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Reproducibility of Regional Pulse Wave Velocity in Healthy Subjects

  • Im Jae-Joong;Lee, Nak-Bum;Rhee Moo-Yong;Na Sang-Hun;Kim, Young-Kwon;Lee, Myoung-Mook;Cockcroft John R.
    • International Journal of Vascular Biomedical Engineering
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    • v.4 no.2
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    • pp.19-24
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    • 2006
  • Background: Pulse wave velocity (PWV), which is inversely related to the distensibility of an arterial wall, offers a simple and potentially useful approach for an evaluation of cardiovascular diseases. In spite of the clinical importance and widespread use of PWV, there exist no standard either for pulse sensors or for system requirements for accurate pulse wave measurement. Objective of this study was to assess the reproducibility of PWV values using a newly developed PWV measurement system in healthy subjects prior to a large-scale clinical study. Methods: System used for the study was the PP-1000 (Hanbyul Meditech Co., Korea), which provides regional PWV values based on the measurements of electrocardiography (ECG), phonocardiography (PCG), and pulse waves from four different sites of arteries (carotid, femoral, radial, and dorsalis pedis) simultaneously. Seventeen healthy male subjects with a mean age of 33 years (ranges 22 to 52 years) without any cardiovascular disease were participated for the experiment. Two observers (observer A and B) performed two consecutive measurements from the same subject in a random order. For an evaluation of system reproducibility, two analyses (within-observer and between-observer) were performed, and expressed in terms of mean difference ${\pm}2SD$, as described by Bland and Altman plots. Results: Mean and SD of PWVs for aorta, arm, and leg were $7.07{\pm}1.48m/sec,\;8.43{\pm}1.14m/sec,\;and\;8.09{\pm}0.98m/sec$ measured from observer A and $6.76{\pm}1.00m/sec,\;7.97{\pm}0.80m/sec,\;and\;\7.97{\pm}0.72m/sec$ from observer B, respectively. Between-observer differences ($mean{\pm}2SD$) for aorta, arm, and leg were $0.14{\pm\}0.62m/sec,\;0.18{\pm\}0.84m/sec,\;and\;0.07{\pm}0.86m/sec$, and the correlation coefficients were high especially 0.93 for aortic PWV. Within-observer differences ($mean{\pm}2SD$) for aorta, arm, and leg were $0.01{\pm}0.26m/sec,\;0.02{\pm}0.26m/sec,\;and\;0.08{\pm}0.32m/sec$ from observer A and $0.01{\pm}0.24m/sec,\;0.04{\pm}0.28m/sec,\;and\;0.01{\pm}0.20m/sec$ from observer B, respectively. All the measurements showed significantly high correlation coefficients ranges from 0.94 to 0.99. Conclusion: PWV measurement system used for the study offers comfortable and simple operation and provides accurate analysis results with high reproducibility. Since the reproducibility of the measurement is critical for the diagnosis in clinical use, it is necessary to provide an accurate algorithm for the detection of additional features such as flow wave, reflection wave, and dicrotic notch from a pulse waveform. This study will be extended for the comparison of PWV values from patients with various vascular risks for clinical application. Data acquired from the study could be used for the determination of the appropriate sample size for further studies relating various types of arteriosclerosis-related vascular disease.

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Analysis of Heterogeneous Tree-Ring Growths of Pinus densiflora with Various Topographical Characteristics in Mt. Worak Using GIS (GIS 기법을 이용한 지형적 특성에 따른 월악산 소나무 연륜생장의 이질성 규명)

