• KIEAE Journal
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• 제10권5호
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• pp.139-150
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• 2010

Until now, the eco-friendly construction (green construction) has been focused on reducing environmental impacts in use(operation and maintenance) phase. Considering the environmental influence along the life cycle of construction project, the impact in execution phase is rather lower than that in use phase. However, that impact is thought to be greatly decreased by well-organized activities. Based on its urgency and requirement for timely action, this study aimed to discuss the greenhouse gas (GHG) reduction plan in execution phase from a broad perspective. To achieve this purpose, the green building rating systems in domestic and foreign countries have been reviewed, and the practice in Japan was investigated. In order to improve current on-site greenhouse gas management, the integration among construction phases, participants, and environmental factors, and institutional supports are required as well as the contractor's efforts.

• ALGAE
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• 제30권1호
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• pp.59-66
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• 2015

The growth and hole formation of Ulva australis were examined at seven coastal areas of Korea between July and August, 2013. Animal species and weight growing on the Ulva fronds were estimated at Haseom, Pohang, and Woedo. The effects of wave exposure on the morphological features and residential animals of Ulva fronds were investigated at wave-exposed and sheltered sites of Seongsan on October 19, 2013. U. australis had different frond areas ($82-665cm^2$), hole areas ($2.5-6.3cm^2$), and hole numbers (9.8-41.3 holes) at the seven sites. Within $0.1m^2$ of Ulva frond, hole areas ranged from 0.37 to $5.94cm^2$, and between 4.9 and 36.2 holes were observed. Fourteen residential animal species were observed at the three evaluated sites, 75.0 (Haseom) to 408.7 individuals $100g^{-1}$ Ulva (Pohang) per site. The dominant residential species at each site differed with Amphithoe sp. at Haseom, Monodonta spp. at Pohang, and Pagurus sp. at Woedo. The growth (frond area, wet weight) and hole number of Ulva fronds, and the number of residential animals were significantly greater in samples collected from the sheltered shore than the wave-exposed shore of Seongsan. The present results showed U. australis grew well at sheltered shores and had more holes on the fronds due to abundance of residential animals. The dominant residential animals (crabs, gammaridea, and snails) were similar in the Ulva populations of sheltered and wave-exposed shores, but greater species diversity was observed at the exposed shore (18 species ver. 11 species). In conclusion, U. australis is a keystone species providing habitat to various invertebrates and frond holes are positively correlated to the number of residential animals.

• 약학회지
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• 제40권6호
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• pp.705-712
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• 1996

We have previously shown that determination of glucose uptake using ${\alpha}$-methylglucose(${\alpha}$-MG) is very sensitive and rapid parameter for the assessment of loss of cellular fu nction in renal cell line($LLC-PK_1$). The present study was designed to elucidate the mechanism of inhibition of ${\alpha}$-MG uptake and the intracellular site of toxic action of cisplatin(CIS). $LLC-PK_1$ cells were exposed to various concentrations(5 ${\mu}$M-l00 ${\mu}$M) of CIS for 5 hrs or 24 hrs and ${\alpha}$-MG uptake was determined. Mitochondrial function was evaluated by measuring intracellular ATP content and MTT reduction. The activities of marker enzymes for the basolateral membrane(Na$^+$-K$^+$ ATPase) and brush border membrane (alkaline phosphatase: ALP) were also measured. CIS treatment significantly inhibited the ${\alpha}$-MG uptake in a time- and dose-dependent manner above 25 ${\mu}$M for 5 hrs. Intracellular ATP content and MTT reduction were affected by 24 hr-treatment of 50 ${\mu}$M CIS. The activities of Na$^+$-K$^+$ ATPase and ALP were significantly decreased at 10 ${\mu}$M and 5 ${\mu}$M of CIS for 24 hrs, respectively. The incubation with CIS for 5 hrs had no effects on the intracellular ATP content, MTT reduction and the activities of marker enzymes up to 100 ${\mu}$M. These results partly indicate that inhibition of ${\alpha}$-MG uptake by CIS may not be attributed to the disturbance of mitochondrial function or inhibition of the activity of Na$^+$-K$^+$ ATPase and can be resulted from direct effect of CIS on the Na$^+$/glucose cotransporter in brush border membrane. This study shows that additional mechanistic information, indicating the intracellular site of nephrotoxic action, can be gained by coupling the ${\alpha}$-MG uptake and ATP content or the activity of Na$^+$-K$^+$ ATPase.

