• Korean Journal of Clinical Pharmacy
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• v.31 no.2
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• pp.125-135
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• 2021

Background: Generally, pharmacokinetics (PK) models could be stratified into two models. The compartment PK model uses the concept of simple compartmentalization to describe complex bodies, and the physiologically based pharmacokinetic (PBPK) model describes the body using multi-compartment networking. Notwithstanding sharing a theoretical background in both models, there was still a lack of knowledge to enhance compatibility in both models. Objective: This study aimed to evaluate the compatibility among PBPK, lumping model and compartment PK model with voriconazole PK case study. Methods: The number of compartments and blood flow on each tissue in the PBPK model were modified using the lumping method, considering physiological similarities. The concentration-time profiles and area under the concentration-time curve (AUC) parameters were simulated at each model, assuming taken voriconazole oral 400 mg single dose. After that, those mentioned PK parameters were compared. Results: The PK profiles and parameters of voriconazole in the three models were similar that proves their compatibility. The AUC of central compartment in the PBPK and lumping model was within a 2-fold range compared to those in the 2- compartment model. The AUC of non-eliminating tissues compartment in the PBPK model was similar to those in the lumping model. Conclusion: Regarding the compatibility of the three PK models, the utilization of the lumping method was confirmed by suggesting its reliable PK parameters with PBPK and compartment PK models. Further case studies are recommended to confirm our findings.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.5 no.1
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• pp.29-37
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• 2007

A conventional single compartment model cannot simulate reasonably the migration phenomenon of contaminants through unsaturated zone, due to the intrinsic unrealistic assumption of the compartment model that contaminants entering a compartment are immediately and uniformly mixed. Although, a multi-compartments model, in which even physically identical layer is divided into multiple compartments, may be used for explaining the retardation of contaminant mass flux along with increasing number of compartments, its numerical modeling is usually time-consuming and appropriate analytical solutions have not been reported yet. In order to improve the conventional compartment models on contaminant migration through unsaturated zone, a series of analytical solutions for multi-compartments model were derived and a generalized constraint under which the results from multi-compartments model can be simply approximated by single compartment model was proposed. The simplified approximation method was verified by a simple numerical analysis on the constraint under hypothetical conditions. It was also proved that the influent contaminant transfer rate from the bulk unsaturated zone can be generally represented into a time-dependent nominal transfer rate rather than a constant. In addition, the nominal transfer rate turned out to be very sensitive to the contaminant transfer rate between compartments in unsaturated zone, but to be almost insensitive to the transfer rate from contaminated zone. It is expected that the simplified approximation method developed in this study can be used for rapid and reasonable estimation of the migration phenomenon of contaminant through unsaturated zone, instead of time-consuming multi-compartments modeling.

• Journal of fish pathology
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• v.21 no.2
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• pp.119-127
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• 2008

Oxytetracycline (OTC) has been widely used in eel culture as a therapeutic and prophylactic agent because of its broad-spectrum activity against gram-positive and -negative bacteria. The oral treatment dosage of OTC approved for the treatment of edwardsiellosis, furunculosis and vibriosis in eel is 50 mg/kg/day for 3-7 days in Korea. To determine new optimum dose of OTC in eel, the pharmacokinetics of OTC after single oral administration (100 mg/kg B.W., 200 mg/kg B.W.) in cultured eel, Anguilla japonica was examined. In oral dosage of 100 and 200 mg/kg body weight, the highest plasma concentrations of OTC were 1.19±0.42 ㎍/㎖ and 2.69±0.57 ㎍/㎖, respectively. Plasma concentrations of OTC were not detected after 720 h post-dose in all experiments. The kinetic profile of absorption, distribution and elimination of OTC in plasma wwas calculated fitting to a 1- and 2-compartment model by WinNonlin program. The following parameters were obtained for a single dosage of 100 and 200 mg/kg respectively: 1-compartment model, AUC= 82.48 and 432.68 ㎍*h/㎖, Tmax= 3.93 and 14.24 hr, Cmax= 0.94 and 2.34 ㎕/㎖; 2-compartment model, AUC= 448.73 and 530.65 ㎍*h/㎖, Tmax= 6.37 and 8.96 hr, Cmax= 0.90 and 3.21 ㎕/㎖.

