• Journal of Technologic Dentistry
• /
• v.40 no.2
• /
• pp.63-69
• /
• 2018

Purpose: The purpose of this study is to investigate the non-precious metal core materials used in the dental laboratory to fabricate the implant superstructure by CAD / CAM method. And to observe and compare the morphology and distribution of the osteoblasts in relation to implant osseointegration. Methods: In this study, the mandibular right first molar tooth model was selected as an international standard to produce a single core. Using this model, the impression was made with the silicone rubber, the tooth model was scanned, and a single core was designed and 5-axis milling was performed. The materials used were Cobalt-Chromium and Nickel-Chromium, and the cores for dental implant top structures were fabricated according to the procedures of the dental labs. After the fabrication, the marginal area of the core was separated and cell culture experiment was performed. The osteoblast cells used MC3T3-E1, which is currently widely used. For morphological analysis of osteoblasts, cells were posttreated and observed using CLSM (Confocal Laser Scanning Microscope) and compared. Results: The cell adhesion behavior of the specimen surface measured by CLSM was uniformly distributed in specimen A (Cobalt-Chromium) than in specimen B (Nickel-Chromium). The distribution and changes of the cells were different in the two specimens. Conclusion : It is possible to confirm that specimen A (Cobalt-Chromium) is suitable for the living body through adhesion and proliferation of osteoblasts related to implant osseointegration in the non-precious metal superstructure used after implantation. It is considered that it is preferable to use Co-Cr when fabricating the superstructure.

• Steel and Composite Structures
• /
• v.18 no.4
• /
• pp.853-871
• /
• 2015

Up to now, Japan has more than 200 corrugated steel web composite beam bridges which are under construction and have been constructed, and China has more than 30 corrugated steel web composite beam bridges. The bridge type includes the simply supported beam, continuous beam, continuous rigid frame and cable stayed bridge etc. The section form has developed to the single box and multi-cell box girder from the original single box and single chamber. From the stress performance and cost saving, the span range of 50~150 m is the most competitive. At present, the design mostly adopts the computational analytical method combining the spatial bar system model, plane beam grillage model and solid model. However, the spatial bar system model is short of the refinement analysis on the space effect, such as the shear lag effect, effective distribution width problem, and eccentric load factor problem etc. Due to the similarity of the plane beam grillage method in the equivalence principle, it cannot accurately reflect the shearing stress distribution and local stress of the top and bottom plates of the box type composite beam. The solid model is very difficult to combine with the overall calculation. Moreover, the spatial grid model can achieve the refinement analysis, with the integrity of the analysis and the comprehensiveness of the stress checking calculation, and can make up the deficiency of the analytical method currently. Through the example verification of the solid model and spatial grid model, it can be seen that the calculation results for the stress and the displacement of two models are almost consistent, indicating the applicability and precision of the spatial grid model.

• Genomics & Informatics
• /
• v.14 no.4
• /
• pp.205-210
• /
• 2016

Interleukin-10 (IL10) plays an important role in initiating and maintaining an appropriate immune response to non-Hodgkin lymphoma (NHL). Previous studies have revealed that the transcription of IL10 mRNA and its protein expression may be infl uenced by several single-nucleotide polymorphisms in the promoter and intron regions, including rs1800896, rs1800871, and rs1800872. However, the impact of polymorphisms of the IL10 gene on NHL prognosis has not been fully elucidated. Here, we investigated the association between IL10 polymorphisms and NHL prognosis. This study involved 112 NHL patients treated at the National Cancer Center, Korea. The median age was 57 years, and 70 patients (62.5%) were men. Clinical characteristics, including age, performance status, stage, and extra-nodal involvement, as well as cell lineage and International Prognostic Index (IPI), were evaluated. A total of four polymorphisms in IL10 with heterozygous alleles were analyzed for hazard ratios of overall survival (OS) and progression-free survival (PFS) using Cox proportional hazards regression analysis. Diffuse large B-cell lymphoma was the most common histologic type (n = 83), followed by T-cell lymphoma (n = 18), mantle cell lymphoma (n = 6), and others (n = 5). Cell lineage, IPI, and extra-nodal involvement were predictors of prognosis. In the additive genetic model results for each IL10 polymorphism, the rs1800871 and rs1800872 polymorphisms represented a marginal association with OS (p = 0.09 and p = 0.06) and PFS (p = 0.05 and p = 0.08) in B-cell lymphoma patients treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). These findings suggest that IL10 polymorphisms might be prognostic indicators for patients with B-cell NHL treated with R-CHOP.

