• Korean Journal of Clinical Pharmacy
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• v.28 no.3
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• pp.188-193
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• 2018

Background: Previous studies have noted that the simultaneous use of sulfonylureas and antimicrobials, which is common, could increase the risk of hypoglycemia. In particular, an age of 65 years or older is a known risk factor for sulfonylurea-related hypoglycemia in hospitalized patients. Therefore, we performed this study to determine the potential risk of hypoglycemia from the concurrent use of antimicrobials and sulfonylureas. Methods: We performed a cross-sectional study on the National Health Insurance Service-National Sample Cohort from 2013. The eligibility criteria included patients of 65 years of age or older taking a sulfonylurea with 25 different antimicrobials. Different risk ratings of severity in drug-drug interactions (potential DDIs), level X, D, or C in Lexi-$Interact^{TM}$ online, and contraindicated, major, or moderate severity level in $Micromedex^{(R)}$ were included. SAS version 9.4 was used for data analysis. Results: A total of 6,006 elderly patients with 25,613 prescriptions were included. The largest age group was 70 to 74 (32.7%), and 39.7% of patients were men. The mean number of prescriptions was 4.3 per patient. The most frequently used antimicrobials were levofloxacin (6,583, 25.7%), ofloxacin (6,549, 25.6%), fluconazole (4,678, 18.0%), and ciprofloxacin (2,551, 9.8%). Among sulfonylureas, glimepiride was prescribed most frequently, followed by gliclazide, glibenclamide, and glipizide. Conclusion: Of the antimicrobials with a high potential of hypoglycemia, levofloxacin, ofloxacin, fluconazole, and ciprofloxacin were used frequently. Thus, the monitoring of clinically relevant interactions is required for patients concurrently administered sulfonylureas and antimicrobials.

• Journal of Korea Multimedia Society
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• v.12 no.3
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• pp.345-353
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• 2009

It is for sure that a stable game managing system is absolutely needed to accept simultaneous interfacing of many users for P2P on-line game system. The proposed P2P on-line game system in this paper is able to get smart and stable game managing taking care of extensive players through reorganizing numerous RS(Region Server) and mutual communications among RS's which can be avoid congestion on one region. Moreover, it is possible to synchronize for game nodes in time stamp utilizing Global Zone Buffer of Monitoring Server which leads to breakup loads. The system manages middleware layers in the so-called sub area, and it is able to execute no matter how big the game sizes are. That means, in some ways, we got everything we try to ensure such as the problems of high cost server and stabilization of message transmission. This paper welcomes to prove efficiency of the suggested system through the simulation.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.37 no.3
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• pp.249-254
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• 2004

The hydro-acoustic method is widely used for estimating biomass and distribution of fisheries resources along the coast and in the ocean. High costs and time are necessary to construct systems for this method and to initially educate specialists. It has been used in fisheries of advanced nations like Japan and Norway, because it is more efficient than other methods. In order to research the behavior of fish around an artificial reef using an echo sounder, volume backscattering strength (SV) and fish per cubic meter (FPCM) of darkbanded rockfish around the model artificial reef in a water tank were measured. Moreover, behavior of fish was observed in an adjacent artificial reef, which was constructed at Tongyeong marine ranching area. Following that, an acoustics survey was conducted at Mirukdo around the Tongyeong marine ranching area, in order to understand the spatial distribution and strength of fisheries resources. Very high patches of fish were found in a wide area around the artificial reef. It is thought that an approaching fish school around the artificial reef can be measured accurately by using an echo sounder of high resolution. Moreover, use of other monitoring methods like of diving or ROV simultaneous with an echo sounder is required in order to grasp the species and ecology of fish inhabiting the area around the artificial reef.

