• Title/Summary/Keyword: Site of action

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Long-Term Biodiversity Research Programme for Mindanao, Philippines

  • Amoroso, Victor B.
    • The Korean Journal of Ecology
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    • v.23 no.2
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    • pp.141-147
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    • 2000
  • The Long-Term Biodiversity Research Programme (LTBRP) for Mindanao is envisioned to be a collaborative programme of the Philippines. It will be a programmatic research on biodiversity - its status, threats. and conservation and management. The chosen research site is Mt. Malindang in Misamis Occidental of Mindanao. The BRP will support a set of research projects that will generate knowledge on biological and ecological, socio-economic. cultural and policy aspects of biodiversity conservation. It will also enable researchers to develop and try new methods for research on these aspects, separately or crossing boundaries of academic disciplines. Moreover. the BRP will implement support programmes which will provide the linkages of research activities to development issues and needs in the research site. The support programmes will also draw from the research projects, the knowledge that can be lent or immediately available to policy and programme formulation. The support programmes will comprise: human resource development or capability-building; information, education and communication; database; networking; community organizing: and development action. The BRP will be undertaken by a group of academie and research institutions from the Philippines, in partnership with their respective government entities and local government units in Mindanao. The Biodiversity Research Programme (BRP) will comprise a set of research projects to be undertaken by small research teams in the site. Researchable areas have been identified initially through the National Biodiversity Research Agenda. and later enriched in the Participatory Rural Appraisal (PRA) Analysis workshops by the Mindanao researchers and Philippine resource persons. Results of the PRA are presented in the paper.

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A study on hazard rate decrease plan in plant construction site by improving foreman's role (플랜트 건설현장의 작업반장 역할개선을 통한 위험율 저감방안 연구)

  • Eun, Nam-Gwon;Kim, Chang-Eun
    • Journal of the Korea Safety Management & Science
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    • v.17 no.3
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    • pp.33-44
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    • 2015
  • Domestic plant construction sites have a tendency to become bigger, more various and complicated. Moreover frequency of industrial incident is increasing due to short project period, coexistence work condition and using heavy construction equipment. Installing safety facilities and safety training contribute to prevent incident. But mostly incident happens due to workers' unsafe action and wrong work method. Technically, it is very difficult for us to closely manage workers preventing incident. Therefore, the role of foreman who ordinarily works together with his workers is considered more important. Specific execution plan was drawn through industrial incident statistics from Ministry of Labor and questionnaire survey to interest parties(supervisor, safety staff and foreman). If foreman has raised sense of belonging and responsibility by conducting practical safety training for his workers, manages job site and receives proper compensation for these roles, it will be expected that it fully influences incident decrease.

Calculation and field measurement of earth pressure in shield tunnels under the action of composite foundation

  • Chi Zhang;Shi-ju Ma;Yuan-cheng Guo;Ming-yu Li;Babak Safaei
    • Geomechanics and Engineering
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    • v.34 no.1
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    • pp.17-27
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    • 2023
  • Taking a subway shield tunnel in a certain section of Zhengzhou Metro Line 5 as an example, the field tests of shield cutting cement-soil monopile composite foundation were carried out. The load and internal force of the tunnel lining under the action of composite foundation were tested on-site and the distribution characteristics and variation laws of earth pressure around the tunnel under the load holding state of the composite foundation were analyzed. Five different load combinations (i.e., overburden load theory + q0, Terzaghi's theory + q0, Bierbaumer's theory + q0, Xie's theory + q0, and the proposed method (the combination of compound weight method and Terzaghi's theory) + q0) were used to calculate the internal force of the tunnel structure and the obtained results were compared with the measured internal force results. The action mode of earth pressure on the tunnel lining structure was evaluated. Research results show that the earth pressure obtained by the calculation method proposed in this paper was more consistent with the measured value and the deviation between the two was within 5%. The distribution of the calculated internal force of the tunnel structure was more in line with the distribution law of field test data and the deviation between the calculated and measured values was small. This effectively verified the rationality and applicability of the proposed calculation method. Research results provided references for the design and evaluation of shield tunnels under the action of composite foundations.

Mode of Action of the Bacteriocan from Lactobacillus sp. GM7311 against Gram Negative Bacteria (Lactebacillus sp. GM7311이 생산하는 박테리오신의 Gram 음성균에 대한 작용형태)

  • KANG Ji-Hee;LEE Myung-Suk
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.32 no.2
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    • pp.139-143
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    • 1999
  • The antimicrobial action of bacteriocin produced by lactobacillus sp. GM7311 against three Gram negative bacteria, Proteus mirabilis, Vibrio parahaemolyticus, and Escherichia coli, was investigated, When the bacteriocin was added to the culture at different stages, viable cells of all of the indicator strains tested were decreased, even though the most inhibited indicator cell growth stages were different. Transmission electron microscopic observation of indicator strains treated with bacteriocin revealed cell Iysis, indicating the cell membrane appears to be the primary site of action. The amino acids concentration of indicator strains treated with bacteriocin were diminished and fatty acids compositions were changed as compared with controls.

