• 한국광학회지
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• 제8권5호
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• pp.377-381
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• 1997

MgO가 2 mole% 첨가된 LiNbO$_{3}$ 결정을 3 V/cm, 5 V/cm, 7 V/cm의 전기장에서 poling하여, 5 V/cm의 전기장이 최적의 조건임을 제2고조파발생의 온도의존도특성을 관찰하여 알 수 있었다. 결정에 공간적으로 변조된 전기장을 인가하여 온도 위상 정합 모양이 찌그러짐을 관찰하였으며, 이 결과와 잘 일치하는 계산값을 정량적으로 구할 수 있었다. 이것으로부터 제2고조파의 온도위상정합모양을 이용하여 결정의 균일성을 판단할 수 있음을 증명하였다. 5 V/cm로 poling된 단결정의 온도 위상 정합 모양으로부터 온도에 따른 복굴절의 변화율, c-축으로 전기장을 인가하여 변화된 위상 정합 온도로부터 전기장에 따른 복굴절의 변화율을 계산하였다.

• Genomics & Informatics
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• 제6권2호
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• pp.91-94
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• 2008

Single nucleotide polymorphisms (SNPs) are the most abundant form of human genetic variation and are a resource for mapping complex genetic traits. A genome is covered by millions of these markers, and researchers are able to compare which SNPs predominate in people who have a certain disease. The International HapMap Project, launched in October, 2002, motivated us to start the Korean HapMap Project in order to support Korean HapMap infrastructure development and to accelerate the finding of genes that affect health, disease, and individual responses to medications and environmental factors. A Korean SNP and haplotype database system was developed through the Korean HapMap Project to provide Korean researchers with useful data-mining information about disease-associated biomarkers for studies on complex diseases, such as diabetes, cancer, and stroke. Also, we have developed a series of software programs for association studies as well as the comparison and analysis of Korean HapMap data with other populations, such as European, Chinese, Japanese, and African populations. The developed software includes HapMapSNPAnalyzer, SNPflank, HWE Test, FESD, D2GSNP, SNP@Domain, KMSD, KFOD, KFRG, and SNP@WEB. We developed a disease-related SNP retrieval system, in which OMIM, GeneCards, and MeSH information were integrated and analyzed for medical research scientists. The kHapMap Browser system that we developed and integrated provides haplotype retrieval and comparative study tools of human ethnicities for comprehensive disease association studies (http://www.khapmap.org). It is expected that researchers may be able to retrieve useful information from the kHapMap Browser to find useful biomarkers and genes in complex disease association studies and use these biomarkers and genes to study and develop new drugs for personalized medicine.

• Asian-Australasian Journal of Animal Sciences
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• 제23권12호
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• pp.1543-1551
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• 2010

A major aim of cattle genome research is to identify candidate genes associated with meat quantity and quality through QTL analysis for application in the livestock industry. Therefore, this study focused on discovery of useful SNPs within the LOC534614 gene, containing 12273_165 SNP which is located on the same site as the QTL on chromosome 6, and evaluation of the association between SNP and body weight and cold carcass weight in Hanwoo (Korean cattle) As a result of a BLAST search of the NCBI web site, we discovered that the mRNA sequence of the LOC534614 gene was similar to that of the coiled-coil domain containing 158 (CCDC158) for dog and human. According to the direct DNA sequence from the CCDC158 gene, we identified 19 polymorphic SNPs within exons and their flanking regions. Among them, 17 polymorphic SNPs were selected for genotyping in Hanwoo (n = 476) and seventeen marker haplotypes containing 12273_165 SNP (frequency >0.1) were identified. As a result of the association between 17 polymorphic SNPs and Hanwoo (n = 476), g.8778G>A SNP in exon 6 was found to be a non-synonymous SNP, and was significantly associated with body weight and cold carcass weight (p<0.05). We discovered 19 polymorphic SNPs in the CCDC158 gene on the QTL region of BTA 6 in Hanwoo and identified that the g.8778G>A SNP was significantly associated with body weight and cold carcass weight (p<0.05), which causes an amino acid variation from valine to methionine. Furthermore, statistical analysis demonstrated that the CCDC158 gene is strongly associated with body weight and cold carcass weight in Hanwoo. In this regard, the g.8778G>A SNP in the CCDC158 gene can be useful as a positional candidate for body weight and cold carcass weight for marker-assisted selection in Hanwoo.