• 한국조경학회지
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• 제42권1호
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• pp.41-49
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• 2014

본 연구는 미국 샌프란시스코시 수목 음영이 개별 건물 지붕 및 옥상에 입사되는 태양에너지 잠재량에 미치는 영향을 LiDAR를 이용한 고해상도 3차원 수치모델을 이용하여 공간적으로 정량화하였다. 최근 분산형 태양광 발전이 기후변화 대응에 중요한 부분으로 주목받고 있으나, 이러한 도심 태양광 발전은 주변부의 지형, 건물, 지붕모양, 수목 등의 음영에 의해 발전량이 제한되는 특성이 있다. 특히 건물 주변의 수목의 경우 도시열섬현상의 저감, 냉난방 에너지 수요량의 절감 등의 순기능과 태양광 발전량 감소의 역기능을 동시에 가지고 있어 두 가지 효용의 상충을 최소화하기 위해 해당 위치에 대한 공간적 분석이 요구된다. 샌프란시스코시 전체 건물 지붕면적의 태양에너지 총량은 년간 18,326,671 MWh으로, 수목의 음영에 의한 감소량은 326,406 MWh로 총량의 1.78%에 해당하였다. 건물지붕의 단위 면적당 일조량은 $34.4kWh/m^2/year$에서 $1,348.4kWh/m^2/year$ 범위로 산출되었다. 본 연구를 통해 도심 수목에 의한 건물별 일조에너지 감소량의 공간자료가 구축되었으며, 개별 건물지붕에 일조량의 변이를 주변 수목의 밀도, 평균수고, 수고의 분산값을 이용한 회귀모델을 통해 설명하였다. 본 연구는 도심수목의 환경적 순기능을 유지함과 동시에 태양광 발전 감소량의 최소화 할 수 있는 방법을 제공함으로써 지속가능한 도시를 구축하는데 기여할 것으로 기대된다.

• The Korean Journal of Physiology and Pharmacology
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• 제5권3호
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• pp.213-221
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• 2001

The amygdala is known as a site for inducing analgesia, but its action on the trigeminal nucleus has not been known well. Little information is available on the effect of dynorphin on NMDA receptor-mediated electrophysiological events in the trigeminal nucleus. The purpose of this study was to investigate the changes in the single neuron spikes at the trigeminal nucleus caused by the amygdala and the action of dynorphin on the trigeminal nucleus. In the present study, extracellular single unit recordings were made in the dorsal horn of the medulla (trigeminal nucleus caudalis) and the effects of microiontophoretically applied compounds were examined. When [D-Ala2, N-Me-Phe4, Glys5-ol]enkephalin (DAMGO, 10-25 mM), a ${\mu}-opioid$ receptor agonist, was infused into the amygdala, the number of NMDA-evoked spikes at the trigeminal nucleus decreased. However, the application of naloxone into the trigeminal nucleus while DAMGO being infused into the amygdala increased the number of spikes. Low dose (1 mM) of dynorphin in the trigeminal nucleus produced a significant decrease in NMDA-evoked spikes of the trigeminal nucleus but the NMDA-evoked responses were facilitated by a high dose (5 mM) of dynorphin. After the ${\kappa}$ receptors were blocked with naloxone, dynorphin induced hyperalgesia. After the NMDA receptors were blocked with AP5, dynorphin induced analgesia. In conclusion, dynorphin A exerted dose-dependent dual effects (increased & decreased spike activity) on NMDA-evoked spikes in the trigeminal nucleus. The inhibitory effect of the dynorphin at a low concentration was due to the activation of ${\kappa}$ receptors and the excitatory effect at a high concentration was due to activation of NMDA receptors in the trigeminal neurons.

• The Korean Journal of Physiology
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• 제15권2호
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• pp.67-71
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• 1981

Experiments were conducted to test morphine sensitivity of the flexion reflex in the anemic decerebrate cats. Animals were immobilized with gallamine triethiodide(Flxaedil) and were artificially ventilated. The sural nerve was electrically stimulated(20V, 0.5 msec) and the flexion reflex was obtained by recording compound action potentials from the nerve innervated to the semitendinosus muscle. Intravenous injection of morphine $(0.5{\sim}2.0\;mg/kg)$ was found to have following effects on the flexion reflex. 1) Morphine tended to depress the early component of the flexion reflex and the effect was widely variable between animal preparations. 2) Morphine significantly depressed the late component of the flexion reflex, the effect being proportional to the dose of morphine. 3) The morphine effect on the flexion reflex was reversed by a small dose of naloxone hydrochloride$(0.025{\sim}0.1\;mg/kg)$. 4) Naloxone hydrochloride alone did not appear to facilitate the flexion reflex. 5) The main site for the morphine action was found to be the brain stem. From these results and those reported in literatures, we conclude that the late component of the flexion reflex well represents the pain sensation, thus the late component of the flexion reflex can be used as a reasonable subjective index of pain in experimental animals.

