• 한국콘텐츠학회:학술대회논문집
• /
• 한국콘텐츠학회 2011년도 춘계 종합학술대회 논문집
• /
• pp.201-202
• /
• 2011

본 연구에는 7.0T 동물용 자기공명영상장치를 이용하여 인간의 췌장암 세포인 CFPAC-1를 이종 이식한 쥐에서 자기공명영상을 획득하여 최적화된 검사 Protocol을 정립하며, 동물 실험에서 밝혀진 종양특성과 확산강조영상과의 비교 분석을 해보고 현성확산계수 영상이 췌장암 이종이식 모형의 종양 세포 내부 구조에 관하여 어떠한 정보를 제공 할 수 있는지 알아보고자 한다. 13마리의 쥐의 26개의 종양을 전형적으로 주입 후에 2~4주 뒤에 직경이 5~10mm가 되었을 때 imaged 하였으며, pathologic specimenm을 위해 sacrificed 하였다. isofluoran gas anesthesia를 이용하여 동물 마취 하였다. 사용된 장비로는 small-animal MR images (7.0-T)를 (Bruker BioSpin GmbH, Rheinstetten, Germany)이용하여 Fast T2-weighted 와 single-shot EPI DW image를 얻었다. 종양은 H&E 염색과 CD31와 VEGF에 대한 면역조직학 염색을 하여 종양의 cellularity와 microvessel density(MVD), 종양 내 괴사 정도를 평가하였다. CFPAC-1의 현성확산계수값은 $0.7327{\pm}0.1075{\pm}10^{-3}mm2/s$이였으며, 현성확산계수는 종양내 괴사 정도와 연관성을 보였다(R = 0.7417, p = 0.0001) 이처럼 현성확산계수는 종양 내 괴사 정도 등의 현미경적구조변화를 반영하는 대리인자로 사용될 수 있음을 확인하였다.

• 한국군사과학기술학회지
• /
• 제13권2호
• /
• pp.336-341
• /
• 2010

The burning interruption between the initiator and the delay column in a Zr-Ni K1 delay system used for a K510 fuze occurs with long-time storage. About 10 % failure probability of 15-years stored delay systems shows the failure mode in open literature. This paper shows storage lifetime improvement results for the delay system through changing the single-base delay column into double-base ones and controlling the manufacturing processes especially the initial inclusion of humidity. The double-base delay columns was implemented by inserting one delay column of fast burning rates between the initiator and the previous delay column of slow burning rates. Accelerated aging tests of the delay systems with double-base columns, and then the firing tests were performed to evaluate the improved lifetime. The double-base delay columns shows improved storage lifetime of the delay system through preventing the failure mode.

• 대한기계학회논문집
• /
• 제12권3호
• /
• pp.534-540
• /
• 1988

본 연구에서는 디이젤분무 주위기체의 유동특성중에서 유동속도에 관하여 보 고 하였다. 본모에서는 분무기간중 분사압력의 시간경과특성이 상이한 두 종류의 분 사계를 사용하여 생성된 분무와 주위 기체와의 유동방향의 시간경과 및 유입시기, 정 상유입속도 도달시간등을 분무의 축방향과 반경방향에 대하여 상세한 측정결과를 얻었 기에 보고한다.

• Clinical and Experimental Reproductive Medicine
• /
• 제44권1호
• /
• pp.52-55
• /
• 2017

The aim of this study was to report a successful pregnancy using completely immotile frozen-thawed spermatozoa selected by laser. A single laser shot was used to detect the presence of viable immotile spermatozoa in fresh and frozen-thawed testicular spermatozoa. The viability rate was 55.8% after the laser detection, and cryopreservation was carried out immediately. The thawing test was performed on the day of oocyte pick-up, and no motile sperm were observed after extending the culture for another 4 hours, while a survival rate of 39.8% was detected using the laser. In all, five mature oocytes were injected, resulting in four cases of normal fertilization (80%) on day 1. Further, two high-quality day 3 embryos were transferred, which resulted in a singleton pregnancy. Our study demonstrates that completely immotile spermatozoa are worth cryopreserving for further intracytoplasmic sperm injection, which provides a new insight into male fertility preservation in cases of completely immotile spermatozoa.

• 한국음향학회지
• /
• 제16권6호
• /
• pp.36-40
• /
• 1997

결석 치료에 있어서, 체외 충격파 결석 파쇄 장치(Extracorporeal Shock Wave Lithotripter)의 유효성은 잘 알려져 있지만 , 충격파 조사시의 물리적 특성에 관한 기초적인 연구보고는 드문 실정이다. 따라서, 본 연구는 충격파에 의한 파쇄과정에 있어서의 물리적 특성을 조사하기 위하여, 체외 충격파 결석 파쇄 장치에 의한 대상물 파쇄시에 발생하는 음을 분석하는 연구를 행한다. 또한, 본 논문에서는, 결석모델로서 chalk를 선정하여, 단발 충격을 가할 시의 방사음의 특징을 조사하고, 아울러, 임상용 결석 파쇄 장치를 사용한 모의실험에 의해 전술한 실험결과를 확인한다. 그 결과, 고유 진동의 피크 주파수가 충격횟수에 따라 변환되는 것이 확인되어, 실제로 장치를 임상용으로 사용할 때, 파쇄 과정 감시에 충분히 활용 가능하다.

