• 대한치과교정학회지
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• 제19권1호
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• pp.219-243
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• 1989

The purpose of this study was to evaluate the effects of the chincap therapy on the craniofacial structure in persons with skeletal Class III malocclusion. The patients selected for this study were treated with extra-oral chincap therapy only. Both control and treatment samples were obtained from Seoul National University Hospital where these longitudinal data were gathered. 55 treated patients and 14 control patients were studied. The mean ages at the 1st evaluation was 8 years 3 months in the treatment sample and 9 years 4 months in the control sample. The duration of chincap therapy was variable but averaged 2 years of treatment. Post-treatment observation procedeeded for 1 year 2 months. Active treatment and post treatment effects were evaluated. The results were as follows: 1. Neither significant restraint nor acceleration of growth was found in the cranial base and maxilla during treatment. 2. A distal rotation of the mandibular complex was seen. 3. Some amount of restraint of growth was found in mandibular body length, ramus height, mandibular length during treatment. 4. The genial angle was reduced. 5. After removal of the chin-cap, forward displacement of the mandible took place.

• Journal of Chest Surgery
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• 제25권4호
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• pp.347-355
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• 1992

The precise mechanism of the Excitation-Contraction Coupling is still uncertain. But the concept that Ca2+ induced Ca2+ release [CICR] from the Ryanodine receptor in the sarcoplasmic reticulum [foot structure] may play a major role in E-C coupling has been widely accepted since 1970`s. It is believed that increased cytosolic Ca2+ followed by CICR is main contributor for E-C coupling of striated muscle. Resulting phenomena of ischemic /post-reperfusion myocyte is increased cytosolic Ca2+, even to the absence of Ca2+ in reperfusate. So intracellular inhibitor to CICR might prevent the ischemic and reperfusion damage of myocardial cells. The relatively purified foot protein, especially heavy sarcoplasmic reticulum rich, of the skeletal muscle was incorporated into the black lipid bilayer [Phosphatidyl ethanolamine: Phosphatidyl serine=l: 1]. Under the steady state of membrane potential [+20 mV], ionic current through Ryanodine receptor was measured with Cs+ as charge carrier. In the cis chamber [Cytoplasmic side], Mg2+ strongly inhibited CICR of Ryanodine receptor[Kd=6.2 nM]. In conclusion, naturally existing intracellular free Mg2+ can inhibit CICR from intracellular Ca2+ reservior [heavy SR]. So post-ischemic or post-reperfusing myocardium could be preserved using additional free Mg2+ in cardioplegic solution or reperfusate, otherwise the optimal concentration is undetermined.

• 대한치과교정학회지
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• 제24권4호
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• pp.799-817
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• 1994

The purpose of this study was to evaluate the initial skeletal pattern and growth change of whom had responsed well to chincap therapy. 93 patients seleted for this study were in mixed dentition and treated with chincap for more than 2 years. And 54 subjects were selected from these total samples and classified into two groups by the improvement of four measurements : ANB difference, APDI, Wits appraisal, and AF-BF. One was good response group which consisted of 26 children and the other was poor response group with 19 patients. Various measures of the craniofacial structure in the initial lateral cephalograms and the annual increments were calculated and analyzed by comparing two groups with t-test. The results were as follows : 1. Good response group had more horizontal growth pattern in initial stage of treatment than poor response group, and the contributing factors of this result were anterior posterior facial height ratio, gonial angle, lower genial angle and SN-mandibular plane angle. 2. The maxilla was positioned more anteriorly in good response group. 3. The amounts of vertical growth of maxilla was smaller but the horizontal growth of maxilla was larger in good response group. 4. The mandible rotated more infero-posteriorly in good response group. 5. The good response group had more vertical growth pattern of mandibular condyle.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2003년도 추계학술대회
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• pp.1373-1377
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• 2003

Current prostheses for amputees are generally extrinsic wearing socket type that the coupling between body stump and appliance wraps the soft tissue and this structure causes several problems :applying direct weight to soft tissue such as skin and muscle, skin trouble of contacting area and pain. In this study, osseointegration implant is a method to directly connect prosthesis to the residual stump skeletal tissue of arm, finger and leg through surgical operation. Technology presented in this paper essentially solves the problems of pain and abnormal weight transfer system indicated above and recovers the functions of the amputated arm and leg. In this paper, implant shape was designed for the first step for the development of osseointegration implant and then we studied the possibility to apply this osseointegration implant to human body by performing implant insertion operation to beagle tibia for the clinical animal test and normal beagle's gait analysis was executed in order to quantitatively verify the beagle's skeletal functions after the implant insertion.

• 한국응용과학기술학회지
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• 제24권1호
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• pp.61-66
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• 2007

X-ray diffraction studies have been made to investigate the effects of binding of ADP, ADP+Vi, ADP+AIF4, $ADP+BeF_3$ on the structure of glycerinated rabbit skeletal muscle in the rigor state. Although these phosphate analogs are known to bind actively cycling myosin heads, it is not clear whether they can bind to the attached heads in the rigor muscle. We have found that these analogs can bind to the myosin heads attached to actin filaments in the rigor state. The present results indicate that (1) bound myosin heads altered their conformation in the proximal end toward the plane perpendicular to the fiber axis when MgADP bound to them, and (2) myosin heads were dissociated substantially (up to 50%) from actin filaments but still remained in the vicinity of actin filaments when MgADP and metallofluorides (AIF4 and BeF3) or vanadate bound to them. We detected new conformations of myosin heads attached to actin filaments when they had MgADP or ADP.Pi analogs. We report here these findings on the effects of MgADP and MgADP+phosphate analogs to the rigor crossbridges.

