• Asian Pacific Journal of Cancer Prevention
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• 제16권16호
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• pp.7003-7006
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• 2015

Background: Nanoparticles of gold and silver are offering revolutionary changes in the field of cancer therapy. N-heterocyclic carbene (NHC) metal complexes possess diverse biological activities and are being investigated as potential chemotherapeutic agents. The purpose of this study was to examine the cytotoxicity and possible mechanisms of action of two types of newly synthesized nanofiber composites containing BIAN N-heterocyclic gold carbene complexes in two types of human cancer cells, namely breast cancer (MCF7) and liver cancer (HepG2) cells and also in normal human embryonic kidney cells (HEK 293). Materials and Methods: Cytotoxicity was assessed by MTT cell viability assay and oxidative stress by checking the total glutathione level. Results: Both compounds affected the cell survival of the tested cell lines at very low concentrations (IC50 values in the micro molar range) as compared to a well-known anti-cancer drug, 5 fluorouracil. A 60-80% depletion in total glutathione level was detected in treated cells. Conclusions: Reduction in total glutathione level is one of the biochemical pathways for the induction of oxidative stress which in turn could be a possible mechanism of action by which these compounds induce cytotoxicity in cancer cell lines. The in vitro toxicity towards cancer cells found here means that these molecules could be potential anticancer candidates.

• 한국진공학회지
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• 제22권3호
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• pp.156-161
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• 2013

연속적인 1차원의 나노섬유를 제작하는데 빠르고 효과적인 방법인 전기방사법을 이용하여 Ag 나노섬유로 이루어진 투명전극을 제작하고 그 특성을 측정하였다. 전기방사를 통해 제조된 Ag 나노섬유는 큰 종횡비를 갖게 되며 열처리를 통해 생성된 섬유사이의 fused junction이 접촉저항을 낮추어 전기적 특성을 향상시킨다. Ag/고분자 용액을 졸-겔 방법을 이용하여 제조한 후 glass 기판위에 방사시켜 Ag/고분자 나노섬유 구조체를 제작하고 $200{\sim}500^{\circ}C$, 2시간 열처리하여 고분자가 일정부분 제거되고 전도성이 향상된 Ag 나노섬유 투명전극을 제조하였다. Ag 나노섬유의 모폴로지를 FE-SEM을 통해 확인하였고 Ag 나노섬유 투명전극의 투과도와 면저항을 UV-vis-NIR spectroscopy와 I-V특성 측정장치를 사용하여 측정하였다. 투과도 83%에서 면저항 $250{\Omega}/sq$의 투명전극을 제작하였으며 전도성필름에 적합한 수준이다. Ag 나노섬유로 이루어진 투명 전극은 전기적, 광학적, 기계적 특성이 우수하여 차세대 유연 디스플레이에 적용 가능성을 보여준다.