• Journal of Nutrition and Health
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• 제33권5호
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• pp.491-496
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• 2000

Food intake is regulated by both central and peripheral mechanisms. In the central nervous, the hypothalamus acts for autonomic and endocrine homeostasis. The paraventricular nucleus(PVN) of hypothalamus is an imprtant site of interaction in central feeding pathways. Neuroepetide Y(NPY)is one of the most powerful neurochemical stimulants of food intake known. Also brain nitric oxide(NO), known as neurotransmitter, is involved in the mechanisms that regulate food intake. In this experiment, 24h fasting mice and anorexia mutant mice have been to examine the expression of NPY, which is the major neuropeptide increasing food intake. Double staining with NPY and nicotinamide-adenine-dinucleotide-phosphate diaphorase(NADPH-d), followed by immunohistochemical method and image analysis, have been used to observe coexisting neurons and the level of expression of each neurons. The results were as follows. 1) NPY-immunoreactivitys reduced immune response of the hypothalamus, particularly paraventricular nucleus(PVN), in anorexia mutant mice. Decreased level of NPY is assumed to be a major pathological factor in anorexia mutant mice. On the other hand, PVN in hypothalamus of fasting mice showed increased immunoreactivity which is in agreement of other researchers. 2) NPY and NADPH-d double staining revealed coexisting neurons in the cerebral cortex. Fasting mice had a tendency to have increased level of coexisting neurons compared to the control group. Compared to the control group, fasting mice express is not increase level of NPY-immunoreactivity, while anorexia mutant mice tended to have a decreased level.

• Nuclear Engineering and Technology
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• 제50권8호
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• pp.1387-1401
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• 2018

An aircraft impact (AI) on a nuclear power plant (NPP) is considered to be a beyond-design-basis event that draws considerable attention in the nuclear field. As some NPPs have already adopted the seismic isolation technology, and there are relevant standards to guide the application of this technology in future NPPs, a new challenge is that nuclear power engineers have to determine a reasonable method for performing AI analysis of base-isolated NPPs. Hence, dynamic influences of the seismic isolation on the vibration and structural damage characteristics of the base-isolated CPR1000 containment are studied under various aircraft loads. Unlike the seismic case, the impact energy of AI is directly impacting on the superstructure. Under the coupled influence of the seismic isolation and the various AI load, the flexible isolation layer weakens the constraint function of the foundation on the superstructure, the results show that the seismic isolation bearings will produce a large horizontal deformation if the AI load is large enough, the acceleration response at the base-mat will also be significantly affected by the different horizontal stiffness of the isolation bearing. These concerns require consideration during the design of the seismic isolation system.

• 한국염색가공학회지
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• 제32권4호
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• pp.185-192
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• 2020

A novel binding site for metal ion made by designing molecule with tetrazolo quinoline with hydrazine carboxamide (TQC) and the designed molecule successfully synthesized. The probe works by selectively detecting Al3+ ion via both fluorimetric and colorimetric approach. The probe's effectiveness towards aluminium ion detection is highly sensitive and selective with no substantial interference with other competing ions. The added Al3+ ion to TQC fetched a rapid change of visual color to yellow from colorless, also the response of fluorescence turn-on. The fluorescence turn-on and color change visibly by the probe TQC with Al3+ ion credited to the ICT phenomenon (intramolecular charge-transfer transition). The likely interaction of the probe with aluminium ion has also been there predicted from ESI-MS spectral analysis results. The usefulness of the probe confirmed by practical utility by making a test kit to monitor Al3+ ion in water which showed a naked eye detection by notable color change.