• International Journal of Aeronautical and Space Sciences
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• v.16 no.3
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• pp.380-393
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• 2015

This study presents how we can evaluate stereo camera systems for the structural deformation monitoring. A stereo camera system, consisting of a set of stereo cameras and reflective markers attached on the structure, is introduced for the measurement and the stereo pattern recognition (SPR) method is utilized for the full-field structural deformation estimation. Performance of this measurement system depends on many parameters including types and specifications of the cameras, locations and orientations of them, and sizes and positions of markers; it is difficult to experimentally identify the effects of each parameter on the measurement performance. In this study, a simulation framework for evaluating performance of the stereo camera systems with various parameters has been developed. The maximum normalized root-mean-square (RMS) error is defined as a representative index of stereo camera system performance. A plate structure is chosen for an introductory example. Its several modal harmonic vibrations are generated and estimated in the simulation framework. Two cases of simulations are conducted to see the effects of camera locations and the resolutions of the cameras. An experimental validation is carried out for a few selected cases from the simulations. Using the simultaneous laser displacement sensor (LDS) measurements as the reference, the measurement errors are obtained and compared with the simulations.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.15 no.3
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• pp.261-269
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• 2005

To investigate the field applicability of a diffusive sampler (3M OVM #3500, passive sampling method) authors conducted a simultaneous measurement of personal organic solvents exposure in the air of the workplaces by charcoal tube with low volume sampler (active sampling method) and diffusive sampler. Samples were collected and analyzed by NIOSH method ($NMAM^{(R)}$) from thirty-eight workers in 12 factories who work in 6 different processes. Geometric mean (GM) and geometric standard deviation (GSD) were used to describe the result. To compare the results of the two methods, paired t-test was used. According to the manual of the exposure assessment of the mixed organic solvents (Ministry of Labor, Korea), Em was calculated. Simple linear regression was used to evaluate the relationship between the two methods. Results were as follows; 1. Eight different solvents (ethyl acetate, n-hexane, toluene, xylene, acetone, isopropyl alcohol, methyl ethyl ketone (MEK), and methyl isobutyl ketone) were detected simultaneously in the two methods and the concentrations of the personal exposure were lower than 0.5 TLV level. The concentration of the charcoal tube method was higher than that of a diffusive sampler in n-hexane and MEK (p<0.05). 2. Em of the charcoal tube method was higher than that of diffusive sampler method but not significantly different and was lower than the OEL (Occupational Exposure Limit) in all 6 processes. 3. There was a significant correlation between the two methods in low concentrations of the 8 organic solvents (p<0.05). In conclusion, there was no difference in charcoal tube method and diffusive sampler method in low concentrations of some organic solvents, diffusive sampler can be applied to assess the personal monitoring in low level exposure.

• Korean Journal of Pharmacognosy
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• v.49 no.1
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• pp.76-83
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• 2018

A traditional herbal formula, Gyeji-tang has been used to treat the early colds, headache, chills, and fever in Asian countries. In this study, we were performed simultaneous determination of the 14 bioactive marker compounds, gallic acid, spinosin, paeoniflorin, albiflorin, liquiritin apioside, liquiritin, 6'''-feruloylspinosin, liquilitigenin, coumarin, cinnmamic acid, benzoylpaeoniflorin, cinnamaldehyde, glycyrrhizin, and 6-gingerol in Gyeji-tang using an ultra-performance liquid chromatography-electrospray ionization-mass spectrometry (UPLC-ESI-MS/MS). Analytical column was used a Waters Acquity UPLC BEH $C_{18}$ analytical column ($2.1{\times}100mm$, $1.7{\mu}m$) and maintained at $45^{\circ}C$ with a flow rate of 0.3 mL/min. The mobile phase consists of 0.1% (v/v) formic acid in water and acetonitrile with gradient elution. The MS analysis was conducted using multiple reaction monitoring in the positive and negative modes by a Waters ACQUITY TQD LC-MS/MS system. The calibration curves of 14 bioactive marker compounds showed linearity with correlation coefficients ${\geq}0.9798$. The limits of detection and quantification values were in the range of 0.11-6.66 ng/mL and 0.34-19.99 ng/mL, respectively. As a result of the analysis using the established LC-MS/MS method, the amounts of tested 14 compounds in the lyophilized Gyeji-tang sample were detected up to $85.7{\mu}g/g$. These results may be useful for quality assessment of a traditional herbal formulas.