  • 서정욱;김재수;박원규
    • The Korean Journal of Ecology
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    • v.23 no.1
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    • pp.25-32
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    • 2000
  • To analyze the relationship between climatic factors (monthly temperatures and precipitations) and the radial growths or Pinus densiflora with different topographical settings in Worak National Park, Korea, 20 stands were chosen and 10 trees were selected from each stand. After crossdating, each ring-width series was double detrended (standardized) by fitting first a negative exponential or straight regression line and secondly a 60-year cubic spline. The growth patterns coud be categorized by four groups using cluster analysis. Cluster Ⅰ stand has north aspect, but others have south or southwest aspects. Cluster Ⅰ (one), cluster Ⅱ (ten), and cluster Ⅲ (two) stands are located in lower. elevation (305∼580 m), however, cluster Ⅳ (seven) stands are located in higher elevation, mostly in 560~870 m. Cluster Ⅱ and Ⅲ stands are located at similar elevation with the same aspect, however, cluster Ⅱ stands are located on more rocky and stiff slope with shallow soil depth. The response functions were used to examine the difference in the relationships between climatic factors and tree growths among the 4 cluster chronologies. The climatic factors are not limiting the growth in the cluster Ⅰ stand as highly as in other cluster plots because of rather mesic conditions in the north slope. The precipitation in the spring appears to be the main limiting factor in the cluster Ⅱ stands. The topographical characteristics of the sites of cluster Ⅱ, shallow soil depths on the rocky slope in the south aspect at lower elevation, may enhance the sensitivity of growth to moisture stress. In cluster Ⅲ and cluster Ⅳ, winter and spring temperature prior to the growth become more important than for cluster Ⅱ. This pattern is com-mon for Pinus densiflora trees growing in higher. elevation (equation omitted 800 m) in South Korea. It nay be re-lated with preconditioning effects of temperature as the temperature decreases with increasing elevation (cluster Ⅳ) or in the valley (cluster Ⅲ). The results obtained by tree-ring analysis were digitalized by GIS and spatio-temporal information on tree-ring data and topographic setting were analyzed and displayed simultaneously. The results of this study can be used to predict the future change of Pinus densiflora ecosystem to climate change expected in central Korea.

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Comparative Analysis of the Q Value between the Crust of the Seoul Metropolitan Area and the Eastern Kyeongsang Basin (수도권과 경상 분지 동부 지역 지각의 Q 값 비교 분석)

  • Park, Yoon-Jung;Kyung, Jai-Bok;Do, Ji-Young
    • Journal of the Korean earth science society
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    • v.28 no.6
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    • pp.720-732
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    • 2007
  • For the Seoul metropolitan area and the eastern Kyeongsang Basin, we simultaneously calculated $Q_P^{-1}$ and $Q_S^{-1}$ by applying the extended coda-normalization method for 98 seismograms of local Earthquakes. As frequency increases from 1.5 Hz to 24 Hz, the result decreased from $(4.0{\pm}9.2){\times}10^{-3}$ to $(4.1{\pm}4.2){\times}10^{-4}$ for $Q_P^{-1}$ and $(5.5{\pm}5.6){\times}10^{-3}$ to $(3.4{\pm}1.3){\times}10^{-4}$ for $Q_S^{-1}$ in Seoul Metropolitan Area. The result of eastern Kyeongsang basin also decreased from $(5.4{\pm}8.8){\times}10^{-3}$ to $(3.7{\pm}3.4){\times}10^{-4}$ for $Q_P^{-1}$ and $(5.7{\pm}4.2){\times}10^{-3}$ to $(3.5{\pm}1.6){\times}10^{-4}$ for $Q_S^{-1}$. If we fit a frequency-dependent power law to the data, the best fits of $Q_P^{-1}$ and $Q_S^{-1}$ are $0.005f^{-0.89}$ and $0.004f^{-0.88}$ in Seoul metropolitan Area, respectively. The value of $Q_P^{-1}$ and $Q_S^{-1}$ in the eastern Kyeongsang basin are $0.007f^{-1.02}$ and $0.006f^{-0.99}$, respectively. The $Q_S^{-1}$ value of the eastern Kyeongsang basin is almost similar to Seoul metropolitan area. But the $Q_P^{-1}$ value of the eastern Kyeongsang basin is a little higher than that of Seoul metropolitan area. This may be that the crustal characteristics of the eastern Kyeongsang basin is seismologically more heterogeneous. However, these $Q_P^{-1}$ values in Korea belong to the range of seismically stable regions all over the world.

