• Toxicological Research
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• v.18 no.2
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• pp.205-213
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• 2002

This study was undertaken to develop a subacute murine model for predicting occurrence of systemic anaphylaxis and to evaluate efficacy of various immunological parameters as the monitoring indices for the occurrence of anaphyalxis. The murine anaphyalxis model was developed through intraperitoneally sensitizing 100 $\mu\textrm{g}$ ovalbumin (OVA) in the presence of 1 mg alum and 300 ng cholera toxin twice a week interval followed by challenging 500 $\mu\textrm{g}$. OVA intravenously. Typical anaphylaxis symptoms were demonstrated at the both BALB/c mice, a strain prone to type-2 response, and C57BL/6 mice. a strain prone to type-1 response. Level of plasma histamine was approximately 50-fold or 30-fold higher in the mice sensitized with OVA than the mice sensitized with alum plus cholera toxin or the saline-treated mice after OVA challenge, respectively. Sensitization and challenge with OVA significantly enhanced plasma leukotriene $B_4$ level but not IgE levels in comparison with the control mice, which indicated the role of leukotriene $B_4$ for progression of anaphyalxis. Furthermore, among mice suffered from anaphylaxis, levels of OVA-specific IgGl were significantly higher in the BALB/c mice than in the C57BL/6 mice, which implied the genetic susceptibility for the induction of systemic anaphylaxis. Conclusively, simultaneous evaluation of histamine, leukotriene $B_4$, and allergen-specific IgG isotype may serve as more efficient monitoring tool for vaccine-related anaphyalxis.

• Proceedings of the Korean Society of Crop Science Conference
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• 2017.06a
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• pp.60-60
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• 2017

It is important to measure the gas exchange activity of the crops in canopy scale to understand the process of biomass production and yield formation. Thermal imaging of the canopy surface temperature is a powerful tool to detect the gas exchange activity of the crop canopy. The simultaneous measurement of the canopy temperature and the meteorological data enables us to calculate the canopy diffusive conductance ($g_c$) based on the heat flux model (Monteith et al. 1973, Horie et al. 2006). It is, however, difficult to realize the long-term and continuous monitoring of $g_c$ due to the occurrence of the calculation error caused by the fluctuation of the environmental condition. This is partly because the model assumption is too simple to describe the meteorological and aerodynamic conditions of the crop canopy in the field condition. Here we report the novel method of the direct measurement of the aerodynamic resistance ($r_a$) of the crop canopy, which enables us the stable and continuous measurement of the gas exchange capacity of the crop plants. The modified heat balance model shows the improved performance to quantify $g_c$ under the fluctuating meteorological condition in the field. The relationship between $g_c$ and biomass production of rice and soybean varieties is also discussed in the presentation.

• Journal of Environmental Impact Assessment
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• v.15 no.2
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• pp.121-127
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• 2006

The conventional water quality measurements by point sampling provide only site specific temporal water quality information but not the synoptic geographic coverage of water quality distribution. To circumvent these limitations in temporal and spatial measurements, the use of remote sensing is increasingly involved in the water quality monitoring research. In other to assess a trophic state of Yongdam reservoir using satellite imagery data, I obtained Landsat ETM data and water quality data on 16th September and 18th October 2001. The approach involved acquisition of water quality samples from boats at 33 sites on 16th September and 30 sites on 18th October 2001, simultaneous with Landsat-7 satellite overpass. The correlation coefficients between the DN values of the imagery and the concentrations of chlorophyll-a were analyzed. The visible bands(band 1,2,3) and near infrared band(band 4) data of September image showed the correlation coefficient values higher than 0.9. The October image showed the correlation coefficient values about 0.7 due to the atmospheric effect and low variation of chlorophyll-a concentration. Regression models between the chrophyll-a concentration and DN values of the Landsat imagery data have been developed for each image. The regression model was determined based on the spectral characteristics of chlorophyll, so the green band(band 2) and near infrared band(band 4) were selected to generate a trophic state map. The coefficient of determination(R2) of the regression model for 16th September was 0.95 and that of the regression model for 18th October was 0.55. According to the trophic state map made based on Aizaki's TSI and chlorophyll-a concentration, the trophic state of Yongdam reservoir was mostly eutrophic state during this study.

