• Journal of the Korean Institute of Landscape Architecture
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• v.33 no.5 s.112
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• pp.104-113
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• 2005

This landscape design proposal was presented for a competition for mixed-use development project by project financing in Asan Baebang which was held by the Korea National Housing Corporation in July of 2005. The site is a center of Asan Baebang New Town Development District and has a commercial area of $57,929m^{2}$. Design guidelines and judging criteria of this competition were to build a symbolic center and cultural core for district, to elevate positive image and identity of Asan New Town by attractive place making, to link with separated block in the site and regional context, and to make environmentally sustainable design by creating an attractive waterfront of Jang Jae stream passing through the site. This is the most important condition for the design. Therefore, the authors developed design concept and strategy within the guidelines and this conditions. The schema of the design was introduced by the water in the site. To evolve design concept, we reinterpreted water and context in the site combining with landscape design strategy. So the proposal set the main design concept as 'all that is solid melt into water' as if Marshall Berman said. By doing that, design concept of the proposal evolved as follows: 'extension' of water and greer, 'a joint' of space,'newness' of experience, 'breath' of consensus with each other. The spatial concept of this project was developed by expressing five theme spaces; eco zone, entertainment zone, art zone, culture zone, leisure zone. These theme spaces were consecutively placed along the pedestrian path and to consists of vertical layer in each level and diverse design technique and spatial effects are used.

• The Korean Journal of Physiology and Pharmacology
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• v.15 no.6
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• pp.389-395
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• 2011

Repeated administration of psychostimulants such as cocaine leads to the development of behavioral sensitization. Extracellular signal-Regulated Kinase (ERK), an enzyme important for long-term neuronal plasticity, has been implicated in such effects of these drugs. Although the nucleus accumbens (NAcc) is the site mediating the expression of behavioral sensitization by drugs of abuse, the precise role of ERK activation in this site has not been determined. In this study we demonstrate that blockade of ERK phosphorylation in the NAcc by a single bilateral microinjections of PD98059 (0.5 or $2.0{\mu}g/side$), or U0126 (0.1 or $1.0{\mu}g/side$), into this site dose-dependently inhibited the expression of cocaine-induced behavioral sensitization when measured at day 7 following 6 consecutive daily cocaine injections (15 mg/kg, i.p.). Acute microinjection of either vehicle or PD98059 alone produced no different locomotor activity compared to saline control. Further, microinjection of PD98059 ($2.0{\mu}g/side$) in the NAcc specifically lowered cocaine-induced increase of ERK phosphorylation levels in this site, while unaffecting p-38 protein levels. These results indicate that ERK activation in the NAcc is necessary for the expression of cocaine-induced behavioral sensitization, and further suggest that repeated cocaine evokes neuronal plasticity involving ERK pathway in this site leading to long-lasting behavioral changes.

• Archives of Pharmacal Research
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• v.13 no.1
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• pp.82-96
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• 1990

Ten (E)-and (Z)-isomers of 2-phenylcyclopropylamine (PCA), 1-Me PCA, 2-Me-PCA, N-Me-PCA, and N, N-diMe PCA and fifteen o-. m-, p- isomers of (E) PCA with substituents of Me, Cl, F, OMe, OH were synthesized in this laboratory and tested for the inhibition of rat brain mitochondrial MAO-A and MAO-B. The effects of substituents, their positions, and stereochemistry on the inhibition were assessed for the compounds with substituents at cyclopropyl and amino groups and QSAR analyses were performed using the potency data of ring-substituted compounds. The best correlated QSAR equations are as follows : pI$_{50}$ = 0.804 $\pi^2$-0.834 Blo-1.069 Blm + 0.334 Lp-1.709 HDp +7.897 (r = 0.945, s =0.211, F = 16.691, p = 0.000) for the inhibition of MAO-A;PI$_{50}$= 1.815$\pi$-0.825 $\pi^2$-1.203R + 0.900 Es$^2$ + 0.869 Es$^3$ + 0.796 Es$^4$-0.992 HDp + 0.562 HAo + 3.893 (r = 0.982, s =0.178, F = 23.351, p = 0.000) for the inhibition of MAO-B. Based on the potency difference between stereoisomers of cyclopropylamine-modified compounds and an QSAR cavity near para position, two hydrophobic carities interacting with Me group, a hydrophobic site near para position, and an amino group binding site and that in addition to the same two hydrophotic cavities, hydrophotic area, steric boundaries, hydrogen-acceptor site, and amino group binding site, another steric boundary near para position and a hydrogen donating site near ortho position constitute active sites of MAO-B.