• Korean Journal of Food Science and Technology
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• v.36 no.6
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• pp.863-871
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• 2004

Analyses of residual pesticides in raw materials used for dietary supplements were performed using multi-ingredients simultaneous analysis method. Pesticides such as BHC, chlorpyrifos, and quintozene were detected in 12 domestic and 7 imported samples, suggesting need for monitoring pesticides in domestic and imported raw materials and establishing residual limit of each pesticide.

• Advances in pediatric surgery
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• v.14 no.1
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• pp.27-36
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• 2008

Fundoplication is a common surgical procedure for gastroesophageal reflux disease (GERD). Recently the procedure has been performed with increased frequency laparoscopically. The aim of this study is to review our 11 years experience with fundoplication in infants and children. From October 1994 to December 2005, 59 fundoplications in 55 patients were performed at Sungkyunkwan University Samsung Medical Center. Medical records and laboratory results of these children were retrospectively reviewed for sex, age, symptoms and signs, coexisting disease, diagnostic methods, treatment modalities and length of operative time. Open fundoplication was performed in 41 cases and laparoscopic fundoplication in 18 cases. Simultaneous gastrostomy was done in 27 cases. Recurrent GERD symptom occurred in four patients (7.2 %) within 2 years after first fundoplication and all 4 patients had re-do fundoplication. There were no intra- and immediate post-operative complications. Gastrointesitnal symptoms were the most common indication for fundoplication in neurologically normal patients. The most frequent diagnostic studies were upper gastrointestinal series (76.3 %) and 24 hour esophageal pH monitoring (78.2 %). Fundoplication had been increased since 2004 and mostly done laparoscopically. In conclusion, our 11 years' practice of open and laparoscopic fundoplication indicates that both approaches are safe and effective in the treatment of GERD for infants and children.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.45 no.9
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• pp.67-74
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• 2008

This paper proposes, designs and implements an architecture of a server involved with the network camera based video surveillance systems to solve common problems including lack of inter-network operability at the video information sharing, drawback of bandwidth and processing-overhead caused by increase of the number of users, and difficulty of continuous monitoring over changes of network configurations. The proposed saver was designed to manage and service numerous network cameras and users as well as solving the existing problems by providing video distribution facility. Through the empirical study after applying the implemented server to a real video surveillance system we proved that the server can provide reasonable service quality while it processes several hundreds of simultaneous user connections under persisting more than one hundred connections to network cameras. We expect the developed video distribution server to enhance service quality of the large scale video surveillance systems for citizen-wide services such as traffic reporting informatics or natural calamities supporting.

• The Korean Journal of Mycology
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• v.37 no.2
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• pp.161-166
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• 2009

The purpose of the present study is to develop a simple, fast and sensitive LC/MS method for simultaneous separation and the determination of an active component in the oriental medicinal mushroom Cordyceps militaris. Based on this work, the contents of cordycepin in Cordyceps militaris fruiting cultivated on various media were determined and compared. And also, the nutritional components such as minerals and vitamins were determined in order to provide useful information to consumer as a food material. The analysis methods of nutritional components were chosen on the basis of AOAC. The optimum separation for cordycepin was achieved using a solvent gradient consisting of the mixture of 0.1% formic acid in methanol (solvent B) in a background of 0.1% formic acid in water (solvent A) as a mobile phase and a 3.0${\times}$150 Waters XTera column. Selective ion monitoring (SIR) mode ([M+H]+ at m/z 252) was used for quantitative analysis of cordycepin. The cultivated Cordyceps militaris on various media contained 1~14 /g of cordycepin, 0.65~1.08% of thiamine, 0.86~7.17% of riboflavin, and 3.01~5.26% of niacin. The content of mineral components varied on categories, especially contained 500~3500% of potassium as a major mineral. Cordycepin, niacin and potassium were found much higher in the fruiting cultivated with soy power media (gold 10) than other media.