• The Korean Journal of Nuclear Medicine
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• v.29 no.1
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• pp.48-53
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• 1995

This study investigates a simple mathematical model for the quantitative estimation of regional myocardial blood flow in experimental canine coronary artery thrombosis using Rb-82 dynamic myocardial positron emission tomography. The coronary thrombosis was induced using the new catheter technique by narrowing the lumen of coronary vessel gradually, which finally led to partial obstruction of coronary artery. Ten Rb-82 dynamic myocardial PET scans were performed sequentially for each experiment using our 5, 10 and 20 second acquisition protocol, respectively, and three regions of interest were drawn on the transaxial slices, one on left ventricular chamber for input function and the other two on normal and decreased perfusion segments for the flow estimation in those regions. Single compartment model has been applied to the measured sets of regional PET data, and the rate constants of influx to myocardial tissue were calculated for regional myocardial flow estimates with the three parameter fits of raw data by the Levenberg-Marquardt method. The results showed that, (1) single compartment model suggested by Kety-Schmidt could be used for the simple estimation of regional myocardial blood flow, (2) the calculated regional myocardial blood flow estimates were dependent on the selection of input function, which reflected partial volume effect and left ventricular wall motion, and (3) mathematically fitted input and tissue time activity curves were more suitable than the direct application of the measured data in terms of convergence.

• Proceedings of the Korea Institute of Fire Science and Engineering Conference
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• 2008.04a
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• pp.290-293
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• 2008

In this study, the Computational Fluid Dynamics (CFD) has been used to analyze the smoke movement and the carbon monoxide concentration distribution, both vertically and longitudinally, in a compartment, based on conservation laws. The Fire Dynamics Simulator (FDS) developed by National Institute of Standards and Technology (NIST) was used for numerical simulations using Reynolds averaged Navier-Stokes equations (RANS) model to solve for time-averaged properties. Results show, as a function of time, a detailed distribution of temperature and carbon monoxide concentration changing against the height above the floor and those changes alongside the distance away from the fire source. Fire-induced smoke and toxic gases like CO are more dangerous in a confined space. The result of study may contribute in designing the smoke evacuation system based on the precise tenable condition.

• Nuclear Engineering and Technology
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• v.43 no.3
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• pp.271-278
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• 2011

When performing fire PSA in a nuclear power plant, an event mapping method, using an internal event PSA model, is widely used to reduce the resources used by fire PSA model development. Feasible initiating events and component failure events due to fire are identified to transform the fault tree (FT) for an internal event PSA into one for a fire PSA using the event mapping method. A surrogate event or damage term method is used to condition the FT of the internal PSA. The surrogate event or the damage term plays the role of flagging whether the system/component in a fire compartment is damaged or not, depending on the fire being initiated from a specified compartment. These methods usually require explicit states of all compartments to be modeled in a fire area. Fire event scenarios, when using explicit identification, such as surrogate or damage terms, have two problems: (1) there is no consideration of multiple fire propagation beyond a single propagation to an adjacent compartment, and (2) there is no consideration of simultaneous fire propagations in which an initiating fire event is propagated to multiple paths simultaneously. The present paper suggests a fire propagation equation to identify all possible fire event scenarios for an explicitly treated fire event scenario in the fire PSA. Also, a method for separating fire events was developed to make all fire events a set of mutually exclusive events, which can facilitate arithmetic summation in fire risk quantification. A simple example is given to confirm the applicability of the present method for a $2{\times}3$ rectangular fire area. Also, a feasible asymptotic approach is discussed to reduce the computational burden for fire risk quantification.

