• Radiation Oncology Journal
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• v.17 no.4
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• pp.275-280
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• 1999

Purpose : To assess the feasibility and the toxicity of the neoadjuvant chemotherapy on the treatment of patients with locoregionally advanced nasopharyngeal carcinoma. Methods and Materials : We analyzed 77 previously untreated and histologically confirmed advanced stage nasopharyngeal carcinoma patients treated with neoadjuvant chemotherapy followed by radiation therapy at the Seoul National University Hospital between 1984 and 1996. The stage distribution was as follows : AJCC stage III-2, stage IV-75. Sixty-six patients received infusion of 5-FU (1000 mg/m$^2$, on Day 1$\~$5) and cisplatin (100 mg/m$^2$, on Day 1), eleven patients received infusion of 5-FU (1000 mg/m$^2$, on Day 1 $\~$5) and carboplatin (300 mg/m$^2$, on Day 1) as neoadjuvant chemotherapy Prior to radiation therapy. The median follow-up for surviving patients was 44 months. Results : The overall chemotherapy response rates were 87$\%$. The toxicities of chemotherapy were mild. Only 3 patients experienced Grade 3 toxicities (1 for cytopenia, 2 for nause/vomiting). The degree of radiation induced mucositis was not severe, and ten patients developed Grade 2 mucositis. The 5-year overall survival rates were 68$\%$ and the 5-year disease free survival rates were 65$\%$. The 5-year freedom from distant metastasis rates were 82$\%$ and 5-year locoregional control rates were 75$\%$. Conclusion : This single institution experience suggests that neoadjuvant chemotherapy improves overall survival and disease free survival for patients with advanced stage nasopharyngeal carcinoma without increase of toxicity.

• Earthquakes and Structures
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• v.12 no.4
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• pp.397-407
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• 2017

To estimate the structural seismic demand, some methods are based on an equivalent linear system such as the Capacity Spectrum Method, the N2 method and the Equivalent Linearization method. Another category, widely investigated, is based on displacement correction such as the Displacement Coefficient Method and the Coefficient Method. Its basic concept consists in converting the elastic linear displacement of an equivalent Single Degree of Freedom system (SDOF) into a corresponding inelastic displacement. It relies on adequate modifying or reduction coefficient such as the inelastic deformation ratio which is usually developed for systems with known ductility factors ($C_{\mu}$) and ($C_R$) for known yield-strength reduction factor. The present paper proposes a rational approach which estimates this inelastic deformation ratio for SDOF bilinear systems by rigorous nonlinear analysis. It proposes a new inelastic deformation ratio which unifies and combines both $C_{\mu}$ and $C_R$ effects. It is defined by the ratio between the inelastic and elastic maximum lateral displacement demands. Three options are investigated in order to express the inelastic response spectra in terms of: ductility demand, yield strength reduction factor, and inelastic deformation ratio which depends on the period, the post-to-preyield stiffness ratio, the yield strength and the peak ground acceleration. This new inelastic deformation ratio ($C_{\eta}$) is describes the response spectra and is related to the capacity curve (pushover curve): normalized yield strength coefficient (${\eta}$), post-to-preyield stiffness ratio (${\alpha}$), natural period (T), peak ductility factor (${\mu}$), and the yield strength reduction factor ($R_y$). For illustrative purposes, instantaneous ductility demand and yield strength reduction factor for a SDOF system subject to various recorded motions (El-Centro 1940 (N/S), Boumerdes: Algeria 2003). The method accuracy is investigated and compared to classical formulations, for various hysteretic models and values of the normalized yield strength coefficient (${\eta}$), post-to-preyield stiffness ratio (${\alpha}$), and natural period (T). Though the ductility demand and yield strength reduction factor differ greatly for some given T and ${\eta}$ ranges, they remain take close when ${\eta}>1$, whereas they are equal to 1 for periods $T{\geq}1s$.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.23 no.2
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• pp.199-208
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• 2010

A friction damper installed at a building shows nonlinear behavior since its stick and slip states are occurred repeatedly depending on the amplitude of external loadings to dissipate input energy. Friction damping is existed for the building with a friction damper. In additionally viscous one is inherently included. Therefore, the building installed in such combined damping is quite involved to find the analytical solution. In this study, first, displacement and acceleration characteristics are identified based on the exact solution for a single-degree-freedom building with a friction damper having both friction and viscous damping. Second, in free vibration, the equivalent viscous damping ratio is obtained by the energy dissipation. Third, numerical analysis is carried out to find response configuration with various friction force ratios. Fourth, corresponding equivalent viscous damping ratio is derived with the finding that the response reaches into steady-state for both friction and viscous damped structure. It is deduced using balance of input external energy and output dissipation energy for steady-state response. Finally, the equivalent viscous damping ratios of free or harmonic vibration are verified through nonlinear analysis.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.5 no.3
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• pp.127-136
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• 1985

A simplified single degree of freedom analog with mass-spring-dashpot is proposed in this study. The simplified analog can describe the dynamic behavior of a rigid circular footings whose contact pressures are parabolic. The analog proposed in this study shows remarkable agreement when compared with the elastic half-space theory the analog is also compared with vertical vibration test results of model concrete footings. For the vibration experiments, 11 circular footings with different mass ratio are constructed. The elastic half-space is represented by compacted sand layer. A constant force excitation vibrator is used for the dynamic loading. The frequency range for vibration tests is 30 to 100 Hz. From the dynamic experiments, it is found that the measured resonant frequencies agree very well with the analog results, however, the ratio of theoretical and measured resonant amplitudes vary between 0.5 and 1.7. It is also found that, when the dynamic force is increased, the resonant frequency is decreased slightly and the resonant amplitude is increased slightly.