• Imaging Science in Dentistry
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• 제47권1호
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• pp.1-9
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• 2017

Purpose: This retrospective study aimed to evaluate the nasopharyngeal and oropharyngeal dimensions of individuals with skeletal class II, division 1 and division 2 patterns during the pre-peak, peak, and post-peak growth periods for comparison with a skeletal class I control group. Materials and Methods: Totally 124 lateral cephalograms (47 for skeletal class I; 45 for skeletal class II, division 1; and 32 for skeletal class II, division 2) in pre-peak, peak, and post-peak growth periods were selected from the department archives. Thirteen landmarks, 4 angular and 4 linear measurements, and 4 proportional calculations were obtained. The ANOVA and Duncan test were applied to compare the differences among the study groups during the growth periods. Results: Statistically significant differences were found between the skeletal class II, division 2 group and other groups for the gonion-gnathion/sella-nasion angle. The sella-nasion-B-point angle was different among the groups, while the A-point-nasion-B-point angle was significantly different for all 3 groups. The nasopharyngeal airway space showed a statistically significant difference among the groups throughout the growth periods. The interaction among the growth periods and study groups was statistically significant regarding the upper oropharyngeal airway space measurement. The lower oropharyngeal airway space measurement showed a statistically significant difference among the groups, with the smallest dimension observed in the skeletal class II, division 2 group. Conclusion: The naso-oropharyngeal airway dimensions showed a statistically significant difference among the class II, division 1; class II, division 2; and class I groups during different growth periods.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제22권4호
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• pp.397-410
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• 2000

Skeletal class III had been classified by the position of the maxilla, the mandible, the maxillary alveolus, the mandibular alveolus and vertical development. This morphologic approach is simple and useful for clinical use, but it is insufficient to permit understanding of the pathophysiology of dysmorphoses. The author hypothesizes that there are different patterns of mutual relation of the skeletal components which have contributed pathologic equilibrium of skeletal class III. The purpose of this study are threefold: 1) to classify skeletal class III in subgroups, which can show the architectural characteristics of the deformity, 2) to analyse the craniofacial architecture of each subgroup on etio-pathogenic basis, and 3) to characterize and visualize the pattern as a prototype. Materials used in this study were lateral cephalograms of 106 skeletal class III adults, which were analysed with modified Delaire's architectural and structural analysis. Linear and angular measurements of the individual subject were obtained and cluster analysis was used for the subgrouping. Data were evaluated for verification of the statistical significances. The following results were obtained. 1. By the modified Delaire's architectural and structural analysis and cluster analysis, skeletal class III adults were classified into 7 clusters and presented as prototypes, which could show the pathophysiology of the skeletal architecture 2. There was significant relationship in measurement variables of each cluster, which could reflect characteristics of the skeletal pattern of growth. 3. The flexure of cranial base had a close relationship to the anterior rotational growth of the maxilla and contributes to understand the etio-pathology of skeletal class III. 4. The proportion of craniospinal area in cranial depth, craniocervical angle and vertical position of point Om had a close relationship to rotational growth of the mandible and direction of condylar growth. They contribute to understand the etio-pathology of skeletal class III. In summary, the cranium and the craniocervical area must be considered in diagnosis and treatment planning of dentofacial deformity. And the occlusal plane can be considered as a representative which shows the mutual relationships of the skeletal components.

• 한방비만학회지
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• 제12권1호
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• pp.9-19
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• 2012

Objectives This study was designed to find out the relationships between obesity and growth, skeletal maturity among children by analyzing body composition and bone age. Methods Subjects were composed of 577 children from six years to seventeen years of age, without any other diseases related to growth, were measured their body composition and bone age. Results As obesity index was increased, the RH-MPH(%) and skeletal maturity significantly was also increased. The RH-MPH(%) of the obesity group was significantly increased than that of normal weight group; the skeletal maturity was more increased in th obesity group. It means the recent height of obese children was more taller than that of inherited from the parents, while skeletal maturity of obese children was more rapidly progressing. The RH-MPH(%) was increased in children who revealed stage of second sexual character; skeletal maturity was decreased in children who developed secondary sexual character. Conclusions Obesity children might be taller than what it supposed to be. However, obesity could cause the increase of skeletal maturity. It means the growth plate of obese children has been closed early.