• Journal of Chest Surgery
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• v.14 no.3
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• pp.228-234
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• 1981

Measurement of cardiac output by thermodilution method is easy to perform and can be repeated at very short intervals and offers a number of theoretical and practical advantages. The purpose of this paper is to reevaluate the accuracy and reproducibility of the thermodilution cardiac output by comparing the results with those obtained by the direct Fick technique. From January through April 1981 [4 months], 26 simultaneous cardiac output measurements were made using thermodilution and direct Fick methods in 12 patients in the intensive care unit of Severance Hospital following open heart surgery. The average age of the patients was $34.8{\pm}12.0$ [SD] years [range; 17-57 years]. For cardiac output determination by thermodilution technique [$CO_TD$], a Swan-Ganz Thermodilution Catheter, Model 93A-131-7F [Edwards Laboratories], a Cardiac Output Computer, Model 9520A, and Strip Chart Recorder, Model 9810 [Edwards Laboratories] were used. For the determination of cardiac output by direct Fick principle [$CO_Fick$], a Van Slyke Manometric Apparatus [Thomas] for the measurements of arteriovenous oxygen content difference and a Collin`s Respirometer with Kymograph for the measurement of oxygen consumption were used. The correlation between the simultaneously measured $CO_TD$ and $CO_Fick$ was found to be $CO_Fick$ = 0.95.$CO_TD$ + 0.1073, [r= 0.9777, P < 0.001 ]. For 26 double or triple determinations of $CO_TD$, the values ranged from 1.77 L/min to 6.66 L/min, with a reproducibility of 2.18%. The maximum difference of $CO_TD$ for $CO_Fick$ was between +11.99% and -12,99% [$Mean{\pm}SD$ = $6.07{\pm}3.97$%]. Measurement of cardiac output by thermodilution method provides a simple, rapid, reproducible and highly accurate method for multiple cardiac output measurements suitable for use at the bedside. Comparison of Cardiac Output Determination by Direct Fick and Thermodilution Method in Man.

• Fire Science and Engineering
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• v.30 no.1
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• pp.31-36
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• 2016

This study investigates the characteristics of thermal decomposition of an epoxy-based intumescent paint using thermogravimetric analysis (TGA) and numerical simulation. A mathematical and numerical model is introduced to describe mass loss profiles of the epoxy-based intumescent coating induced by the thermal decomposition process. The decomposition scheme covers a range of complexity by employing simplified 4-step sequential reactions to describe the simultaneous thermal decomposition processes. The reaction rates are expressed by the Arrhenius law, and reaction parameters are optimized to fit the degradation behavior seen during thermogravimetric (TG) experiments. The experimental results show a major 2-step degradation under nitrogen and a 3-step degradation in an air environment. The experiment also shows that oxygen takes part in the stabilization of the intumescent coating between 200 and $500^{\circ}C$. The simulation results show that the proposed model effectively predicts the experimental mass loss as a function of time except for temperatures above $800^{\circ}C$, which were intentionally not included in the model. The maximum error in the simulation was less than 3%.

• Journal of the Korea institute for structural maintenance and inspection
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• v.20 no.5
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• pp.66-74
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• 2016

The objective of this study is the investigation of the influence of carbonation on the penetration of chloride ions in reinforced concrete sections for different mix proportions and environmental conditions. A comprehensive numerical model based on the change of the pore structure and the chemical equilibrium was used for this combined action of carbonation and chloride ingress. The empirical formulae of some parameters in this model are estimated according to numerous experimental data. And, a set of data analysis is carried out to simplify the estimation of model variables to reduce the computational cost. A coupled simulation of the transports of carbon dioxide, chloride ions, heat and moisture is carried out. Then, the parametric analysis is given and the numerical results show that the effect of carbonation of the free chloride ingress is significant and depends on the binder types and concrete mix proportion.

