• Journal of Advanced Navigation Technology
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• v.6 no.1
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• pp.77-83
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• 2002

The emergence of Bluetooth as a radio interface scheme has allowed electronic devices to be instantly interconnected as ad-hoc networks. These short range ad-hoc wireless networks are called piconets, operated in the unlicensed 2.45 GHz ISM(Industrial, Scientific, Medical) band where up to eight devices may be used to configure single or overlapping piconets. In this paper, we have simulated the PER(Packet Error Rate), the ratio of received packet and payload BER(Bit Error Rate) of piconet with packet types of Bluetooth ACL/SCO(Asynchronous Connection Less/Synchronous Connection Oriented) link over wireless ad-hoc environment. The Rayleigh fading effects are considered as channel model, and the simulation results are based on the baseband model of Bluetooth specification. From the simulation results, the PER and the throughput of Bluetooth piconet are sensibly affected by the packet type of ACL/SCO link.

• The Korean Journal of Pain
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• v.23 no.2
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• pp.99-108
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• 2010

Chronic pain is a multifactorial condition with both physical and psychological symptoms, and it affects around 20% of the population in the developed world. In spite of outstanding advances in pain management over the past decades, chronic pain remains a significant problem. This article provides a mechanism- and evidence-based approach to improve the outcome for pharmacologic management of chronic pain. The usual approach to treat mild to moderate pain is to start with a nonopioid analgesic. If this is inadequate, and if there is an element of sleep deprivation, then it is reasonable to add an antidepressant with analgesic qualities. If there is a component of neuropathic pain or fibromyalgia, then a trial with one of the gabapentinoids is appropriate. If these steps are inadequate, then an opioid analgesic may be added. For moderate to severe pain, one would initiate an earlier trial of a long term opioid. Skeletal muscle relaxants and topicals may also be appropriate as single agents or in combination. Meanwhile, the steps of pharmacologic treatments for neuropathic pain include (1) certain antidepressants (tricyclic antidepressants, serotonin and norepinephrine reuptake inhibitors), calcium channel ${\alpha}2-{\delta}$ ligands (gabapentin and pregabalin) and topical lidocaine, (2) opioid analgesics and tramadol (for first-line use in selected clinical circumstances) and (3) certain other antidepressant and antiepileptic medications (topical capsaicin, mexiletine, and N-methyl-d-aspartate receptor antagonists). It is essential to have a thorough understanding about the different pain mechanisms of chronic pain and evidence-based multi-mechanistic treatment. It is also essential to increase the individualization of treatment.

• The Korean Journal of Physiology and Pharmacology
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• v.7 no.6
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• pp.375-379
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• 2003

$Ca^{2+}$ influx appears to be important for triggering myoblast fusion. It remains, however, unclear how $Ca^{2+}$ influx rises prior to myoblast fusion. Recently, several studies suggested that NMDA receptors may be involved in $Ca^{2+}$ mobilization of muscle, and that $Ca^{2+}$ influx is mediated by NMDA receptors in C2C12 myoblasts. Here, we report that other types of ionotropic glutamate receptors, non-NMDA receptors (AMPA and KA receptors), are also involved in $Ca^{2+}$ influx in myoblasts. To explore which subtypes of non-NMDA receptors are expressed in C2C12 myogenic cells, RT-PCR was performed, and the results revealed that KA receptor subunits were expressed in both myoblasts and myotubes. However, AMPA receptor was not detected in myoblasts but expressed in myotubes. Using a $Ca^{2+}$ imaging system, $Ca^{2+}$ influx mediated by these receptors was directly measured in a single myoblast cell. Intracellular $Ca^{2+}$ level was increased by KA, but not by AMPA. These results were consistent with RT-PCR data. In addition, KA-induced intracellular $Ca^{2+}$ increase was completely suppressed by treatment of nifedifine, a L-type $Ca^{2+}$ channel blocker. Furthermore, KA stimulated myoblast fusion in a dose-dependent manner. CNQX inhibited not only KA-induced myoblast fusion but also spontaneous myoblast fusion. Therefore, these results suggest that KA receptors are involved in intracellular $Ca^{2+}$ increase in myoblasts and then may play an important role in myoblast fusion.

