• 대한기관윤리심의기구협의회지
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• 제2권1호
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• pp.6-22
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• 2020

Purpose: Clinical studies require institutional review board (IRB) approval based on the ethical principle and regulations. While the number of clinical studies has been increased and diversified, duplicated IRB review for multi-center studies has become a major issue. Therefore, single IRB system has been suggested in revised Common Rule. This study aimed to identify and assess the current status of single IRB in Korea and the anticipated needs of single IRB from researchers and IRB member or administrators. Methods: We developed 14 questions including perceived advantages and disadvantages of single IRB, and anticipated problems. The online survey collected opinions on single IRB from researchers, IRB members and IRB administrators. We also interviewed five IRB administrators who have an experience of single IRB. Results: A total of 80 responses were analyzed in this study. Although efficiencies were suggested for the advantages of single IRB in terms of reducing burden of duplicated review, respondents also perceived that the different review criteria between single IRB and each IRB would be a major hurdle for adopting single IRB system. Therefore, the standardization of standard of procedures (SOP) and the standardization of IRB submission materials should be preceded. According to the small group experiences of single IRB in Korea, we also observed the similar anticipated problems of single IRB. Conclusion: Single IRB system has many advantages for conducting multi-center trial. However, many specialists still have a lot of concerns about introducing a single IRB system in Korea. Therefore, a gradual, step-by-step process for conducting a single IRB system in Korea will be needed. Many studies for improving currently suggested single IRB system and the improvement of awareness about the essential of single IRB system would be needed.

• Bulletin of the Korean Chemical Society
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• 제31권7호
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• pp.2061-2064
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• 2010

• Journal of Electrical Engineering and Technology
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• 제4권4호
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• pp.476-484
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• 2009

This paper deals with improvements to the special protection schemes (SPS) which have been applied to the low probability and high impact contingencies in the Korea Electric Power Corporation (KEPCO) system since 2004. Among them, the SPS for voltage instability in the Seoul metropolitan area is considered in this paper, and is a form of event-based undervoltage load shedding with a single-step scheme. Simulation results based upon a recent event that occurred on 765kV lines show that the current setting values of the SPS have to be revised and enhanced. In addition, by applying response-based multi-step undervoltage load shedding (UVLS) schemes to severe contingencies in the system, more effective results than those of the existing single-step SPS can be obtained. Centralized and distributed UVLS schemes are considered in the simulation. ULTC-based load recovery models and over excitation limiters (OXL) for the KEPCO system are also included in the long-term voltage instability studies.

• 한국군사과학기술학회지
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• 제14권4호
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• pp.676-683
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• 2011

In this paper, we propose a robust method which can detect and track a high-speed small approaching target in a cluttered environment for Korean Active Protection System. The proposed method uses a temporal and spatial filter, tracking filter to detect and track a single target in consecutive order. And it is comprised of a candidate target detection step, a prior target selection step and a target tracking. Field tests on real infrared image sequences show that the proposed method could stably track a high speed and small target in complex background and target occlusion.

• Journal of Radiation Protection and Research
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• 제26권3호
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• pp.167-175
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• 2001

Semiconductor diode detectors coated with neutron reactive material are presently under investigation for various uses, such as remote sensing of thermal neutrons, fast neutron counting, and thermal neutron radiography. Theory indicates that single-coated devices can yield thermal neutron efficiencies from 4% to 11 %, which is supported by experimental evidence. Radiation endurance measurements indicate that the devices function well up to a limiting thermal neutron fluence of $10^{13}/cm^2$, beyond which noticeable degradation occurs. Thermal neutron contrast images of step wedges and simple phantoms, taken with dual in-line pixel devices, show promise for thermal neutron imaging detectors.

• 한국안전학회지
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• 제33권5호
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• pp.21-27
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• 2018

The purpose of this study is to develop a SOP (Standard Operating Procedure) for a distribution board that can monitor the leakage current of a load distribution line in real time. The developed distribution board was fabricated by applying IEC 61439-1. It consists of the distribution board and an alarm device. The work process for making the distribution board was compliant with the KEMC (Korea Electrical Manufacturers Cooperative) regulations. And the AC distribution board range is 1,000 V. In addition, the voltage in DC is less than 1500 V. The distribution board receives a 3-phases and 4-wires power supply system and can supply power to the load of a maximum of 32 single or three phase distribution circuits. Also, leakage current measured on the power distribution board was used by sensors installed. The SOP of the developed distribution board consists of the installation standards for the short circuit alarm device and sensor, the surge protection device, switches and indication lamps, and other devices. The operation procedure was prepared so that each manufacturing step of the distribution board must be confirmed by the persons in charge of preparation, production, quality control and approval before moving forward to the next step.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제13권6호
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• pp.3299-3315
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• 2019

Deniable authentication (DA) is a protocol in which a receiver can generate an authenticator that is probabilistically indistinguishable from a sender. DA can be applied in many scenarios that require user privacy protection. To enhance the security of DA, in this paper, we construct a new deniable authenticated encryption (DAE) scheme that realizes deniable authentication and confidentiality in a logical single step. Compared with existing approaches, our approach provides proof of security and is efficient in terms of performance analysis. Our scheme is in an identity-based environment; thus, it avoids the public key certificate-based public key infrastructure (PKI). Moreover, we provide an example that shows that our protocol is applicable for e-voting systems.

