• Title/Summary/Keyword: Single-case study

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A Multicenter Matched Case Control Study of Breast Cancer Risk Factors among Women in Karachi, Pakistan

  • Shamsi, Uzma;Khan, Shaista;Usman, Sheheryar;Soomro, Saleem;Azam, Iqbal
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.1
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    • pp.183-188
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    • 2013
  • Background: Breast cancer (BC), the most common female cancer in Pakistan, is associated with a very high mortality. However, the roles of individual risk factors for BC among Pakistani women are still controversial. To assess potential risk factors for BC, a matched case-control study was conducted in two tertiary care hospitals of Karachi, Pakistan. Materials and Methods: The study population included 297 pathologically confirmed incident cases of BC patients diagnosed between January 2009 and December 2010. 586 controls without any history of BC were matched on hospital and ${\pm}5$ years of ages. Results: Positive family history of BC (MOR=1.72; 95%CI: 1.10, 2.80 for first degree vs. none), single marital status (MOR=1.55; 95%CI: 1.10, 2.39 for single/divorced/widowed women vs. married women), older age at menopause (MOR=3.92; 95%CI: 2.52, 6.18 for menopausal women aged below 45 years, MOR=6.42; 95%CI: 3.47, 11.98 for menopausal women above 45 years of age compared with premenopausal women) conferred an increased risk of BC for women. Increasing parity decreased the risk of BC (MOR=0.90; 95%CI: 0.85, 0.97 for each live birth). Intake of Vitamin D supplements (MOR=0.30; 95%CI: 0.12, 0.81 for ${\leq}3$ years and MOR=0.27; 95%CI: 0.13, 0.56 for >3 years) was protective compared to non-users of Vitamin D. Conclusions: This study confirmed only few of the recognized risk factors in Pakistani women. The protective effect of Vitamin D is important from public health perspective and needs to be further explored through a randomized controlled trial.

A Case Study on the Paradigm Shift to Digital Logistics Platform : The Case of Maersk

  • So Hyung KIM
    • Journal of Distribution Science
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    • v.22 no.4
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    • pp.105-114
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    • 2024
  • Purpose : Due to the uncertainty of the global trade environment and the trade downturn, the shipping industry continues to face challenges. This study aims to investigate in-depth analysis of crisis overcoming strategies through case study of a company that is leader in the shipping and logistics industry. Research Desigh and Methodology : In order to conduct an in-depth analysis, a single case analysis was selected as a qualitative study. For this purpose, various secondary sources were used, and indirect interview data were also used. In this study, Maersk was selected because it has grown from a traditional shipping logistics company to a digital platform company. Results: Maersk has transformed itself into a comprehensive, digital logistics platform with several key strategies to respond to the long-term slump in the shipping industry. First, it leveraged Maersk's diversification and portfolio optimization strategy. Second, Maersk is transforming its logistics and transport processes through digitalization and technological innovation. Conclusion: Maersk, which is responding to the long-term recession facing the shipping industry, looked at how it has leveraged its strengths and explored new opportunities through a number of strategies and changes. This study provides insight into a digital logistics platform that will benefit the other companies as well.

In vivo molecular and single cell imaging

  • Hong, Seongje;Rhee, Siyeon;Jung, Kyung Oh
    • BMB Reports
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    • v.55 no.6
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    • pp.267-274
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    • 2022
  • Molecular imaging is used to improve the disease diagnosis, prognosis, monitoring of treatment in living subjects. Numerous molecular targets have been developed for various cellular and molecular processes in genetic, metabolic, proteomic, and cellular biologic level. Molecular imaging modalities such as Optical Imaging, Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), Single Photon Emission Computed Tomography (SPECT), and Computed Tomography (CT) can be used to visualize anatomic, genetic, biochemical, and physiologic changes in vivo. For in vivo cell imaging, certain cells such as cancer cells, immune cells, stem cells could be labeled by direct and indirect labeling methods to monitor cell migration, cell activity, and cell effects in cell-based therapy. In case of cancer, it could be used to investigate biological processes such as cancer metastasis and to analyze the drug treatment process. In addition, transplanted stem cells and immune cells in cell-based therapy could be visualized and tracked to confirm the fate, activity, and function of cells. In conventional molecular imaging, cells can be monitored in vivo in bulk non-invasively with optical imaging, MRI, PET, and SPECT imaging. However, single cell imaging in vivo has been a great challenge due to an extremely high sensitive detection of single cell. Recently, there has been great attention for in vivo single cell imaging due to the development of single cell study. In vivo single imaging could analyze the survival or death, movement direction, and characteristics of a single cell in live subjects. In this article, we reviewed basic principle of in vivo molecular imaging and introduced recent studies for in vivo single cell imaging based on the concept of in vivo molecular imaging.

