plate beam to-column connections have been used in the precast concrete industry for many years. They have many advantages over other jointing methods in component production, quality control, transportation and assembly. However, there is at present limited information concerning their detailed structural behaviour under bending and shear loadings. The experimental work has involved the determination of moment-rotation relationships for semi-rigid precast concrete connections in full scale connection tests. The study reported in this paper was undertaken to clarify the behaviour of such connections under symmetrical vertical loadings. A series of full-scale tests was performed on sample column for which the column geometry and weld arrangements conformed with successful commercial practice. Proprietary hollow core slabs were tied to the beams by tensile reinforcing bars, which also provide the in-plane continuity across the connections. The strength of the connections in the double sided tests was at least 0.84 times the predicted moment of resistance of the composite beam and slab. The secant stiffness of the connections ranged from 0.7 to 3.9 times the flexural stiffness of the attached beam. When the connections were tested without the floor slabs and tie steel, the reduced strength and stiffness were approximately a third and half respectively. This remarkable contribution of the floor strength and stiffness to the flexural capacity of the joint is currently neglected in the design process for precast concrete frames. In general, the double sided connections were found to be more suited to a semi-rigid design approach than the single sided ones. The behaviour of double sided welded plate connection test results are presented in this paper. The behaviour of single sided welded plate connection test results is the subject of another paper.

Desmin Binding Property of Nebulin Isoforms

  • Jeon Eun-Hee;Lee Yeong-Mi;Lee Min-A;Kim Ji-Hee;Choi Jae-Kyong;Park Eun-Ran;Kim Hyun-Suk;Ahn Seung-Ju;Min Byung-In;Joo Young-Mi;Kim Chong-Rak
    • 대한의생명과학회지
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    • 제12권2호
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    • pp.73-79
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    • 2006
  • Nebulin is a giant ($600{\sim}900$ kDa), modular sarcomeric protein proposed to regulate the assembly, and to specify the precise lengths of actin filamints in vertebrate skeletal muscles. Recently, There is an evidence that the nebulin also expressed in non muscle tissue, brain and liver. We identified a new isoform of nebulin from adult brain library by PCR screening. It contains two simple-repeats exon 165, 166 and linker-repeats exon $154{\sim}161$ except exon 159. The nebulin modules M160 to M170 (exon 150 to exon 161) has been shown to bind desmin. In mature striated muscle, desmin intermediate filaments surround Z-discs and link individual myofibrils laterally at their Z-discs and to other intracellular structures, including the costameres and the intercalated discs of the sarcolemma, sarcoplasmic reticulum, mitochondria, T-tubules, and nuclei. Therefore, it is an interesting possibility that the differential splice pathways within the linker region of nebulin modify the affinity of nebulin's interaction with desmin. The specific interactions of nebulin and desmin were confirmed in vivo by yeast two hybrid experiments. To verify in the cellular level the interaction between nebulin isoform and desmin, we transfected COS-7 cell with EGFP-tagged nebulin and DsRed-tagged desmin. Based on evidence showing that despite exon 159 was deleted, the new isoform of nebulin was interact with desmin. This suggest that nebulin in brain may interact with another intermediate filament. The conservation of these ligand-binding capacity in brain and skeletal nebulins suggest that nebulins may have conserved roles in brain and skeletal muscle.

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Diverse modeling techniques, parameters, and assumptions for nonlinear dynamic analysis of typical concrete bridges with different pier-to-deck connections: which to use and why

