• Journal of Nutrition and Health
• /
• v.50 no.3
• /
• pp.217-224
• /
• 2017

Purpose: Although it is well known thatmortality and morbidity due to cardiovascular diseases are higher in salt-sensitive subjects than in salt-resistant subjects, their underlying mechanisms related to obesity remain unclear. Here, we focused on salt-sensitive gene variants unrelated to monogenic obesity that interacted with sodium intake in humans. Methods: This review was written based on the modified $3^rd$ step of Khans' systematic review. Instead of the literature, subject genes were based on candidate genes screened from our preliminary Genome-Wide Association Study (GWAS). Finally, literature related to five genes strongly associated with salt sensitivity were analyzed to elucidate the mechanism of obesity. Results: Salt sensitivity is a measure of how blood pressure responds to salt intake, and people are either salt-sensitive or salt-resistant. Otherwise, dietary sodium restriction may not be beneficial for everyone since salt sensitivity may be associated with inherited susceptibility. According to our previous GWAS studies, 10 candidate genes and 11 single nucleotide polymorphisms (SNPs) associated with salt sensitivity were suggested, including angiotensin converting enzyme (ACE), ${\alpha}$-adducin1 (ADD1), angiotensinogen (AGT), cytochrome P450 family 11-subfamily ${\beta}$-2 ($CYP11{\beta}$-2), epithelial sodium channel (ENaC), G-protein b3 subunit (GNB3), G protein-coupled receptor kinases type 4 (GRK4 A142V, GRK4 A486V), $11{\beta}$-hydroxysteroid dehydrogenase type-2 (HSD $11{\beta}$-2), neural precursor cell-expressed developmentally down regulated 4 like (NEDD4L),and solute carrier family 12(sodium/chloride transporters)-member 3 (SLC 12A3). We found that polymorphisms of salt-sensitive genes such as ACE, $CYP11{\beta}$-2, GRK4, SLC12A3, and GNB3 may be positively associated with human obesity. Conclusion: Despite gender, ethnic, and age differences in genetics studies, hypertensive obese children and adults who are carriers of specific salt-sensitive genes are recommended to reduce their sodium intake. We believe that our findings can contribute to the prevention of early-onset of chronic diseases in obese children by facilitating personalized diet-management of obesity from childhood to adulthood.

• Experimental and Molecular Medicine
• /
• v.50 no.12
• /
• pp.11.1-11.9
• /
• 2018

Estrogen has diverse effects on cardiovascular function, including regulation of the contractile response to vasoactive substances such as serotonin. The serotonin system recently emerged as an important player in the regulation of vascular tone in humans. However, hyperreactivity to serotonin appears to be a critical factor for the pathophysiology of hypertension. In this study, we examined the modulatory mechanisms of estrogen in serotonin-induced vasoconstriction by using a combinatory approach of isometric tension measurements, molecular biology, and patch-clamp techniques. $17{\beta}$-Estradiol (E2) elicited a significant and concentration-dependent relaxation of serotonin-induced contraction in deendothelialized aortic strips isolated from male rats. E2 triggered a relaxation of serotonin-induced contraction even in the presence of tamoxifen, an estrogen receptor antagonist, suggesting that E2-induced changes are not mediated by estrogen receptor. Patch-clamp studies in rat arterial myocytes showed that E2 prevented Kv channel inhibition induced by serotonin. Serotonin increased Src activation in arterial smooth muscle required for contraction, which was significantly inhibited by E2. The estrogen receptor-independent inhibition of Src by E2 was confirmed in HEK293T cells that do not express estrogen receptor. Taken together, these results suggest that estrogen exerts vasodilatory effects on serotonin-precontracted arteries via Src, implying a critical role for estrogen in the prevention of vascular hyperreactivity to serotonin.

• The Journal of the Acoustical Society of Korea
• /
• v.40 no.4
• /
• pp.359-369
• /
• 2021

In underwater communications, to compensate performance degradation induced from rapidly changing channel transfer characteristic, multi-band communication method which allocate the same data to different frequency bands is used. However, the multi-band configuration may have worse performance than the single-band one because performance degradation in a particular band affects the output from the entire bands. This problem can be solved through a receiving end that analyzes error rates of each band, sets threshold values and allocates lower weights to inferior bands. Therefore, this paper proposed a weighting algorithm based on estimated Bit Error Rate (BER) which analyzes reliability of received data based on the performance difference between demodulated and decoded data. Employing turbo codes with coding rate of 1/3, we evaluate the performance of the proposed weighted multi-band transmission model in real underwater environments based on optimal simulation parameters. Through the sea trial experiment, we confirmed error performance was improved by applying the proposed weighting algorithm.

