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가중평균 해석법을 이용한 래핑된 베어링강 어닐링재료의 깊이방향에 대한 잔류응력분포 측정 (Measurement of Residual Stress Distribution in the Depth Direction of Annealed Materials of Lapped Bearing Steel Using Weighted Averaging Analysis Method)

한창석;이찬우
- 한국재료학회지
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- 제33권5호
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- pp.205-213
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- 2023
This paper reports the results of an experimental examination using X-rays to test annealing materials for lapped bearing steel (STB2), to confirm the validity of the weighted averaging analysis method. The distribution behavior for the α_𝜓-sin²𝜓 diagram and the presence or absence of differences in the peak method, half-value breadth method, and centroid method were investigated. When lapping the annealed bearing steel (STB2) material, a residual stress state with a non-directional steep gradient appeared in the surface layer, and it was found that the weighted averaging analysis method was effective. If there is a steep stress gradient, the sin²𝜓 diagram is curved and the diffraction intensity distribution curve becomes asymmetric, resulting in a difference between the peak method, half-value breadth method, and centroid method. This phenomenon was evident when the stress gradient was more than 2~3 kg/mm²/㎛. In this case, if the position of the diffraction line is determined using the centroid method and the weighted averaging analysis method is applied, the stress value on the surface and the stress gradient under the surface can be obtained more accurately. When the stress gradient becomes a problem, since the curvature of the sin²𝜓 diagram appears clearly in the region of sin²𝜓 > 0.5, it is necessary to increase the inclination angle 𝜓 as much as possible. In the case of a lapping layer, a more accurate value can be obtained by considering 𝜎₃ in the weighted averaging analysis method. In an isotropic biaxial residual stress state, the presence or absence of 𝜎₃ can be determined as the presence or absence of strain for sin²𝜓≈0.4.
https://doi.org/10.3740/MRSK.2023.33.5.205 인용 PDF

Suppressive Effect of Sinomenine Combined with 5-Fluorouracil on Colon Carcinoma Cell Growth

Zhang, Ji-Xiang;Yang, Zi-Rong;Wu, Dan-Dan;Song, Jia;Guo, Xu-Feng;Wang, Jing;Dong, Wei-Guo
- Asian Pacific Journal of Cancer Prevention
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- 제15권16호
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- pp.6737-6743
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- 2014
It is reported that sinomenine (SIN) and 5-fluorouracil (5-FU) both are effective for colon cancer, but their cooperative suppressive effects and toxicity remain to be clarified in detail. This study aimed to determine suppressive effects and toxicity of sinomenine (SIN) plus 5-fluorouracil (5-FU) on LoVo colon carcinoma cells in vitro and in vivo. CCK-8, Hoechst 33258 staining and an annexin V-FITC/PI apoptosis kit were used to detect suppressive effects. Western blotting was applied to investigate the essential mechanism underlying SIN and 5-FU-induced apoptosis. SIN or 5-FU or both were injected into nude mice, and then suppressive effects and side effects were observed. SIN plus 5-FU apparently inhibited the proliferation of LoVo cells and induced apoptosis. Moreover the united effects were stronger than individually (p<0.05). The results of annexin V-FITC/PI staining and Hoechst 33258 staining showed that the percentage of apoptotic cells induced by SIN and 5-FU combined or alone was significantly higher than the control group (p<0.05). Expression of Bax and Bcl-2 was up-regulated and down-regulated respectively. SIN or 5-FU significantly inhibited effects on the volume of tumour xenografts and their combined suppressive effects were stronger (p<0.05). No obvious side effects were observed. It was apparent that the united effects of SIN and 5-FU on the growth of colorectal carcinoma LoVo cells in vitro and in vivo were superior to those using them individually, and it did not markedly increase the side effects of chemotherapy.
https://doi.org/10.7314/APJCP.2014.15.16.6737 인용 PDF KSCI