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Analysis of the Load Carrying Behavior of Shear Connection at the Interface of Encased Composite Beams (매입형 합성보의 전단합성거동에 대한 비교분석)

  • Shin, Hyun Seop;Heo, Byung Wook;Bae, Kyu Woong;Kim, Keung Hwan
    • Journal of Korean Society of Steel Construction
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    • v.20 no.1
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    • pp.67-79
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    • 2008
  • In this study, a bending test with three encased composite beams were carried out and analyzed using FEM in order to find how chemical adhesion, interface interlock, friction and composite action by shear studs contribute to stiffness, strength and composite action in the interface of encased compo site beams. The test and results of the FEM analysis showed that the difference in the ultimate moment capacity of the composite beams with and without studs is under 10%. The reason is that the effect of chemical adhesion, interface interlock, and friction in the interface on the composite action is so high that the encased beams have a moment capacity above some defined magnitude. Also, the increment of moment capacity up to plastic moment is not large and the increase of linearly proportioned.

Design and Implementation of u-Learning Hub Site based on Learning Activity Oriented Components (학습활동 중심의 컴포넌트 기반 u-러닝 허브 사이트 설계 및 구현)

  • Park, Chan;Seong, Dong-Ook;Jang, Young-Hee;Lee, Hye-Jin;Yoo, Jae-Soo;Yoo, Kwan-Hee
    • The Journal of the Korea Contents Association
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    • v.9 no.1
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    • pp.446-454
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    • 2009
  • In this paper, we propose u-learning hub site systems which are designed and implemented based on learning activities oriented components. The proposed systems are composed of component which can process the functionalities for coming into action of learning activities through various devices. Specially, each component is broken into class units by which learning activities of users can be performed on various devices. When users try to connect u-learning system in hub site, the system explores devices of users and connection program and then selects components that are fit to the activities and combines them in realtime. Through the methodology of u-learning hub site, the system proposed in this paper provides u-learning environment so that users can use the learning activity services taking no influence on time, place, devices and programs under the consistent system. That is different to traditional e-learning system which cannot support various devices of users directly.

A STUDY ON CYCLIC AMP IN ALVEOLAR BONE TREATED BY ORTHODONTIC FORCES (교정력에 의한 치조골의 cyclic AMP에 관한 연구)

  • Ahn, Dae Sik;Lee, Jong Heun;Yang, Won Sik
    • The korean journal of orthodontics
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    • v.11 no.1
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    • pp.7-15
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    • 1981
  • Tooth movement by orthodontic force is based upon alveolar bone resorption at compression site and bone formation at tension site of tooth. The function of cyclic AMP is to participate not only in initial action of bone cells by mechanical forces but also in the continuous cellular response leading to bone remodeling. This experiment was performed to clarify the role of cyclic AMP in bone remodeling by mechanical forces. The orthodontic forces of about 80 gm and 100 gm were applied to the right canines of maxillary and mandibular bone, respectively, in cats, treated for periods of time ranging from one hour to 28 days. Alveolar bones were obtained from compression and tension sites surrounding tipping maxillary and mandibular canines as well as from contralateral control sites. The samples were extracted, boiled and homogenized, and the supernatants were assayed for cyclic AMP by a radioimmunoassay method. The results were as follows: 1. The orthodontic movement of canines was increased to the end of experimental period and the action of orthodontic forces on tooth movement was more effective in maxillary canine. 2. The cyclic AMP levels of alveolar bones in compression and tension sites initially decreased, then increased and remained elevated to the end of experiment. The differences of the cyclic AMP levels between treated sites and non-treated sites were gradually increased. 3. The cyclic AMP levels in treated sites of mandibular alveolar bone was higher than that of maxillary alveolar bone.