• Asian-Australasian Journal of Animal Sciences
• /
• v.28 no.3
• /
• pp.303-310
• /
• 2015

The study was conducted to analyze the genetic parameters of somatic cell score (SCS) of Holstein cows, which is an important indicator to udder health. Test-day records of somatic cell counts (SCC) of 305-day lactation design from first to fifth lactations were collected on Holsteins in Korea during 2000 to 2012. Records of animals within 18 to 42 months, 30 to 54 months, 42 to 66 months, 54 to 78 months, and 66 to 90 months of age at the first, second, third, fourth and fifth parities were analyzed, respectively. Somatic cell scores were calculated, and adjusted for lactation production stages by Wilmink's function. Lactation averages of SCS ($LSCS_1$ through $LSCS_5$) were derived by further adjustments of each test-day SCS for five age groups in particular lactations. Two datasets were prepared through restrictions on number of sires/herd and dams/herd, progenies/sire, and number of parities/cow to reduce data size and attain better relationships among animals. All LSCS traits were treated as individual trait and, analyzed through multiple-trait sire models and single trait animal models via VCE 6.0 software package. Herd-year was fitted as a random effect. Age at calving was regressed as a fixed covariate. The mean LSCS of five lactations were between 3.507 and 4.322 that corresponded to a SCC range between 71,000 and 125,000 cells/mL; with coefficient of variation from 28.2% to 29.9%. Heritability estimates from sire models were within the range of 0.10 to 0.16 for all LSCS. Heritability was the highest at lactation 2 from both datasets (0.14/0.16) and lowest at lactation 5 (0.11/0.10) using sire model. Heritabilities from single trait animal model analyses were slightly higher than sire models. Genetic correlations between LSCS traits were strong (0.62 to 0.99). Very strong associations (0.96 to 0.99) were present between successive records of later lactations. Phenotypic correlations were relatively weaker (<0.55). All correlations became weaker at distant lactations. The estimated breeding values (EBVs) of LSCS traits were somewhat similar over the years for a particular lactation, but increased with lactation number increment. The lowest EBV in first lactation indicated that selection for SCS (mastitis resistance) might be better with later lactation records. It is expected that results obtained from these multi-trait lactation model analyses, being the first large scale SCS data analysis in Korea, would create a good starting step for application of advanced statistical tools for future genomic studies focusing on selection for mastitis resistance in Holsteins of Korea.

• Journal of Korean Institute of Industrial Engineers
• /
• v.33 no.1
• /
• pp.126-137
• /
• 2007

This study addresses the analytic models for estimating the capacity and performance of the multi-carrierCDMA system where several carriers would be assigned to a single cell to accommodate the required trafficdemand. Two key features of the multi-carrier CDMA system, carrier selections of new calls and inter-camerhard handoffs, are accommodated in the models, Computation experiments are conducted to show the effectiveness of the proposed model.

• Journal of KIISE:Databases
• /
• v.30 no.6
• /
• pp.573-584
• /
• 2003

Recent massive data generation by genomics and proteomics requires bioinformatic tools to extract the biological meaning from the massive results. Here we introduce ROSPath, a database system to deal with information on reactive oxygen species (ROS)-mediated cell signaling pathways. It provides a structured repository for handling pathway related data and tools for querying, displaying, and analyzing pathways. ROSPath data model provides the extensibility for representing incomplete knowledge and the accessibility for linking the existing biochemical databases via the Internet. For flexibility and efficient retrieval, hierarchically structured data model is defined by using the object-oriented model. There are two major data types in ROSPath data model: ‘bio entity’ and ‘interaction’. Bio entity represents a single biochemical entity: a protein or protein state involved in ROS cell-signaling pathways. Interaction, characterized by a list of inputs and outputs, describes various types of relationship among bio entities. Typical interactions are protein state transitions, chemical reactions, and protein-protein interactions. A complex network can be constructed from ROSPath data model and thus provides a foundation for describing and analyzing various biochemical processes.