• International Journal of Advanced Culture Technology
• /
• v.10 no.3
• /
• pp.146-155
• /
• 2022

The purpose of this study is to investigate the recyclability of Shenlong in China using SWOT. The main analysis results are as follows. First, provided that the company's current capacity utilization rate is seriously insufficient, reducing staff is one among the effective ways. Second, Shenlong should open a web store to cater to young people's online shopping behavior, and further expand the brand visibility using national mainstream media and online shopping platforms like Taobao and JingDong to market Dongfeng Peugeot and Dongfeng Citroen on the whole network. Third, under the premise of maintaining the present best-selling models, Shenlong should appropriately reduce the amount of models, adjust the assembly capacity ratio of every model and every displacement in real time per the newest market trends, increase the agility of auto companies' production, and timely meet the wants of domestic consumers. Fourth, dual-brand coordination and channel integration are very necessary, and also the profitability and profitability of dealers are going to be further improved, thereby increasing sales. Fifth, target building new energy leading products of Shenlong, strive to attain the forefront of the industry within the sales of recent energy vehicles within 5 years, and gradually expand new energy vehicle products from passenger vehicles to passenger vehicles and commercial vehicles. Finally, the marketing field of Shenlong Automobile should achieve "three major changes", that is, change from a goal-driven type to a demand-driven type, cancel the bundling of outlet invoicing goals and delivery incentive tiers; start from basic capabilities, and set pragmatic and challenging goals; focus Channels, to realize following the activation of outlets, and single store sales increase.

• Smart Structures and Systems
• /
• v.29 no.2
• /
• pp.301-309
• /
• 2022

Protective coatings are most widely used anticorrosive structures for steel structures. The corrosion under the coating damages the host material, but this damage is completely hidden. Therefore, a field-applicable under-coating-corrosion visualization method has been desired for a long time. Laser ultrasonic technology has been studied in various fields as an in situ nondestructive inspection method. In this study, a comparative analysis was carried out between a guided-wave ultrasonic propagation imager (UPI) and pulse-echo UPI, which have the potential to be used in the field of under-coating-corrosion management. Both guided-wave UPI and pulse-echo UPI were able to successfully visualize the corrosion. Regarding the field application, the guided-wave UPI performing Q-switch laser scanning and piezoelectric sensing by magnetic attachment exhibited advantages owing to the larger distance and incident angle in the laser measurement than those of the pulse-echo UPI. Regarding the corrosion visualization methods, the combination of adjacent wave subtraction and variable time window amplitude mapping (VTWAM) provided acceptable results for the guided-wave UPI, while VTWAM was sufficient for the pule-echo UPI. In addition, the capability of multiple sensing in a single channel of the guided-wave UPI could improve the field applicability as well as the relatively smaller size of the system. Thus, we propose a guided-wave UPI as a tool for under-coating-corrosion management.

• Journal of Advanced Navigation Technology
• /
• v.27 no.2
• /
• pp.203-208
• /
• 2023

In this study, we propose a method to improve the precision of contact resistance measurement circuits using constant current method and voltage drop method, and implement a dashboard that monitors the measured data of contact resistance measurement systems through MQTT broker server. The contact resistance measurement system measures the resistance value and transmits the measured value to the MQTT broker server using wireless communications. This developed dashboard uses Node-RED and Node-RED-Dashboard to receive the resistance values of up to four contact resistance measurement systems and show them to user's monitor screen. Users can manage multiple measurement data using a single dashboard and easily interface with other devices through the MQTT broker server. Through the experimental results from real data measurements, the relative standard deviation about precision is improved to average 40.37% and maximum 64.73% respectively.

