• The Korea Journal of Herbology
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• v.33 no.6
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• pp.71-78
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• 2018

Objectives : This study was fulfilled to investigate nominee materials as anti-inflammatory agent from ethanol extract of Chinese medicinal plants in Yanjin. Among the 20 candidates, we selected most effective one, the ethanol extract of Cicuta virosa L. (CVL). The mechanism underlying the anti-inflammatory effects of CVL is not clearly identified as yet. Accordingly, we clarified the anti-inflammatory effects of CVL and its underlying molecular mechanisms in LPS-stimulated RAW 264.7 macrophages. Methods : RAW264.7 macrophages were incubated with CVL (12.5, 25, or $50{\mu}M$) and/or lipopolysaccharide (LPS) ($1{\mu}g/m{\ell}$). Cytotoxicity was determined using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide assay and the level of nitric oxide (NO) production was measured with Griess reagent. The prostaglandin $E_2$ ($PGE_2$) production was measured with enzyme immunoassay kits and the protein expression of inducible nitric oxide synthase (iNOS) was determined using Western blot analysis. Results : Among the 20 ethanol extract of Chinese medicinal plants of Yanjin tested, CVL significantly reduced the production of NO in a dose-dependent manner via inhibition the protein expressions of iNOS without cytotoxicity on the LPS-stimulated RAW 264.7 macrophages. In addition, CVL also effectively declined the production of $PGE_2$ in LPS-simulated RAW 264.7 macrophages. Conclusions : Taken together, these data presented in this study demonstrate that CVL possesses anti-inflammatory activity by suppressing the production of pro-inflammatory mediators NO and $PGE_2$, and pro-inflammatory protein iNOS expression in LPS-stimulated RAW 264.7 macrophages.

• Ocean and Polar Research
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• v.44 no.4
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• pp.269-285
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• 2022

The interaction between ocean and ice shelf is a critical physical process in relation to water mass transformations and ice shelf melting/freezing at the ocean-ice interface. However, it remains challenging to thoroughly understand the process due to a lack of observational data with respect to ice shelf cavities. This is the first study to simulate the variability and circulation of water mass both overlying the continental shelf and underneath an ice shelf and an ice tongue in the Terra Nova Bay (TNB), East Antarctica. To explore the properties of water mass and circulation patterns in the TNB and the corresponding effects on sub ice shelf basal melting, we explicitly incorporate the dynamic-thermodynamic processes acting on the ice shelf in the Regional Ocean Modeling System. The simulated water mass formation and circulation in the TNB region agree well with previous studies. The model results show that the TNB circulation is dominated by the geostrophic currents driven by lateral density gradients induced by the releasing of brine or freshwater at the polynya of the TNB. Meanwhile, the circulation dynamics in the cavity under the Nansen Ice shelf (NIS) are different from those in the TNB. The gravity-driven bottom current induced by High Salinity Shelf Water (HSSW) formed at the TNB polynya flows towards the grounding line, and the buoyance-driven flow associated with glacial meltwater generated by the HSSW emerges from the cavity along the ice base. Both current systems compose the thermohaline overturning circulation in the NIS cavity. This study estimates the NIS basal melting rate to be 0.98 m/a, which is comparable to the previously observed melt rate. However, the melting rate shows a significant variation in space and time.

• Journal of Korea Water Resources Association
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• v.55 no.12
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• pp.991-998
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• 2022

The purpose of this study is to develop GPU (Graphics Processing Unit) acceleration technique for 2-dimensional model and to assess the effectiveness for high resolution flood simulation in wide area In this study, GPU acceleration technique was implemented in the G2D (Grid based 2-Dimensional land surface flood model) model, using implicit scheme and uniform square grid, by using CUDA. The technique was applied to flood simulation in Jinju-si. The spatial resolution of the simulation domain is 10 m × 10 m, and the number of cells to calculate is 5,090,611. Flood period by typhoon Mitag, December 2019, was simulated. Rainfall radar data was applied to source term and measured discharge of Namgang-Dam (Ilryu-moon) and measured stream flow of Jinju-si (Oksan-gyo) were applied to boundary conditions. From this study, 2-dimensional flood model could be implemented to reproduce the measured water level in Nam-gang (Riv.). The results of GPU acceleration technique showed more faster flood simulation than the serial and parallel simulation using CPU (Central Processing Unit). This study can contribute to the study of developing GPU acceleration technique for 2-dimensional flood model using implicit scheme and simulating land surface flood in wide area.