• 대한치과교정학회지
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• 제20권1호
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• pp.157-168
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• 1990

This study was undertaken to investigate the interrelationships between the degrees of skeletal maturity of cervical vertebrae and the hand-and-wrist in skeletal Class III malocclusions. In 185 skeletal Class III malocclusions (male 62, female 123) having the lateral cephalogram and hand-wrist radiogram which were taken on the same day, 6 skeletal maturity stages of cervical vertebrae were compared with 11 skeletal maturity indicators of the hand-and-wrist. On the basis of findings of this study, the following results were obtained: 1. The stages of cervical vertebral maturity are one of the methods possible to assess the individual maturity. 2. Mean ages of male and female were obtained in each cervical vertebral stage. 3. Cervical vertebral stages 1 and 2 are considered to the accelerative growth phase, cervical vertebral stages 3 and 4 are corresponded to the peak height velocity, and cervical vertebral stages 5 and 6 were observed to occur during the decelerative phase of growth after peak height velocity in both sexes. 4. In cervical vertebral stages 1, 2, 3, 4, and 5, the degrees of skeletal maturity of cervical vertebrae in males were more retarded than females. 5. There was the high correlation between the degrees of skeletal maturity of cervical vertebrae and hand-and-wrist.

• Molecules and Cells
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• 제28권5호
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• pp.495-499
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• 2009

Although insulin-like growth factor-I (IGF-I) and androgen receptor (AR) are well known effectors of skeletal muscle, the molecular mechanism by which signaling pathways integrating AR and IGF-I in skeletal muscle cells has not been previously examined. In this study, the role of PI3K/Akt on IGF-I-induced gene expression and activation of AR in skeletal muscle cells was investigated. C2C12 cells were treated with IGF-I in the absence or presence of inhibitors of PI3K/Akt pathway (LY294002 and Wortmannin). Inhibition of the PI3K/Akt pathway with LY294002 or Wortmannin led to a significant decrease in IGF-I-induced AR phosphorylation and total AR protein expression. Furthermore, IGF-I-induced AR mRNA and skeletal ${\alpha}-actin$ mRNA were blocked by LY294002 or Wortmannin. Confocal images showed that IGF-I-induced AR translocation from cytosol to nucleus was inhibited significantly in response to treatment with LY294002 or Wortmannin. The present results suggest that modulating effect of IGF-I on AR gene expression and activation in C2C12 mouse skeletal muscle cells is mediated at least in part by the PI3K/Akt pathway.

• 대한치과교정학회지
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• 제29권3호
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• pp.303-315
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• 1999

골격성 III급 부정교합자의 하악골 회전성장 양상이 하악이부 및 상하악절치부의 형태와 어떠한 관련이 있는지 알아보고자 본 연구를 시행하였다. 하악 전돌의 악골부조화를 보이며 교정치료의 경험이 없는 골격성 III급 부정교합자 성인 남녀 86명을 Skieller등이 하악골 회전성장 양상을 파악하기 위해 제안한 방법을 통해 전방회전성장군과 후방회전성장군으로 분류하여, 골격성 III급 부정 교합자에서 하악골 회전성장 양상에 따른 골격관계, 하악이부의 형태와 상하악절치의 위치에 관하여 분석한 결과 다음과 같은 결론을 얻었다. 1. 전방회전성장군에서 후방회전성장군에 비해 수평적인 두개안면 골격관계에서 SNA, SNB가 모두 유의성 있게 크게 나타났다. 또한 수직적인 두개안면 골격관계에 대해서는 모든 항목에서 차이가 있었다. 2. 하악이부 및 상하악절치부 형태와 하악골의 회전성장 양상 사이의 관계에서는 후방회전성장군에서 하악절치가 더 설측경사되고, 하악절치의 치조부 순설폭경이 좁으며 상악절치의 치조부에서 구개평면까지의 거리가 더 증가되었다. 3. 하악평면을 기준으로 계측한 symphysis ratio는 전방회전성장군과 후방회전성장군 사이에 유의한 차이가 없었다. 4. 하악골의 회전성장 양상과 하악이부 및 상하악절치부 형태에 대한 계측항목과의 상관분석에서, 후방회전성장 양상으로 성장할수록 overbite의 감소, 하악절치의 설측경사, 하악절치의 치조부 순설폭경 및 symphysis width의 감소가 나타났다.