• Geomechanics and Engineering
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• v.6 no.3
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• pp.293-320
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• 2014

In this study, in order to evaluate adequacy of considering local site effect, excluding soil-structure interaction (SSI) effects in inelastic dynamic analysis and design of mid-rise moment resisting building frames, three structural models including 5, 10, and 15 storey buildings are simulated in conjunction with two soil types with the shear wave velocities less than 600 m/s, representing soil classes $D_e$ and $E_e$ according to the classification of AS1170.4-2007 (Earthquake actions in Australia) having 30 m bedrock depth. Structural sections of the selected frames were designed according to AS3600:2009 (Australian Standard for Concrete Structures) after undertaking inelastic dynamic analysis under the influence of four different earthquake ground motions. Then the above mentioned frames were analysed under three different boundary conditions: (i) fixed base under direct influence of earthquake records; (ii) fixed base considering local site effect modifying the earthquake record only; and (iii) flexible-base (considering full soil-structure interaction). The results of the analyses in terms of base shears and structural drifts for the above mentioned boundary conditions are compared and discussed. It is concluded that the conventional inelastic design procedure by only including the local site effect excluding SSI cannot adequately guarantee the structural safety for mid-rise moment resisting buildings higher than 5 storeys resting on soft soil deposits.

• Journal of Periodontal and Implant Science
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• v.27 no.3
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• pp.647-668
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• 1997

6 beagle dogs aged over one and half years and weighed 14 to 16 Kg were utilized in this study, Horizontal furcation defects were induced around 2nd, 3rd, and 4th premolars bilaterally, PDGF-BB in conjunction with EGF and PDGF-BB only were applied in the right and left premolars respectively. 2 animals were sacrificed at 4weeks, 8 weeks, and 12 weeks, after regenerative surgery respectively. Semi-thin sections using glass-knife were stained with toluidine blue for light microscopic study. The results were as follows: 1. At 4 weeks after regenerative surgery, bone formation in the PDGF-BB-applied site was thriving, but bone formation in the PDGF-BB-and-EGF-applied site was depressed. 2. Bony ankylosis was surely shown along the whole exposed root surface applied with PDGF-BB, but it was shown at the root surface near the base of the bone defect where was applied with PDGF-BB in conjunction with EGF. 3. Active bone formation was made from 8 weeks after regenerative surgery in the PDGF-BB- and-EGF-applied site. 4. Bone maturity as well as speed of bone formation in the PDGF-BB-applied site was superior to those in the PDGF-BB-and-EGF-applied site throughout the whole experimental period. Within the above results, PDGF-BB had the strong capability to form the new bone and EGF was not able to prevent the bony ankylosis thoroughly. However, EGF may have the possibility to prevent the bony ankylosis through the suppression of bone formation.

• Korean Journal of Construction Engineering and Management
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• v.18 no.5
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• pp.68-76
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• 2017

A recent issue of fine dust is particulate matter with a diameter of less than $10{\mu}g/m^3$. It's classified as a pollutant that has a fatal effect on the human body when inhaled. The fugitive dust must be well controlled, since the adverse effects of dust on the surroundings are increased when the dust is blown away by the wind. Since the construction site is the place where the most fugitive dust is discharged in Korea, managing the fugitive dust discharged from the construction site can be an important issue to solve the problem of domestic fine dust. However, since the construction industry in Korea is the largest in Korea, it is difficult to control the emission of fugitive dust in the domestic construction site. In this paper, we compare and analyze the fugitive dust regulations applied to construction sites in major cities and propose the improvement plans to help control the fugitive dust generated in domestic construction sites.

• Korean Journal of Agricultural Science
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• v.45 no.4
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• pp.725-732
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• 2018

The vaccination for foot-and-mouth disease (FMD) is an effective way to control FMD. However, the injection of FMD vaccine causes abnormalities in pork meat by the incidence of lesions at the injection site. This study was conducted to investigate the inhibition effects of dietary bromelain, a natural protease derived from pineapple stems, on the incidence of lesions at the vaccination site on pigs. A total of 335 pigs (LYD [Landrace ${\times}$ Yorkshire ${\times}$ Duroc]; 7-week-old) were randomly allotted to two dietary treatments: control (basic diet) and bromelain treatment (diet supplemented with bromelain 1 kg/ton). The injection of FMD vaccine was conducted on 56- and 84-day-old pigs. Pigs with the bromelain treatment were fed a diet supplemented with bromelain for 14 days from 5 days before the vaccine injection. After slaughtering the pigs, the number of carcasses that had abnormal meat at the injection site of the vaccine and the amount of abnormal meat, discarded meat, and trimmings were recorded. Pork from the bromelain treated pigs had a lower incidence of abnormal meat caused by vaccine injection as well as a lower amount of abnormal meat, discarded meat, and trimmings than those of the control (p < 0.05). Our result suggests that dietary bromelain could improve the quality of pork meat by inhibiting incidence of lesions at the vaccine injection site.

