• Journal of Life Science
• /
• v.18 no.6
• /
• pp.764-769
• /
• 2008

Mutations in the human connexin 32 (Cx32) gene are responsible for X-linked Charcot-Marie-Tooth (CMTX) disease. Although over 300 different mutations have been identified the detailed molecular etiology of CMTX disease is poorly understood. Several studies reported that connexin membrane channels share most biophysical properties with their parental gap junction channels. In this study, two connexin mutant membrane channels (one mutant channel called the M34T channel in which the methionine residue at the $34^{th}$ position of the Cx32 protein is replaced with threonine residue and the other mutant channel called the T86C channel in which the threonine residue at the $86^{th}$ position is replaced with cysteine residue) associated with CMTX mutations were characterized at the single-channel level instead of using mutant gap junction channels. The biophysical properties of the M34T channel were very similar to those of the gap junction channel formed by M34T mutation. In addition, the mutant membrane channel study revealed the reversal of the gating polarity, the loss of fast gating and the gain of slow gating. The T86C channel also behaves like its parental wild type Cx32 membrane channel. Taken together, these results suggest that a study using connexin membrane channels is useful to characterize CMTX mutants.

• Korean Journal of Remote Sensing
• /
• v.29 no.1
• /
• pp.95-104
• /
• 2013

In this study, a novel method is proposed for retrieving relative surface temperature from single-channel middle infra-red (MIR, 3-5 ${\mu}m$) remotely sensed data. In order to retrieve absolute temperature from MIR data, it is necessary to accommodate at least atmospheric effects, surface emissivity and reflected solar radiance. Instead of retrieving kinematic temperature of each target, we propose an alternative to retrieve the relative temperature between two targets. The core idea is to minimize atmospheric effects by assuming that the differential at-sensor radiance between two targets experiences the same atmospheric effects. To reduce effective simplify atmospheric parameters, each atmospheric parameter was examined by MODTRAN and MIR emissivity derived from ASTER spectral libraries. Simulation results provided a required accuracy of 2 K for materials with a temperature of 300 K within 0.1 emissivity errors. The algorithm was tested using MODIS band 23 MIR day time images for validation. The accuracy of retrieved relative temperature was $0.485{\pm}1.552$ K. The results demonstrated that the proposed algorithm was able to produce relative temperature with a required accuracy from only single-channel radiance data. However, this method has limitations when applied to materials having very low temperatures using day time MIR images.

• Journal of the Institute of Electronics Engineers of Korea SP
• /
• v.42 no.3 s.303
• /
• pp.31-40
• /
• 2005

In this paper, we develop an approach toward JSC(Joint Source-Channel Coding) method for MPEG-4 based FGS(Fine Granular Scalability) video coding and transmission in fixed and mobile receiving environment(Digital Audio Broadcasting, DAB). The source coder used MPEG-4 FGS video codec, the channel coder used RCPC(Rate Compatible Punctured Convolution) code and the modulation method used QPSK modulation. We have considered channel environment of AWGN and mobile receiving environment. This study determined optimum Trade-off point between source bit rate and channel coding rate in variable channel states. We compared FGS-JSC method and general single layer CBR(Constant Bit Rate) transmission. In this results, FGS-JSC was appeared better performance than CBR transmission.

• Parasites, Hosts and Diseases
• /
• v.59 no.4
• /
• pp.329-339
• /
• 2021

Ion channels are important targets of anthelmintic agents. In this study, we identified 3 types of ion channels in Ascaris suum tissue incorporated into planar lipid bilayers using an electrophysiological technique. The most frequent channel was a large-conductance cation channel (209 pS), which accounted for 64.5% of channels incorporated (n=60). Its open-state probability (P_o) was ~0.3 in the voltage range of -60~+60 mV. A substate was observed at 55% of the main-state. The permeability ratio of Cl^- to K⁺ (P_Cl/P_K) was ~0.5 and P_Na/P_K was 0.81 in both states. Another type of cation channel was recorded in 7.5% of channels incorporated (n=7) and discriminated from the large-conductance cation channel by its smaller conductance (55.3 pS). Its Po was low at all voltages tested (~0.1). The third type was an anion channel recorded in 27.9% of channels incorporated (n=26). Its conductance was 39.0 pS and P_Cl/P_K was 8.6±0.8. P_o was ~1.0 at all tested potentials. In summary, we identified 2 types of cation and 1 type of anion channels in Ascaris suum. Gating of these channels did not much vary with voltage and their ionic selectivity is rather low. Their molecular nature, functions, and potentials as anthelmintic drug targets remain to be studied further.

• Nuclear Engineering and Technology
• /
• v.56 no.2
• /
• pp.558-567
• /
• 2024

Diagnostic support systems are being researched to assist operators in identifying and responding to abnormal events in a nuclear power plant. Most studies to date have considered single abnormal events only, for which it is relatively straightforward to obtain data to train the deep learning model of the diagnostic support system. However, cases in which multiple abnormal events occur must also be considered, for which obtaining training data becomes difficult due to the large number of combinations of possible abnormal events. This study proposes an approach to maintain diagnostic performance for multiple abnormal events by training a deep learning model with data on single abnormal events only. The proposed approach is applied to an existing algorithm that can perform feature selection and multi-label classification. We choose an extremely randomized trees classifier to select dedicated monitoring parameters for target abnormal events. In diagnosing each event occurrence independently, two-channel convolutional neural networks are employed as sub-models. The algorithm was tested in a case study with various scenarios, including single and multiple abnormal events. Results demonstrated that the proposed approach maintained diagnostic performance for 15 single abnormal events and significantly improved performance for 105 multiple abnormal events compared to the base model.