• 유통과학연구
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• 제19권7호
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• pp.61-73
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• 2021

Purpose: This study offers suggestions to e-commerce companies for increasing shoppers' repurchase intention by considering the effect of distribution information in online shopping. It applies complexity theory to incorporate habitual information search behavior and shopper characteristics into the Stimulus-Organism-Response model and indicates how these complex factors work together in online shopping. Research design, data, and methodology: This study used an interview survey of 158 Vietnamese consumers with an experience of online shopping. A fuzzy-set Qualitative Comparative Analysis (fsQCA) was used to examine the relationship between antecedents and outcomes depending on complex conditions in the given contexts. Results: The results (1) indicate the importance of observing information search patterns and investigating their influence on online distribution, and (2) clarify what kind of configurations, under what conditions, predict a high or low outcome; this provides evidence and hints for the development of frameworks for future studies. Conclusions: The findings suggest that shoppers' unconscious, habitual behavior can work with conscious attitude factors, such as satisfaction, to increase their repurchase intention. Hence, e-commerce companies should consider how to present useful distribution information and create functions that allow shoppers to engage with a variety of information while increasing their repurchase intention on the site.

• Earthquakes and Structures
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• 제22권3호
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• pp.263-275
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• 2022

Structural collapses can occur as a result of a dynamic amplification of either, the building's seismic response or the ground shaking by local site effects; one of the reasons is a resonance effect due to the proximity of the structural elastic fundamental period TE and the soil fundamental period TS. We evaluate the vulnerability to resonance effects in Guadalajara, México, in a three-step schema: 1) we define structural systems in the building environment of western Guadalajara, in terms of their construction materials and structural components; 2) we estimate TE with different equations, to obtain a representative value in elastic conditions for each structural system; and, 3) we evaluate the resonance vulnerability by the analysis of the ratio between TE and TS. We observe that the larger the soil fundamental period, the higher the resonance vulnerability for buildings with height between 17 and 39 m. For the sites with a low TS, the most vulnerable buildings will be those with a height between 2 and 9 m. These results can be a helpful tool for disaster prevention, by avoiding the construction of buildings with certain heights and structural characteristics that would result in a dangerous proximity between TE and TS.

• 동남아시아연구
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• 제22권1호
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• pp.207-245
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• 2012

With rapid industrialization and urbanization, numerous cities are faced with urban slum phenomenon combined with housing shortage fueled by population explosion. In Kuala Lumpur, the capital city of Malaysia, the government hereby embarked on supply of public housing to resolve such pending issue. This study aims to understand the periodic changes of public housing as a common basis for basic housing policies with analysis specific features of site plan, block layout, and unit plans. For this purposes, the filed survey during January, 2011 were proceeded. We hereby visited and surveyed a total of 40 apartment complexes for the 1970s~the 2000s (10 complexes respectively on a decade basis). Consequently, Malaysian public apartments prove to offer a very uniform pattern based upon standard plans. Their early plans aren't fairly distincted from those of other countries, but their layouts of plan become differentiated compared with other nations as they actively apply a ventilator called 'air well' in response to tropical climate amid the change of times. This study is expected to broaden our understanding of Malaysia's unique housing culture and lifestyle.

• 대한안전경영과학회지
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• 제26권1호
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• pp.45-53
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• 2024

A Smart factories are systems that enable quick response to customer demands, reduce defect rates, and maximize productivity. They have evolved from manual labor-intensive processes to automation and now to cyber-physical systems with the help of information and communication technology. However, many small and medium-sized enterprises (SMEs) are still unable to implement even the initial stages of smart factories due to various environmental and economic constraints. Additionally, there is a lack of awareness and understanding of the concept of smart factories. To address this issue, the Cooperation-based Smart Factory Construction Support Project was launched. This project is a differentiated support project that provides customized programs based on the size and level of the company. Research has been conducted to analyze the impact of this project on participating and non-participating companies. The study aims to determine the effectiveness of the support policy and suggest efficient measures for improvement. Furthermore, the research aims to provide direction for future support projects to enhance the manufacturing competitiveness of SMEs. Ultimately, the goal is to improve the overall manufacturing industry and drive innovation.