• 대한치과교정학회지
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• 제48권1호
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• pp.39-47
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• 2018

Objective: The aim of this study was to establish the normative data of dentofacial transverse dimensions according to the skeletal maturation stage in Korean adolescents with good occlusion, assess gender differences and determine correlations between transverse variables. Methods: A total of 577 Korean subjects between ages 7 to 19 years and exhibiting skeletal Class I occlusion were categorized by skeletal maturation index (SMI) of Fishman using hand-wrist radiographs. Dentofacial transverse dimensions were assessed using posteroanterior cephalograms. Independent two-sample t-tests were used to analyze differences between genders. Pearson correlation coefficient was used to determine the correlation between transverse measurements. Results: Dentofacial transverse norms relevant to skeletal maturation stages were established. The average maxillomandibular width difference and ratio at growth completion was 22.16 mm and 77.01% for males; 23.70 mm and 74.06% for females, respectively. Males had greater facial, maxillary and mandibular widths compared to females at every SMI stage. The maxillary and mandibular intermolar widths showed the strongest correlation for both sexes (r = 0.826 for males, r = 0.725 for females). Conclusions: Dentofacial transverse norms of Korean adolescents were established according to developmental stage. All dentofacial widths were greater in males at growth completion. Maxillary and mandibular intermolar widths were strongly correlated. This study may serve as a guideline for the assessment of dentofacial transverse growth according to skeletal maturation stage in Korean adolescents with good occlusion.

• 대한소아치과학회지
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• 제46권3호
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• pp.233-238
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• 2019

본 연구의 목적은 한국 소아청소년 표준 골연령 도표를 이용하여 평가한 SMI 및 MP3 단계별 골연령을 조사하여 최대 성장기에 해당하는 단계를 알아보고, 이를 통해 성장 중인 부정교합 환자의 치료 계획 수립, 치료방법 및 시기에 중요한 영향을 미치는 성장 발육평가 자료를 제공하고자 함이다. 이대목동병원 소아청소년과에 내원한 363명의 환자의 수완부 방사선 사진에서 한국 소아 청소년의 표준 골연령 도표를 바탕으로 영상의학과 의사에 의해 판정된 골연령을 조사하였다. 동일한 방사선 사진에서 평가된 SMI 및 MP3 단계에 따른 평균 골연령을 산출하였다. 본 연구 결과 사춘기 최대 성장기가 남아에서는 SMI 4 - 5단계 및 MP3 FG - G단계, 여아에서는 SMI 3 - 4단계 및 MP3 F - FG단계에서 나타남을 확인하였다.

• 대한치과교정학회지
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• 제18권2호
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• pp.343-366
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• 1988

Craniofacial complex is influenced by numerical skeletal elements. Though the analysis of growth change has been done by various analytical methods, it was dependent on any method of registration and superimposition, based on reference plane and reference point. However, the craniofacial growth is composed of a number of local growth elements. Therefore, it will be necessary to use a clinically useful method for estimating craniofacial skeletal growth independently. The author analysed longitudinal cephalometric roentgenogram of 15 Korean males and 15 Korean females aged from 6 to 12 years by the finite element method and results were as follows : 1. The finite element method for craniofacial skeletal complex and soft tissue made it possible to analyze the independent local growth. 2. Regression equations from the value of each strain will make it possible to predict the craniofacial growth. 3. The growth of anterior cranial base was different from that of other facial bone. 4. The growth of posterior cranial base influenced the growth of upper pharyngeal region, midfacial region, maxilla and posterior region of mandible. 5. The growth of maxillary complex was vertical rather than horizontal. 6. The growth direction of ramus, mandibular body, alveolar bone was various. 7. The relation between hard tissue and soft tissue by finite element method was variant.

• 대한한방소아과학회지
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• 제22권2호
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• pp.19-35
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• 2008

Objectives : As obese children have been increased, the interest in the impact of obesity on growth also have been increased. This study is to examine relations between obesity and skeletal maturity by analyzing body compositions and bone age. Methods : Subjects were composed of 233 children from 6 years to 17 years of age, without any other diseases related to growth, who visited the department of pediatrics, OO oriental medicine hospital and measured their body composition (body mass index, body fat ratio, fitness score) and bone age. Results : 1. As body mass index was increased, the skeletal maturity significantly was also increased. 2. As the mean of bone maturity was increased, the BMI was increased from the underweight type to the normal type to the overweight type; the bone maturity was increased as the fat ratio was increased from the normal type to the obese type to the excessively obese type; and the bone maturity was higher in the weak, obese type than the normal type when classified according to the Fitness Score. 3. The bone maturity of the overweight group in the BMI classification and excessively obese group in the fat ratio classification significantly were increased. 4. Skeletal maturity significantly was increased in children who developed secondary sexual character. 5. The significance of obesity causing increase of the skeletal maturity was higher in boys than in girls. 6. Only in the case of children without development of secondary sexual character, obesity caused an significant increases in the skeletal maturity. Conclusions : Obesity could cause the increase of skeletal maturity, and the obesity could affect more to the boys than girls and more to the children than teenagers.