• Asian-Australasian Journal of Animal Sciences
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• 제26권4호
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• pp.455-462
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• 2013

NLR family pyrin domain containing 3 (NLRP3) is a key component of the inflammasome, whose assembly is a crucial part of the innate immune response. The aim of the present study was to evaluate the association between exon 3 polymorphisms of NLRP3 and the susceptibility to digestive disorders in rabbits. In total, five coding single-nucleotide polymorphisms (cSNPs) were identified; all of which are synonymous. Among them, c.456 C> and c.594 G> were further genotyped for association analysis based on case-control design (n =162 vs n =102). Meanwhile, growing rabbits were experimentally induced to digestive disorders by feeding a fiber-deficient diet, subsequently they were subjected to mRNA expression analysis. Association analysis revealed that haplotype H1 (the two cSNPs: GT) played a potential protective role against digestive disorders (p<0.001). The expression of NLRP3 in the group $H1HX_1$ ($H1HX_1$ is composed of H1H1, H1H3 and H1H4) was the lowest among four groups which were classified by different types of diplotypes. Those results suggested that the NLRP3 gene was significantly associated with susceptibility to digestive disorders in rabbit.

• Asian-Australasian Journal of Animal Sciences
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• 제33권9호
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• pp.1378-1386
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• 2020

Objective: Chinese indigenous sheep breeds can be classified into the following three categories by their tail morphology: fat-tailed, fat-rumped and thin-tailed sheep. The typical sheep breeds corresponding to fat-tailed, fat-rumped, and thin-tailed sheep are large-tailed Han, Altay, and Tibetan sheep, respectively. Detection of copy number variation (CNV) and selection signatures provides information on the genetic mechanisms underlying the phenotypic differences of the different sheep types. Methods: In this study, PennCNV software and F-statistics (F_ST) were implemented to detect CNV and selection signatures, respectively, on the X chromosome in three Chinese indigenous sheep breeds using ovine high-density 600K single nucleotide polymorphism arrays. Results: In large-tailed Han, Altay, and Tibetan sheep, respectively, a total of six, four and 22 CNV regions (CNVRs) with lengths of 1.23, 0.93, and 7.02 Mb were identified on the X chromosome. In addition, 49, 34, and 55 candidate selection regions with respective lengths of 27.49, 16.47, and 25.42 Mb were identified in large-tailed Han, Altay, and Tibetan sheep, respectively. The bioinformatics analysis results indicated several genes in these regions were associated with fat, including dehydrogenase/reductase X-linked, calcium voltage-gated channel subunit alpha1 F, and patatin like phospholipase domain containing 4. In addition, three other genes were identified from this analysis: the family with sequence similarity 58 member A gene was associated with energy metabolism, the serine/arginine-rich protein specific kinase 3 gene was associated with skeletal muscle development, and the interleukin 2 receptor subunit gamma gene was associated with the immune system. Conclusion: The results of this study indicated CNVRs and selection regions on the X chromosome of Chinese indigenous sheep contained several genes associated with various heritable traits.

• 한국멀티미디어학회논문지
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• 제7권7호
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• pp.859-876
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• 2004

본 논문에서는 객체 데이타베이스에서 객체지향 질의의 효율적 처리를 위한 다차원 경로 색인구조(Multidimensional Path Indexes: MPIs)의 최적 구성방법을 제시한다. MPI는 중포속성과 여러 클래스 계층이 포함된 중포술어를 효율적으로 지원하기 위하여 다차원 색인구조를 이용한다. $B^+$-tree와 같은 일차원 색인구조를 이용한 중포속성 색인구조로서는 이와 같은 술어를 잘 지원할 수 없다. 본 논문에서는 타겟 클래스 또는 도메인 클래스의 대치가 있는 경로식으로 표현된 여러 중포술어들의 접속으로 구성된 복합질의의 관점에서 MPI 색인들의 구성에 관하여 분석한다. 먼저, 데이타베이스의 변경에 따른 MPI 색인구조의 운용과 하나의 중포술어를 가지는 질의의 경우에 대한 MPI 색인의 사용에 대하여 색인구성을 분석한다. 그리고 겹침 경로와 비겹침 경로 상에 주어지는 여러 개의 중포술어들로 구성된 보다 일반적인 질의의 관점에서 MPI 색인의 구성에 관하여 분석한다. 겹침 경로는 경로들 사이에 공통의 부경로가 있는 것이고, 비겹침 경로는 공통의 부경로가 없는 것이다.

• 한국정보통신학회논문지
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• 제9권6호
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• pp.1167-1173
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• 2005

본 논문에서는 DS-CDMA 신호들의 코드 타이밍을 획득하기 위하여 안테나 어레이의 이용에 관한 내용을 다루고자 한다. 다중 사용자 환경의 시변 Rayleigh 페이딩 채널 하에서 다중의 고정 빔들을 기존의 MUSIC 동기 획득 방법에 적용함으로서 동기 획득 확률들을 평가한다. 전 방위각 영역을 공간 필터링을 위해서 안테나의 수만큼 나누어서 각각의 고정 빔이 각 방위각 구역을 맡도록 한다. 간섭 신호 억제 능력을 가진 고정 빔들은 부가적인 자유도를 제공한다. 그리하여 단 하나의 안테나를 사용하는 기존의 MUSIC 알고리즘보다 더 많은 사용자들의 동기 획득을 위해서 다중 빔 기반의 MUSIC 추정기를 사용할 수 있도록 한다. 이러한 다중 빔 기반의 부분공간 접근 방법을 다중 사용자 시나리오에서 단 하나의 안테나를 사용하는 MUSIC 기법의 성능을 상당히 개선할 수 있음을 검증하기 위해서 시뮬레이션을 수행한다.