A STUDY ON MICROLEAKAGE OF PIT AND FISSURE SEALANT AFTER ENAMEL SURFACE TREATMENT (법랑질 표면처리방법에 따른 치면열구전색재의 미세누출에 관한 비교연구)

  • Hyun, Hong-Keun;Kim, Jung-Wook;Lee, Sang-Hoon
    • Journal of the korean academy of Pediatric Dentistry
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    • v.28 no.3
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    • pp.512-521
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    • 2001
  • Recently. the reintroduction of air-abrasion technology in dentistry has added a new potential method of pretreating teeth prior to placing sealants. The purpose of this in vitro study was to investigate microleakages of several pit and fissure sealants following various surface pre-treatment methods to the enamel, because there was a question concerning the validity of claim that this method was better than the conventional acid etching. Permanent molars were divided randomly into nine groups and treated accordingly: acid etching(group 1, 4, 7), air-abrasion(group 2, 5, 8), acid etching after air-abrasion(group 3, 6, 9). Then the authors placed and cured the three kinds of sealants(group $1\sim3$: Teethmate-F, group $4\sim6$: Ultraseal XT plus, group $7\sim9$: Denseal) according to the manufacturer's order. They were observed to determine the degree of microleakage. And these specimens were separated from the corresponding enamels and examined by Scanning Electron Microscope. The following results were obtained: 1. In comparing microleakage among tooth surface treatment methods, air-abrasion group(group 2, 5, 8) showed the greatest microleakage, while combination(air-abrasion + acid etching) group showed the least (p<0.05). However, no significant differences were found between group 7 and 9. 2. The mean microleakages were ranked as follows(p<0.05): In acid etching groups, group 7> group 4> group 1. In air-abrasive groups, group 8>groups 5> group 2. In combination groups, group 9>group 3> group 6. However, no significant differences were found between group 4 and 7 between group 2 and 5 and between group 3 and 6. 3. SEM showed that comparably longer resin tags were distributed regularly in acid etching groups and that shorter ones irregularly in air-abrasion groups. It also showed that these two kinds of tags were distributed simultaneously in combination groups.

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Variation of Suspended Solid Concentration, Electrical Conductivity and pH of Stream Water in the Regrowth and Rehabilitation Forested Catchments, South Korea (개벌 재생림유역과 사방지 혼효림유역에서 강수시 계류수의 부유물질농도 및 전기전도도와 pH 변화)

  • Jun, Jaehong;Kim, Kyongha;Yoo, Jaeyun;Choi, Hyung Tae;Jeong, Yongho
    • Journal of Korean Society of Forest Science
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    • v.96 no.1
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    • pp.21-28
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    • 2007
  • This study was conducted to investigate how the qualities of the stream water vary during the event in the regrowth and rehabilitation catchments in Yangju, Gyeonggido, from June to September 2005. During the observation periods, we sampled the stream water continuously by an auto-sampler (ISCO, 6712FR). The sampled waters were analyzed for suspended solid concentration, electrical conductivity and pH. The suspended solid concentration during the event increased concurrently with the stream flow. The peak of suspended solid concentration usually precedes the peak flow. The maximum value of suspended solid concentration was 420.89 mg/l in the event 1 at the regrowth catchment. Among the events simultaneously sampled at both catchments, the maximum values of suspended solid concentration were 212.8 mg/l and 58.24 mg/l in the event 3 at the regrowth and rehabilitation catchment respectively. The maximum value of EC in each event showed in the early stage of rising limb. EC decreased during the rising limb, and then showed minimum value at peak flow. EC gradually increased to pre-event value after minimum one. pH varied in similar pattern with EC. The maximum value of suspended solid concentration during each event was 2.8 to 4.3 times higher at the regrowth catchment than at the rehabilitation catchment. And the EC during each event was higher at the regrowth catchment than at the rehabilitation catchment. This results indicate that a disturbed forest soil during clear cutting at regrowth catchment still has been unstable.

Inferential Structure and Reality Problem in Diagnosis of Oriental Medicine (한의 진단의 추론형식과 실재성)