• Nuclear Engineering and Technology
• /
• 제48권3호
• /
• pp.799-804
• /
• 2016

A miniature X-ray tube based on a carbon-nanotube electron emitter has been employed for the application to a dental radiography. The miniature X-ray tube has an outer diameter of 7 mm and a length of 47 mm. The miniature X-ray tube is operated in a negative high-voltage mode in which the X-ray target is electrically grounded. In addition, X-rays are generated only to the teeth directions using a collimator while X-rays generated to other directions are shielded. Hence, the X-ray tube can be safely inserted into a human mouth. Using the intra-oral X-ray tube, a dental radiography is demonstrated where the positions of an X-ray source and a sensor are reversed compared with a conventional dental radiography system. X-ray images of five neighboring teeth are obtained and, furthermore, both left and right molar images are achieved by a single X-ray shot of the miniature X-ray tube.

• 한국방송∙미디어공학회:학술대회논문집
• /
• 한국방송공학회 2009년도 IWAIT
• /
• pp.601-605
• /
• 2009

We have proposed a measurement system for measuring a whole shape of an object easily. The proposed system consists of a camera and a cylinder whose inside is coated by a mirror layer. A target object is placed inside the cylinder and an image is captured by the camera from right above. The captured image includes sets of points that are observed from multiple viewpoints: one is observed directly, and others are observed via the mirror. Therefore, the whole shape of the object can be measured using stereo vision in a single shot. This paper shows that a prototype of the proposed system was implemented and an actual object was measured using the prototype. A method based on a pattern matching which uses a value of SSD (Sum of Squared Difference), and a method based on DP (Dynamic Programming) are employed to identify a set of corresponding points in warped captured images.

• 한국진공학회:학술대회논문집
• /
• 한국진공학회 2014년도 제46회 동계 정기학술대회 초록집
• /
• pp.240.2-240.2
• /
• 2014

Characteristics of pulse-discharged plasma in liquid and its biological applications to proteins are investigated by making use of high voltage Marx generator. The Marx generator has been consisted of 5 stages, where each charging capacitor is $0.5{\mu}F$ to generate a high voltage pulse with rising time of $1{\mu}s$. We have applied an input voltage of 6 kV to the each capacitor of $0.5{\mu}F$. The high voltage pulsed plasma has been generated inside a polycarbonate tube by a single-shot operation, where the breakdown voltage is measured to be 7 kV, current of 1.2 kA, and pulse width of ${\sim}1{\mu}s$ between the two electrodes of anode-cathode made of stainless steel, which are immersed into the liquids. For the investigation of the influence of pulsed plasma on biomolcules, we have focused on the amino acids, DNA, proteins, cell and cholesterol.

• 한국전기전자재료학회:학술대회논문집
• /
• 한국전기전자재료학회 2003년도 하계학술대회 논문집 Vol.4 No.1
• /
• pp.80-83
• /
• 2003

In this paper, the programming characteristics of the multi-bit devices based on SONOS structure are investigated. Our devices have been fabricated by $0.35\;{\mu}m$ complementary metal-oxide-semiconductor (CMOS) process with LOCOS isolation. In order to achieve the two-bits per cell operation, charges must be locally trapped in the nitride layer above the channel near the junction. Channel hot electron (CHE) injection for programming can operate in multi-bit using localized trap in nitride film. CHE injection in our devices is achieved with the single power supply of 5 V. To demonstrate CHE injection, substrate current (Isub) and one-shot programming curve were investigated. The multi-bit operation which stores two-bit per cell is investigated with a reverse read scheme. Also, hot hole injection for fast erasing is used. Due to the ultra-thin gate dielectrics, our results show many advantages which are simpler process, better scalability and lower programming voltage compared to any other two-bit storage flash memory. This fabricated structure and programming characteristics are shown to be the most promising for the multi-bit flash memory.

• 한국정밀공학회지
• /
• 제22권7호
• /
• pp.200-207
• /
• 2005

This study compares two different methods of measuring brain-BOLD activation. By comparing two different methods of measurement i.e., one method calculating the neural activation area (the number of activated voxels), while the other measured the neural activation intensity (the mean intensity of selected activated yokels), this study identified the more precise method of measuring brain activation which results from the completion of a visuospatial task. 16 right-handed male college students (mean age 23.2 years) participated in this study as subjects. Functional brain images were scanned on them using a 3T MRI single-shot EPI method. No correlation was found between the levels of cognitive performance and number of activated yokels in the activated brain areas. However, a significant correlation was found between the levels of cognitive performance and the mean intensity of selected activated yokels in the parietal, frontal, and other areas. In conclusion, the method of mean intensity was considered a better index of brain activity rather than the activated yokels measurement method.