• 한국지하수토양환경학회지:지하수토양환경
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• 제18권6호
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• pp.8-17
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• 2013

The contamination of chlorinated ethenes at an industrial complex, Wonju, Korea, was examined based on sixteen rounds of groundwater quality data collected from 2009 to 2013. Remediation technologies such as soil vapor extraction, soil flushing, biostimulation, and pumping-and-treatment have been applied to eliminate the contaminant sources of trichloroethylene (TCE) and to prevent the migration of TCE plume from remediation target zones. At each remediation target zone, temporal monitoring data before and after the application of remediation techniques showed that the aqueous concentrations of TCE plume present at and around the main source areas decreased significantly as a result of remediation technologies. However, the TCE concentration of the plumes at the downstream area remained unchanged in response to the remediation action, but it showed a great fluctuation according to seasonal recharge variation during the monitoring period. Therefore, variations in the contaminant flux across three transects were analyzed. Prior to the remediation action, the concentration and mass discharges of TCE at the transects were affected by seasonal recharge variation and residual DNAPLs sources. After the remediation, the effect of remediation took place clearly at the transects. By tracing a time-series of plume evolution, a greater variation in the TCE concentrations was detected at the plumes near the source zones compared to the relatively stable plumes in the downstream. The difference in the temporal profiles of TCE concentrations between the plumes in the source zone and those in the downstream could have resulted from remedial actions taken at the source zones. This study demonstrates that long term monitoring data are useful in assessing the effectiveness of remediation practices.

• International Journal of Clinical Preventive Dentistry
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• 제14권4호
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• pp.228-234
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• 2018

Objective: The authors have experimented for the artificial plaque removal effect of several kinds of 360 degree rotating head typed tooth-brushes with sonic vibratory actioned by using of automatic machine for horizontal scrub method in order to find the better toothbrush type for plaque removal. Methods: The experiment was conducted on three medium to 360 degree rotating head toothbrushes, a medium sized toothbrush and a medium sized toothbrush, and a flat toothbrush consisting of 30 ordinary toothbrushes. A brushing machine with horizontal scrubbing was manufactured and had variations of the end of the bristle attached to or near the surface of the teeth, a vibrating wave action force of 16,000 or 18,000 cycles per minute, and a working time of 2 or 3 minutes. The tooth removal effect was confirmed by scanning and analyzing images with a computer program after automatic brushing with the machine. The elimination rate results for each group were analyzed using the independent t-test and one-way ANOVA test. Results: It revealed the most in removal effect for the artificial plaque in such conditions as action at near the tooth surface with 18,000 cycle for 3 minutes in case of using A, B, and C tooth-brush. And it has more removal effect rate than for using the plane tooth-brush (p<0.05). Conclusion: It was recommended to develop the 360 degree rotating head and vibratory toothbrush focusing to use near the tooth surface with 18,000 cycles of vibration for 3 minutes at one site of the teeth area.

• 생물정신의학
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• 제19권4호
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• pp.187-192
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• 2012

Objectives Although antipsychotic drug clozapine has superior efficacy, this is hampered by metabolic side effects such as weight gain and diabetes. Recent studies demonstrate that clozapine induces insulin resistance. However, the identity and location of insulin resistance induced by clozapine has not been clarified. In this study, the effect of clozapine on central insulin response was investigated in rats. Methods Male Sprague-Dawley rats received intraperitoneal injection of clozapine or vehicle, which was followed by intracerebroventricular injection of insulin or its vehicle. The effects of clozapine on insulin-induced changes in blood glucose level and Akt phosphorylation in hypothalamus were investigated. Results Intraperitoneal injection of clozapine (20 mg/kg) increased blood glucose in rats. Intracerebroventricular injection of insulin reduced blood glucose in rats, which was blunted by pretreatment of clozapine. Accompanied with the antagonistic effect of clozapine to central insulin action in terms of blood glucose, clozapine inhibited the insulin-induced phosphorylation of Akt at Ser473 in rat hypothalamus. Conclusion Administration of clozapine inhibited the central insulin-induced changes in blood glucose and Akt phosphorylation in rat hypothalamus. These findings suggest that hypothalamus could be the site of action for the clozapine-induced insulin resistance.

• 한국산업보건학회지
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• 제33권3호
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• pp.265-272
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• 2023

Objectives: Since the material safety data sheets(MSDS) submission and non-disclosure review system was introduced in January 2021, the implementation status of MSDS for chemical manufacturing and importing workplaces being supervised for the first time. Methods: A supervisory team consisting of two labor inspectors and one from the Korea Occupational Safety and Health Agency directly visited the selected workplaces to check compliance with the MSDS system as a whole. Results: As a result of supervising 214 chemical substance manufacturing/importing workplaces, a total of 241 violations of the law were found in 121 workplaces, or 57% of them. In response, the Ministry of Employment and Labor took legal action on 8 cases in 6 locations, imposed a fines totaling of 249.69 million won on 120 chemical handling workplaces, and took action to correct the violations immediately. Conclusions: Major violations were in the order of non-request for warning signs, non-submission of MSDS, non-execution of MSDS training, and non-posting of MSDS. This shows the reality that employers who handle chemical substances are sufficiently communicating chemical information to workers. In the future, the government will actively implement preparation and submission support and system guidance for the implementation of the MSDS system, while making efforts to ensure that the MSDS system works well in the field through thorough on-site supervision in the future.