• BMB Reports
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• v.54 no.6
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• pp.311-316
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• 2021

Ethanol often causes critical health problems by altering the neuronal activities of the central and peripheral nerve systems. One of the cellular targets of ethanol is the plasma membrane proteins including ion channels and receptors. Recently, we reported that ethanol elevates membrane excitability in sympathetic neurons by inhibiting Kv7.2/7.3 channels in a cell type-specific manner. Even though our studies revealed that the inhibitory effects of ethanol on the Kv7.2/7.3 channel was diminished by the increase of plasma membrane phosphatidylinositol 4,5-bisphosphate (PI(4,5)P₂), the molecular mechanism of ethanol on Kv7.2/7.3 channel inhibition remains unclear. By investigating the kinetics of Kv7.2/7.3 current in high K⁺ solution, we found that ethanol inhibited Kv7.2/7.3 channels through a mechanism distinct from that of tetraethylammonium (TEA) which enters into the pore and blocks the gate of the channels. Using a non-stationary noise analysis (NSNA), we demonstrated that the inhibitory effect of ethanol is the result of reduction of open probability (P_O) of the Kv7.2/7.3 channel, but not of a single channel current (i) or channel number (N). Finally, ethanol selectively facilitated the kinetics of Kv7.2 current suppression by voltage-sensing phosphatase (VSP)-induced PI(4,5)P₂ depletion, while it slowed down Kv7.2 current recovery from the VSP-induced inhibition. Together our results suggest that ethanol regulates neuronal activity through the reduction of open probability and PI(4,5)P₂ sensitivity of Kv7.2/7.3 channels.

• Proceedings of the KIEE Conference
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• 2007.07a
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• pp.2070-2071
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• 2007

본 연구에서는 변압기의 주 소음원인이 되는 120[Hz]와 240[Hz]및 360[Hz] 주파수에 대한 다중음/단일채널 적응 능동제어기법을 이용한 능동 제어시스템을 구성하였다. 이 능동 제어시스템을 이용하여 변압기에서 발생되어 나오는 소음을 저감시켰고 모의실험을 통해 소음이 감쇄되는 것을 확인하였다.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.8 no.5
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• pp.113-119
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• 2008

Conventional 1-1-1 cooperative protocol offers path-loss gain as advantage of multi-hop and spatial diversity which is equivalent to MIMO system. This protocol is enable to get higher reliability and reduction of power consumption than those of the single-hop or multi-hop. But the 1-1-1 cooperative protocol get only the diversity order 2 and limited path-loss reduction gain because this protocol has a single cooperative relay. We propose 1-2-1 cooperative protocol using two cooperative relays R1, R2. The 1-2-1 cooperative protocol can improve path-loss reduction and increase diversity order 3. Moreover, the cooperative relay R2 attains diversity order 2. The signaling method in transmission uses DF (Decode and Forward) or DR (Decode and Reencode) and 1-2-1 DF/DR cooperative protocol are applied to clustering based wireless sensor networks (WSNs). Simulations are performed to evaluate the performance of the protocols under Rayleigh fading channel plus AWGN (Additive White Gaussian Noise).

• The Korean Journal of Physiology and Pharmacology
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• v.5 no.5
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• pp.413-421
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• 2001

An impaired smooth muscle cell (SMC) relaxation of coronary artery by alteration of $K^+$ channels would be the most potential explanation for reduced coronary reserve in left ventricular hypertrophy (LVH), however, this possibility has not been investigated. We performed morphometrical analysis of the coronary artery under electron microscopy and measured $Ca^{2+}-activated\;K\;(K_{Ca})$ currents and delayed rectifier K $(K_{dr})$ currents by whole-cell and inside-out patch-clamp technique in single coronary arterial SMCs from rabbits subjected to isoprenaline-induced cardiac hypertrophy. Coronary arterial SMCs underwent significant changes in ultrastructure. The unitary current amplitude and the open-state probability of $K_{Ca}$ channel were significantly reduced in hypertrophy without open-time and closed-time kinetic. The concentration-response curve of $K_{Ca}$ channel to $Ca^{2+}$ is shifted to the right in hypertrophy. The reduction in the mean single channel current and increase in the open channel noise of $K_{Ca}$ channel by TEA were more sensitive in hypertrophy. $K_{dr}$ current density is significantly reduced in hypertrophy without activation and inactivation kinetics. The sensitivity of $K_{dr}$ current on 4-AP is significantly increased in hypertrophy. This is the first study to report evidence for alterations of $K_{Ca}$ channels and $K_{dr}$ channels in coronary SMCs with LVH. The findings may provide some insight into mechanism of the reduced coronary reserve in LVH.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.21 no.4
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• pp.399-407
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• 2010

SC-FDMA system uses DFT-spreading method for reducing the PAPR of OFDM signal, which improves the power efficiency. Block type pilot is used in SC-FDMA system. However, there are ICI due to the inevitable phase noise and frequency offset that can be generated from the Doppler frequency and inaccuracy between the transceiver oscillators. This ICI definitely degrades the BER performance. To overcome this problem and estimate the channel efficiently, we like to propose ICI compensation algorithm for the SC-FDMA system with comb type pilot. SLM method is additionally included for the PAPR reduction when pilot is assigned in comb type. Finally, it is confirmed that the ICI due to the phase noise and frequency offset is efficiently compensated by the suggested algorithm.