• Journal of Microbiology and Biotechnology
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• v.17 no.11
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• pp.1868-1874
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• 2007

We have developed a robotic system for an automated parallel cell cultivation process that enables screening of induction parameters for the soluble expression of recombinant protein. The system is designed for parallelized and simultaneous cultivation of up to 24 different types of cells or a single type of cell at 24 different conditions. Twenty-four culture vessels of about 200 ml are arranged in four columns${\times}$six rows. The system is equipped with four independent thermostated waterbaths, each of which accommodates six culture vessels. A two-channel liquid handler is attached in order to distribute medium from the reservoir to the culture vessels, to transfer seed or other reagents, and to take an aliquot from the growing cells. Cells in each vessel are agitated and aerated by sparging filtered air. We tested the system by growing Escherichia coli BL21(DE3) cells harboring a plasmid for a model protein, and used it in optimizing protein expression conditions by varying the induction temperature and the inducer concentration. The results revealed the usefulness of our custom-made cell cultivation robot in screening optimal conditions for the expression of soluble proteins.

• Tunnel and Underground Space
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• v.12 no.4
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• pp.312-320
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• 2002

It is well-known that when single rock fractures undergo shear displacement, they are influenced by the boundary conditions and fracture roughness. In this case, aperture geometry will change by means of dilation due to the shear displacement. As fractures become the flow paths, fluid flow through rock fractures is affected by the void geometry. In this study, therefore, the influence of roughness on shear behavior of fractures has been investigated, and the resulting hydraulic behavior has been analyzed. In order for this study, a statistical method has been used to generate rough fractures, and they have been adopted into new conceptual models fur fracture shearing and flow calculations. The main contributions of this study are as follows: firstly, fracture shear behavior becomes less brittle with decreasing fracture roughness and increasing normal stress. Then, the characteristics of aperture distribution becomes those of roughness of fractures indicating its hydraulic significance. Finally, it is observed that with decreasing fracture roughness the breakdown of channel flow occurs more slowly.

• Journal of the Society of Naval Architects of Korea
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• v.48 no.5
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• pp.390-395
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• 2011

The main purpose of ice model basin is to assess and evaluate the performance of the Arctic ships and offshore structures because the full-scale tests in ice covered sea are usually very expensive and difficult. There are various ice conditions, such as level ice, brash ice, pack ice and ice ridge, in the real sea. To estimate their capacities in ice tank accurately, an appropriate model ice sheet and prepared ice conditions copied from actual sea ice conditions are needed. Pack ice is a floating ice that has been driven together into a single mass and a mixture of ice fragments of varying size and age that are squeezed together and cover the sea surface with little or no open water. So Ice-class vessels and Icebreaker are usually operated in pack ice conditions for the long time of her voyage. The most ice model tests include the pack ice test with the change of pack ice concentration. In this paper, the effect of pack ice size and channel breadth in pack ice model test is conducted and analyzed. Also we presented some techniques for the calculation of pack ice concentration in the model test. Finally, we developed a new model test methodology of pack ice condition in square type ice tank.

• Journal of The Korean Society of Clinical Toxicology
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• v.9 no.2
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• pp.105-108
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• 2011

Aconitine is an anti-inflammatory agent with therapeutic uses in oriental medicine as an analgesic and for treatment of stroke. Because of its sodium channel effect, aconitine can promote undesirable, wide complex tachyarrhythmia. If tachycardia develops during use of aconitine, class Ia and class III anti arrhythmic drugs can be utilized for treatment. However there are no single anti-arrhythmia agents which are uniformly effective. We report a case, characterized by wide complex tachyarrhythmia and severe hypotension, which was successfully treated by simultaneous injections of amiodarone and lidocaine. A 59-year-old woman exhibiting clinical signs of drowsiness as a result of ingesting 6 g of aconitine, was admitted to the emergency department. Initially, wide complex tachyarrhythmia (ventricular tachycardia and pulse rate of 180 beats/min) and severe hypotension (blood pressure of 53/26 mmHg) was observed. After simultaneous injection of amiodarone and lidocaine, the patient's rhythm pattern changed to an accelerated junctional rhythm with ventricular premature complex. Two hours later, the patient's heart pattern became a sinus rhythm. As demonstrated by this case, simultaneous injections of amiodarone and lidocaine can be useful in treating ventricular arrhythmia induced by aconitine.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2008.05a
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• pp.149-152
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• 2008