• Steel and Composite Structures
• /
• v.24 no.5
• /
• pp.549-559
• /
• 2017

As few multi-tower single-box multi-cell cable-stayed bridges with corrugated steel webs have been built, analysis is mostly achieved by combining single-girder model, beam grillage model and solid model in support of the design. However, such analysis methods usually suffer from major limitations in terms of the engineering applications: single-girder model fails to account for spatial effect such as shear lag effect of the box girder and the relevant effective girder width and eccentric load coefficient; owing to the approximation in the principle equivalence, the plane grillage model cannot accurately capture shear stress distribution and local stress state in both top and bottom flange of composite box girder; and solid model is difficult to be practically combined with the overall calculation. The usual effective width method fails to provide a uniform and accurate "effective length" (and the codes fail to provide a unified design approach at those circumstance) considering different shear lag effects resulting from dead load, prestress and cable tension in the construction. Therefore, a novel spatial grid model has been developed to account for shear lag effect. The theoretical principle of the proposed spatial grid model has been elaborated along with the relevant illustrations of modeling parameters of composite box girder with corrugated steel webs. Then typical transverse and longitudinal shear lag coefficient distribution pattern at the side-span and mid-span key cross sections have been analyzed and summarized to provide reference for similar bridges. The effectiveness and accuracy of spatial grid analysis methods has been finally validated through a practical cable-stayed bridge.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.17
• /
• pp.7097-7103
• /
• 2014

Over-expression of de novo lipogenesis (DNL) genes is associated with the prognosis of various types of cancers. However, the effects of single nucleotide polymorphisms (SNPs) in these genes on recurrence and survival of non-small cell lung cancer (NSCLC) patients after surgery are still unknown. In this study, a total of 500 NSCLC patients who underwent surgery treatment were included. Eight SNPs in 3 genes (ACACA, FASN and ACLY) of the DNL pathway were examined using the Sequenom iPLEX genotyping system. Multivariate Cox proportional hazards regression and Kaplan-Meier curves were used to analyze the association of SNPs with patient survival and tumour recurrence. We found that two SNPs in the FASN gene were significantly associated with the recurrence of NSCLC. SNP rs4246444 had a significant association with lung cancer recurrence under additive model (hazard ratio [HR], 0.82; 95% confidence interval [95%CI], 0.67-1.00; p=0.05). Under the dominant model, rs4485435 exhibited a significant association with recurrence (HR, 0.75; 95%CI, 0.56-1.01; p=0.05). Additionally, SNP rs9912300 in ACLY gene was significantly associated with overall survival in lung cancer patients (HR, 1.41; 95%CI, 1.02-1.94, p=0.04) under the dominant model. Further cumulative effect analysis showed moderate dose-dependent effects of unfavorable SNPs on both survival and recurrence. Our data suggest that the SNPs in DNL genes may serve as independent prognostic markers for NSCLC patients after surgery.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.22 no.8
• /
• pp.1755-1764
• /
• 1997

In this paper, we proposed the mechanism for the buffer allocation and a cell scheduling method with logical separation a single buffer in the ATm switch, and analyzed the cell loss probability and the delay of each trafic (CBR/VBR/ABR) based on the weighted value and the dynamic cell service scheduling algorithm. The proposed switch buffering system classifies composite trafics incoming to the switch, according to the characteristic of traffic, then stores them in the logically separated buffers, and adopts the round-robin service with weighted value in order to transmit cells in buffers though one output port. We analyzed 4 cell service scheduling algorithms with dynamic round-robinfor each logically separated service line of a single buffer, in which buffers have the respective weighted values and 3 classes on mixed traffic which characteristized by traffic descriptor. In simulation, using SIMCRIPT II.5., we model the VBR and the ABR traffics as ON/OFF processes, and the CBR traffic as a Poisson processes. As the results of analysis according to the proposed buffer management mechanism and cell service algorithm, we have found that the required QoS of each VC can be quaranteed depends on a scale of weighted values allocated to buffers that changed the weighted values, and cell scheduling algorithm.

• Architectural research
• /
• v.12 no.2
• /
• pp.93-98
• /
• 2010

This paper describes a numerical method for estimating the elastic moduli of cement paste. The cement paste is modeled as a unit cell which consists of three components: the unhydrated cement grain, the gel, and the capillary pore. In the unit cell, the volume fractions of the constituents are quantified using a single kinetic function calculating the degree of hydration. The elastic moduli of cement paste are calculated from the total displacements of constituents when a uniform pressure is applied to the gel contact area. The cement paste is assumed to be a homogenous isotropic matrix. Numerical simulations were conducted through the finite element analysis of the three-dimensional periodic unit cell. The model predictions are compared with experimental results. The predicted trends are in good agreement with experimental observations. This approach and some of the results might also be relevant for other technical applications.