• Journal of KIISE:Computer Systems and Theory
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• v.33 no.1_2
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• pp.110-118
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• 2006

Cryptographic protocol design in a two-party setting has of tel ignored the possibility of simultaneous message transmission by each of the two parties (i.e., using a duplex channel). In particular, most protocols for two-party key exchange have been designed assuming that parties alternate sending their messages (i.e., assuming a bidirectional half-duplex channel). However, by taking advantage of the communication characteristics of the network it may be possible to design protocols with improved latency. This is the focus of the present work. We present three provably-secure protocols for two-party authenticated key exchange (AKE) which require only a single round. Our first, most efficient protocol provides key independence but not forward secrecy. Our second scheme additionally provides forward secrecy but requires some additional computation. Security of these two protocols is analyzed in the random oracle model. Our final protocol provides the same strong security guarantees as our second protocol, but is proven secure in the standard model. This scheme is only slightly less efficient (from a computational perspective) than the previous ones. Our work provides the first provably- secure one-round protocols for two-party AKE which achieve forward secrecy.

• Journal of Korea Water Resources Association
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• v.31 no.4
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• pp.415-427
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• 1998

FIAS (Flood Inundation Analysis System) using Arc/Info is developed and applied to the South Han River basin. The DWOPER model is revised and expanded to handle simultaneous multiple overtopping and/or breaking and to estimate the inundation depth and extents. The model is applied to an actual levee overtopping case, which occurred on August 23~27, 1995 in the South Han River. Stage hydrographs inside and outside of the levee are compared, then inundated discharges from overbank spilling are computed. The Graphic User Interface is developed with AML(Arc/Info Macro Language). Two-and three-dimensional inundation maps by Arc/Info are presented. The computed inundation extends agree with observations in terms of inundation depth and flooded area. Keywords : River, Floodwave, Flood Inundation, Geographic Information System.

• Journal of the Korean Data and Information Science Society
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• v.24 no.1
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• pp.161-170
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• 2013

The FX (Foreign Exchange) is a form of exchange for the global decentralized trading of international currencies. The simple sense of Forex is simultaneous purchase and sale of the currency or the exchange of one country's currency for other countries'. We can find the consistent rules of trading by comparing the gradient boosting method and the decision trees methods. Methods such as time series analysis used for the prediction of financial markets have advantage of the long-term forecasting model. On the other hand, it is difficult to reflect the rapidly changing price fluctuations in the short term. Therefore, in this study, gradient boosting method and decision tree method are applied to analyze the short-term data in order to make the rules for the revenue structure of the FX market and evaluated the stability and the prediction of the model.

• Journal of Sasang Constitutional Medicine
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• v.26 no.2
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• pp.165-179
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• 2014

Objectives To evaluate the neuroprotective effects of Hyangsayangwi-tang (HY), a Korean traditional medicinal prescription in a Parkinson's disease mouse model. Methods Four groups(each of 10 mouse per group) were used in this study. The neuroprotective effect of HY was examined in a Parkinson's disease mouse model. C57BL/6 mouse treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 30mg/kg/day), intraperitoneal (i.p.) for 5 days. Slow behavioral responses and memory disorder is the major clinical symptoms of PD. In order to investigate the effect of HY on recovery of behavioral deficits and memory, we examined the motor function and memory by using Morris water maze and Forced swimming test. Ischemic mouse brain stained with TTC(2,3,5 triphenyl tetrazolium chloride) in the MPTP-induced Parkinson's disease to find out ischemia and tissue damage in mouse. The convenient, simple, and accurate high-performance liquid chromatography (HPLC) method was established for simultaneous determination of neurotransmitters in MPTP-HY group. To measure the amount of dopamine in mice brain, striatum-substantia nigra, was examined by Bradford assay. Immunohistochemistry was examined in the MPTP-induced Parkinson's disease (PD) mouse to evaluate the neuroprotective effects of Hyangsayangwi-tang on hippocampal lesion, ST and SNpc. Results and Conclusions Hyangsayangwi-tang (HY) prevents MPTP-induced loss of serotonin, hippocampus and TH-ir cell.