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Influence of Prostaglandin $F_{2{\alpha}}$ given intracerebroventricularly on the renal function of the rabbits (가토(家兎)의 신장기능(腎臟機能)에 미치는 측뇌실내(側腦室內) Prostaglandin $F_{2{\alpha}}$의 영향(影響))

  • Kook, Young-Johng;Ko, Kwang-Hoo
    • The Korean Journal of Pharmacology
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    • v.12 no.2 s.20
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    • pp.43-49
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    • 1976
  • The facts that $PGE_2$ produced diuresis in the rabbit when given into a lateral ventricle of the brain and that $PGF_{2{\alpha}}$ is abundantly found in the brain prompted us to investigate the effects of $PGF_{2{\alpha}}$ introduced directly into the ventricle on the renal function. $PGF_{2{\alpha}}$ given intraventriculary in doses of $10{\mu}g\;and\;100{\mu}g$ elicited prompt diuresis, 10-fold increase of sodium excretion and two-fold increment of potassium excretion. Free water reabsorption also increased along with the increased osmolar clearance. Neither renal plasma flow nor glomerular filtration rate did change significantly. This, along with the fact that the percentage of reabsorbed sodium filtered decreased from 99.5 to 93.9, indicates the tubular site of the diuretic and natriuretic action. Atropine pretreatment did not influence the renal effects of intraventricular $PGF_{2{\alpha}}$. Intravenously administered $PGF_{2{\alpha}}$ in doses of 30 to $100{\mu}g$ did not produce any significant change in renal function. Intraventricular $PGF_{2{\alpha}}$ had no effect on the systemic blood pressure, whereas intravenous administration brought about a transient hypotension. These observations suggest that $PGF_{2{\alpha}}$ induces diuresis and natriuresis via central mechanism, that the site of the action resides in renal tubules, and that the reabsorption of sodium is inhibited in the proximal tubule, possibly through mediation of certain humoral agent. Overall, it is suggested that $PGF_{2{\alpha}}$ might play a roll in regulating renal function through the center.

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Studies on the Adrenergic Alpha-Receptor in the Guinea Pig Ileum (해명 회장 운동에 대한 아드레나린성 ${\alpha}$-수용체에 관한 연구)

  • Ko, Chang-Mann
    • The Korean Journal of Pharmacology
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    • v.19 no.1
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    • pp.85-92
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    • 1983
  • Intestine is innervated by an interconnected plexus of both sympathetic and parasympathetic nerve fibers. Sympathetic influence causes inhibition of intestinal motility mediated by both ${\alpha}-\;and\;{\beta}-adrenergic$ receptors. The mechanism of intestinal relaxation by ${\beta}-receptors$ has been extensively studied, but the function of ${\alpha}-receptors$ in intestinal motility is still unclear. Although it is suggested that catecholamine reduces acetylcholine release and this may play an important role in ${\alpha}-receptor$ mediated intestinal relaxation, there is no definite evidences about the mechanism and site of action of ${\alpha}-receptor$ mediated relaxation. In this experiment, therefore, the effect and site of action of ${\alpha}-receptor$ agonists were investigated in the guinea pig ileum using electrical field stimulation. The results are summarized as follows : 1) Electrical field stimulation elicited tonic contraction in isolated guinea pig ileum ana this contraction was completely inhibited by the pretreatment of tetrodotoxin or atropine. 2) Norepinephrine, epinephrine and dopamine inhibited the contraction induced by electrical field stimulation but methoxamine and phenylephrine had little effects. 3) Inhibitory effects of norepinephrine and dopamine was partially blocked by yohimbine and phentolamine pretreatment. But haloperidol and propranolol pretreatment cause no effects on the electrical field stimulation induced contraction. Inhibitory effect of dopamine was completely blocked by both haloperidol and yohimbine pretreatment. 4) Inhibitory effects of norepinephrine and dopamine were little affected by the pretreatment with hexamethonium. It is suggested that electrical field stimulation causes tonic contraction of guinea pig ileum by releasing acetylcholine from postganglionic fiber, and this release is blocked by presynaptic ${\alpha}-receptor$ activation.

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Mode of action anf active site of xylanase II from Trichoderma koningii ATCC 26113 (Trichoderma koningii ATCC 26113에서 분리된 xylanase II의 작용양상과 활성부위)

  • Kim, Hyun-Ju;Kang, Sa-Ouk;Hah, Yung-Chil
    • Korean Journal of Microbiology
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    • v.32 no.4
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    • pp.306-314
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    • 1994
  • The action mode of xylanase II from Trichoderma koningii ATCC 26113 on xylan and related oligosaccharides (xylotriose, xylotetraose, and arabinoxylotriose) indicated that xylanase II is an endo-enzyme and also has trans-xylosidase activity. The $^1HNMR$-NMR studies of the reaction products formed by xylanase II revealed that all the hydrolysis products of xylooligosaccharides by the enzyme have only ${\beta}$-1,4-xylosidic linkage(s). Chemical modification of the enzyme with iodoacetamide showed that two cysteine residues per molecule of the enzyme was essential for the activity. Modification of the enzyme with N-bromosuccinimide demonstrated that four of the eight tryptophan residues were involved in its active site.

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