  • Park, Geong-Mo;Choi, Seong-Hoon;Ahn, Gyu-Seok
    • Journal of The Association for Neo Medicine
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    • v.2 no.1
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    • pp.55-84
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    • 1997
  • Inferential structure and reality problem is a serious issue to O.M.(oriental medicine). The study will analyze this issue through a philosophical and historical comparative study of W.M.M(Western modern medicine) and O.M. First, I presuppose some basic ideas. The first is the division of the 'the philosophy of medicine' and 'the medicine itself'. Second, there is a 'visibility' that discriminate between 'the abstractive concept' and 'the concrete object' in diagnostic terminology. The third is the separation of disease, the entity and disease, the phenomenon. Finally, the distinction between the cause of disease and the nature of disease. Through these basic concepts, this study will analyze O.M's diagnostic methodology, 'Pattern identification of the S.A.S(sign and symptom)'. The results are follows: 1. O.M's views disease as a phenomenon. So, the S.A.S, which is visible, is the disease itself. Tough the analysis and inference of the S.A.S, 證(zheng) the essence is derived. 2. 證(zheng) can be considered as 'the abstractive concept' reflecting the essence of a disease. 3. 證(zheng) is not arrived through causal sequence reasoning but rather by analogical reasoning. 4. 證(zheng) is 'the non-random correlative combination of S.A.S', pattern. These patterns secure the abstractive deduction in reality. that is, The causality, the positivism, the view of disease as entity, and anatomical knowledge are the traits peculiar to W.M.M. But, these properties can not be applied universally to every medical systems. Also, these properties do not indicate the superiority or inferiority of any medical system. 5. 證(zheng) summarizes the patients condition simultaneously with the S.A.S. However, 證(zheng) doesn't necessarily indicate the knowledge about the actual internal organ. That is, Early in O.M.'s history, the diagnostic terminologies including 證(zheng) were analogical reflections of a naive knowledge of internal organs and external environmental factors. Later, the naive knowledge in 證(zheng) changed int new nature, an abstractive concept. The confusion of the concept of disease, the indiscriminate acceptance of Western anatomical knowledge, and the O.M.'s theoretical evolution et are the challenge facing modern O.M. To find solutions, this study looks at the sequence of the birth of W.M.M. and then compares it's system with the O.M. system. The confusion of the concept of disease, the indiscriminate acceptance of Western anatomical knowledge, and the O.M.'s theoretical evolution et are the challenge facing modern O.M. To find solutions, this study looks at the sequence of the birth of W.M.M. and then compares it's system with the O.M. system. It is recommended that O.M. diagnostics should pay close attention to the ambiguity of the diagnostic methodology in order to further development. At present time, the concept and the system peculiar to O.M. can not be explained by common language. but O.M.'s practitioner can not persist in this manner an: longer. Along with the internal development of O.M., the adjustment of O.M.'s diagnostic terminology needs to be adopted.

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Optimal Incentives for Customer Satisfaction in Multi-channel Setting (멀티채널에서의 고객만족제고 인센티브 연구)

  • Kim, Hyun-Sik
    • Journal of Distribution Research
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    • v.15 no.1
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    • pp.25-47
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    • 2010
  • CS is one of the major concerns of managers in the world because it is well known to be a key medium construct for firms' superior outcome. One of the major agents for CS management is retailers. Firms try to manage not only employees but also retailers to promote CS behaviors. And so diverse incentives are used to promote their CS behaviors under diverse channel setting such as multi-channel. However in spite of the rising needs there has been scarce studies on the optimal incentive structure for a manufacturer to offer competing retailers at the multi-channel. In this paper, we try to find better way for a manufacturer to promote the competing retailers' CS behaviors. We investigated how to promote the retailers' CS behavior via game-theoretic modeling. Especially, we focus on the possible incentive, CS bonus type reward introduced in the studies of Hauser, Simester, and Wernerfelt(1994) and Chu and Desai(1995). We build up a multi stage complete information game and derive a subgame perfect equilibrium using backward induction. Stages of the game are as following. (Stage 1) Manufacturer sets wholesale price(w) and CS bonus($\eta$). (Stage 2) Both retailers in competition set CS effort level($e_i$) and retail price($p_i$) simultaneously. (Stage 3) Consumers make purchasing decisions based on the manufacturer's initial reputation and retailers' CS efforts.

