• IMMUNE NETWORK
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• v.20 no.5
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• pp.41.1-41.11
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• 2020

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) is a positive-sense single-stranded RNA (+ssRNA) that causes coronavirus disease 2019 (COVID-19). The viral genome encodes twelve genes for viral replication and infection. The third open reading frame is the spike (S) gene that encodes for the spike glycoprotein interacting with specific cell surface receptor - angiotensin converting enzyme 2 (ACE2) - on the host cell membrane. Most recent studies identified a single point mutation in S gene. A single point mutation in S gene leading to an amino acid substitution at codon 614 from an aspartic acid 614 into glycine (D614G) resulted in greater infectivity compared to the wild type SARS-CoV2. We were interested in investigating the mutation region of S gene of SARS-CoV2 from Korean COVID-19 patients. New mutation sites were found in the critical receptor binding domain (RBD) of S gene, which is adjacent to the aforementioned D614G mutation residue. This specific sequence data demonstrated the active progression of SARS-CoV2 by mutations in the RBD of S gene. The sequence information of new mutations is critical to the development of recombinant SARS-CoV2 spike antigens, which may be required to improve and advance the strategy against a wide range of possible SARS-CoV2 mutations.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.14 no.5
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• pp.109-119
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• 2004

The home network environment can be defined as a network environment, connecting digital home devices such as computer systems, digital appliances, and mobile devices. In this kind of home network environments, there will be numerous local/remote interactions to monitor and control the home network devices and the home gateway. Such an environment may result in communication bottleneck. By applying the mobile agents that can migrate among the computing devices autonomously and work on behalf of the user, remote interactions and network traffics can be reduced enormously. The mobile agent authentication is necessary to apply mobile agent concept to the home network environments, as a prerequisite technology for authorization or access control to the home network devices and resources. The existing mobile agent systems have mainly used the public key based authentication scheme, which is not suitable to the home network environments, composed of digital devices of limited computation capability. In this paper, we propose a shared key based mobile agent authentication scheme for single home domain and expand the scheme to multiple domain environments with the public key based authentication scheme. Application of the shared key encryption scheme to the single domain mobile agent authentication enables to authenticate the mobile agent with less overhead than the public key based authentication scheme.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.39 no.5
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• pp.544-555
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• 2002

The aim of this study is to develop the $^1H$-MRS data postprocessing software for both single-voxel and multi-voxel technique, which plays and important role as a diagnostic tool in clinical field. This software is based on graphical user interface(GUI) under windows operating system of personal computer(PC). In case of single-voxel MRS, both of raw data in time-domain and spectrum data in frequency-domain are simultaneously displayed in a screen. Several functions such as DC correction, zero filling, line broadening, Lorentz-Gauss filtering and phase correction, etc. are included to increase the quality of spectrum data. In case of multi-voxel analysis, spectroscopic image reconstructed by 3-D FFT was displayed as a spectral grid and overlapped over previously obtained T1- or T2-weighted image for the spectra to be spatially registered with the image. The analysis of MRS peaks were performed by obtaining the ratio of peak area. In single-voxel method, statistically processed peak-area ratios of MRS data obtained from normal human brain are presented. Using multi-voxel method, MR spectroscopic image and metabolite image acquired from brain tumor are demonstrated.

• Korean Journal of Optics and Photonics
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• v.23 no.1
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• pp.23-31
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• 2012

In this paper, we developed a frequency-domain diffuse optical imaging (DOI) system for imaging non-invasively using near-infrared (NIR) light sources and detectors. 70-MHz modulation and a homodyne scheme were adopted. By calibration of the coupling coefficients, concurrent detection measurements by 4 detector sets were optimized. We presented experimental reconstruction images of absorption and scattering coefficients in a liquid phantom, located an anomaly in the phantom and determined its optical properties. The images by the multi-channel concurrent detection were improved over the results by single-channel sequential detection. Tomographic slices of absorption and scattering coefficients in the phantom with an anomaly were also presented.

• Steel and Composite Structures
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• v.10 no.6
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• pp.541-561
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• 2010

This paper presents finite element analyses, experimental measurements and finite element model updating of an arch type steel laboratory bridge model using semi-rigid connections. The laboratory bridge model is a single span and fixed base structure with a length of 6.1 m and width of 1.1m. The height of the bridge column is 0.85 m and the maximum arch height is 0.95 m. Firstly, a finite element model of the bridge is created in SAP2000 program and analytical dynamic characteristics such as natural frequencies and mode shapes are determined. Then, experimental measurements using ambient vibration tests are performed and dynamic characteristics (natural frequencies, mode shapes and damping ratios) are obtained. Ambient vibration tests are performed under natural excitations such as wind and small impact effects. The Enhanced Frequency Domain Decomposition method in the frequency domain and the Stochastic Subspace Identification method in the time domain are used to extract the dynamic characteristics. Then the finite element model of the bridge is updated using linear elastic rotational springs in the supports and structural element connections to minimize the differences between analytically and experimentally estimated dynamic characteristics. At the end of the study, maximum differences in the natural frequencies are reduced on average from 47% to 2.6%. It is seen that there is a good agreement between analytical and experimental results after finite element model updating. Also, connection percentages of the all structural elements to joints are determined depending on the rotational spring stiffness.

