• Title/Summary/Keyword: Site of action

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Effect of structure configurations and wind characteristics on the design of solar concentrator support structure under dynamic wind action

  • Kaabia, Bassem;Langlois, Sebastien;Maheux, Sebastien
    • Wind and Structures
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    • v.27 no.1
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    • pp.41-57
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    • 2018
  • Concentrated Solar Photovoltaic (CPV) is a promising alternative to conventional solar structures. These solar tracking structures need to be optimized to be competitive against other types of energy production. In particular, the selection of the structural parameters needs to be optimized with regards to the dynamic wind response. This study aims to evaluate the effect of the main structural parameters, as selected in the preliminary design phase, on the wind response and then on the weight of the steel support structure. A parametric study has been performed where parameters influencing dynamic wind response are varied. The study is performed using a semi-deterministic time-domain wind analysis method. Unsteady aerodynamic model is applied for the shape of the CPV structure collector at different configurations in conjunction with a consistent mass-spring-damper model with the corresponding degrees of freedom to describe the dynamic response of the system. It is shown that, unlike the static response analysis, the variation of the peak wind response with many structural parameters is highly nonlinear because of the dynamic wind action. A steel structural optimization process reveals that close attention to structural and site wind parameters could lead to optimal design of CPV steel support structure.

Experimental Study on the Flexural Capacity of the U-Flanged Truss Hybrid Beam (U-플랜지 트러스 복합보의 휨 내력에 대한 실험 연구)

  • Oh, Myoung Ho;Kim, Young Ho;Kim, Myeong Han
    • Journal of Korean Association for Spatial Structures
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    • v.18 no.4
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    • pp.123-130
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    • 2018
  • U-flanged truss beam is composed of u-shaped upper steel flange, lower steel plate of 8mm or more thickness, and connecting lattice bars welded on the upper and lower sides. The hybrid beam with U-flanged steel truss is made in the construction site through pouring the concrete, and designated as U-flanged truss hybrid beam. In this study the structural experiments on the 4 hybrid beams with the proposed basic shapes were performed, and the flexural capacities from the tests were compared with those from the theoretical approach. The failure modes of each specimen were quite similar. The peak load was reached with the ductile behavior after yielding, and the failure occurred through the concrete crushing. The considerable increasement of deformation was observed up to the concrete crushing. The composite action of concrete and steel member was considered to be reliable from the behavior of specimens. The flexural strength of hybrid beam has been evaluated exactly using the calculation method applied in the boubly reinforced concrete beam. The placement of additional rebars in the bottom instead of upper side is proposed for the efficient design of U-flanged truss hybrid beam.

Aspect-based Sentiment Analysis of Product Reviews using Multi-agent Deep Reinforcement Learning

  • M. Sivakumar;Srinivasulu Reddy Uyyala
    • Asia pacific journal of information systems
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    • v.32 no.2
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    • pp.226-248
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    • 2022
  • The existing model for sentiment analysis of product reviews learned from past data and new data was labeled based on training. But new data was never used by the existing system for making a decision. The proposed Aspect-based multi-agent Deep Reinforcement learning Sentiment Analysis (ADRSA) model learned from its very first data without the help of any training dataset and labeled a sentence with aspect category and sentiment polarity. It keeps on learning from the new data and updates its knowledge for improving its intelligence. The decision of the proposed system changed over time based on the new data. So, the accuracy of the sentiment analysis using deep reinforcement learning was improved over supervised learning and unsupervised learning methods. Hence, the sentiments of premium customers on a particular site can be explored to other customers effectively. A dynamic environment with a strong knowledge base can help the system to remember the sentences and usage State Action Reward State Action (SARSA) algorithm with Bidirectional Encoder Representations from Transformers (BERT) model improved the performance of the proposed system in terms of accuracy when compared to the state of art methods.

Anti-tumor Substance from Panax Kin.ienk Roots (고려인삼 뿌리에 있는 항종량 물질)

  • Hiroshi Yamamoto;Mitsuo Katario;Hisashi Matsunaga
    • Journal of Ginseng Research
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    • v.14 no.2
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    • pp.244-252
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    • 1990
  • Antitumor polyacetylenic alcohol, panaxytriol (Cl7 H26O3), was isolated and purified from a powder of the root of Pnnnx tin.1.encl C.A. Meyer. Panaxytriol possesses unusual property of being soluble in both water and organic solvents. Panaxytriol inhibited the growth of various kinds of human cultured cell lines in dose-dependent fashion in vitro. The in vivo effects of panaxytriol were tested against C57BL/6 mice transplanted with Bl6 melanomas. Panaxytriol (8 and 40 mg/kg) administered intra-muscularly(im) produced significant tumor growth delays in mice. Although a detailed mechanism of growth inhibition by panaxytriol is unknown, preliminary results appear to implicates a surface membrane site of action. And its action seems to be more dose-dependent than time-dependent. Finally, panaxytriol pharmacokinetics was evaluated in mice given single 8 mg/kg doses intraperitoneally (ip) or im. Serum panaxytriol content was measured using both tumor growth inhibitory assay and a gas chromatographic method. The maximum serum panaxytriol content after ip and im administration was 35.0 and 1.6 $\mu$g/ml respectively. These results indicate that the compound may act as cytotoxic substance even in patients.