    Structure of the Model We investigated four issues about the topic as following: (1) How much total incentive is adequate for a firm of a specific level of reputation to promote retailers' CS behavior under multi-channel setting ?, (2) How much total incentive is adequate under diverse level of complimentary externalities between the retailers' CS efforts to promote retailers' CS behavior?, (3) How much total incentive is adequate under diverse level of cost to make CS efforts to promote retailers' CS behavior?, (4) How much total incentive is adequate under diverse level of competition between retailers to promote retailers' CS behavior? Our findings are as following. (1) The higher reputation has the manufacturer, the higher incentives for retailers at multi-channel are required in the equilibrium.
    shows the increasing pattern of optimal incentive level along the manufacturer's reputation level(a) under some parameter conditions(b=1/2;c=0;$\beta$=1/2). (2) The bigger complimentary externalities exists between the retailers' CS efforts, the higher incentives are required in the equilibrium.
    shows the increasing pattern of optimal incentive level along the complimentary externalities level($\beta$) under some parameter conditions(a=1;b=1/2;c=0). (3) The higher is the retailers' cost, the lower incentives are required in the equilibrium.
    shows the decreasing pattern of optimal incentive level along the cost level(c) under some parameter conditions(a=1;b=1/2;$\beta$=1/2). (4) The more competitive gets those two retailers, the higher incentives for retailers at multi-channel are required in the equilibrium.
    shows the increasing pattern of optimal incentive level along the competition level(b) under some parameter conditions(c=0;a=1;$\beta$=1/2). One of the major contribution points of this study is the fact that this study is the first to investigate the optimal CS incentive system under multi-channel setting.

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A Study on Emergence of Innovative Retailing and Its Development Process (혁신적인 소매업태의 출현과 발전과정에 관한 연구)

  • Park, Chul-Ju;Jeong, Tae-Seok
    • Journal of Distribution Science
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    • v.9 no.1
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    • pp.29-38
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    • 2011
  • Since a distribution market was opened in 1993 after the conclusion of the Uruguay Round (UR), various new businesses emerged in the Korean retail industry, such as convenience shops, supermarkets, specialty stores, non-store marketing methods, and cyber shopping malls, in addition to traditional markets and department stores. Competition among these retail businesses has intensified. According to the National Statistical Office (NSO), the growth rate of the total retail industry has shown a 32% increase in the past 5 years. While department stores, supermarkets, specialty stores, and other non-store retailing venues have shown signs of stagnation at a growth rate of 20-30%, which is similar to the growth rate of the entire retail industry, convenience shops and non-store marketing have shown 60-70% growth over the same period. By comparison, the growth rate of cyber shopping malls has nearly tripled. When applying development aspects of retail businesses through the competition to the retail life cycle, mom-and-pop stores and traditional markets have already entered the decline phase as specialty stores reach their maturity phase and demonstrate their limit of growth. Department stores are now in the latter part of the growth phase, which is still considered to have some growth potential. Big super markets are still in the early part of their growth stage although they were introduced 20 years ago. Meanwhile, retail businesses such as convenience stores, supermarkets, mail order houses, and warehouse stores are entering the middle growth phase and are expected to continue with their quantitative growth. At a time when most retail businesses in Korea are in a state of development or in the full growth stage, what kind of new innovative retailing will appear and develop? Moreover, what growth engine will drive it? This study analyzes the appearance of innovative retailing and its development process by establishing a discussable consumer's choice model through the interlocking mutual behavior of differentiated competitiveness and consumers' choice based on an awareness of this issue. The analysis of the results of this study can be summarized as follows. First, if a new vacuum zone emerges at the retail market level, innovative retailing such as low price/low service or high price/high service will emerge simultaneously. Second, if the number of new businesses in the vacuum zone increases, this will create competitiveness among the businesses, and each retailer will develop raising of level. Third, if a new business that raises the level develops, competition between the new and the existing retailer will occur, and an assimilation process between the existing retailing and the new retailing will be unfolded. Fourth, each retailing will promote distribution innovations in order to break the frontier of the existing distribution technology, and other retailing will follow the innovator. On the basis of an analysis of the abovementioned results, this study presents the following three suggestions. First, responding to the consumer's decision-making process on the attributes of retail shops that promote differentiation in strategies, this study established a consumer's choice model that can be discussed in relation to changes in market share. Second, this study provided an analysis of the emerging and developmental processes of innovative retail businesses using a more precise logical structure on the basis of the consumer's choice model described in this study. Third, the development process of retail businesses discussed in this study presented retailing solutions regarding management aspects on how to compose a strong retail mix that can help retail businesses gain competitive advantages in the market.