• The Journal of Industrial Distribution & Business
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• v.12 no.2
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• pp.29-40
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• 2021

Purpose: In this study, with the transaction amount of foreign direct Purchase and foreign direct sales increasing, South Korea is in a situation where foreign direct sales are focused on China. We looked at the impact of consumer innovation and site characteristics on repurchase ability among the characteristics of overseas direct purchase consumers as a way to make direct overseas sales to various overseas countries. Research design, data and methodology: Consumer innovativeness consists of four variables: functional, hedonistic, social, and cognitive, and the site characteristics consisted of four variables: product price, product assortment, convenience, and service. The study was conducted on consumers with foreign direct purchase experience, and was finally used in 252 additional analyses. Results: The main findings of this study were first, that the impact on the degree of re-purchase among consumer innovativeness of foreign direct purchase consumers had a significant impact in the order of cognitive innovativeness, hedonistic innovativeness, and functional innovativeness. Social innovativeness did not affect the degree of re-purchase. Second, site characteristics have been found to have a significant impact on the degree of re-purchase in order of product assortment, commodity price, and service. Convenience did not affect the degree of re-purchase. Conclusions Taken together these results can be called the biggest characteristic of the cognitive innovativeness of the consumer's inclination to use the overseas direct purchase, the price or quick response of the goods sold on the site is a factor that affects the re-purchase, above all it is important to have a variety of products. We will present this element as a way to make direct sales abroad to various countries. In addition, foreign direct purchase is a lot of transactions in China, the United States, EU, but the share of China is high in foreign direct sales, and the U.S. and EU have a very low performance, it is important to consider the reasons why they prefer Korean products in China to study the social and cultural characteristics of U.S. and European consumers in the future, and to support and active marketing that companies and sellers can increase sales.

• Journal of the Korean Geotechnical Society
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• v.22 no.3
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• pp.23-35
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• 2006

Equivalent linear analysis is widely used in estimating local seismic site effects. The soil behavior in the analysis is often assumed to be rate-independent and is not influenced by the seismic loading frequency. Laboratory results, however, indicate that cohesive soil behavior is greatly influenced by the loading frequency. A new equivalent linear analysis method that accounts for the loading frequency dependent soil behavior is developed and used to perform a series of one dimensional site response analyses. Results indicate that while frequency dependent shear modulus has limited influence on computed site response, frequency dependent soil damping greatly filters out high frequency components of the ground motion and thus results in lower response.

• Journal of Ecology and Environment
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• v.42 no.4
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• pp.210-218
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• 2018

Background: Soil respiration (Rs) is a major factor of the absorption and accumulation of carbon through photosynthesis in the ecosystem carbon cycle. This directly affects the amount of net ecosystem productivity, which affects the stability and sustainability of the ecosystem. Understanding the characteristics of Rs is indispensable to scientifically understand the carbon cycle of ecosystems. It is very important to study Rs characteristics through analysis of environmental factors closely related to Rs. Rs is affected by various environmental factors, such as temperature, precipitation, soil moisture, litter supply, organic matter content, dominant plant species, and soil disturbance. This study was conducted to analyze the effects of micro-topographical differences on Rs in forest vegetation by measuring the Rs on the ridge and southern slope sites of the broadly established Quercus mongolica forest in the central Korean area. Method: Rs, Ts, and soil moisture data were collected at the southern slope and ridge of the Q. mongolica forest in the Mt. Jeombong area in order to investigate the effects of topographical differences on Rs. Rs was collected by the closed chamber method, and data collection was performed from May 2011 to October 2013, except Winter seasons from November to April or May. For collecting the raw data of Rs in the field, acrylic collars were placed at the ridge and southern slope of the forest. The accumulated surface litter and the soil organic matter content (SOMC) were measured to a 5 cm depth. Based on these data, the Rs characteristics of the slope and ridge were analyzed. Results: Rs showed a distinct seasonal variation pattern in both the ridge and southern slope sites. In addition, Rs showed a distinct seasonal variation with high and low Ts changes. The average Rs measurements for the two sites, except for the Winter periods that were not measured, were $550.1\;mg\;CO_2m^{-2}h^{-1}$ at the ridge site and $289.4\;mg\;CO_2m^{-2}h^{-1}$ at the southern slope, a difference of 52.6%. There was no significant difference in the Rs difference between slopes except for the first half of 2013, and both sites showed a tendency to increase exponentially as Ts increased. In addition, although the correlation is low, the difference in Rs between sites tended to increase as Ts increased. SMC showed a large fluctuation at the southern slope site relative to the ridge site, as while it was very low in 2013, it was high in 2011 and 2012. The accumulated litter of the soil surface and the SOMC at the depth range of 0~5 cm were $874g\;m^{-2}$ and 23.3% at the ridge site, and $396g\;m^{-2}$ and 19.9% at the southern slope site. Conclusions: In this study, Rs was measured for the ridge and southern slope sites, which have two different results where the surface litter layer is disturbed by strong winds. The southern slope site shows that the litter layer formed in autumn due to strong winds almost disappeared, and while in the ridge site, it became thick due to the transfer of litter from the southern slope site. The mean Rs was about two times higher in the ridge site compared to that in the southern slope site. The Rs difference seems to be due to the difference in the amount of litter accumulated on the soil surface. As a result, the litter layer supplied to the soil surface is disturbed due to the micro-topographical difference, as the slope and the change of the community structure due to the plant season cause heterogeneity of the litter layer development, which in turn affects SMC and Rs. Therefore, it is necessary to introduce and understand these micro-topographical features and mechanisms when quantifying and analyzing the Rs of an ecosystem.