• Investigative Magnetic Resonance Imaging
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• 제11권2호
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• pp.127-132
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• 2007

비강 및 부비동에 발생하는 신경내분비암종(neuroendocrine carcinoma)은 매우 드물고, 자기공명영상 소견에 대한 보고가 거의 없다. 이에 본 저자들은 비출혈을 주소로 내원한 62세 남자와 74세 남자에서 발생한 신경내분비암종의 2 증례에 대하여 전산화단층촬영과 자기공명영상의 소견을 중심으로 보고하고자 한다. 2예 모두 전산화단층촬영에서 비강과 부비동내에 비교적 크고 경계가 불분명한 종괴가 있었으며, 인접한 골 파괴를 동반하였다. 자기공명영상에서 종괴는 T1강조영상에서 등신호 강도를 보였고, T2강조영상에서는 등신호와 고신호가 섞여있는 양상을 보였으며, 조영 증강시 불균질한 조영 증강을 보였고 내부에는 괴사가 포함되어 있었다. 자기공명영상에서도 종괴에 인접한 골 파괴가 관찰되었다. 2예에서 모두 인접한 접형동내에 T1강조영상에서 고신호 강도를 보이는 점액낭 혹은 종양주변 낭성 부위가 관찰되었다. 2예 모두 전산화단층촬영과 자기공명영상에서 일반적인 비강과 부비동에 발생하는 악성 종양의 비특이적인 소견을 보였으나 종양 주변 낭성 부위의 의미에 대해서는 보다 많은 연구가 필요할 것으로 보인다.

• 대한자기공명의과학회:학술대회논문집
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• 대한자기공명의과학회 2000년도 춘계학술대회 제4차 심포지움
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• pp.147-163
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• 2000

• 대한두경부종양학회지
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• 제12권1호
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• pp.47-51
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• 1996

Malignant tumors of the sinonasal tract constitute about 2% of those arising in the head and neck. Exposure to industrial fumes has been associated with an increased incidence of this malignant tumor. Early symptomatology of this cancer is identical to the symptomatology seen in benign conditions, such as swelling on forehead, headache, diplopia, and rhinorrhea. Thereby, delayed diagnosis leads to poor prognosis. Squamous cell carcinoma is the most common malignancy of the sinonasal tract, constituting about 80%, and primary carcinoma of the frontal sinus is extremely rare. Recently, authors experienced a case of primary carcinoma of the frontal sinus in a 60 year old male and performed transcranial resection. Now we report this case with brief review of literatures.

• 대한영상의학회지
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• 제82권1호
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• pp.225-230
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• 2021

고립성 외안근 전이는 매우 드물게 나타나며, 그중에서도 양측 다발성 외안근 전이는 더욱 드물다. 횡문근육종은 주로 소아에게 생기는 드문 연조직 악성 종양으로, 고립성 외안근 전이를 일으키는 원발암 중 하나로 알려져 있다. 이에 저자는 부비동에서 발생한 횡문근육종 환자에서 발견된 양측 다발성 외안근 전이의 한 증례를 보고하고, 이와 더불어 이전에 보고된 횡문근육종의 고립성 외안근 전이 10예에 대해 간략히 고찰하고자 한다.

• 대한두경부종양학회지
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• 제18권2호
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• pp.157-162
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• 2002

Background and Objectives: Adenoid cystic carcinoma (ACC) is a unique tumor characterized by frequent and delayed distant metastasis (DM) with uncommon regional lymph node metastasis. We evaluated the factors affecting DM of ACC and survival after appearance of DM. Materials and Methods: Medical records, radiographs and pathologic slides were reviewed for 94 patients from 1979 through 2001. Results: DM of ACC occurred in 46 patients, and developed more frequently in patients with tumors of the solid histologic subtype than in patients with tubular or cribriform subtypes. DM occurred less frequently in the sinonasal tract, and development of DM was not affected by tumor stage. Disease-specific 5- and 10-year survival rates were 88% and 72% for patients without DM, respectively and 76% and 48% for those with DM(p=0.02). Regarding the site of DM and its impact on outcomes, 30 patients had lung metastasis alone, 5 patients bone metastasis alone and 6 patients developed both lung and bone metastasis. Median survivals after appearance of DM among patients with isolated lung metastases and those with bone metastases with or without lung involvement were 54 and 21 months, respectively (p=0.04). Conclusions: Development of DM in ACC is predicted by solid histologic subtype, and major salivary gland or oral/pharyngeal rather than sinonasal primary site. Those patients with bone involvement with our without lung metastases had worse outcomes than those with pulmonary metastasis only.