  • Morkos, B.N.;Farag, M.M.N.;Salem, S.;Mehanny, S.S.F.;Bakhoum, M.M.
    • Earthquakes and Structures
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    • 제22권3호
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    • pp.245-261
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    • 2022
  • Key questions to researchers interested in nonlinear analysis of skeletal structures are whether the distributed plasticity approach - albeit computationally demanding - is more reliable than the concentrated plasticity to adequately capture the extent and severity of the inelastic response, and whether force-based formulation is more efficient than displacement-based formulation without compromising accuracy. The present research focusing on performance-based seismic response of mid-span concrete bridges provides a pilot holistic investigation opting for some hands-on answers. OpenSees software is considered adopting different modeling techniques, viz. distributed plasticity (through either displacement-based or force-based elements) and concentrated plasticity via beam-with-hinges elements. The pros and cons of each are discussed based on nonlinear pushover analysis results, and fragility curves generated for various performance levels relying on incremental dynamic analyses under real earthquake records. Among prime conclusions, distributed plasticity modeling albeit inherently not relying on prior knowledge of plastic hinge length still somewhat depends on such information to ensure accurate results. For instance, displacement-based and force-based approaches secure optimal accuracy when dividing, for the former, the member into sub-elements, and satisfying, for the latter, a distance between any two consecutive integration points, close to the expected plastic hinge length. On the other hand, using beam-with-hinges elements is computationally more efficient relative to the distributed plasticity, yet with acceptable accuracy provided the user has prior reasonable estimate of the anticipated plastic hinge length. Furthermore, when intrusive performance levels (viz. life safety or collapse) are of concern, concentrated plasticity via beam-with-hinges ensures conservative predicted capacity of investigated bridge systems.

가물치(Channa argus) 젖산탈수소효소 동위효소들의 정제 및 특성 (Purification and Characterization of Lactate Dehydrogenase Isozymes in Channa argus)

  • 박은미;염정주
    • 생명과학회지
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    • 제20권2호
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    • pp.260-268
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    • 2010
  • 가물치(Channa argus) 조직의 젖산탈수소효소 동위효소(EC 1.1.1.27, lactate dehydrogenase, LDH)를 정제하고 생화학적, 면역학적 및 역학적 방법으로 특성을 연구하였다. LDH 활성은 골격근이 380.4 units로 가장 높고 심장 13.4, 눈 3.5, 뇌 조직 5.4 units이었으며, 심장의 CS 활성은 20.7 unit로 가장 높고, LDH/CS는 골격근 172.9, 심장 0.6, 눈 0.32, 뇌 0.47이고, 단백질 양은 골격근 14.7 mg/g이며, 특이활성(units/mg)은 골격근 25.88, 심장 0.79, 눈 0.31, 뇌 1.38 units/mg이었으므로 골격근은 혐기적이고, 심장은 호기적이었다. LDH $A_4$, $B_4$, eye-specific $C_4$에 대한 항혈청을 사용한 Western blot, 면역침강반응 및 native-polyacrylamide gel electrophoresis에 의해 $A_4$, $A_3B$, $A_2B_2$, $AB_3$$B_4$가 모든 조직에서 확인되었고, 눈 조직에서 $C_4$$AC_3$, $A_2C_2$, $AC_3$, 뇌 조직에서 $A_3C$도 확인되었다. LDH $A_4$, $A_3B$, $A_2B_2$, $AB_3$, $B_4$, eye-specific $C_4$ 동위효소는 affinity chromatography와 Preparative PAGE Cell에 의해 정제되었다. LDH $A_4$ 동위효소는 $NAD^+$ 유입 후 정제되었고, eye-specific $C_4$$A_4$에 이어 용출되기 시작하였으며 $B_4$는 buffer 유입 후 용출되었다. 정제한 결과 $A_4$$B_4$ 및 eye-specific $C_4$와 분자구조의 일부가 유사하였지만 $B_4$$C_4$는 서로 다른 것으로 나타났으므로, 하부단위체 A는 보존적이고, 하부단위체 B는 A보다 더 빠르게 진화된 것으로 보인다. 피루브산 10 mM에서 $A_4$ 동위효소 39.98%, $A_2B_2$ 21.28%, $B_4$ 19.67% 및 eye-specific $C_4$ 16.87%의 활성이 남아있었고, 피루브산에 대한 $Km^{PYR}$$A_4$ 0.17 mM, $B_4$ 0.27 mM, eye-specific $C_4$ 0.133 mM였다. $A_4$, $B_4$, eye-specific $C_4$, $A_2B_2$, $A_3B$$AB_3$의 최적 pH는 각각 pH 6.50, pH 8.5, pH 5.5, pH 6.0-6.5, 5.0 및 pH 7.5였고, 동질사량체 $A_4$와 이질사량체 동위효소들은 넓은 pH 영역에서 안정하였다. 특히 골격근은 LDH 활성이 크므로 활동성이 크며, 눈조직에서 피루브산 친화력이 강한 eye-specific $C_4$에 의해 피루브산 대사가 빠르게 일어나고, 이어서 $A_4$에 의해 젖산이 산화되어지는 것으로 사료되므로, 종의 생태환경 및 먹이 획득 양식에 따라 LDH-C 발현, 기질에 대한 친화도 및 대사 시간이 다른 것으로 사료된다.