• Atmosphere
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• v.31 no.5
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• pp.625-635
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• 2021

South Korea established the 2050 Carbon Neutral Plan in response to the climate crisis, and to achieve this policy, it is very important to monitor domestic carbon emissions and atmospheric carbon concentration. Both CO₂ and CO are emitted from fossil fuel combustion processes, but the relative ratios depend on the combustion efficiency and the strength of local emission regulations. In this study, the relationship between CO₂ and CO was analyzed using ground observation data for the period of 2018~2020 at Anmyeon-do site and the CO/CO₂ ratio according to regional origin during high CO₂ cases was investigated based on the footprint simulated from Stochastic Time-Inverted Lagrangian Transport (STILT) model. CO₂ and CO showed a positive correlation with correlation coefficient of 0.66 (p < 0.01), and averaged footprints during high CO₂ cases confirmed that air particles mainly originated from eastern and north-eastern China, and inland of Korean Peninsula. In addition, it was revealed that among the cases of high CO₂ concentration, when the CO/CO₂ ratio is high, the industrial area of eastern China is greatly affected, and when the ratio is low, the contribution of the domestic region is relatively high. The ratio of CO₂ and CO in this study is significant in that it can be used as a useful factor in determining the possibility of domestic and foreign origins of climate pollutants.

• Journal of Korean Elementary Science Education
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• v.42 no.1
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• pp.17-33
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• 2023

This study examined inservice elementary teachers' thoughts on the development of educational apps by preservice elementary teachers and implications for TPACK education for preservice elementary teachers. A case study was conducted in which preservice elementary teachers developed a science education app, and the three teachers were surveyed for their thoughts regarding this. The results regarding the characteristics of the developed app by preservice teachers were as follows. First, "inquiry" had the highest value among educational goals intended by the preservice teachers. In addition, the scores for tool-type apps and apps in which interaction between learners and instructors occurs were relatively high. Second, most of the preservice teachers developed apps to meet curriculum goals, but their apps showed low-level characteristics in terms of the constructive and cooperative dimensions. The results of the analysis of the thinking of elementary school teachers regarding the education development apps are as follows. First, elementary school teachers assigned the lowest scores to the effectiveness of the apps, and to this problem, the achievement standard with respect to the curriculum and the evaluation and modification activities fir the apps were proposed. Second, the teachers indicated that it would be appropriate to provide the experience of making apps to directly improve the TPACK of preservice teachers. Third, the respondents thought that preservice teachers should develop block coding literacy to create apps using App Inventor. Fourth, the teachers considered it necessary to emphasize simulated instructions, as well as the experience of collecting and handling data through apps to improve preservice teachers' TPACK app development for educational use.

• Journal of the Korean Geotechnical Society
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• v.23 no.6
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• pp.53-66
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• 2007

A series of model tests were performed to investigate the soil arching effect in embankments supported by piles with geosynthetics. In the model tests, model piles with isolated cap were inserted through the holes in a steel plate, which could be operated up and down. Then geosynthetics was laid on the pile caps below sand fills. The settlement of soft ground was simulated by lowering the plate. As the plate was lowered, the soil arching was mobilized in the embankments. The deformation of both the sand fills and geosynthetics were captured by camera. Also the loads acting on pile cap and the tensile strain of geosynthetics were monitored by data logging system. Model tests showed that the embankment loads transferred on pile cap by soil arching Increased rapidly with settlement of the soft ground. In case of the absence of geosynthetics, the loads acting on pile caps dropped to residual value after peak value, whereas loads on pile caps gradually increased until constant value in case of geosynthetic-reinforced. This illustrated that reinforcing with the geosynthetics has a good effect to restrain the settlement of embankments. Also, the deformation shape of geosynthetics between pile caps was circular. The embankment loads transferred on pile caps can be estimated by considering both soil arching and tensile strain of geosynthetics in embankments supported by piles with geosynthetics.

• Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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• v.7 no.6
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• pp.239-246
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• 2017

This paper compares the speech signal parameters between Korean and Chinese for Korean pronunciation /ㄹ/, which is caused many errors by Chinese leaners. Allophones of /ㄹ/ in Korean is divided into lateral group and tap group. It has been investigated the reasons for these errors by studying the similarity and the differences between Korean /ㄹ/ pronunciation and its corresponding Chinese pronunciation. In this paper, for the purpose of comparison the speech signal parameters such as energy, waveform in time domain, spectrogram in frequency domain, pitch based on ACF, Formant frequencies are used. From the phonological perspective the speech signal parameters such as signal energy, a waveform in the time domain, a spectrogram in the frequency domain, the pitch (F0) based on autocorrelation function (ACF), Formant frequencies (f1, f2, f3, and f4) are measured and compared. The data, which are composed of the group of Korean words by through a philological investigation, are used and simulated in this paper. According to the simulation results of the energy and spectrogram, there are meaningful differences between Korean native speakers and Chinese leaners for Korean /ㄹ/ pronunciation. The simulation results also show some differences even other parameters. It could be expected that Chinese learners are able to reduce the errors considerably by exploiting the parameters used in this paper.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.29 no.6B
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• pp.503-512
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• 2009