• Publications of The Korean Astronomical Society
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• v.28 no.1
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• pp.7-13
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• 2013

We present a multi-dimensional reduction method of the surveyed cube database obtained using a single- dish radio telescope in Taeduk Radio Astronomy Observatory (TRAO). The multibeam receiver system installed at the 14 m telescope in TRAO was not optimized at the initial stage, though it became more stabilized in the following season. We conducted a Galactic Plane survey using the multibeam receiver system. We show that the noise level of the first part of the survey was higher than expected, and a special reduction process seemed to be definitely required. Along with a brief review of classical methods, a multi-dimensional method of reduction is introduced; It is found that the 'background' task within IRAF (Image Reduction and Analysis Facility) can be applied to all three directions of the cube database. Various statistics of reduction results is tested using several IRAF tasks. The rms value of raw survey data is 0.241 K, and after primitive baseline subtraction and elimination of bad channel sections, the rms value turned out to be 0.210 K. After the one-dimensional reduction using 'background' task, the rms value is estimated to be 0.176 K. The average rms of the final reduced image is 0.137 K. Thus, the image quality is found to be improved about 43% using the new reduction method.

• The KIPS Transactions:PartC
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• v.13C no.6 s.109
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• pp.749-756
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• 2006

Broadcast nature of wireless medium and path-loss reduction create a favourable condition for collaborative communications (CC) among single-antenna users to gain the powerful benefits of multi-antenna system without the demand for physical arrays. This paper proposes a CC strategy adapting to the propagation environment changes by optimizing the transmit signal amplification factors to simplify the structure of maximum likelihood (ML) detector and to obtain the minimum error probability as well. The closed-form BER expression was also derived and compared to the simulation results to evaluate the performance of the suggested solution. A variety of numerical results revealed the cooperation significantly outperforms non-cooperative counterpart under flat Rayleigh fading channel plus AWGN (Additive White Gaussian Noise).

• The Journal of the Acoustical Society of Korea
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• v.25 no.8
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• pp.383-388
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• 2006

This Paper presents a novel approach to single channel microphone speech enhancement in noisy environments. Widely used noise reduction techniques based on the spectral subtraction are generally expressed as a spectral gam depending on the signal-to-noise ratio (SNR). The well-known decision-directed(DD) estimator of Ephraim and Malah efficiently reduces musical noise under the background noise conditions, but generates the delay of the a prioiri SNR because the DD weights the speech spectrum component of the Previous frame in the speech signal. Therefore, the noise suppression gain which is affected by the delay of the a priori SNR, which is estimated by the DD matches the previous frame rather than the current one, so after noise suppression. this degrades the noise reduction performance during speech transient periods. We propose a computationally simple but effective speech enhancement technique based on the sigmoid type function for the weight Parameter of the DD. The proposed approach solves the delay problem about the main parameter, the a priori SNR of the DD while maintaining the benefits of the DD. Performances of the proposed enhancement algorithm are evaluated by ITU-T p.862 Perceptual Evaluation of Speech duality (PESQ). the Mean Opinion Score (MOS) and the speech spectrogram under various noise environments and yields better results compared with the fixed weight parameter of the DD.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.18 no.4 s.119
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• pp.379-388
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• 2007

This paper presents a real-time respiration and heartbeat detector comprised of a 1.6 GHz single-channel Doppler sensor and analog/digital signal processing block for remote vital sign detection. The RF front end of the Doppler sensor consists of an oscillator, mixer, low noise amplifier, branch-line hybrid and patch antenna. We apply artificial transmission lines(ATLs) to the branch-line hybrid, which leads to a size reduction of 40 % in the hybrid, while its performance is very comparable to that of a conventional hybrid. The analog signal conditioning block is implemented using second order Sallen-Key active filters and the digital signal processing block is realized with a LabVIEW program on a computer. The respiration and heartbeat detection is demonstrated at a distance of 50 cm using the developed system.

• Journal of Satellite, Information and Communications
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• v.6 no.1
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• pp.86-96
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• 2011

In this paper we propose a Pre-rake system applied with a frequency domain equalizer in TDD/CDMA multi-code transmission. The Pre-rake system has been well known technique in TDD/CDMA to make a receiver simple. However, it still has residual losses of path diversity and signal to noise ratio (SNR). However, gathering all the residual paths demands an additional hardware such as a rake combiner at the receiver. For the reason Pre/Post-rake system has already been proposed at up/downlink correlated channel conditionunder the assumption of noisier channel. There is a trade-off between the first purpose of Pre-rake that makes hardware simple at the receiver and the performance improvement. From the point the frequency domain equalizer (FDE) can be considered in Pre/Post-rake to supply the receiver with the flexible equalizing methods with rather reduced complexity compared with time domain rake combiner or equalizers. Pre-rake itself increases the number of multipath, which results from the convolution of Pre-rake filter and wireless channel, and FDE must be well matched to Pre/Post-rake, while it considers the relationship of hardware complexity and the performance. In this paper, the Pre-rake/Post-FDE system is introduced at TDD/CDMA multi-code transmission. In addition, the cyclic prefix reduction method in the proposed system is introduced, and the theoretical analysis to the proposed system is given by assuming Gaussian approximation, and finally the numerical simulation results are provided.