• Journal of Yeungnam Medical Science
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• 제21권1호
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• pp.120-126
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• 2004

Sinonasal Undifferentiated Carcinoma (SNUC) is a very rare, highly aggressive malignant tumor of the nasal cavity and paranasal sinuses. SNUC tends to present with advanced-stage disease, often with intracranial invasion. It requires an aggressive multimodality therapy that includes surgical resection. A cure rate of less than 20% is generally reported in the literature, with most patients dying within 1 year of onset of the disease. Three patients diagnosed as SNUC were treated at the Yeungnam University Medical Center between the years 2000 and 2003 were analyzed retrospectively. All patients presented with the disease very advanced. The three cases were given chemotherapy or chemotherapy with radiotherapy. Two patients died of the disease, surviving only 6 and 11 months following treatment, respectively. We did a follow-up on just the one remaining case with incomplete controlled disease for 27 months. The overall prognosis of SNUC is very poor. We consider that more intensive multimodality therapies are recommended for all patients with SNUC.

• 대한두경부종양학회지
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• 제32권2호
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• pp.91-94
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• 2016

A 37 year-old male presented with sudden right proptosis and bilateral nasal obstruction. A huge tumor was noted in bilateral nasal cavities, ethmoid sinuses and central frontal sinus on magnetic resonance imaging. Right posterior frontal sinus wall and bilateral medial orbital wall was destructed by the tumor. Complete resection of the tumor was performed via minimal invasive craniofacial resection. Histopaghologic examination revealed sinonasal undifferentiated carcinoma (SNUC). Cerebrospinal fluid leakage was developed after 2 days of the surgery. On the 5th day, anterior skull base was reconstructed with forearm free flap (FFF). The patient got 6000cGy of radiotherapy and survived in 27 months of follow up.

• Journal of Ginseng Research
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• 제45권6호
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• pp.695-705
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• 2021

Background: Ginsenosides have beneficial effects on several airway inflammatory disorders primarily through glucocorticosteroid-like anti-inflammatory activity. Among inflammatory cells, eosinophils play a major pathogenic role in conferring a risk of severe refractory diseases including chronic rhinosinusitis (CRS). However, the role of ginsenosides in reducing eosinophilic inflammation and CRS pathogenesis is unexplored. Methods: We investigated the therapeutic efficacy and underlying mechanism of ginsenoside F1 (G-F1) in comparison with those of dexamethasone, a representative glucocorticosteroid, in a murine model of CRS. The effects of G-F1 or dexamethasone on sinonasal abnormalities and infiltration of eosinophils and mast cells were evaluated by histological analyses. The changes in inflammatory cytokine levels in sinonasal tissues, macrophages, and NK cells were assessed by qPCR, ELISA, and immunohistochemistry. Results: We found that G-F1 significantly attenuated eosinophilic inflammation, mast cell infiltration, epithelial hyperplasia, and mucosal thickening in the sinonasal mucosa of CRS mice. Moreover, G-F1 reduced the expression of IL-4 and IL-13, as well as hematopoietic prostaglandin D synthase required for prostaglandin D2 production. This therapeutic efficacy was associated with increased NK cell function, without suppression of macrophage inflammatory responses. In comparison, dexamethasone potently suppressed macrophage activation. NK cell depletion nullified the therapeutic effects of G-F1, but not dexamethasone, in CRS mice, supporting a causal link between G-F1 and NK cell activity. Conclusion: Our results suggest that potentiating NK cell activity, for example with G-F1, is a promising strategy for resolving eosinophilic inflammation in CRS.

• 대한두경부종양학회:학술대회논문집
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• 대한두경부종양학회 1993년도 제10차 학술대회 연제순서 및 초록집
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• pp.276.2-277
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• 1993

• Radiation Oncology Journal
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• 제36권4호
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• pp.341-347
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• 2018

Surgical excision along with use of postoperative radiotherapy forms an integral management of sinonasal teratocarcinosarcoma (SNTCS). However, given the rarity of the tumor, no standardised guidelines, dose, technique and target delineation exist especially in the era of modern radiation delivery techniques. This is a case of 55-year-old male diagnosed as SNTCS treated with radical ethmoidectomy followed by volumetric modulated radiotherapy, showing good local control and acceptable toxicity profile.