• 대한두경부종양학회지
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• 제15권1호
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• pp.22-28
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• 1999

Purpose: We performed this study retrospectively to evaluate local control, survival, prognostic factors, and failure patterns in patients with non-Hodgkin's lymphoma of Waldeyer's ring. Materials and Methods: From April 1984 to November 1996,41 patients with non-Hodgkin's lymphoma of Waldeyer's ring were treated with combined chemotherapy and radiation therapy. Age was ranged from 19 to 73 years old with a median age of 55 years, and there were 26 male and 15 female patients. Primary site was tonsil in 26 and base of the tongue in 7 and nasopharynx in 8, and stage distribution showed stage I in 12 and stage II in 29 patients. Pathologic classification was done according to Working Formulation. There were 1 with follicular mixed small cleaved and large cell, 8 with diffuse small cleaved cell, 7 with diffuse mixed small and large cell, and 25 cases with diffuse large cell. All patients were treated with combination of chemotherapy and radiation therapy. Chemotherapy regimen consisted of either CHOP-Bleo(cyclophosphamide, adriamycin, vincristine, prednisolone, bleomycin) or COP-BLAM III(cyclophosphamide, vincristine, prednisolone, bleomycin, adriamycin, procarbazine). Radiation dose ranged from 3600cGy to 6620cGy with a median dose of 5040cGy. Follow-up time was ranged from 15 months to 159 months(median 55 months). Results: The complete response was achieved in 98%(40/41) and partial response in 2%(1/41). The complete response rate were the followings: 66.7% for stage I and 51.7% for stage II after chemotherapy, 100% for stage I and 96.6% for stage II after overall treatment respectively. The overall survival rate and disease-tree survival rates at 5 years were 82.6% and 79.5%, respectively. Prognostic factors for overall survival were age(p=0.007), stage(p=0.03), nodal status(p=0.006) and radiation dose(p=0.003). The factors associated with disease-tree survival were stage(p=0.04), nodal status(p=0.004) and radiation dose(p=0.009). The failure patterns were analized in evaluable 35 patients with complete response. Locoregional failure was noted in 2 patients and distant metastasis in 5 patients. Conclusion: Our results suggest that combined modality therapy is the appropriate treatment for stage I-II intermediate grade non-hodgkin's lymphoma of the Waldeyer's ring. However, our material is small and the analysis is retrospective. Randomized prospective studies for combined therapy, radiation therapy alone and chemotherapy alone are needed.

• Radiation Oncology Journal
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• 제10권2호
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• pp.213-217
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• 1992