Effects of chamber configuration on combustion characteristic velocity of full-scale combustion chamber for 30-tonf-class liquid rocket engine were studied. The configurations of combustion chamber are ablative and channel cooling chamber (${\varepsilon}$=3.2) which have detachable mixing head, and single body regenerative cooling chamber which has nozzle expansion ratio of 3.5 and 12, respectively. The combustion chambers have chamber pressure of 53${\sim}$60 bar and propellant mass flow rate of 89 kg/s, and the injectors of all combustion chamber have recess number 1.0 and double-swirl characteristics. The hot firing test results at design point show that the combustion characteristic velocity of the regenerative cooling chamber which has nozzle expansion ratio of 12 is higher than that of other combustion chambers. The reasons for the above result are the increases of combustion pressure and enthalpy of kerosene which is heated due to cooling of the chamber wall before injection into the combustion field.

• Journal of the Korean Institute of Telematics and Electronics A
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• v.32A no.10
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• pp.43-50
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• 1995

A laser diode(LD) structure consisting of a single 150$\AA$ $Al_{0.07}$Ga$_{0.93}$As quantum well active region operating at ${\lambda}$=809nm, cladded with an AlGaAs graded-index separate confinement heterostructure, has bes been grown by MOCVD. Temperature coefficient of wavelength is approximately 0.2nm $^{\circ}C$ for the diode. The active aperture consists of five emitters separated from each other by means of SiO$_{2}$ deposition and stripe formation, which creates insulating regions that channel the current to 100-$\mu$m-wide stripes placed on 450-$\mu$m centers. From a typical uncoated LD, the output power of 0.8W has been obtained at a 1$\mu$s, 1kHz pulsed current level of 2.0$\AA$, which results in about 64% external quantum efficiency. The threshold current density is 736A/cm$^{2}$ for the case of 500$\mu$m cavity length LD's. The measure of an internal quantum efficiency was 75.8% and the internal loss 4.83$cm^{-1}$ . Finally, 3.1W output power has been obtained at a 1$\mu$s, 1kHz pulsed current level of 9A from the 500$\mu$m-aperture LD array with 460-$\mu$m- cavity length.

• Korean Journal of Agricultural Science
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• v.37 no.1
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• pp.81-86
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• 2010

The urban thermal environment can be an important index to detect heat island phenomena and manage it to improve urban life quality. Cheongju is a typical plain-city that main part has been formed and developed in lowland. The Mushim stream crosses the city from south to north. We reviewed the use of thermal remote sensing in stream around areas and the thermal environments, focusing primarily on the Urban Heat Island(UHI) effect. The purpose of this study is to determine the relationship between the stream nearby urban area and the stream cooling effect of UHI. The objectives are to determine the usefulness of KOMPSAT-2 bands MS3 and MS4 for vegetation cover mapping, and the usefulness of LANDSAT TM band 6 in identifying thermal environmental characteristics and UHI. Land Surface Temperatures (LST) are retrieved by single-channel algorithm to study the UHI from the 6th band (thermal infrared band) of LANDSAT TM images and thermal radiance thermometer based on remote sensing method and the LST distribution maps are accomplished according to the retrieval results. There is also comparison of satellite-derived and in situ measured temperature. The results indicated that the LST of urban center is higher than that of suburban area, the temperature of mountain and water are the lowest area, so it is clearly proved that there are obvious UHI effects by stream. The surface temperature distribution of Mushim stream is detected $2^{\circ}C$ lower than urban area.