Watershed models, which are a tool for water cycle mechanism, are classified as the distributed model and the lumped model. Currently, the distributed models have been more widely used than lumped model for many researches and applications. The lumped model estimates the parameters in the conceptual and empirical sense, on the other hand, in the case of distributed model the first-guess value is estimated from the grid-based watershed characteristics and rainfall data. Therefore, the distributed model needs more detailed parameter adjustment in its calibration and also one should precisely understand the model parameters' characteristics and sensitivity. This study uses Jungnang basin as a study area and $Vflo^{TM}$ model, which is a physics-based distributed hydrologic model, is used to analyze its parameters' sensitivity. To begin with, 100 years frequency-design rainfall is derived from Huff's method for rainfall duration of 6 hours, then the discharge is simulated using the calibrated parameters of $Vflo^{TM}$ model. As a result, hydraulic conductivity and overland's roughness have an effect on runoff depth and peak discharge, respectively, while channel's roughness have influence on travel time and peak discharge.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.17 no.7
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• pp.1951-1975
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• 2023

Recent advances in Cognitive Radio Networks (CRN) have elevated them to the status of a critical instrument for overcoming spectrum limits and achieving severe future wireless communication requirements. Collaborative spectrum sensing is presented for efficient channel selection because spectrum sensing is an essential part of CRNs. This study presents an innovative cooperative spectrum sensing (CSS) model that is built on the Firefly Algorithm (FA), as well as machine learning artificial neural networks (ANN). This system makes use of user grouping strategies to improve detection performance dramatically while lowering collaboration costs. Cooperative sensing wasn't used until after cognitive radio users had been correctly identified using energy data samples and an ANN model. Cooperative sensing strategies produce a user base that is either secure, requires less effort, or is faultless. The suggested method's purpose is to choose the best transmission channel. Clustering is utilized by the suggested ANN-FA model to reduce spectrum sensing inaccuracy. The transmission channel that has the highest weight is chosen by employing the method that has been provided for computing channel weight. The proposed ANN-FA model computes channel weight based on three sets of input parameters: PU utilization, CR count, and channel capacity. Using an improved evolutionary algorithm, the key principles of the ANN-FA scheme are optimized to boost the overall efficiency of the CRN channel selection technique. This study proposes the Artificial Neural Network with Firefly Algorithm (ANN-FA) for cognitive radio networks to overcome the obstacles. This proposed work focuses primarily on sensing the optimal secondary user channel and reducing the spectrum handoff delay in wireless networks. Several benchmark functions are utilized We analyze the efficacy of this innovative strategy by evaluating its performance. The performance of ANN-FA is 22.72 percent more robust and effective than that of the other metaheuristic algorithm, according to experimental findings. The proposed ANN-FA model is simulated using the NS2 simulator, The results are evaluated in terms of average interference ratio, spectrum opportunity utilization, three metrics are measured: packet delivery ratio (PDR), end-to-end delay, and end-to-average throughput for a variety of different CRs found in the network.

• Steel and Composite Structures
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• v.48 no.2
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• pp.207-233
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• 2023

Steel-concrete composite box girder bridges are widely used in the construction of highway and railway bridges both domestically and abroad due to their advantages of being light weight and having a large spanning ability and very large torsional rigidity. Composite box girder bridges exhibit the effects of shear lag, restrained torsion, distortion and interface bidirectional slip under various loads during operation. As one of the most commonly used calculation tools in bridge engineering analysis, one-dimensional models offer the advantages of high calculation efficiency and strong stability. Currently, research on the one-dimensional model of composite beams mainly focuses on simulating interface longitudinal slip and the shear lag effect. There are relatively few studies on the one-dimensional model which can consider the effects of restrained torsion, distortion and interface transverse slip. Additionally, there are few studies on vehicle-bridge integrated systems where a one-dimensional model is used as a tool that only considers the calculations of natural frequency, mode and moving load conditions to study the dynamic response of composite beams. Some scholars have established a dynamic analysis model of a coupled composite beam bridge-train system, but where the composite beam is only simulated using a Euler beam or Timoshenko beam. As a result, it is impossible to comprehensively consider multiple complex force effects, such as shear lag, restrained torsion, distortion and interface bidirectional slip of composite beams. In this paper, a 27 DOF vehicle rigid body model is used to simulate train operation. A two-node 26 DOF finite beam element with composed box beams considering the effects of shear lag, restrained torsion, distortion and interface bidirectional slip is proposed. The dynamic analysis model of the coupled composite box girder bridge-train system is constructed based on the wheel-rail contact relationship of vertical close-fitting and lateral linear creeping slip. Furthermore, the accuracy of the dynamic analysis model is verified via the measured dynamic response data of a practical composite box girder bridge. Finally, the dynamic analysis model is applied in order to study the influence of various mechanical effects on the dynamic performance of the vehicle-bridge system.