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Anti-tumor Substance from Panax Kinsenk Roots

  • Hiroshi Yamamoto;Mitsuo Katano;Hisashi Matsunaga
    • Proceedings of the Ginseng society Conference
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    • 1990.06a
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    • pp.102-110
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    • 1990
  • Antitumor polyacetylenlc alcohol, panaxytriol (Ci7 H2603), was isolated and purified from a Powder of the root of Panax ginseng C.A. Meyer. Panaxytriol Possesses unusual Property of being soluble in both water and organic solvents. Panaxytriol inhibited the growth of various kinds of human cultured cell lines in dose-dependent fashion in vitro. The in vivo effects of panaxytriol were tested against C57BU6 mice transplanted with Bl6 melanomas. Panaxytriol (8 and 40 mg/kg) administered intramuscularly (im) produced significant tumor growth delays in mice. Although a detailed mechanism of growth inhibition by panaxytriol is unknown, preliminary results appear to implicate a surface membrane site of action. And its action seems to be more dose-dependent than time-dependent. Finally, panaxytriol pharmacokinetics was evaluated in mice given single 8 mgrkg doses intraperitoneally(ip) or im. Serum panaxytriol content was measured using both tumor growth inhibitory assay and a gas chromatographic method. The maximum serum panaxytriol content after ip and im administration was 35.0 and 1.61 ug/ml respectively. These results indicate that the compound may act as cytotoxic substance even in-patients. Keywords Panax ginseng, panaxytriol, tumor growth inhibition

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A Study on Web Vulnerability Assessment and Prioritization of Measures by Vulnerabilities (웹 취약점 점검 및 취약점별 조치 우선 순위 산정에 관한 연구)

  • Seong, JongHyuk;Lee, HooKi;Ko, InJe;Kim, Kuinam J.
    • Convergence Security Journal
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    • v.18 no.3
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    • pp.37-44
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    • 2018
  • Today we live in a flood of web sites and access numerous websites through the Internet to obtain various information. However, unless the security of the Web site is secured, Web site security can not be secured from various malicious attacks. Hacking attacks, which exploit Web site security vulnerabilities for various reasons, such as financial and political purposes, are increasing. Various attack techniques such as SQL-injection, Cross-Site Scripting(XSS), and Drive-By-Download are being used, and the technology is also evolving. In order to defend against these various hacking attacks, it is necessary to remove the vulnerabilities from the development stage of the website, but it is not possible due to various problems such as time and cost. In order to compensate for this, it is important to identify vulnerabilities in Web sites through web vulnerability checking and take action. In this paper, we investigate web vulnerabilities and diagnostic techniques and try to understand the priorities of vulnerabilities in the development stage according to the actual status of each case through cases of actual web vulnerability diagnosis.

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Development of a Methodology for Estimating Radioactivity Concentration of NORM Scale in Scrap Pipes Based on MCNP Simulation

  • Wanook Ji;Yoomi Choi;Zu-Hee Woo;Young-Yong Ji
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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    • v.21 no.4
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    • pp.481-487
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    • 2023
  • Concerning the apprehensions about naturally occurring radioactive materials (NORM) residues, the International Atomic Energy Agency (IAEA) and its member nations have acknowledged the imperative to ensure the radiation safety of NORM industries. Residues with elevated radioactivity concentrations are predominantly produced during NORM processing, in the form of scale and sludge, referred to as technically enhanced NORM (TENORM). Substantial quantities of TENORM residues have been released externally due to the dismantling of NORM processing factories. These residues become concentrated and fixed in scale inside scrap pipes. To assess the radioactivity of scales in pipes of various shapes, a Monte Carlo simulation was employed to determine dose rates corresponding to the action level in TENORM regulations for different pipe diameters and thicknesses. Onsite gamma spectrometry was conducted on a scrap iron pipe from the titanium dioxide manufacturing factory. The measured dose rate on the pipe enabled the estimation of NORM concentration in the pipe scale onsite. The derived action level in dose rate can be applied in the NORM regulation procedure for on-site judgments.