• Journal of the Korean Magnetics Society
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• v.18 no.1
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• pp.28-31
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• 2008

We studied the effect of easy magnetization axis orientation with respect to the strip direction by measuring the magnetoresistance(MR), the magneto-optic Kerr effect(MOKE), and real-time domain evolution. The five strips were patterned on a single chip with the easy axis orientation of each strip relative to the longitudinal direction by around $0^{\circ}$, $18^{\circ}$, $36^{\circ}$, $54^{\circ}$ and $72^{\circ}$, respectively. The overall shape of field dependent MR was mostly governed by the anisotropy magnetoresistnace. The relative change of the longitudinal MR was significantly increased with increasing angle between the easy axis and strip direction, whereas, the transverse MR variation rate was decreased with increasing angle. Several MR steps were observed during the magnetization reversal, and the simultaneous measurement of the MOKE and the domain images identified that the MR steps were associated with evolution of the oppositely directed magnetic domain.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• v.2
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• pp.359-364
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• 2006

Interference can seriously degrade the performance of GPS receiver because GPS signal has extremely low power at earth surface. This paper presents a Narrowband Interference Excision Filter (NIEF) in frequency domain that removes narrowband interferences with small signal loss. A NIEF transforms the received GPS signals with interferences into the frequency domain with FFT and then compute statistics such as mean and standard deviation to determine an excision threshold. All spectrums exceeding the threshold are removed and the remaining spectrums are restored by IFFT. A NIEF effectively can remove various and strong interferences with a simple structure. However, the signal power loss is unavoidable during FFT and IFFT. Besides the hamming window and overlap technique, a threshold-whitening technique and an adaptive detection threshold are adopted to effectively reduce the signal power loss. The performance of implemented NIEF is evaluated using real signals obtained by 12 bit GPS signal acquisition board. The output of NIEF is fed into the Software Defined Receiver to evaluate the acquisition and tracking performance. Experimental results shows that many types of interference such as single-tone CWI, AM, FM, swept CWI and multi-tones CWI are effectively mitigated with small signal power loss.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.11 no.6
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• pp.115-125
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• 2001

Authentication and access control are essential requirements for the information security of distributed environment. Delegation is process whereby an initiator principal in a distributed environment authorizes another principal to carry out some functions on behalf of the former. Delegation of access rights also increases the availability of services offer safety in distributed environments. A delegation easily provides principal to grant privileges in the single domain with Role-Based Access Control(RBAC). But in the multi-domain, initiators who request delegation may require to limit the access right of their delegates with restrictions that are called delegate restriction to protect the abuse of privilege. In this paper, we propose the delegation view as function of delegation restrictions. Proposed delegation view model not only prevent over-exposure of documents from granting multiple step delegation to document sharing in multi-domain with RBAC infrastructure but also reduce overload of security administrator and communication.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.12
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• pp.6155-6157
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• 2012

Background: Mutations in the MAPK (Mitogen Activated Protein Kinase) signaling pathway - EGFR/Ras/RAF/MEK have been associated with the development of several carcinomas. ERK2, a downstream target of the MAPK pathway and a founding member of the MAPK family is activated by cellular signals emanating at the cell membrane. Activated ERK2 translocates into the nucleus to transactivate genes that promote cell proliferation. MKP - a dual specific phosphatase - interacts with activated ERK2 via the common docking (CD) domain of the later to inactivate (dephosphorylate) and effectively terminate further cell proliferation. A constitutively active form of ERK2 carrying a single point mutation - E322K in its CD domain, was earlier reported by our laboratory. In the present study, we investigated the prevalence of this CD domain E322K mutation in 88 well differentiated OSCC tissue samples. Materials and Method: Genomic DNA specimens isolated from 88 oral squamous cell carcinoma tissue samples were amplified with primers flanking the CD domain of the ERK2 gene. Subsequently, PCR amplicons were gel purified and subjected to direct sequencing to screen for mutations. Results: Direct sequencing of eighty eight OSCC samples identified an E322K CD domain mutation in only one (1.1%) OSCC sample. Conclusions: Our result indicates that mutation in the CD domain of ERK2 is rare in OSCC patients, which suggests the role of genetic alterations in other mitogenic genes in the development of carcinoma in the rest of the patients. Nevertheless, the finding is clinically significant, as the relatively rare prevalence of the E322K mutation in OSCC suggests that ERK2, being a common end point signal in the multi-hierarchical mitogen activated signaling pathway may be explored as a viable drug target in the treatment of OSCC.

• Proceedings of the Materials Research Society of Korea Conference
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• 1994.11a
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• pp.133-136
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• 1994

A microcechanical analysis based on the single fiber model has studied in the standpoint of stress-strain hysteresis response. A comparative study of constraint and unconstraint effects ha been taken into account to investigate includes the stress grouping technique to evaluate the domain-based field quantities. Results indicated that the development of significant fiber stresses both for the tensile and compressive loading, due to the constraint effects, provides an important contribution to the composited strengthening