• Journal of Radiation Protection and Research
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• 제42권2호
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• pp.91-97
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• 2017

Background: A gamma energy identifying algorithm using spectral decomposition combined with smoothing method was suggested to confirm the existence of the artificial radio isotopes. The algorithm is composed by original pattern recognition method and smoothing method to enhance the performance to identify gamma energy of radiation sensors that have low energy resolution. Materials and Methods: The gamma energy identifying algorithm for the compact radiation sensor is a three-step of refinement process. Firstly, the magnitude set is calculated by the original spectral decomposition. Secondly, the magnitude of modeling error in the magnitude set is reduced by the smoothing method. Thirdly, the expected gamma energy is finally decided based on the enhanced magnitude set as a result of the spectral decomposition with the smoothing method. The algorithm was optimized for the designed radiation sensor composed of a CsI (Tl) scintillator and a silicon pin diode. Results and Discussion: The two performance parameters used to estimate the algorithm are the accuracy of expected gamma energy and the number of repeated calculations. The original gamma energy was accurately identified with the single energy of gamma radiation by adapting this modeling error reduction method. Also the average error decreased by half with the multi energies of gamma radiation in comparison to the original spectral decomposition. In addition, the number of repeated calculations also decreased by half even in low fluence conditions under $10^4$ ($/0.09cm^2$ of the scintillator surface). Conclusion: Through the development of this algorithm, we have confirmed the possibility of developing a product that can identify artificial radionuclides nearby using inexpensive radiation sensors that are easy to use by the public. Therefore, it can contribute to reduce the anxiety of the public exposure by determining the presence of artificial radionuclides in the vicinity.

• 조명전기설비학회논문지
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• 제22권1호
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• pp.141-148
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• 2008

본 논문에는 22.9 kV-Y 배전계통의 1선 지락고장이 인체의 안전 및 저압설비의 보호에 대한 실험적 결과를 기술하였다. 새로이 제정된 KS C IEC 60364 규격군에 따른 고압 충전도체가 대지에 접촉되는 지락고장에 의한 위험전압과 저압기기의 스트레스전압을 평가하기 위해서 22.9[kV] 중성점 다중접지계통에 대한 실증실험을 수행하였다. 실험결과로부터 KS C IEC 60364 규격군을 기존의 국내배전계통에 적용할 때 부합되지 않는 중대한 문제점을 도출하였으며, 22.9 kV-Y 다중접지와 수용가설비접지를 공용하는 공통접지계통에서 발생하는 지락고장에 의한 일시적 과전압에 대한 효과적인 보호대책을 제시하였다. 결국 22.9 kV-Y계통과 저압설비를 공통접지로 하는 경우 인체와 저압설비의 안전을 위한 효과적인 보호대책의 구현에는 등전위본딩이 중요한 필수적 요건임이 밝혀졌다.

• 한국식품영양과학회지
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• 제26권6호
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• pp.1173-1180
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• 1997

Hepatotoxicity of caffeine and acetaminophen was investigated in this study. Special attention was paid to the effect of vitamins on the reduction of hepatotoxicity caused by the chemicals. Rat hepaocytes isolated by two-step perfusion method were cultured in two differents methods-suspension, monolayer cultures-, and exposed to caffeine and/or acetaminophen for 24hrs. Caffeine or acetaminophen exhibited no significant hepatotoxicity in terms of intracellular glutathione(GSH) level and lipid peroxidation(MDA), but GSH level was significantly decreased after administrated acetaminophen, and the toxicity caused by the chemicals showed a dose-dependent manner. The synergistic effect of caffeine and acetaminophen was observed when both caffeine and acetaminophen were supplemented to culture medium. At the concentration 1mM, caffeine enhanced the intracellular GSH depletion and MDA formation by 63% and 64%, respectively, compared to single supplementation of 10mM acetaminophen in culture medium. This hepatotoxicity induced membrane integrity loss was observed by lightmicroscope on the simultaneous administration of caffeine and acetaminophen in monolayer cultured hepatocytes. Co-supplementation of vitamins with caffeine/acetaminophen to culture medium results in the protection of hepatocytes from hepatotoxic attach by caffeine/acetaminophen. Especially, vitamin E was superior to vitamin C and $\beta$-carotene from the standpoints of GSH depletion and MDA formation. From this results, it has been speculated that vitamin E may play a role of antioxidant scavenging radicals produced from acetaminophen. Taken all together, in vitro culture system like monolayer culture of hepatocytes may be a useful tool for the evaluation of hepatotoxicity or protection ability of food ingredients.