• Archives of Pharmacal Research
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• v.11 no.1
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• pp.45-51
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• 1988

The feature of resolution enhancement by derivative operation is linked to one of the multivariate analysis, which is multiple linear regression with two options, all possible and stepwise regression. Examined samples were synthetic mixtures of 5 vitamins, thiamine mononitrate, riboflavin phosphate, nicotinamide, pyridoxine hydrochloride and ascorbic acid. All components in mixture were quantified with reasonably good accuracy and precision. Whole data processing procedure was accomplished on-line by the development of three computer programs written in APPLESOFT BASIC language.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.20 no.44
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• pp.333-341
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• 1997

The purpose of this paper is to compare the manufacturing process with random covariate using multiple comparison procedure. The methodology that compares each manufacturing process by inspecting the number of nonconforming items out of k-treatment, has serveral limitations and problems according to the method and contect of the analysis. The proper way of analysis, therefore, could be obtained by the multiple comparison procedure of simultaneous confidence region of variance components. Effections that affect a manufactuing process may be predictive of responce to treatments are called covariates. In the study of comparing several treatments, prsense of covariate may bias the estimates of treatment effects.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.5
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• pp.3100-3106
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• 2014

This paper develops power measurement system with multiple sensor input channels (voltage-8 channels and current-10 channels) that simultaneously can monitor power components for both supply and load side of power system. The hardware implementation of the proposed system is based on TMS320C42 DSP and signal processing program algorithm to calculate power components use the definition of IEEE Standard 1459-2010 related power quality. The performance of the developed system is tested by using standard ac power source device, and the test results showed that accuracy of the developed system is less than 0.2 %. Also, field test of the proposed system in the three-phase and four-wire power system was implemented. Simultaneous multiple channel measurement and analysis of power components in commercial and industrial electrical power system using the proposed system will be necessary to reduce power quality problems.

• Journal of the Korean Society of Tobacco Science
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• v.4 no.1
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• pp.61-66
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• 1982

Essential oil components were isolated from Korean aromatic tobaccos by using a simultaneous distillation and extraction apparatus. The essential oils were analyzed by GC/M S and date system. Forty-two volatile components were identified on the basis of their mass spectra. Determination of contents of essential oil components from Hyangcho and Sohyang was achieved by pseudo-multiple ion selection (Ml S) technique. Varietal differences were detected from the quantitative comparison of the MIS data.

• Natural Product Sciences
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• v.27 no.4
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• pp.264-273
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• 2021

Simultaneous quantification of multiple marker compounds in herbal medicine by high performance liquid chromatography (HPLC) analysis is still a challenge due to the complexity in various parameters to be considered and co-existing multi-components. As a case study, a reliable HPLC method for simultaneous quantification of paeoniflorin from Paeoniae Radix and decursin from Angelicae Gigantis Radix in various commercial herbal medicine was developed based on analytical quality by design (AQbD) strategy. As a first step, risk assessment was performed to select the critical method parameters (CMPs) which were decided as organic mobile phase ratio and column oven temperature. In order to evaluate the effect of the CMPs on critical method attributes (CMAs) of peak resolution and tailing, central composite design (CCD) was employed. The final chromatographic conditions were optimized as follows: column- C₁₈, 4.6 × 250 mm, 5 ㎛ particle size; mobile phase- A: acetonitrile, B: 0.1% acetic acid water; detection wavelength- 235 nm for paeoniflorin, 325 nm for decursin; column oven temperature- 25℃; flow rate- 1.0 mL/min; gradient mobile phase system as Time (min) : % A, 0:14, 25:14, 30:50, 60:50, 61:100, 65:100, 66:14, 75:14. The method was successfully validated according to the International Conference on Harmonization (ICH) guidelines and piloted for ten commercial herbal medicines.

• Proceedings of the Korea Inteligent Information System Society Conference
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• 2005.11a
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• pp.516-525
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• 2005

Case-based reasoning (CBR) has been widely used in various areas due to its convenience and strength in complex problem solving. Generally, in order to obtain successful results from CBR, effective retrieval of useful prior cases for the given problem is essential. However, designing a good matching and retrieval mechanism for CBR systems is still a controversial research issue. Most prior studies have tried to optimize the weights of the features or selection process of appropriate instances. But, these approaches have been performed independently until now. Simultaneous optimization of these components may lead to better performance than in naive models. In particular, there have been few attempts to simultaneously optimize the weight of the features and selection of the instances for CBR. Here we suggest a simultaneous optimization model of these components using a genetic algorithm (GA). We apply it to a customer classification model which utilizes demographic characteristics of customers as inputs to predict their buying behavior for a specific product. Experimental results show that simultaneously optimized CBR may improve the classification accuracy and outperform various optimized models of CBR as well as other classification models including logistic regression, multiple discriminant analysis, artificial neural networks and support vector machines.