A Study on Process Safety Incident Precursors to Prevent Major Process Safety Incidents in the Yeosu Chemical Complex

  • Baek, Seung-Hyun;Kwon, Hyuck-Myun;Byun, Hun-Soo
    • Korean Chemical Engineering Research
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    • v.56 no.2
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    • pp.212-221
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    • 2018
  • Process safety incidents and loss events can be prevented if we identify and adequately take measures on process safety incident precursors in a timely manner. If we look into and take action against the process safety hazard factors causing the incident in the refinery and petrochemical plant, major process safety incidents can be prevented through eliminating or decreasing hazardous factors. We conducted a survey for the major process safety incident precursor to look specifically into the potential process safety hazardous factors of refineries and petrochemical plants in the Yeosu chemical complex. A self-assessment checklist, which was published by Center for Chemical Process Safety "Recognizing catastrophic incident warning signs in the process industry" on major incidents warning sign, was used for the survey. Through this survey, the major process safety incident leading indicators in the process industry were found by process safety management elements, and each site and/or facility can use these leading indicators for activities for process safety incident prevention. In addition, we proposed action items required to eliminate the root cause of those process safety incident leading indicators.

Antagonistic Mode of Action of Fenoxaprop-P-ethyl Phytotoxicity with Bentazon (Fenoxaprop-P-ethyl의 제초활성에 대한 Bentazon의 길항작용기구)

  • Ma, S.Y.;Kim, S.W.;Chun, J.C.
    • Korean Journal of Weed Science
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    • v.18 no.2
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    • pp.161-170
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    • 1998
  • Antagonistic mode of action of fenoxaprop-P-ethyl [ethyl(R)2-4-{(6-chloro-2-benzoxazolyloxy) phenoxy}propionate] with bentazon was investigated with respect to absorption, translocation, metabolism, and change in target site response of fenoxaprop-P-ethyl using four-leaf stage of rice(Oryza sativa L.) and barnyardgrass [Echinochloa eras-galli (L.) P. Beauv.]. Shoots of rice and barnyardgrass was more sensitive to fenoxaprop-P-ethyl than the roots. More than 90% of fenoxaprop-P-ethyl was absorbed within 6 hours after treatment and 30% of the absorbed was acropetally and basipetally translocated at 24 hours after treatment. Fenoxaprop-P-ethyl was rapidly transformed to its acid form, fenoxaprop(2-[4-(6-chloro-2-benzoxazolyloxy)phenoxy]propionic acid), which was subsequently metabolized to polar conjugates. However, changes in absorption, translocation, and metabolism of fenoxaprop-P-ethyl by bentazon treatment were not found in both species. Background activity of acetyl-CoA carboxylase(ACCase) in rice and barnyardgrass was 26.5 and 23.2nmol/min/mg, respectively. Concentration required to inhibit fifty percent enzyme activity$(I_{50})$ in vitro was 6.5~7.4${\mu}M$ of fenoxaprop-P-ethyl and more than 500${\mu}M$ of bentazon. There were no significant differences in $I_{50}$ value between two treatments of fenoxaprop-P-ethyl alone and its bentazon mixture. However, bentazon reduced ACCase activity in vivo and inhibited electron transport in chloroplast thylakoid. Based on the results obtained, it is concluded that the antagonistic effect of bentazon occurs due not to direct effect on target site of fenoxaprop-P-ethyl, but to indirect involvement in reducing herbicidal activity of fenoxaprop-P-ethyl through physiological disturbances caused by bentazone at whole chloroplast level.

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Do Opioid Receptors Play a Role in Blood Pressure Regulation?

  • Rhee, H.M.;Holaday, J.W.;Long, J.B.;Gaumann, M.D.;Yaksh, T.L.;Tyce, G.M.;Dixon, W.R.;Chang, A.P.;Mastrianni, J.A.;Mosqueda-Garcia, R.;Kunos, G.
    • The Korean Journal of Pharmacology
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    • v.24 no.2
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    • pp.153-164
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    • 1988
  • The potential role of endogenous opioid peptides (EOPS) in cardiovascular regulation has only recently been entertained. EOPS have been localized in brain, spinal cord, autonomic ganglia, particularly the adrenal gland, and many other peripheral tissues. There are at least five major types of opioid receptors; namely ${\mu},\;{\delta},\;k,\;{\sigma},\;and\;{\varepsilon}$ and Experimental evidence indicates that cardiovascular actions of the peptide are mediated primarily by ${\mu},\;{\delta}$ and k receptors, and that these receptor types may be allosterically coupled. In anesthetized rabbits met-enkephalin decreased blood pressure and heart rate, which closely paralleled a reduction in sympathetic discharge. Naloxone, but not naloxone methobromide, antagonized these effects, which suggests a central site of action of met-enkephalin. A number of autonomic agents, particularly adrenergic ${\alpha}$-and, ${\beta}-agonists$ and antagonists modify the cardiovascular actions of met-enkephalin. Experiments in reserpine-treated and adrenalectomized rats provide no evidence of sympathetic nervous system involvement in the pressor responses to intravenous injection of opioid peptides, but rather suggest a direct peripheral action. Finally, activation of a beta-endorphinergic pathway projecting from the arcuate nucleus to the nucleus tractos solitarii in rats can cause naloxone reversible hypotension and bradycardia. There is evidence to implicate this pathway in antihypertensive drug action and in the modulation of baroreflex activity.

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