대표근육 자극을 통한 EMS 기반 역감 제어방법론 제안 (EMS based Force Feedback Methodology through Major Muscle Group Activation)

  • 김효민;권재성;오용환;양우성
    • 로봇학회논문지
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    • 제12권3호
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    • pp.270-278
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    • 2017
  • The electrical muscle stimulator (EMS) based human machine interface (HMI) free to mechanical constraint and muscle fatigue problems are proposed for force feedback in a virtual reality. The device was designed to provide force feedback up to 4.8 N and 2.6 N each to the thumb and forefingers. The main objective of the HMI is to make unnecessary mechanical structures to attach on the hand or fingers. It employs custom EMSs and an interface arranged in the forearm. In this work, major muscle groups such as extensor pollicis brevis (EPB), extensor indicis proprius (EIP), flexor pollicis longus (FPL) and flexor digitorum profundus (FDP) are selected for efficient force feedback and controlled individually. For this, a human muscular-skeletal analysis was performed and verified. The validity of the proposed multi-channel EMS based HMI was evaluated thorough various experiments with ten human subjects, interacting with a virtual environment.

정상 척추체 모델을 이용한 척추측만증 모델 자동 생성 프로그램 개발 (Development of a Special Program for Automatic Generation of Scoliotic Spine FE Model with a Normal Spine Model)

  • 유한규;김영은
    • 한국정밀공학회지
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    • 제23권3호
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    • pp.187-194
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    • 2006
  • Unexpected postoperative changes, such as growth in rib hump and shoulder unbalance, have been occasionally reported after corrective surgery for scoliosis. However there has been neither experimental data fer explanation of these changes, nor the suggestion of optimal correction method. Therefore, the numerical study was designed to investigate the post-operative changes of vertebral rotation and rib cage deformation after the corrective surgery of scoliosis. A mathematical finite element model of normal spine including rib cage, sternum, both clavicles, and pelvis was developed with anatomical details. In this study, we also developed a special program which could convert a normal spine model to a desired scoliotic spine model automatically. A personalized skeletal deformity of scoliosis model was reconstructed with X-ray images of a scoliosis patient from the normal spine structures and rib cage model. The geometric mapping was performed by translating and rotating the spinal column with an amount analyzed from the digitized 12 built-in coordinate axes in each vertebral image. By utilizing this program, problems generated in mapping procedure such as facet joint overlapping, vertebral body deformity could be automatically resolved.

뉴랄 네트워크에 의한 선체 중앙단면 최적구조설계 (Optimum Design of Midship Section by Artificial Neural Network)

  • 양영순;문상훈;김신형
    • 대한조선학회논문집
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    • 제33권2호
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    • pp.44-55
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    • 1996
  • 1960년대 중반 전산기를 이용한 선체 구조설계가 최초로 시도된 후 국내에서도 1980년부터 중앙단면 최적설계에 관한 많은 연구가 이루어져 왔다. 선급규정에 의한 선체 중앙단면 최적설계를 할 경우, 야기되는 문제로서는 부재 치수, 부재 개수와 같은 이산변수를 다루어야 하는 어려움이 있어, 이러한 문제를 해결하고자 유전자 알고리즘이나 인공신경망 등의 새로운 최적화 기법의 개발에 관한 연구 등이 진행되고 있다. 이와 같은 관점에서 본 연구에서는 선체 구조설계 문제에 효율적인 최적화 방법을 개발함에 있어, 홉필드 네트워크 모델과 시뮬레이티드 어닐링을 결함하여 Neuro-Optimizer를 개발하고, 이를 토대로 구조공학 문제의 하나인 간단한 트러스 구조물의 최적설계와 선체의 중앙단면 최적설계에 적용하여, 새로운 최적화 기법으로서 가능성이 있음을 확인하였다.

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