The Evacuation Characteristics of Elementary School Student According to Working of Single Unit Fireproof Shutter for Fires (화재 시 일체형 방화셔터 작동유무에 따른 초등학생의 피난특성)

  • Lee, Seung-Chul;Hong, Yi-Pgo;Kim, Sang-Il
    • Fire Science and Engineering
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    • v.27 no.4
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    • pp.35-40
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    • 2013
  • This study investigated the evacuation characteristics of student of elementary school with single unit fireproof shutter. In particular, we gathered the data about fireproof shutter and checked the data. And we made comparison and did an analysis of the evacuation characteristics of elementary school student according to working of single unit fireproof shutter for fires. As a result, it took the last occupant 130 seconds to escape from the school with no fire shutter case. But it took time 190 seconds to escape when the single unit fireproof shutter worked. Some of elementary school students could not open the door installed on the shutter when the single unit fireproof shutter worked. Considering this circumstance, it can be led to time delays of escaping when the single unit fireproof shutter work. And many students can be exposed to the fire hazards. Therefore, the study on the power to open the door installed on the shutter must be done in the future.

Comparison of Force Control Characteristics Between Double-Rod and Single-Rod Type Electro-Hydrostatic Actuators (I): Tracking Performance (양로드형과 편로드형 EHA의 힘 제어 특성 비교(I): 추종 성능)

  • Kim, Jong Hyeok;Hong, Yeh Sun
    • Journal of Drive and Control
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    • v.14 no.4
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    • pp.9-16
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    • 2017
  • In this study, the force tracking performance of the single-rod and double-rod type EHAs (Electro-Hydrostatic Actuators) was compared by computer simulation and experiments. The force-controlled EHAs exhibit non-linear behavior that are significantly dependent on operation conditions. The investigation focused on localizing the parameters that provide significant rise to the non-linearity. For this, the single-rod and double-rod type EHAs were mathematically expressed to derive their linear models. In parallel, they were modeled by a commercial simulation program including non-linear properties based on experimental results. It was shown that the dependency of the bulk modulus of oil with entrapped air on working pressure dominated the non-linearity in force control performance in case of the double-rod type EHA. The force control of the single-rod type EHA was influenced by much more elements. Besides the asymmetrical piston geometry and the non-linear bulk modulus of oil, its pilot-operated check valves made it dependent not only on the magnitude of reference input but also on its direction.

Impacts of surface irregularity on vibration analysis of single-walled carbon nanotubes based on Donnell thin shell theory

  • Selim, Mahmoud M.;Althobaiti, Saad;Yahia, I.S.;Mohammed, Ibtisam M.O.;Hussin, Amira M.;Mohamed, Abdel-Baset A.
    • Advances in nano research
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    • v.12 no.5
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    • pp.483-488
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    • 2022
  • The present work is an attempt to study the vibration analysis of the single-walled carbon nanotubes (SWCNTs) under the effect of the surface irregularity using Donnell's model. The surface irregularity represented by the parabolic form. According to Donnell's model and three-dimensional elasticity theory, a novel governing equations and its solution are derived and matched with the case of no irregularity effects. To understand the reaction of the nanotube to the irregularity effects in terms of natural frequency, the numerical calculations are done. The results obtained could provide a better representation of the vibration behavior of an irregular single-walled carbon nanotube, where the aspect ratio (L/d) and surface irregularity all have a significant impact on the natural frequency of vibrating SWCNTs. Furthermore, the findings of surface irregularity effects on vibration SWCNT can be utilized to forecast and prevent the phenomena of resonance of single-walled carbon nanotubes.