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Biological treatment process for Food wastewater Using ER-1 bioreactor (다단 수직형 호기성반응기(ER-1)를 이용한 음식물 폐수의 생물학적 처리기술)

  • Lee, Jae-ki;Choi, Hong-Bok;Shin, Eung-Bai;Park, Ju-Hyoung;Choi, Eun-Ju;Kim, Jung-Rae;Park, Young-Sook
    • Journal of the Korea Organic Resources Recycling Association
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    • v.14 no.4
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    • pp.113-120
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    • 2006
  • Wastewater generated through the food waste recycling process have known high concentration, BOD 20,000~150,000 mg/L, which has to treat to the proper level because of a ban on reclamation. But it is impossible to treat less than 10 days by existing water treatment plant. Ecodays Ltd. is to treat this wastewater during 2~4 days by ER-1, which can simultaneously induce the modified PFR(Plug Flow Reactor) of the oxygen transfer rate, MLVSS concentration, and influent concentration to top from bottom of reactor. We tested the pilot test about low concentration food wastewater(BOD 16,500 mg/L) and high concentration food wastewater(64,431 mg/L) at the food waste recycling plant of H-Gun(20t/d). Hydraulic retention time(HRT) of ER-1 for low concentration food wastewater is 2.5day. In low concentration conditions, ER-1 treatment efficiency is to appear BOD 99%, COD 98%, TN 97%, and TP 96%. While ER-1 process for high concentration food wastewater treatment is composed 2 stages, which are to be HRT 2.5day for law wastewater and HRT 1.5 day for secondary treatment. In high concentration conditions, ER-1 treatment efficiency is to appear BOD 97%, COD 84%, TN 66%, and TP 95%. It is treated without temperature control about high temperature($50^{\circ}C$) to appear low treatment efficiency in high concentration conditions.

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Results of Arthroscopic-assisted Minimally Invasive Removal of a Lateral Periarticular Plate used for the Treatment of AO Type-C Distal Femoral Fractures (AO C-형 원위 대퇴골 골절의 치료로 삽입된 관외측 금속판의 절경 보조하 최소 침습적 제거의 결과)

  • Kim, Young-Mo;Lee, June-Kyu;Yang, Jae-Hoon;Kim, Bo-Kun;Lee, Won-Gu
    • Journal of the Korean Arthroscopy Society
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    • v.13 no.1
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    • pp.46-52
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    • 2009
  • Purpose: To evaluate the usefulness of minimally invasive arthroscopy-assisted plate removal of a laterally inserted periarticular distal femur plate used for the treatment of AO type-C distal femur fractures. Materials and Methods: From October 2002 to November 2005, we evaluated 17 patients whose plates were removed through minimally invasive arthroscopy-assisted plate-removal technique and 15 patients who got their plates removed through conventional method without using arthroscopy, 32 patients in total. All these patients included in this study initially underwent open reduction and internal fixation of the distal femoral fractures with a lateral plate, and complained of continued pain over the lateral femoral condyle after the fracture fixation. The average age was 42.6 (ranges: 20~66) and initial fracture types included 16 cases of C1, 11 cases of C2, and 5 cases of C3 following AO/ASIF classification guidelines. Measured outcomes included: associated intra-articular pathologies, time needed to return to activities of daily living, patients' overall satisfaction, complications following the removal of hardware, and pain before and 6 months after the operation. Results: The distal-most end of the plate was placed in the knee joint in all cases and damage of the lateral articular capsule was found in 23 cases. Continuous wound discharge after surgery was found in one case who underwent arthroscopy-assisted plate removal, and it was treated by irrigation and re-suture. Average time needed to return to activities of daily living was 7 days in arthroscopy assisted group and 7.6 days in conventionally removed group. Fourteen patients (82.4%) who underwent arthroscopyassisted plate-removal reported above 'fair' satisfaction and the Visual analog scale pain score decreased from 4.9 to 1.9, six months after the plate removal. Thirteen patients(86.7%) who underwent conventional plate removal reported above 'fair' satisfaction and the Visual analog scale pain score decreased from 5.2 to 2.5, six months after the operation. Conclusion: Through minimally invasive arthroscopic-assisted plate removal, intrarticular pathology of the knee joint was able to be simultaneously identified and treated at the time of hardware removal. Damage of lateral capsule of the knee joint caused by the inserted plate for the treatment of type C distal femoral fracture was very frequently found and following the plate removal, patients experienced an improvement in pain score. We therefore recommend routine lateral distal femoral plate removal if the bony union is attained in such cases as type C distal femoral fractures whose distal most end of the plates are located in the joint.

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