• Journal of the Korea Society for Simulation
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• v.26 no.3
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• pp.1-11
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• 2017

Blast injuries in a compartment are investigated, and the effects of obstacles on blast injury are particularly analyzed by comparing injuries in the compartments with or without protruding obstacles inside. Even if blast pressure profile tends to be complicated in a confined space unlike in open field, it can be obtained in a relatively short time by using some empirical fast running models for simple confined spaces. However, a finite element method should be employed to obtain blast pressure profiles in a case with obstacles in confined spaces, because the obstacles heavily disturb blast waves. On the other hand, Axelsson SDOF(Single degree of freedom) model and ASII(Adjusted severity of injury index) injury level are employed to estimate blast injury in compartments, because the usual pressure-impulse injury criterion based on the ideal Friedlander waves in open the field cannot be applied to personnel in a confined space due to complexity of blast waves inside. In cases with obstacles, chest wall velocity was reduced by 26 to 76 percent(%) and the personnel injury in the compartment caused by blast was also reduced.

• Journal of Radiation Protection and Research
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• v.8 no.2
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• pp.8-14
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• 1983

The doses to Korean adult by a single and chronic intake of tritiated water are determined using a three compartment model, which describes the retention of tritium radionuclide in body water and in bound organic form in the body. The results show that the total dose of a single intake, using retention half-time for the three-compartment of 9, 30, and 450 days, is 17.64 mrads ($176.4{\mu}Gy$) per 1mCi/kg ($3.7{\times}10^7Bq/kg$) intake, 97% of which is due to tritium in body water and 3% to bound tritium in tissue. In the chronic intake of 1mCi/day($3.7{\times}10^7Bq/day$) tritiated water, the total dose is 85.5 mrad/day(0.855mGy/day). Furthermore, in this study (MPC) a and (MPC)w values of tritium for Korean man are calculated by using the modified formula originated from ICRP Publication-2. From the results, we found that the (MPC) a, w values of ICRP underestimated approximately 50%, the (MPC)a, w values of Korean man must be elevated as high as approximately 50% than that of ICRP.

• Journal of KSNVE
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• v.8 no.2
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• pp.239-250
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• 1998

Traditionally, intake noise from internal combustion engine has not recevied much attention compared to exhaust noise. But nowadays, intake noise is a major contributing factor to automotive passenger compartment noise levels. The main objective of this paper is to identify the mechanism of generation, propagation and radiation of the intake noise. With a simplest geometric model, one of the main noise sources for the intake stroke is found to be the pressure surge, which is generated after intake valve closing. The pressure surge, which has the nonlinear acoustic behavior, propagates and radiates with relatively large amplitude. In this paper, unsteady compressible Navier-Stokes equations are employed for the intake stroke of axisymmetric model having a single moving cylinder and a single moving intake valve. To simulate the periodic motion of the piston and the valve, unsteady deforming mesh algorithm is employed and Thompson's non-reflecting boundary condition is applied to the radiation field. In order to resolve the small amplitude waves at the radiation field, essentially non-oscillatory(ENO) schemes with an artificial compression method (ACM) are used.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.52 no.2
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• pp.88-95
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• 2016

Most grid sorting has been used to sort out flatfish in shrimp fisheries, while double grid systems have been tested to separate smaller shrimp. The escape of juvenile red seabream through separating panels made with steel grids or large mesh tested for masking effects in a two-species system. Fish behavior was observed in a circulating water tank. The escape rate was 20% greater with the separating codends than with the normal codend in the single-species experiments. The rates in the two-species experiments were 30% or 20% greater than the single-species rates for the normal or separating codends, respectively. The seabream retention rates in the grid separator codend decreased as rockfish retention increased, possibly due to a threat effect. Conversely, the retention rate of both species increased concurrently in the net separator, possibly due to a masking effect. The escape rates of juvenile red seabream varied by compartment in the mesh separating codend. These results suggest that grid separating codends can be used in the field as towed fishing gear to reduce juvenile catch.