• PNF and Movement
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• 제7권1호
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• pp.33-46
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• 2009

Purpose : N.A.P.(Neuromuscular Skeletal Plasticity) an integrative neuro-orthopedic concept to facilitate motor strategies in daily life. The primary thesis is, that treatment of body functions and structural impairments should be integrated within goal-oriented activities. The purpose of this article is to demonstrate that the functional activity itself, determines the structure. Material and Methods : A case report of a dentist with brachial plexus lesion after a motor vehicle accident is presented. The necessity for training body functions within relevant tasks is undermined by references which emphasize the importance of training realistic activities to enhance long-term changes in neural representation. Results : The treatment methods presented in this case show significant effects for the patient's ability to participate in his profession within less than a year's time after his motor vehicle accident. Conclusions : Current evidence supports the treatment methods of this concept. The inability to flex his elbow and supinate his forearm placed a considerable doubt to his ability to ever be able to participate in his profession again. Structural reorganization is possible and depends on functional demands, which need to be trained task-specifically. Single case reports may serve as the basis for further randomized controlled studies to support the efficacy of the treatment methods within the N.A.P. concept.

• 운동영양학회지
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• 제24권3호
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• pp.32-38
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• 2020

[Purpose] Sarcopenia is considered one of the major causes of disability in the elderly population and is highly associated with aging. Exercise is an essential strategy for improving muscle health while aging and involves multiple metabolic and transcriptional adaptations. Although the beneficial effects of exercise modalities on skeletal muscle structure and function in aging are well recognized, the exact cellular and molecular mechanisms underlying the influence of exercise have not been fully elucidated. [Methods] We summarize the biochemical pathways involved in the progression and pathogenesis of sarcopenia and describe the beneficial effects of exercise training on the relevant signaling pathways associated with sarcopenia. [Results] This study briefly introduces current knowledge on the signaling pathways involved in the development of sarcopenia, effects of aerobic exercise on mitochondria-related parameters and mitochondrial function, and role of resistance exercise in the regulation of muscle protein synthesis against sarcopenia. [Conclusion] This review suggested that the beneficial effects of exercise are still under-explored, and accelerated research will help develop better modalities for the prevention, management, and treatment of sarcopenia.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1995년도 춘계학술대회
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• pp.64-64
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• 1995

Cholesteryl Ester Transfer Protein (CETP) mediates the transfer of cholesterol ester and triglyceride between high-density lipoprotein (HDL) and other low-density lipoproteins, therefore, it might influence HDL levels. The levels of HDL is closely related to the atherogenic diseases in human and there were several reports that the trasgenic mice expressing CETP had much worse atherosclerosis than non-expressing control one. Therefore, selective inhibitors of CETP have the potential to be used as antiatherosclerotic agents. Continued screening for potent inhibitors of CETP led to the isolation of Suberitenone B from marine sponge. Suberitenone B, sesterterpenoids of a new skeletal class have been isolated from the sponge Suberites sp. collected from King George Island the Antartic. The structure of the metabolite has been determined by NMR experiments and chemical methods.

• 국제초고층학회논문집
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• 제11권1호
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• pp.1-14
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• 2022

Debates on what is the first skyscraper have been ongoing from time to time since the construction of the Home Insurance Building in Chicago in 1885, which is generally recognized as the first built skyscraper. This paper attempts to verify this assertion through a detailed investigation after identifying the criteria that characterize a skyscraper. By considering and examining several competing buildings for the title of "first skyscraper" in terms of their levels of satisfying these criteria, the paper reconfirms that the Home Insurance Building in Chicago indeed qualifies as the first skyscraper and is the harbinger of future skyscrapers. By introducing technological and associated architectural innovations in this pioneering building, its designer William Le Baron Jenney paved the way for the construction of future skyscrapers. In traditional construction, heavy masonry walls especially at lower levels did not allow large window openings in exterior walls that would permit ample daylight. For the Home Insurance Building, originally built with 10 stories, Jenney created a metal-framed skeletal structure that carried the building's loads, making the building lighter and allowed for large windows permitting ample natural light to the building's interior. The exterior iron columns were encased in relatively small masonry piers mainly for fireproofing, weather-protection and façade aesthetics. Relying on the structural framing on the building's perimeter, the exterior masonry thus turned into a rudimentary "curtain wall" system, heralding the use of curtain wall construction in future skyscrapers. This building's innovative structural system led to what is known as the "Chicago Skeleton," and eventually produced remarkable skyscrapers all over the world.

• 대한물리치료과학회지
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• 제13권1호
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• pp.61-74
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• 2006

This study about functional anatomy of the hand. hand injuries are among the most common problems confronting patient, physical therapist and physicians. physical therapist should know about normal hand function and anatomical structure for hand injury, clinical reasoning and intervention. physical therapist should know about the Skeletal of the hand, Function of The Hand, Nerves of the hand, Sensation of the Hand, Intrinsic muscle, Power and Balance and Functional Position of the Hand. In this article, we discuss the physiologic properties of hand structure, biomechanical observation in hand function, sensation and nerves, hand positioning.