• Transactions of the Korean Society of Pressure Vessels and Piping
• /
• v.18 no.2
• /
• pp.37-42
• /
• 2022

An influence analysis on multiple steam generator tube rupture (mSGTR) followed by an unmitigated station blackout is performed to compare the plant responses according to the number of ruptured u-tubes under the assumption of a total of 10 ruptured u-tubes. In all calculation cases, the transient behaviour of major thermal-hydraulic parameters, such as the discharge flow rate through the ruptured u-tubes, reactor header pressure, and void fraction in the fuel channels is found to be overall similar to that of the base case having a single SG with 10 u-tubes ruptured. Additionally, as the conditions of low-flow coolant with high void fraction in the broken loop continued, causing the degradation of decay heat removal, the peak cladding temperature (PCT) would be expected to exceed the limit criteria for ensuring nuclear fuel integrity. However, despite the same total number of ruptured u-tubes, because of the different connection configuration between the SG and pressurizer, a difference is foud in time between the pressurizer low-level signal and reactor header low-pressure signal, affecting the time to trip the reactor and to reach the PCT limit. The present study is expected to provide the technical basis for the accident management strategy for mSGTR transient conditions of CANDU-6 plants.

• Journal of Life Science
• /
• v.25 no.8
• /
• pp.953-959
• /
• 2015

Optogenetics is the combination of optical and molecular strategies to control designated molecular and cellular activities in living tissues and cells using genetically encoded light-sensitive proteins. It involves the use of light to rapidly gate the membrane channels that allows for ion movement. Optogenetics began with the placing of light-sensitive proteins from green algae inside specific types of brain cells. The cells can then be turned on or off with pulses of blue and yellow light. Using the naturally occurring algal protein Channelrhodopsin-2 (ChR2), a rapidly gated light-sensitive cation channel, the number and frequency of action potentials can be controlled. The ChR2 provides a way to manipulate a single type of neuron while affecting no others, an unprecedented specificity. This technology allows the use of light to alter neural processing at the level of single spikes and synaptic events, yielding a widely applicable tool for neuroscientists and biomedical engineers. An improbable combination of green algae, lasers, gene therapy and fiber optics made it possible to map neural circuits deep inside the brain with a precision that has never been possible before. This will help identify the causes of disorders like depression, anxiety, schizophrenia, addiction, sleep disorder, and autism. Optogenetics could improve upon existing implanted devices that are used to treat Parkinson’s disease, obsessive-compulsive disorder and other ailments with pulses of electricity. An optogenetics device could hit more specific subsets of brain cells than those devices can. Applications of optogenetic tools in nonneuronal cells are on the rise.

• Journal of the Korean Institute of Gas
• /
• v.21 no.4
• /
• pp.92-102
• /
• 2017

Fischer-Tropsch synthesis reaction converts syngas (mixture of CO and H2) to valuable hydrocarbon products. Simulation of low temperature Fischer -Tropsch Synthesis reaction and heat transfer at intensified process condition using catalyst filled single and multichannel microchannel reactor is considered. Single channel model simulation indicated potential for process intensification (higher GHSV of $30000hr^{-1}$ in presence of theoretical Cobalt based super-active catalyst) while still achieving CO conversion greater than ~65% and $C_{5+}$ selectivity greater than ~74%. Conjugate heat transfer simulation with multichannel reactor block models considering three different combinations of reactor configuration and coolant type predicted ${\Delta}T_{max}$ equal to 23 K for cross-flow configuration with wall boiling coolant, 15 K for co-current flow configuration with subcooled coolant, and 13 K for co-current flow configuration with wall boiling coolant. In the range of temperature maintained (498 - 521 K), chain growth probability calculated is desirable for low-temperature Fisher-Tropsch Synthesis.

• Journal of Advanced Navigation Technology
• /
• v.14 no.5
• /
• pp.684-690
• /
• 2010

Recently, the NG(Next Generation) system is studied for supporting convergence of various services and multi mode of single terminal. And a demand of user for taking the various services is getting increased, for supporting these services, many systems being able to transmit a large message have been appeared. In the NG system, it has to be supporting the CDMA and WCDMA besides the tele communication systems using OFDM method with single terminal An intergrated system can be improved with adopting of SoC technique. For adopting SoC technique on the intergrated terminal, we have to solve the non linear problem of HPA(High Power Amplifier). Nonlinear characteristic of HPA distorts both amplitude and phase of transmit signal, this distortion cause deep adjacent channel interference. We adopt a polynomial pre-distortion technique for this problem. In this paper, a noble modem design for NG mobile communication service and a method using polynomial pre-distorter with PAPR technique for counterbalancing nonlinear characteristic of the HPA are proposed.