• Proceedings of the KSME Conference
• /
• 2000.04b
• /
• pp.25-30
• /
• 2000

Plate and shell heat exchanger(P&SHE) has been applied to the refrigeration and air conditioning systems as evaporators or condensers fur their high efficiency and compactness. The purpose of this study is to analyze the characteristics of pressure drop in plate and shell heat exchanger. An experiment for single phase (low pressure drop in plate and shell heat exchanger was performed. Also numerical work was conducted using the FLUENT code for $ {\kappa}-{\varepsilon}$ model. The dependence of friction factor on geometrical Parameters was numerically investigated. The study examines the internal flow and the pressure distribution in the channel of plate and shell heat exchanger. The results of CFD analysis compared with experimental data, and the difference of frictor factor in plate side and shell side are 10% and 12%, respectively. Therefore, the CFD analysis model is effectively predict the performance of plate and shell heat exchanger.

• 한국전산유체공학회:학술대회논문집
• /
• 2005.10a
• /
• pp.93-97
• /
• 2005

Air interlacing serves to protect the yarn against damage, strengthens inter-filament compactness or cohesion, and ensures fabric consistency. The air interlacing nozzle is used to introduce intermittent nips to a filament yarn so as to improve its performance in textile processing. This study investigates the effect of interlacing nozzle geometry on the interlacing process. The geometries of interlacing nozzles with multiple air inlets located across the width of a yarn channels are investigated. The basic interlacing nozzle is the yarn channel, with a perpendicular single air inlet in the middle. The yarn channel shapes are cross sections with semicircular or rectangular shapes. This paper presents three doubled sub air inlets with main air inlet and one of them is slightly inclined doubled sub air inlets with main air inlet. The compressed air coming out from the inlet hits the opposing wall of the yarn channel, divides into two branches, flows trough the top side of yarn channel, joins with the compressed air coming out from the sub air inlet and then creates two free jets at both ends of the yarn channel. The compressed air moves in the shape of two opposing directional vortices. The CFD-FASTRAN was used to perform steady simulations of impinging jet flow inside of the interlace nozzles. The vortical structure and the flow pattern such as pressure contour, particle traces, velocity vector plots inside of interlace nozzle geometry are discussed in this paper.

• Transactions of the Korean Society of Automotive Engineers
• /
• v.12 no.2
• /
• pp.91-100
• /
• 2004

Plate heat exchangers (PHE) have been widely used in different industrial applications, because of high heat transfer efficiency per unit volume. Basic study is performed for PHE to the application of intercooler in automobile. In order to understand the flow phenomena in the plate heat exchanger, a channel which was formed by the upper and lower plate in single plate was considered as calculation domains. Because chevrons attached on the upper plate are brazed with chevrons attached on the lower plate, the flow channel has very complex configuration. This complex geometry was analyzed by Fluent. In order to validate this methodology the proper experimental and theoretical data are collected and compared with numerical results. Finally, due to the lack of experimental values for PHE to the application of intercooler, various chevron angles and air velocities at inlet were tested in terms of physical phenomena. From this point of view, results of velocity vector, path lines, static pressure, heat flux, heat transfer coefficient, and Nusselt number are physically reasonable and accepted for the solutions. From these results, the correlations for pressure drop and Nusselt number with respect to chevron angle and Reynolds number in specific PHE are obtained for the design purpose. Thus, the methodology of the flow analysis in the full geometry of the channel was established for the predictions of performance in plate heat exchanger.

• Journal of Korea Multimedia Society
• /
• v.4 no.1
• /
• pp.75-81
• /
• 2001

A EBCOT(Embedded Block Coding with Optimized Truncation) is image compression codec using in JPEG2000, currently the new standard for still image coding. this paper proposes multi-channel video transfer system with EBCOT using a single codec to transfer video to difference band-width channel. This parer testify that compression rate of EBCOT higher than ordinary VLC using RLC and Huffman codec and apply EBCOT to JPEG structure. this structure increases parallelism and error resilience using black coding method. finally it looks into difficult to apply MPEG structure to multi channel video transfer system, and proposes solution using EBCOT.

• 한국전산유체공학회:학술대회논문집
• /
• 2006.05a
• /
• pp.395-397
• /
• 2006

Air interlacing serves to protect the yarn against damage, strengthens inter-filament compactness or cohesion, and ensures fabric consistency. The air interlacing nozzle is used to introduce intermittent nips to a filament yarn so as to improve its performance in textile processing. The effect of various interlacing nozzle geometries on the interlacing process was studied. The geometries of interlacing nozzles with single or multiple air inlets located across the width of yarn channels are investigated. The basis case is the yarn channel, with a perpendicular main air inlet in the middle. Other cases have main air inlets, slightly inclined double sub air inlets, The yarn channel cross sectional shapes are either semicircular or rectangular shapes. The compressed impinging jet from the main air inlet hole hits the opposing bottom wall of the yarn channel, is divided into two branches, joins with the compressed air coming out from sub air inlet at the bottom and creates two free jets at both ends of the yarn channel. The compressed air movement in the cross-section consists of two opposing directional vortices. The CFD-FASTRAN flow parallel solver was used to perform steady simulations of impinging jet flow inside of the interlace nozzles. The vortical structure and the flow pattern such as pressure contour, particle traces, velocity vector plots inside of interlace nozzle geometry are discussed in this pater.