국소적으로 진행된 자궁경부암(종괴크기가 5 cm이상혹은 FIGO병기 III, IV) 환자에 있어 방사선 치료 단독으로 근치적치료를 시행한 경우 골반내에서 약 50$\%$까지의 높은 재발율이 보고되고 있다. 따라서 이들 환자에 있어서 국소관해율 및 생존율을 증가 시키기 위하여 본 연구에서는 방사선 민감제로서 가장 효과적인 약제로 알려진 cisplatin을 방사선치료와 동시에 투여하는 방사선-화학요법을 시행하였다. 1988년 5월부터 1991년 9월까지 인제대학교 부속 서울백병원치료방사선과에서 자궁경부암으로 진단된 환자중 국소적으로 진행된(FIGO병기 III, IV, 종괴크기가 5 cm이상의 IIb) 환자로서 방사선치료와 cispiatin의 동시병행요법이 시행되었던 12명을 대 상으로 후향적 임상분석을 하였다. 12명의 환자에 대한 치료는 골반부위에 5000 cGy이상 (4980-6480 cGy)의 외부방사선치료및 1회이상의 강내치료가 시행되었고 동시에 cisplatin 50 mg을 1주 간격으로 반복투여하였다. 총 투여횟수는 $3\~7$회로 평균 5회였다. 추적기간은 $3\~53$개월 (중앙값 34개월) 이며, 연령 분포는 $26\~69$세(중앙값 54세) 였다. 병기별 분포는 IIb, III, IV가 각각 5, 3, 4명 이었다. 조직학적 분류상 편평상피세포암이 11명 이었다. 11명의 관찰대상중 완전관해는 7명 ($64\%$), 부분관해는 4명 ($35\%$)에서 이루어졌다. 7명의 완전관해중 6명이 무병상태였다. 관찰종로시의 전체국소관해율은 $73\%$로서 완전관해군은 $100\%$, 부분관해군은 $25\%$,에서 국소관해를 보였다. 병기별 생존분포를 보면 FIGO병기 IIb, III, IV에서 각각 4/4, 2/3, l/3 이었으며 5년생존율은 $61\%$이었다. 사망자는 4명으로 이중 3명은 일차적인 질병으로, 1명은 패혈증으로 사망하였다. 재발환자는 3명으로 국소재발이 1명, 원격전이가 1명, 국소재발과 원격전이가 1명 이었다. 병합치료에 의한 독성을 살펴보면 오심증상이 3명, 식욕부진이 4명, 백혈구감소증이 4명, 그리고 혈소판감소증이 1명에서 관찰되었다. 다른 1명은 치료종료후 패혈증으로 사망하였다. 그 외의 혈액적독성, 신독성의 증상을 나타낸 경우는 없어 cisplatin 추가에 의한 독성은 경미한 것으로 나타났다. 국소적으로 진행된 자궁경부암 환자에서 방사선-화학요법을 동시 병행할 경우 국소관해율이 $100\%$(완전관해율이 $64\%$)이었고 골반내 재발율은 $27\%$, 이었으며 cisplatin추가로 인한 독성은 경미하였다. 이는 대조군과 비교할때 보다 나은 성적으로 예비결과이기는 하나 국소적으로 진행된 자궁경부암환자에서 방사선치료와 cisplatin 동시 병행요법이 국소관해율을 향상시킬 수 있을 것으로 기대된다.

• 한국지반공학회논문집
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• 제15권2호
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• pp.3-16
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• 1999

현재 국내에서는 부유식 구조물을 이용하여 소각로 및 담수화 공장을 해상에 축조하는 BMP(Barge Mounted Plant) 시스템에 관한 연구를 수행중에 있다(한국기계연구원 1997). 본 논문에서는 이러한 BMP의 계류 돌핀(mooring dolphin) 구조물하부의 말뚝기초의 거동을 모델하는 기법에 관하여 다루었다. 지반-말뚝계의 축하중 및 횡하중에 대한 거동은 지반을 비선형 스프링으로 모델하고 말뚝을 일축부재 및 보로 모델하여 유한차분적으로 해를 구하는 비선형 지반반력해석을 수행한다. 이러한 말뚝두부에서의 하중-변위관계로부터 지반-말뚝계의 등가강성을 산정할 수 있다. 따라서 본 연구에서는 거제도 주변 해역을 대상으로 지반조사를 수행하였고 이를 토대로 지반의 깊이에 따른 축방향 및 횡방향 하중전이 관계를 도출하였다. 그리고 돌핀하부의 말뚝에 대하여 축하중 및 횡하중에 대한 지반반력해석을 수행하였다. 이러한 해석과정을 통하여 대상지역에 적합한 말뚝의 관입깊이 및 단면을 합리적으로 산정할 수 있었다. 결국 말뚝두부에서의 하중-변위관계로부터 지반-말뚝계의 강성을 모델함으로써, 지반조건을 고려하여 돌핀구조물의 동적해석을 합리적으로 수행할 수 있었다. 해석결과 지반-말뚝계의 강성을 고려할 경우에는 강체로 고려한 경우에 비하여 변위 진폭이 상당히 크게 나타났다. 그리고 돌핀의 케이싱 상부의 모멘트가 더 크게 나타나고 해저지표 말뚝두부에 전달되는 모멘트는 더 작게 나타남을 알 수 있었다.