• 한국정보통신학회논문지
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• 제20권8호
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• pp.1415-1421
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• 2016

무기체계의 기능 및 성능 검증을 위한 시험들이 지속적으로 증가함에 따라 가용 자원들의 효율적인 활용을 위한 방안에 관련된 연구가 대두되고 있으며, 자원할당 복잡도가 증가함에 따라 시험계획 시에 의사결정 지원이 요구되고 있다. 시험자원할당은 전통적인 FJSP(Flexible Job Shop Problem)와 기본적으로 동일한 문제이며, 이는 NP-hard문제로서 기존의 경험기반 시험자원 할당 방법으로는 시간 효율적인 자원할당에 있어서 한계가 존재한다. FJSP에 유전자알고리즘을 적용한 최적해 탐색 연구가 진행되어 왔지만, 하나의 기계조작에 대해 두 개 이상 기계의 동시 작동이 필요한 시험자원할당 도메인에서의 적용은 제한적이다. 이에 본 논문에서는 가변 그룹 유전자알고리즘을 제안한다. 제안하는 알고리즘은 수작업 기반의 기존 시험자원할당을 자동화하고 최적화함으로써 시험 효율을 향상시킬 것으로 기대되며, MATLAB을 이용한 시뮬레이션을 통해 그 적용성을 확인하였다.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2014년도 제46회 동계 정기학술대회 초록집
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• pp.114.1-114.1
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• 2014

Copper is considered to be the most promising substrate for the growth of high-quality and large area graphene by chemical vapor deposition (CVD), in particular, on the (111) facet. Because the interactions between graphene and Cu substrates influence the orientation, quality, and properties of the synthesized graphene, we studied the interactions using angle-resolved photoemission spectroscopy. The evolution of both the Shockley surface state of the Cu(111) and the p band of the graphene was measured from the initial stage of CVD growth to the formation of a monolayer. Graphene growth was initiated along the Cu(111) lattice, where the Dirac band crossed the Fermi energy ($E_F$) at the K point without hybridization with the d-band of Cu. Then two rotated domains were additionally grown as the area covered with graphene became wider. The Dirac energy was about 0.4 eV and the energy of the Shockley surface state of Cu(111) shifted toward the $E_F$) by 0.15 eV upon graphene formation. These results indicate weak interactions between graphene and Cu, and that the electron transfer is limited to that between the Shockley surface state of Cu(111) and the p band of graphene. This weak interaction and slight lattice mismatch between graphene and Cu resulted in the growth of rotated graphene domains ($9.6^{\circ}$ and $8.4^{\circ}$), which showed no significant differences in the Dirac band with respect to different orientations. These rotated graphene domains resulted in grain boundaries which would hinder a large-sized single monolayer growth on Cu substrates.

• 한국재료학회지
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• 제23권6호
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• pp.329-333
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• 2013

The structural phase transformations of $0.7Pb(Mg_{1/3}Nb_{2/3})O_3-0.3PbTiO_3$ (PMN-0.3PT) were studied using high resolution x-ray diffraction (HRXRD) as a function of temperature and electric field. A phase transformational sequence of cubic (C)${\rightarrow}$tetragonal (T)${\rightarrow}$rhombohedral (R) phase was observed in zero-field-cooled conditions; and a $C{\rightarrow}T{\rightarrow}$monoclinic $(M_C){\rightarrow}$ monoclinic ($M_A$) phase was observed in the field-cooled conditions. The transformation of T to $M_A$ phase was realized through an intermediate $M_C$ phase. The results also represent conclusive and direct evidence of a $M_C$ to $M_A$ phase transformation in field-cooled conditions. Beginning from the zero-field-cooled condition, a $R{\rightarrow}M_A{\rightarrow}M_C{\rightarrow}T$ phase transformational sequence was found with an increasing electric field at a fixed temperature. Upon removal of the field, the $M_A$ phase was stable at room temperature. With increasing the field, the transformation temperature from T to $M_C$ and from $M_C$ to $M_A$ phase decreased, and the phase stability ranges of both T and $M_C$ phases increased. Upon removal of the field, the phase transformation from R to $M_A$ phase was irreversible, but from $M_A$ to $M_C$ was reversible, which means that $M_A$ is the dominant phase under the electric field. In the M phase region, the results confirmed that lattice parameters and tilt angles were weakly temperature dependent over the range of investigated temperatures.