• Korean Journal of Food Science and Technology
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• v.30 no.1
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• pp.22-34
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• 1998

The purpose of this study is to develop biosensor for determination of glucose, lactate, and ethanol in foods and food-stuffs simultaneously. The multiple cathode system was prepared with an oxygen electrode having one anode and hexagonal cathode. Glucose oxidase, mutarotase, lactate oxidase, alcohol oxidase and catalase were used for immobilization to determine glucose, lactate, and ethanol. These components including ethanol were simultaneously determined by the immobilized enzymes in the multiple cathode system. The determination of the components by enzyme sensor was based on the maximum slope of oxygen consumption from enzyme reaction of each sensor part. The response time for analysis was 1 min. The optimum condition for glucose, lactate and ethanol sensor was found to be 0.1 M potassium phosphate buffer, pH 7.0 at $40^{\circ}C$. Interferences of various sugars and organic acids were investigated. Less than 10% of error was found in determination of the components except organic acids. This difference was compensated by the modified equation. This system was confirmed by conventional methods. It was concluded that the multiple cathode system of this study is for an effective method to determine sugar, organic acid, ethanol simultaneously in foods.

• Korean Journal of Veterinary Service
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• v.23 no.2
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• pp.137-142
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• 2000

In order to develop a good separation and simultaneous analysis of different sugar in an artificial mixed sugar solution, we analyzed 10 sugar components in an artificial mixed sugar solution composed of fructose, glucose, mannitol, sucrose, maltose, lactose, xylose, xylitol erythritol, and trehalose with using HPLC-ELSD or HPLC-RI. Separation and quantification by HPLC-ELSD was superior to those by HPLC-RI and detection sensitivity by HPLC-ELSD was higher then that by HPLC-RI as micorgram($\mu\textrm{g}$) level. 1. The units of minimal detectable limits were showed $\mu\textrm{g}$/$m\ell$ and ng/$m\ell$ by the HPLC-RI and HPLC-ELSD, respectively. 2. The condition of ELSD was drift tube temperature $82^{\circ}C$, $N_2$ gas flow rate 2.10 SLPM, and colum oven temperature $30^{\circ}C$, respectively. Isolation and recovery rates of single sugar from the multiple sugar solution was higher at the condition (time: flow rate: D.W.:ACN MeOH, min : $m\ell$/min:v:v:v) of linear gradient elution of mobile phase as 0 : 1.00 : 15 : 85 : 0.1 : 1.00 : 6 : 90 : 4, 17 : 1.00 : 10 : 70 : 20, 28 : 1.00 : 15 : 85 : 0 an 35 : 1.00 : 15 : 85 : 0, in order.

• Wind and Structures
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• v.18 no.4
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• pp.347-373
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• 2014

Since its development in the early 1980's the force balance technique has become a standard method in the efficient determination of structural loads and responses. Its usefulness lies in the simplicity of the physical model, the relatively short records required from the wind tunnel testing and its versatility in the use of the data for different sets of dynamic properties. Its major advantage has been the ability to provide results in a timely manner, assisting the structural engineer to fine-tune their building at an early stage of the structural development. The analysis of the wind tunnel data has evolved from the simple un-coupled system to sophisticated methods that include the correction for non-linear mode shapes, the handling of complex geometry and the handling of simultaneous measurements on multiple force balances for a building group. This paper will review some of the components in the force balance data analysis both in historical perspective and in its current advancement. The basic formulation of the force balance methodology in both frequency and time domains will be presented. This includes all coupling effects and allows the determination of the resultant quantities such as resultant accelerations, as well as various load effects that generally were not considered in earlier force balance analyses. Using a building model test carried out in the wind tunnel as an example case study, the effects of various simplifications and omissions are discussed.

• Korean Journal of Pharmacognosy
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• v.47 no.4
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• pp.366-373
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• 2016

Bulhwangeumjeonggisan (BHGJGS) is a traditional herbal formulation generally used in the treatment of cold and gastritis. BHGJGS consists of eight herbal plants; Atractylodis Rhizoma, Magnoliae Cortex, Citri Pericarpium, Glycyrrhizae Radix, Agastachis Herba, Pinelliae Rhizoma, Zingiberis Rhizoma and Zizyphi Fructus. Complete standardization of this formulation has not been done yet. So, a simple and accurate method was developed and validated using Ultra Performance Liquid Chromatography (UPLC) with Diode Array Detector (DAD) for the standardization of BHGJGS. UPLC conditions were optimized using a c18 RP-Amide column with mobile phase; 0.1% phosphate buffer and acetonitrile, detection wavelength; 210 and 325 nm. The linearities of calibration curves were acceptable ($R^2$>0.9994), and the limit of detection and quantification were within the ranges of 0.011-0.091 and $0.034-0.277{\mu}g/ml$ respectively. The relative standard deviation (RSD) of intra- and inter-day precisions were under 3.61%. The RSD of repeatability was under 0.68 %. The results of recovery test were 94.4-107.9%, and the RSD were under 4.6%. The developed method was used to find the contents of standard constituents in BHGJGS mix extract powder, and two commercial formulation (A and B). The data show that the developed method was specific, sensitive, accurate, and precise for analysis of BHGJGS components.