The Effect of Economic Status of Single-Parent famillies on Children's School Adjustment Mediating effects of neglectful rearing attitudes and mental health, Multi-Group Analysis on two-parent famillies (한부모가족의 경제적 수준이 자녀의 학교적응에 미치는 영향: 방임적 양육태도와 정신건강의 매개효과 및 양부모가족과의 다집단 분석)

  • Kim, Hyeon Suk
    • Korean Journal of Family Social Work
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    • no.54
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    • pp.297-331
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    • 2016
  • The purpose of this study was to examine the mediating roles of neglectful rearing attitudes and mental health in the relationship between economic status of single-parent famillies and school adjustment, and the differences between single-parent and two-parent families, using structural equation modeling. Data were obtained from the Middle School 1 Panel(third-wave) of the Korean Child and Youth Panel Survey 2010. This study selected 2,195 middle school 3th-grade students (249 from single-parent families and 1,946 from two-parent families). Data were examined with structural equation modeling and multi-group analysis using AMOS 21.0, and mediating effects were tested using the Sobel test. The results were as follows; First, the single-parent children reported lower levels of economic status and school adjustment, and higher levels of neglectful rearing attitudes than the two-parent children. Second, multi-group analysis showed a statistically significant difference between single-parent and two-parent in structural equation modeling. Economic status of two-parent famillies affected school adjustment of children, but economic status of single-parent famillies did not affect school adjustment of children. Third, as a result of examining for total effect, the variable that most influenced school adjustment of children was neglectful rearing attitudes. Fourth, neglectful rearing attitudes and mental health did play a mediating role in the relationship between economic status and school adjustment in case of two-parent famillies, but neglectful rearing attitudes and mental health did not play a mediating role in case of single-parent famillies. Based on the result, this study stressed the following; First, the study suggested that problem of the single-parent famillies supporting standard which is concentrated on the low income single-parent famillies. Second, the study proposed multifaceted support measures which reflects characteristics of single-parent famillies to increase school adjustment of the single-parent children.

Nanodeformation Behaviors of the Single Crystal Silicon and the Pyrex glass 7740 during Nanoscratch (나노스크래치 공정에서 단결정 실리론 및 파이렉스 7740 의 나노변형거동)

  • 신용래;윤성원;강충길
    • Proceedings of the Korean Society for Technology of Plasticity Conference
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    • 2003.10a
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    • pp.363-366
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    • 2003
  • In nanomachining processes, chemical effects are more dominant factor compared with physical deformation. For example, during the nanoscratch on a silicon surface in the atmosphere, micro protuberances are formed due to the mechanochemical reaction between the diamond tip and the surface. On the contrary, in case of chemically stable materials, such as ceramics or glasse, the surface protuberance are not formed. The purpose of this study is to understand effects of the mechanochemical reaction between tip and surfaces on deformation behaviors of hard-brittle materials. Nanometerscale elasoplastic deformation behavior of single crystal silicon (100) was characterized with the surface protuberance phenomena, and compared with that of borosilicate (Pyrex glass 7740).

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A Case of Superior Vena Cava Syndrome Secondary to Aortic Aneurysm Diagnosed with Single Pass Radionuclide Cardiac Angiography (Single Pass Radionuclide 심혈관 촬영술로 진단된 대동맥류에 의한 상대정맥 증후군 1예)

  • Choi, Ji-Young;Kim, Ki-Woo;Shin, Dong-Jin;Mok, Cha-Soo;Yi, Gang-Wook;Park, So-Bae;Choi, Dae-Seop
    • The Korean Journal of Nuclear Medicine
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    • v.23 no.1
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    • pp.89-93
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    • 1989
  • Single pass radionuclide cardiac angiography was performed in 67-year old woman due to dyspnea and chest discomfort. The study showed markedly dilated ascending aorta and collateral ciculations from left sudclavian vein, and confirmed aortic aneurysm with partial obstruction of superior vena cava.

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The Advanced Protection Coordination Scheme using Phase Angle of Zero-Sequence Current in Ungrounded System (비접지 계통에서 영상전류 위상을 이용한 개선된 보호협조 방안)

  • Choi, Young-Jun;Lim, Hee-Taek;Choi, Myeon-Song;Lee, Seung-Jae
    • The Transactions of The Korean Institute of Electrical Engineers
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    • v.59 no.1
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    • pp.19-25
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    • 2010
  • Most faults are single-phase-to-ground fault in ungrounded system. The fault currents of single-phase-to-ground are much smaller than detection thresholds of measurement devices, so detecting single-phase-to-ground faults is difficult and important in ungrounded system. The protection coordination method using SGR(Selective Ground Relay) and OVGR(Overvoltage Ground Relay) is generally used in ungrounded system. But this method only detects fault line and it has the possibility of malfunction. This paper proposed to advanced protection coordination method in ungrounded system. The method just using zero-sequence current can detect fault line, fault phase, fault section at terminal device. The general protection method is used to back up protection. In the case study, the proposed method has been testified in demo system by Matlab/Simulink simulations.